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Synthesis, cellular evaluation and mechanism-of-action of piperlongumine analogsAdams, DJ, Dai M., Pellegrino G., Wagner BK, Stern AM, Shamji AF, and Schreiber SL, (Submitted) Read More / View Supplemental Materials
2016
APOE polymorphisms influence longitudinal lipid trends preceding intracerebral hemorrhage.Phuah, CL, Raffeld MR, Ayres AM, Gurol ME, Viswanathan A., Greenberg SM, Biffi A., Rosand J., and Anderson CD Neurology. Genetics, 2016/08/01, Volume 2, Issue 4, p.e81, (2016) Read More / View Supplemental Materials
Abstract
Differential dopaminergic regulation of inwardly rectifying potassium channel mediated subthreshold dynamics in striatal medium spiny neurons.Zhao, B., Zhu J., Dai D., Xing J., He J., Fu Z., Zhang L., Li Z., and Wang W. Neuropharmacology, 2016/08/01, Volume 107, p.396-410, (2016) Read More / View Supplemental Materials
Abstract
A highly multiplexed and sensitive RNA-seq protocol for simultaneous analysis of host and pathogen transcriptomes.Avraham, R., Haseley N., Fan A., Bloom-Ackermann Z., Livny J., and Hung DT Nature protocols, 2016/08/01, Volume 11, Issue 8, p.1477-91, (2016) Read More / View Supplemental Materials
Abstract
Calcium intake and colorectal cancer risk: Results from the Nurses' Health Study and Health Professionals Follow-up Study.Zhang, X., Keum N., Wu K., Smith-Warner SA, Ogino S., Chan AT, Fuchs CS, and Giovannucci EL International journal of cancer, 2016/07/28, (2016) Read More / View Supplemental Materials
Abstract
Synthesis of sodium polyhydrides at high pressures.Struzhkin, VV, Kim DY, Stavrou E., Muramatsu T., Mao HK, Pickard CJ, Needs RJ, Prakapenka VB, and Goncharov AF Nature communications, 2016/07/28, Volume 7, p.12267, (2016) Read More / View Supplemental Materials
Abstract
Impaired Autophagy in Macrophages Promotes Inflammatory Eye Disease.Santeford, A., Wiley LA, Park S., Bamba S., Nakamura R., Gdoura A., Ferguson TA, Rao PK, Guan JL, Saitoh T., Akira S., Xavier R., Virgin HW, and Apte RS Autophagy, 2016/07/27, (2016) Read More / View Supplemental Materials
Abstract
Juicebox Provides a Visualization System for Hi-C Contact Maps with Unlimited Zoom.Durand, NC, Robinson JT, Shamim MS, Machol I., Mesirov J. P., Lander E. S., and Aiden EL Cell systems, 2016/07/27, Volume 3, Issue 1, p.99-101, (2016) Read More / View Supplemental Materials
Abstract
Juicer Provides a One-Click System for Analyzing Loop-Resolution Hi-C Experiments.Durand, NC, Shamim MS, Machol I., Rao SS, Huntley MH, Lander E. S., and Aiden EL Cell systems, 2016/07/27, Volume 3, Issue 1, p.95-98, (2016) Read More / View Supplemental Materials
Abstract
Aptamer-Based Proteomic Profiling Reveals Novel Candidate Biomarkers and Pathways in Cardiovascular Disease.Ngo, D., Sinha S., Shen D., Kuhn EW, Keyes MJ, Shi X., Benson MD, O'Sullivan JF, Keshishian H., Farrell LA, Fifer MA, Vasan RS, Sabatine MS, Larson MG, Carr SA, Wang TJ, and Gerszten RE Circulation, 2016/07/26, Volume 134, Issue 4, p.270-85, (2016) Read More / View Supplemental Materials
Abstract
Biomaterials for Metastasis: Bridging the Gap between Basic and Translational Research.Conde, J., Shomron N., and Artzi N. Advanced healthcare materials, 2016/07/26, (2016) Read More / View Supplemental Materials
Abstract
Functional analysis of rare variants found in schizophrenia implicates a critical role for GIT1-PAK3 signaling in neuroplasticity.Kim, MJ, Biag J., Fass DM, Lewis MC, Zhang Q., Fleishman M., Gangwar SP, Machius M., Fromer M., Purcell SM, McCarroll SA, Rudenko G., Premont RT, Scolnick EM, and Haggarty SJ Molecular psychiatry, 2016/07/26, (2016) Read More / View Supplemental Materials
Abstract
The impact of tumor profiling approaches and genomic data strategies for cancer precision medicine.Garofalo, A., Sholl L., Reardon B., Taylor-Weiner A., Amin-Mansour A., Miao D., Liu D., Oliver N., MacConaill L., Ducar M., Rojas-Rudilla V., Giannakis M., Ghazani A., Gray S., Janne P., Garber J., Joffe S., Lindeman N., Wagle N., Garraway LA, et al. Genome medicine, 2016/07/26, Volume 8, Issue 1, p.79, (2016) Read More / View Supplemental Materials
Abstract
Microglia contribute to circuit defects in Mecp2 null mice independent of microglia-specific loss of Mecp2 expression.Schafer, DP, Heller CT, Gunner G., Heller M., Gordon C., Hammond T., Wolf Y., Jung S., and Stevens B. eLife, 2016/07/26, Volume 5, (2016) Read More / View Supplemental Materials
Abstract
