Watch now Broad is accelerating discovery Broad Institute is a multidisciplinary community of researchers on a mission to improve human health. About us Latest News 03.29.2023 Bacterial injection system delivers proteins in mice and human cells With further development, the programmable system could be used in a range of applications including gene therapy and cancer therapy. News 03.29.2023 Study reveals a driver of brain cell damage in neurodegeneration News 03.28.2023 Machine learning experts from around the world compete to improve cancer immunotherapy News 03.20.2023 Researchers identify key source of T cell "exhaustion" All news Our community Join Broad We are a research organization dedicated to better understanding the roots of disease and narrowing the gap between new biological insights and impact for patients. Institute Members Associate and Affiliate Members Professional scientists Early career scientists Administration Affinity groups Partner institutions How we work Research Disease areas Research areas Technology areas Cancer Our scientists are probing the mechanisms of cancer and applying this knowledge to enable precision cancer medicine. /cancer Cardiovascular disease By applying a variety of tools and technologies, researchers here are working to reduce the burden of cardiovascular disease. /cardiovascular-disease Diabetes Our researchers study the cellular roles and physiological impacts of genes associated with type 2 diabetes. /diabetes Infectious disease and the microbiome Researchers across the institute are working to understand infectious diseases, antibiotic resistance, and the human microbiome. /infectious-disease-microbiome Kidney disease Our scientists are cataloging the molecular causes of kidney diseases in order to develop mechanism-based treatments. /kidney-disease Obesity By studying the genetic determinants of body weight, our researchers work to identify targets for future obesity therapies. /obesity Psychiatric disorders We are committed to characterizing psychiatric disorders' molecular roots and turning new findings into new treatments. /psychiatric-disease Rare disease Our scientists search for the risk factors underlying rare genetic diseases to help reveal their biological underpinnings and improve patients' lives. /rare-disease Previous Next Cancer Cardiovascular disease Diabetes Infectious disease and the microbiome Kidney disease Obesity Psychiatric disorders Rare disease Chemical biology and therapeutic science We are fostering a diverse research community engaged in innovative chemical biology and therapeutic research. /chemical-biology-and-therapeutics-science Drug discovery Our Center for the Development of Therapeutics (CDoT) helps scientists advance biological insights to new treatments. /center-development-therapeutics-cdot Genome regulation, cellular circuitry, and epigenomics Our scientists are charting the vast landscape of molecular elements that define and regulate the cell. /genomeregulation-cellcircuitry-epigenomics Immunology Researchers across Broad are defining the immune cells and pathways that regulate physiologic and pathologic processes. /immunology Medical and population genetics An array of scientists here are collaborating to establish genomic variations' roles in human traits and disorders. /medical-population-genetics Metabolism Our researchers aim to decipher the metabolic basis of rare and common human diseases. /metabolism Previous Next Chemical biology and therapeutic science Drug discovery Genome regulation, cellular circuitry, and epigenomics Immunology Medical and population genetics Metabolism Data sciences Members of the Data Sciences Platform build open-source technologies that help researchers everywhere connect to the patients, datasets, and tools they need to do life-changing science. /data-sciences Genetic perturbation The Genetic Perturbation Platform drives the functional study of the genome by developing groundbreaking technologies for perturbing genes at scale. /genetic-perturbation-platform Genomics Genomic scientists here at Broad create foundational resources and study the genomic basis of human traits and diseases. /genomics Imaging Computationally mining cellular images' rich information content can propel discoveries in biology and medicine. /imaging Metabolomics Cells' metabolites reveal unique chemical fingerprints of both normal and pathological disease processes. /metabolomics Proteomics Broad proteomic researchers address important questions in biology, chemistry, and clinical science through collaboration and technology development. /proteomics Previous Next Data sciences Genetic perturbation Genomics Imaging Metabolomics Proteomics Watch the Broad Discovery Series The Broad Discovery Series (formerly Science For All Seasons) brings researchers to the stage to discuss and answer questions about some of the most pressing topics in science and medicine today. Visit the Broad Discovery Center Explore exhibits showcasing how scientists are advancing our understanding of disease. The museum is in the ground floor atrium of the Merkin building at 415 Main Street, Cambridge, MA and is free and open to the public. Rare Disease Day Watch the full event recording of "Accelerating Rare Disease Research: Patients As Partners" from February 27, 2023. Explore classroom resources Broad Institute offers free high school curriculum guides on genomics, cancer research, and more.