Chemical Biology and Therapeutics Science
Mission

The primary mission of the Chemical Biology and Therapeutics Science (CBTS) Program at the Broad Institute is to support community engagement in innovative chemical biology and therapeutics research.

X-ray co-crystal structure of B52 compound (cyan) binding and inhibiting Cyclophilin D protein
Credit: Aziz Rangwala
X-ray co-crystal structure of B52 compound (cyan) binding and inhibiting Cyclophilin D protein

About

The Chemical Biology and Therapeutics Science (CBTS) Program at the Broad Institute brings together a talented and diverse group of researchers that share a deep commitment to advancing biology and medicine through the use of chemistry and related molecular approaches. Recent advances have expanded the scope of chemical biology and therapeutics science to include: 

  • Breakthroughs in the use of macromolecules to study biology and modify our genomes and proteomes in therapeutically relevant ways.
  • Development of technologies that have transformed how small-molecule and macromolecular structure space can be explored to rapidly identify molecules with remarkable biological properties.
  • Innovative use of chemistry to provide an unprecedented view of previously unseen processes in living systems.
  • Integration of data from multiple technologies and knowledge sources to better understand the roles of small molecules in living systems. 
     

Chemical Biology and Therapeutics Science

Areas of Focus

Recent publications

Other Chemical Biology and Therapeutics Science publications
Phenotypic Screening for Small Molecules that Protect β-Cells from Glucolipotoxicity.
The Use of Informer Sets in Screening: Perspectives on an Efficient Strategy to Identify New Probes.
Second-generation DNA-templated macrocycle libraries for the discovery of bioactive small molecules.
Diversity-oriented synthesis yields novel multistage antimalarial inhibitors.
A programmable Cas9-serine recombinase fusion protein that operates on DNA sequences in mammalian cells.
Continuous evolution of Bacillus thuringiensis toxins overcomes insect resistance.
Inhibition of DYRK1A Stimulates Human β-Cell Proliferation.
Correlating chemical sensitivity and basal gene expression reveals mechanism of action.
Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage.
Development of potent in vivo mutagenesis plasmids with broad mutational spectra.

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