An exome array study of the plasma metabolome.Rhee, EP, Yang Q., Yu B., Liu X., Cheng S., Deik A., Pierce KA, Bullock K., Ho JE, Levy D., Florez JC, Kathiresan S., Larson MG, Vasan RS, Clish CB, Wang TJ, Boerwinkle E., O'Donnell CJ, and Gerszten RE Nature communications, 2016/07/25, Volume 7, p.12360, (2016) Read More / View Supplemental Materials
Abstract
Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis.van Rheenen, W., Shatunov A., Dekker AM, McLaughlin RL, Diekstra FP, Pulit SL, van der Spek RA, Võsa U., de Jong S., Robinson MR, Yang J., Fogh I., van Doormaal PT, Tazelaar GH, Koppers M., Blokhuis AM, Sproviero W., Jones AR, Kenna KP, van Eijk KR, et al. Nature genetics, 2016/07/25, (2016) Read More / View Supplemental Materials
Abstract
Genomic insights into the origin of farming in the ancient Near East.Lazaridis, I., Nadel D., Rollefson G., Merrett DC, Rohland N., Mallick S., Fernandes D., Novak M., Gamarra B., Sirak K., Connell S., Stewardson K., Harney E., Fu Q., Gonzalez-Fortes G., Jones ER, Roodenberg SA, Lengyel G., Bocquentin F., Gasparian B., et al. Nature, 2016/07/25, (2016) Read More / View Supplemental Materials
Abstract
The importance of serine metabolism in cancer.Mattaini, KR, Sullivan MR, and Vander Heiden MG The Journal of cell biology, 2016/07/25, (2016) Read More / View Supplemental Materials
Abstract
Local triple-combination therapy results in tumour regression and prevents recurrence in a colon cancer model.Conde, J., Oliva N., Zhang Y., and Artzi N. Nature materials, 2016/07/25, (2016) Read More / View Supplemental Materials
Abstract
Microglia: Phagocytosing to Clear, Sculpt, and Eliminate.Hong, S., and Stevens B. Developmental cell, 2016/07/25, Volume 38, Issue 2, p.126-8, (2016) Read More / View Supplemental Materials
Abstract
Multiplexed and scalable super-resolution imaging of three-dimensional protein localization in size-adjustable tissues.Ku, T., Swaney J., Park JY, Albanese A., Murray E., Cho JH, Park YG, Mangena V., Chen J., and Chung K. Nature biotechnology, 2016/07/25, (2016) Read More / View Supplemental Materials
Abstract
Relations of Arterial Stiffness and Brachial Flow-Mediated Dilation With New-Onset Atrial Fibrillation: The Framingham Heart Study.Shaikh, AY, Wang N., Yin X., Larson MG, Vasan RS, Hamburg NM, Magnani JW, Ellinor PT, Lubitz SA, Mitchell GF, Benjamin EJ, and McManus DD Hypertension, 2016/07/25, (2016) Read More / View Supplemental Materials
Abstract
Immediate Dysfunction of Vaccine-Elicited CD8+ T Cells Primed in the Absence of CD4+ T Cells.Provine, NM, Larocca RA, Aid M., Penaloza-MacMaster P., Badamchi-Zadeh A., Borducchi EN, Yates KB, Abbink P., Kirilova M., Ng'ang'a D., Bramson J., Haining WN, and Barouch DH Journal of immunology (Baltimore, Md. : 1950), 2016/07/22, (2016) Read More / View Supplemental Materials
Abstract
Infection of laboratory colonies of Anopheles mosquitoes with Plasmodium vivax from cryopreserved clinical isolates.Shaw-Saliba, K., Clarke D., Santos JM, Menezes MJ, Lim C., Mascarenhas A., Chery L., Gomes E., March S., Bhatia SN, Rathod PK, Ferreira MU, Catteruccia F., and Duraisingh MT International journal for parasitology, 2016/07/22, (2016) Read More / View Supplemental Materials
Abstract
Creating Single-Copy Genetic Circuits.Lee, JW, Gyorgy A., Cameron DE, Pyenson N., Choi KR, Way JC, Silver PA, Del Vecchio D., and Collins JJ Molecular cell, 2016/07/21, Volume 63, Issue 2, p.329-36, (2016) Read More / View Supplemental Materials
Abstract
Neuron-Targeted Nanoparticle for siRNA Delivery to Traumatic Brain Injuries.Kwon, EJ, Skalak M., Lo Bu R., and Bhatia SN ACS nano, 2016/07/21, (2016) Read More / View Supplemental Materials
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Standardizing terms for clinical pharmacogenetic test results: consensus terms from the Clinical Pharmacogenetics Implementation Consortium (CPIC).Caudle, KE, Dunnenberger HM, Freimuth RR, Peterson JF, Burlison JD, Whirl-Carrillo M., Scott SA, Rehm HL, Williams MS, Klein TE, Relling MV, and Hoffman JM Genetics in medicine : official journal of the American College of Medical Genetics, 2016/07/21, (2016) Read More / View Supplemental Materials
Abstract
Biallelic Mutations in Citron Kinase Link Mitotic Cytokinesis to Human Primary Microcephaly.Li, H., Bielas SL, Zaki MS, Ismail S., Farfara D., Um K., Rosti RO, Scott EC, Tu S., Chi NC, Gabriel S., Erson-Omay EZ, Ercan-Sencicek AG, Yasuno K., Çağlayan AO, Kaymakçalan H., Ekici B., Bilguvar K., Gunel M., and Gleeson JG American journal of human genetics, 2016/07/20, (2016) Read More / View Supplemental Materials
