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Submitted
Synthesis, cellular evaluation and mechanism-of-action of piperlongumine analogsAdams, DJ, Dai M., Pellegrino G., Wagner BK, Stern AM, Shamji AF, and Schreiber SL, (Submitted) Read More / View Supplemental Materials
2016
Prostate Cancer Susceptibility in Men of African Ancestry at 8q24.Han, Y., Rand KA, Hazelett DJ, Ingles SA, Kittles RA, Strom SS, Rybicki BA, Nemesure B., Isaacs WB, Stanford JL, Zheng W., Schumacher FR, Berndt SI, Wang Z., Xu J., Rohland N., Reich D., Tandon A., Pasaniuc B., Allen A., et al. Journal of the National Cancer Institute, 2016/07/01, Volume 108, Issue 7, (2016) Read More / View Supplemental Materials
Abstract
Blood metabolomics analysis identifies abnormalities in the citric acid cycle, urea cycle, and amino acid metabolism in bipolar disorder.Yoshimi, N., Futamura T., Kakumoto K., Salehi AM, Sellgren CM, Holmén-Larsson J., Jakobsson J., Pålsson E., Landén M., and Hashimoto K. BBA clinical, 2016/06/01, Volume 5, p.151-8, (2016) Read More / View Supplemental Materials
Abstract
Circulating Metabolites and Survival Among Patients With Pancreatic Cancer.Yuan, C., Clish CB, Wu C., Mayers JR, Kraft P., Townsend MK, Zhang M., Tworoger SS, Bao Y., Qian ZR, Rubinson DA, Ng K., Giovannucci EL, Ogino S., Stampfer MJ, Gaziano JM, Ma J., Sesso HD, Anderson GL, Cochrane BB, et al. Journal of the National Cancer Institute, 2016/06/01, Volume 108, Issue 6, (2016) Read More / View Supplemental Materials
Abstract
Antidepressant-like effect of low dose ketamine and scopolamine co-treatment in mice.Petryshen, TL, Lewis MC, Dennehy KA, Garza JC, and Fava M. Neuroscience letters, 2016/05/04, Volume 620, p.70-3, (2016) Read More / View Supplemental Materials
Abstract
Atrial Fibrillation and Declining Physical Performance in Older Adults: The Health, Aging, and Body Composition Study.Magnani, JW, Wang N., Benjamin EJ, Garcia ME, Bauer DC, Butler J., Ellinor PT, Kritchevsky S., Marcus GM, Newman A., Phillips CL, Sasai H., Satterfield S., Sullivan LM, Harris TB, and and Health, Aging Body Composition Study Circulation. Arrhythmia and electrophysiology, 2016/05/01, Volume 9, Issue 5, p.e003525, (2016) Read More / View Supplemental Materials
Abstract
Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity.Zhernakova, A., Kurilshikov A., Bonder MJ, Tigchelaar EF, Schirmer M., Vatanen T., Mujagic Z., Vila AV, Falony G., Vieira-Silva S., Wang J., Imhann F., Brandsma E., