Zebrafish as tools for drug discovery.

Nat Rev Drug Discov
Authors
Keywords
Abstract

The zebrafish has become a prominent vertebrate model for disease and has already contributed to several examples of successful phenotype-based drug discovery. For the zebrafish to become useful in drug development more broadly, key hurdles must be overcome, including a more comprehensive elucidation of the similarities and differences between human and zebrafish biology. Recent studies have begun to establish the capabilities and limitations of zebrafish for disease modelling, drug screening, target identification, pharmacology, and toxicology. As our understanding increases and as the technologies for manipulating zebrafish improve, it is hoped that the zebrafish will have a key role in accelerating the emergence of precision medicine.

Year of Publication
2015
Journal
Nat Rev Drug Discov
Volume
14
Issue
10
Pages
721-31
Date Published
2015 Oct
ISSN
1474-1784
URL
DOI
10.1038/nrd4627
PubMed ID
26361349
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