Abstract
Synchronized cycles of bacterial lysis for in vivo delivery.Din, MO, Danino T., Prindle A., Skalak M., Selimkhanov J., Allen K., Julio E., Atolia E., Tsimring LS, Bhatia SN, and Hasty J. Nature, 2016/07/20, (2016) Read More / View Supplemental Materials
Abstract
CRISPR/Cas9 Screens Reveal Requirements for Host Cell Sulfation and Fucosylation in Bacterial Type III Secretion System-Mediated Cytotoxicity.Blondel, CJ, Park JS, Hubbard TP, Pacheco AR, Kuehl CJ, Walsh MJ, Davis BM, Gewurz BE, Doench JG, and Waldor MK Cell host & microbe, 2016/07/19, (2016) Read More / View Supplemental Materials
Abstract
A global call for action to include gender in research impact assessment.Ovseiko, PV, Greenhalgh T., Adam P., Grant J., Hinrichs-Krapels S., Graham KE, Valentine PA, Sued O., Boukhris OF, Al Olaqi NM, Al Rahbi IS, Dowd AM, Bice S., Heiden TL, Fischer MD, Dopson S., Norton R., Pollitt A., Wooding S., Balling GV, et al. Health research policy and systems / BioMed Central, 2016/07/19, Volume 14, Issue 1, p.50, (2016) Read More / View Supplemental Materials
Abstract
Marine ω-3 polyunsaturated fatty acid intake and survival after colorectal cancer diagnosis.Song, M., Zhang X., Meyerhardt JA, Giovannucci EL, Ogino S., Fuchs CS, and Chan AT Gut, 2016/07/19, (2016) Read More / View Supplemental Materials
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Selectivity of ORC binding sites and the relation to replication timing, fragile sites, and deletions in cancers.Miotto, B., Ji Z., and Struhl K. Proceedings of the National Academy of Sciences of the United States of America, 2016/07/19, (2016) Read More / View Supplemental Materials
Abstract
Characterization of Greater Middle Eastern genetic variation for enhanced disease gene discovery.Scott, EM, Halees A., Itan Y., Spencer EG, He Y., Azab MA, Gabriel SB, Belkadi A., Boisson B., Abel L., Clark AG, Greater Middle East Variome Consortium, Alkuraya FS, Casanova JL, and Gleeson JG Nature genetics, 2016/07/18, (2016) Read More / View Supplemental Materials
Abstract
Deletion of DXZ4 on the human inactive X chromosome alters higher-order genome architecture.Darrow, EM, Huntley MH, Dudchenko O., Stamenova EK, Durand NC, Sun Z., Huang SC, Sanborn AL, Machol I., Shamim M., Seberg AP, Lander E. S., Chadwick BP, and Aiden EL Proceedings of the National Academy of Sciences of the United States of America, 2016/07/18, (2016) Read More / View Supplemental Materials
Abstract
Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior.Nott, A., Cheng J., Gao F., Lin YT, Gjoneska E., Ko T., Minhas P., Zamudio AV, Meng J., Zhang F., Jin P., and Tsai LH Nature neuroscience, 2016/07/18, (2016) Read More / View Supplemental Materials
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Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth.Cox, AG, Hwang KL, Brown KK, Evason KJ, Beltz S., Tsomides A., O'Connor K., Galli GG, Yimlamai D., Chhangawala S., Yuan M., Lien EC, Wucherpfennig J., Nissim S., Minami A., Cohen DE, Camargo FD, Asara JM, Houvras Y., Stainier DY, et al. Nature cell biology, 2016/07/18, (2016) Read More / View Supplemental Materials
Abstract
Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types.Kar, SP, Beesley J., Amin Al Olama A., Michailidou K., Tyrer J., Kote-Jarai Z., Lawrenson K., Lindstrom S., Ramus SJ, Thompson DJ, ABCTB Investigators, Kibel AS, Dansonka-Mieszkowska A., Michael A., Dieffenbach AK, Gentry-Maharaj A., Whittemore AS, Wolk A., Monteiro A., Peixoto A., et al. Cancer discovery, 2016/07/17, (2016) Read More / View Supplemental Materials
Abstract
Association of Exome Sequences with Cardiovascular Traits among African Americans in the Jackson Heart Study.Peloso, GM, Lange LA, Varga TV, Nickerson DA, Smith JD, Griswold ME, Musani S., Polfus LM, Mei H., Gabriel S., Quarells RC, Altshuler D., Boerwinkle E., Daly M. J., Neale B., Correa A., Reiner AP, Wilson JG, and Kathiresan S. Circulation. Cardiovascular genetics, 2016/07/15, (2016) Read More / View Supplemental Materials
Abstract
Genome-wide association study of the modified Stumvoll Insulin Sensitivity Index identifies BCL2 and FAM19A2 as novel insulin sensitivity loci.Walford, GA, Gustafsson S., Rybin D., Stančáková A., Chen H., Liu CT, Hong J., Jensen RA, Rice K., Morris AP, Mägi R., Tönjes A., Prokopenko I., Kleber ME, Delgado G., Silbernagel G., Jackson AU, Appel EV, Grarup N., Lewis JP, et al. Diabetes, 2016/07/14, (2016) Read More / View Supplemental Materials
Abstract
