Type 2 diabetes (T2D) affects more than 415 million people worldwide and is a leading cause of morbidity and mortality across the globe.
Many large-scale, genome-wide investigations have sought to identify the genetic roots of T2D. Broad researchers study genes associated with the disease to uncover their molecular functions, their roles in relevant cell models, and their impacts on both mouse and human physiology. At the Broad, a community of scientists known as the Diabetes Research Group is dedicated to studying diabetes, with four major research aims: genetic discovery, functional validation, clinical translation, and therapeutic discovery.
The overarching goal of these efforts is to determine the genetic underpinnings of this disease and translate that knowledge into clinical and therapeutic interventions. Members of the Diabetes Research Group are dedicated to pursuing this new area of genetics research with the aim of contributing to improved medical care for those with or at risk of developing type 2 diabetes.