Ipilimumab for Patients with Relapse after Allogeneic Transplantation.Davids, MS, Kim HT, Bachireddy P., Costello C., Liguori R., Savell A., Lukez AP, Avigan D., Chen YB, McSweeney P., LeBoeuf NR, Rooney MS, Bowden M., Zhou CW, Granter SR, Hornick JL, Rodig SJ, Hirakawa M., Severgnini M., Hodi FS, et al. The New England journal of medicine, 2016/07/14, Volume 375, Issue 2, p.143-53, (2016) Read More / View Supplemental Materials
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CRISPR Screens to Discover Functional Noncoding Elements.Wright, JB, and Sanjana NE Trends in genetics : TIG, 2016/07/13, (2016) Read More / View Supplemental Materials
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Dysbiosis, inflammation, and response to treatment: a longitudinal study of pediatric subjects with newly diagnosed inflammatory bowel disease.Shaw, KA, Bertha M., Hofmekler T., Chopra P., Vatanen T., Srivatsa A., Prince J., Kumar A., Sauer C., Zwick ME, Satten GA, Kostic AD, Mulle JG, Xavier RJ, and Kugathasan S. Genome medicine, 2016/07/13, Volume 8, Issue 1, p.75, (2016) Read More / View Supplemental Materials
Abstract
Loss-of-function mutations in the C9ORF72 mouse ortholog cause fatal autoimmune disease.Burberry, A., Suzuki N., Wang JY, Moccia R., Mordes DA, Stewart MH, Suzuki-Uematsu S., Ghosh S., Singh A., Merkle FT, Koszka K., Li QZ, Zon L., Rossi DJ, Trowbridge JJ, Notarangelo LD, and Eggan K. Science translational medicine, 2016/07/13, Volume 8, Issue 347, p.347ra93, (2016) Read More / View Supplemental Materials
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Mobile genes in the human microbiome are structured from global to individual scales.Brito, IL, Yilmaz S., Huang K., Xu L., Jupiter SD, Jenkins AP, Naisilisili W., Tamminen M., Smillie CS, Wortman JR, Birren BW, Xavier RJ, Blainey PC, Singh AK, Gevers D., and Alm EJ Nature, 2016/07/13, (2016) Read More / View Supplemental Materials
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Type IV collagen drives alveolar epithelial-endothelial association and the morphogenetic movements of septation.Loscertales, M., Nicolaou F., Jeanne M., Longoni M., Gould DB, Sun Y., Maalouf FI, Nagy N., and Donahoe PK BMC biology, 2016/07/13, Volume 14, Issue 1, p.59, (2016) Read More / View Supplemental Materials
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Uncovering the Role of the Methylome in Dementia and Neurodegeneration.Klein, HU, and De Jager PL Trends in molecular medicine, 2016/07/13, (2016) Read More / View Supplemental Materials
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Genome-wide common and rare variant analysis provides novel insights into clozapine-associated neutropenia.Legge, SE, Hamshere ML, Ripke S., Pardinas AF, Goldstein JI, Rees E., Richards AL, Leonenko G., Jorskog LF, Clozapine-Induced Agranulocytosis Consortium, Chambert KD, Collier DA, Genovese G., Giegling I., Holmans P., Jonasdottir A., Kirov G., McCarroll SA, MacCabe JH, Mantripragada K., et al. Molecular psychiatry, 2016/07/12, (2016) Read More / View Supplemental Materials
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Joint Bayesian inference of risk variants and tissue-specific epigenomic enrichments across multiple complex human diseases.Li, Y., and Kellis M. Nucleic acids research, 2016/07/12, (2016) Read More / View Supplemental Materials
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Non-targeted metabolomics combined with genetic analyses identifies bile acid synthesis and phospholipid metabolism as being associated with incident type 2 diabetes.Fall, T., Salihovic S., Brandmaier S., Nowak C., Ganna A., Gustafsson S., Broeckling CD, Prenni JE, Kastenmüller G., Peters A., Magnusson PK, Wang-Sattler R., Giedraitis V., Berne C., Gieger C., Pedersen NL, Ingelsson E., and Lind L. Diabetologia, 2016/07/12, (2016) Read More / View Supplemental Materials
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V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog A Synthetic Modified mRNA Drives Reprogramming of Human Pancreatic Duct-Derived Cells Into Insulin-Secreting Cells.Corritore, E., Lee YS, Pasquale V., Liberati D., Hsu MJ, Lombard CA, Van Der Smissen P., Vetere A., Bonner-Weir S., Piemonti L., Sokal E., and Lysy P. Stem cells translational medicine, 2016/07/12, (2016) Read More / View Supplemental Materials
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The genetic architecture of type 2 diabetes.Fuchsberger, C., Flannick J., Teslovich TM, Mahajan A., Agarwala V., Gaulton KJ, Ma C., Fontanillas P., Moutsianas L., McCarthy DJ, Rivas MA, Perry JR, Sim X., Blackwell TW, Robertson NR, Rayner NW, Cingolani P., Locke AE, Tajes JF, Highland HM, et al. Nature, 2016/07/11, (2016) Read More / View Supplemental Materials
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An Outbreak of Ebola Virus Disease in the Lassa Fever Zone.Goba, A., Khan SH, Fonnie M., Fullah M., Moigboi A., Kovoma A., Sinnah V., Yoko N., Rogers H., Safai S., Momoh M., Koroma V., Kamara FK, Konowu E., Yillah M., French I., Mustapha I., Kanneh F., Foday M., McCarthy H., et al. The Journal of infectious diseases, 2016/07/11, (2016) Read More / View Supplemental Materials
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Type 2 diabetes: genetic data sharing to advance complex disease research.Flannick, J., and Florez JC Nature reviews. Genetics, 2016/07/11, (2016) Read More / View Supplemental Materials
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Estrogen-related receptor gamma implicated in a phenotype including hearing loss and mild developmental delay.Schilit, SL, Currall BB, Yao R., Hanscom C., Collins RL, Pillalamarri V., Lee DY, Kammin T., Zepeda-Mendoza CJ, Mononen T., Nolan LS, Gusella JF, Talkowski ME, Shen J., and Morton CC European journal of human genetics : EJHG, 2016/07/06, (2016) Read More / View Supplemental Materials
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Multiple mechanisms disrupt the let-7 microRNA family in neuroblastoma.Powers, JT, Tsanov KM, Pearson DS, Roels F., Spina CS, Ebright R., Seligson M., de Soysa Y., Cahan P., Theißen J., Tu HC, Han A., Kurek KC, LaPier GS, Osborne JK, Ross SJ, Cesana M., Collins JJ, Berthold F., and Daley GQ Nature, 2016/07/06, Volume 535, Issue 7611, p.246-51, (2016) Read More / View Supplemental Materials
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Polygenic risk of Alzheimer disease is associated with early- and late-life processes.Mormino, EC, Sperling RA, Holmes AJ, Buckner RL, De Jager PL, Smoller JW, Sabuncu MR, and Alzheimer's Disease Neuroimaging Initiative Neurology, 2016/07/06, (2016) Read More / View Supplemental Materials
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Association of a Genetic Risk Score With Body Mass Index Across Different Birth Cohorts.Walter, S., Mejía-Guevara I., Estrada K., Liu SY, and Glymour MM JAMA, 2016/07/05, Volume 316, Issue 1, p.63-9, (2016) Read More / View Supplemental Materials
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A Child's HLA-DRB1 genotype increases maternal risk of systemic lupus erythematosus.Cruz, GI, Shao X., Quach H., Ho KA, Sterba K., Noble JA, Patsopoulos NA, Busch MP, Triulzi DJ, Wong WS, Solomon BD, Niederhuber JE, Criswell LA, and Barcellos LF Journal of autoimmunity, 2016/07/04, (2016) Read More / View Supplemental Materials
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Ebola Virus Epidemiology and Evolution in Nigeria.Folarin, OA, Ehichioya D., Schaffner SF, Winnicki SM, Wohl S., Eromon P., West KL, Gladden-Young A., Oyejide NE, Matranga CB, Deme AB, James A., Tomkins-Tinch C., Onyewurunwa K., Ladner JT, Palacios G., Nosamiefan I., Andersen KG, Omilabu S., Park DJ, et al. The Journal of infectious diseases, 2016/07/04, (2016) Read More / View Supplemental Materials
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Inter-individual variability and genetic influences on cytokine responses to bacteria and fungi.Li, Y., Oosting M., Deelen P., Ricaño-Ponce I., Smeekens S., Jaeger M., Matzaraki V., Swertz MA, Xavier RJ, Franke L., Wijmenga C., Joosten LA, Kumar V., and Netea MG Nature medicine, 2016/07/04, (2016) Read More / View Supplemental Materials
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The landscape of chromosomal aberrations in breast cancer mouse models reveals driver-specific routes to tumorigenesis.Ben-David, U., Ha G., Khadka P., Jin X., Wong B., Franke L., and Golub T. R. Nature communications, 2016/07/04, Volume 7, p.12160, (2016) Read More / View Supplemental Materials
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SwiSpot: Modeling Riboswitches by Spotting Out Switching Sequences.Barsacchi, M., Novoa EM, Kellis M., and Bechini A. Bioinformatics (Oxford, England), 2016/07/04, (2016) Read More / View Supplemental Materials
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Atrial fibrillation without comorbidities: Prevalence, incidence and prognosis (from the Framingham Heart Study).Kim, EJ, Yin X., Fontes JD, Magnani JW, Lubitz SA, McManus DD, Seshadri S., Vasan RS, Ellinor PT, Larson MG, Benjamin EJ, and Rienstra M. American heart journal, 2016/07/01, Volume 177, p.138-44, (2016) Read More / View Supplemental Materials
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Catechol-O-methyltransferase association with hemoglobin A1c.Hall, KT, Jablonski KA, Chen L., Harden M., Tolkin BR, Kaptchuk TJ, Bray GA, Ridker PM, Florez JC, Diabetes Prevention Program Research Group, Mukamal KJ, and Chasman DI Metabolism: clinical and experimental, 2016/07/01, Volume 65, Issue 7, p.961-7, (2016) Read More / View Supplemental Materials
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Control theory meets synthetic biology.Del Vecchio, D., Dy AJ, and Qian Y. Journal of the Royal Society, Interface / the Royal Society, 2016/07/01, Volume 13, Issue 120, (2016) Read More / View Supplemental Materials
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De novo frameshift mutation in COUP-TFII (NR2F2) in human congenital diaphragmatic hernia.High, FA, Bhayani P., Wilson JM, Bult CJ, Donahoe PK, and Longoni M. American journal of medical genetics. Part A, 2016/07/01, (2016) Read More / View Supplemental Materials
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A Frameshift in CSF2RB Predominant Among Ashkenazi Jews Increases Risk for Crohn's Disease and Reduces Monocyte Signaling via GMCSF.Chuang, LS, Villaverde N., Hui KY, Mortha A., Rahman A., Levine AP, Haritunians T., Ng SM, Zhang W., Hsu NY, Facey JA, Luong T., Fernandez-Hernandez H., Li D., Rivas M., Schiff ER, Gusev A., Schumm LP, Bowen BM, Sharma Y., et al. Gastroenterology, 2016/07/01, (2016) Read More / View Supplemental Materials
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The Genetic Landscape of β-Cell Proliferation: Toward a Road Map.Wagner, BK Diabetes, 2016/07/01, Volume 65, Issue 7, p.1789-90, (2016) Read More / View Supplemental Materials
Genome-wide Association Studies of Posttraumatic Stress Disorder in 2 Cohorts of US Army Soldiers.Stein, MB, Chen CY, Ursano RJ, Cai T., Gelernter J., Heeringa SG, Jain S., Jensen KP, Maihofer AX, Mitchell C., Nievergelt CM, Nock MK, Neale BM, Polimanti R., Ripke S., Sun X., Thomas ML, Wang Q., Ware EB, Borja S., et al. JAMA psychiatry, 2016/07/01, Volume 73, Issue 7, p.695-704, (2016) Read More / View Supplemental Materials
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Genome-wide association study identifies multiple susceptibility loci for multiple myeloma.Mitchell, JS, Li N., Weinhold N., Försti A., Ali M., van Duin M., Thorleifsson G., Johnson DC, Chen B., Halvarsson BM, Gudbjartsson DF, Kuiper R., Stephens OW, Bertsch U., Broderick P., Campo C., Einsele H., Gregory WA, Gullberg U., Henrion M., et al. Nature communications, 2016/07/01, Volume 7, p.12050, (2016) Read More / View Supplemental Materials
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Leveraging Genetics to Advance Type 2 Diabetes Prevention.Florez, JC PLoS medicine, 2016/07/01, Volume 13, Issue 7, p.e1002102, (2016) Read More / View Supplemental Materials
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Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.Van Voorhis, WC, Adams JH, Adelfio R., Ahyong V., Akabas MH, Alano P., Alday A., Alemán Resto Y., Alsibaee A., Alzualde A., Andrews KT, Avery SV, Avery VM, Ayong L., Baker M., Baker S., Ben Mamoun C., Bhatia S., Bickle Q., Bounaadja L., et al. PLoS pathogens, 2016/07/01, Volume 12, Issue 7, p.e1005763, (2016) Read More / View Supplemental Materials
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Prostate Cancer Susceptibility in Men of African Ancestry at 8q24.Han, Y., Rand KA, Hazelett DJ, Ingles SA, Kittles RA, Strom SS, Rybicki BA, Nemesure B., Isaacs WB, Stanford JL, Zheng W., Schumacher FR, Berndt SI, Wang Z., Xu J., Rohland N., Reich D., Tandon A., Pasaniuc B., Allen A., et al. Journal of the National Cancer Institute, 2016/07/01, Volume 108, Issue 7, (2016) Read More / View Supplemental Materials
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Relation of genomic variants for Alzheimer disease dementia to common neuropathologies.Farfel, JM, Yu L., Buchman AS, Schneider JA, De Jager PL, and Bennett DA Neurology, 2016/07/01, (2016) Read More / View Supplemental Materials
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Whole-Exome Sequencing in Two Extreme Phenotypes of Response to VEGF-Targeted Therapies in Patients With Metastatic Clear Cell Renal Cell Carcinoma.Fay, AP, De Velasco G., Ho TH, Van Allen EM, Murray B., Albiges L., Signoretti S., Hakimi AA, Stanton ML, Bellmunt J., McDermott DF, Atkins MB, Garraway LA, Kwiatkowski DJ, and Choueiri TK Journal of the National Comprehensive Cancer Network : JNCCN, 2016/07/01, Volume 14, Issue 7, p.820-4, (2016) Read More / View Supplemental Materials
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Roots, Not Parachutes: Research Collaborations Combat Outbreaks.Yozwiak, NL, Happi CT, Grant DS, Schieffelin JS, Garry RF, Sabeti PC, and Andersen KG Cell, 2016/06/30, Volume 166, Issue 1, p.5-8, (2016) Read More / View Supplemental Materials
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Use of Multiple Sequencing Technologies To Produce a High-Quality Genome of the Fungus Pseudogymnoascus destructans, the Causative Agent of Bat White-Nose Syndrome.Drees, KP, Palmer JM, Sebra R., Lorch JM, Chen C., Wu CC, Bok JW, Keller NP, Blehert DS, Cuomo CA, Lindner DL, and Foster JT Genome announcements, 2016/06/30, Volume 4, Issue 3, (2016) Read More / View Supplemental Materials
Abstract
Discovery of a Highly Selective Glycogen Synthase Kinase-3 Inhibitor (PF-04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET Neuroimaging.Liang, SH, Chen JM, Normandin MD, Chang JS, Chang GC, Taylor CK, Trapa P., Plummer MS, Para KS, Conn EL, Lopresti-Morrow L., Lanyon LF, Cook JM, Richter KE, Nolan CE, Schachter JB, Janat F., Che Y., Shanmugasundaram V., Lefker BA, et al. Angewandte Chemie (International ed. in English), 2016/06/29, (2016) Read More / View Supplemental Materials
Abstract
Multiple regulatory variants located in cell type-specific enhancers within the PKP2 locus form major risk and protective haplotypes for canine atopic dermatitis in German shepherd dogs.Tengvall, K., Kozyrev S., Kierczak M., Bergvall K., Farias FH, Ardesjö-Lundgren B., Olsson M., Murén E., Hagman R., Leeb T., Pielberg G., Hedhammar Å., Andersson G., and Lindblad-Toh K. BMC genetics, 2016/06/29, Volume 17, Issue 1, p.97, (2016) Read More / View Supplemental Materials
Abstract
Structural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contacts.Guaitoli, G., Raimondi F., Gilsbach BK, Gómez-Llorente Y., Deyaert E., Renzi F., Li X., Schaffner A., Jagtap PK, Boldt K., von Zweydorf F., Gotthardt K., Lorimer DD, Yue Z., Burgin A., Janjic N., Sattler M., Versées W., Ueffing M., Ubarretxena-Belandia I., et al. Proceedings of the National Academy of Sciences of the United States of America, 2016/06/29, (2016) Read More / View Supplemental Materials
Abstract
Association of tumour microRNA profiling with outcomes in patients with advanced urothelial carcinoma receiving first-line platinum-based chemotherapy.Bellmunt, J., Zhou CW, Mullane SA, Werner L., Taplin ME, Fay AP, Choueiri TK, Orsola A., Takeda DY, Hahn WC, Kim J., Sonpavde G., and Bowden M. British journal of cancer, 2016/06/28, Volume 115, Issue 1, p.12-9, (2016) Read More / View Supplemental Materials
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Excess of Deleterious Mutations around HLA Genes Reveals Evolutionary Cost of Balancing Selection.Lenz, TL, Spirin V., Jordan DM, and Sunyaev SR Molecular biology and evolution, 2016/06/28, (2016) Read More / View Supplemental Materials
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A peptide for targeted, systemic delivery of imaging and therapeutic compounds into acute brain injuries.Mann, AP, Scodeller P., Hussain S., Joo J., Kwon E., Braun GB, Mölder T., She ZG, Kotamraju VR, Ranscht B., Krajewski S., Teesalu T., Bhatia S., Sailor MJ, and Ruoslahti E. Nature communications, 2016/06/28, Volume 7, p.11980, (2016) Read More / View Supplemental Materials
Abstract
The genomic landscape and evolution of endometrial carcinoma progression and abdominopelvic metastasis.Gibson, WJ, Hoivik EA, Halle MK, Taylor-Weiner A., Cherniack AD, Berg A., Holst F., Zack TI, Werner HM, Staby KM, Rosenberg M., Stefansson IM, Kusonmano K., Chevalier A., Mauland KK, Trovik J., Krakstad C., Giannakis M., Hodis E., Woie K., et al. Nature genetics, 2016/06/27, (2016) Read More / View Supplemental Materials
Abstract
Hydrophobic CDR3 residues promote the development of self-reactive T cells.Stadinski, BD, Shekhar K., Gómez-Touriño I., Jung J., Sasaki K., Sewell AK, Peakman M., Chakraborty AK, and Huseby ES Nature immunology, 2016/06/27, (2016) Read More / View Supplemental Materials
Abstract
Information recovery from low coverage whole-genome bisulfite sequencing.Libertini, E., Heath SC, Hamoudi RA, Gut M., Ziller MJ, Czyz A., Ruotti V., Stunnenberg HG, Frontini M., Ouwehand WH, Meissner A., Gut IG, and Beck S. Nature communications, 2016/06/27, Volume 7, p.11306, (2016) Read More / View Supplemental Materials
Abstract
Population genomics studies identify signatures of global dispersal and drug resistance in Plasmodium vivax.Hupalo, DN, Luo Z., Melnikov A., Sutton PL, Rogov P., Escalante A., Vallejo AF, Herrera S., Arévalo-Herrera M., Fan Q., Wang Y., Cui L., Lucas CM, Durand S., Sanchez JF, Baldeviano GC, Lescano AG, Laman M., Barnadas C., Barry A., et al. Nature genetics, 2016/06/27, (2016) Read More / View Supplemental Materials
Abstract
Saturation analysis for whole-genome bisulfite sequencing data.Libertini, E., Heath SC, Hamoudi RA, Gut M., Ziller MJ, Herrero J., Czyz A., Ruotti V., Stunnenberg HG, Frontini M., Ouwehand WH, Meissner A., Gut IG, and Beck S. Nature biotechnology, 2016/06/27, (2016) Read More / View Supplemental Materials
Synthesis and Evaluation of Ciprofloxacin-Nitroxide Conjugates as Anti-Biofilm Agents.Verderosa, AD, Mansour SC, de la Fuente-Núñez C., Hancock RE, and Fairfull-Smith KE Molecules (Basel, Switzerland), 2016/06/27, Volume 21, Issue 7, (2016) Read More / View Supplemental Materials
Abstract
CellProfiler Analyst: interactive data exploration, analysis, and classification of large biological image sets.Dao, D., Fraser AN, Hung J., Ljosa V., Singh S., and Carpenter AE Bioinformatics (Oxford, England), 2016/06/26, (2016) Read More / View Supplemental Materials
Abstract
Subcellular Changes in Bridging Integrator 1 Protein Expression in the Cerebral Cortex During the Progression of Alzheimer Disease Pathology.Adams, SL, Tilton K., Kozubek JA, Seshadri S., and Delalle I. Journal of neuropathology and experimental neurology, 2016/06/26, (2016) Read More / View Supplemental Materials
Abstract
Mice with mutant Inf2 show impaired podocyte and slit diaphragm integrity in response to protamine-induced kidney injury.Subramanian, B., Sun H., Yan P., Charoonratana VT, Higgs HN, Wang F., Lai KV, Valenzuela DM, Brown EJ, Schlöndorff JS, and Pollak MR Kidney international, 2016/06/24, (2016) Read More / View Supplemental Materials
Abstract
Baeyer-Villiger Monooxygenases EthA and MymA Are Required for Activation of Replicating and Non-replicating Mycobacterium tuberculosis Inhibitors.Grant, SS, Wellington S., Kawate T., Desjardins CA, Silvis MR, Wivagg C., Thompson M., Gordon K., Kazyanskaya E., Nietupski R., Haseley N., Iwase N., Earl AM, FitzGerald M., and Hung DT Cell chemical biology, 2016/06/23, Volume 23, Issue 6, p.666-77, (2016) Read More / View Supplemental Materials
Abstract
Mendelian randomisation analysis strongly implicates adiposity with risk of developing colorectal cancer.Jarvis, D., Mitchell JS, Law PJ, Palin K., Tuupanen S., Gylfe A., Hänninen UA, Cajuso T., Tanskanen T., Kondelin J., Kaasinen E., Sarin AP, Kaprio J., Eriksson JG, Rissanen H., Knekt P., Pukkala E., Jousilahti P., Salomaa V., Ripatti S., et al. British journal of cancer, 2016/06/23, (2016) Read More / View Supplemental Materials
Abstract
Integrated genetic and pharmacologic interrogation of rare cancers.Hong, AL, Tseng YY, Cowley GS, Jonas O., Cheah JH, Kynnap BD, Doshi MB, Oh C., Meyer SC, Church AJ, Gill S., Bielski CM, Keskula P., Imamovic A., Howell S., Kryukov GV, Clemons PA, Tsherniak A., Vazquez F., Crompton BD, et al. Nature communications, 2016/06/22, Volume 7, p.11987, (2016) Read More / View Supplemental Materials
Abstract
Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors.Wagner, FF, Weïwer M., Steinbacher S., Schomburg A., Reinemer P., Gale JP, Campbell AJ, Fisher SL, Zhao WN, Reis SA, Hennig KM, Thomas M., Müller P., Jefson MR, Fass DM, Haggarty SJ, Zhang YL, and Holson EB Bioorganic & medicinal chemistry, 2016/06/22, (2016) Read More / View Supplemental Materials
Abstract
Microfluidic neurite guidance to study structure-function relationships in topologically-complex population-based neural networks.Honegger, T., Thielen MI, Feizi S., Sanjana NE, and Voldman J. Scientific reports, 2016/06/22, Volume 6, p.28384, (2016) Read More / View Supplemental Materials
Abstract
RBPJ Controls Development of Pathogenic Th17 Cells by Regulating IL-23 Receptor Expression.Meyer Zu Horste, G., Wu C., Wang C., Cong L., Pawlak M., Lee Y., Elyaman W., Xiao S., Regev A., and Kuchroo VK Cell reports, 2016/06/22, (2016) Read More / View Supplemental Materials
Abstract
Development of autologous blood cell therapies.Kim, AR, and Sankaran VG Experimental hematology, 2016/06/21, (2016) Read More / View Supplemental Materials
Abstract
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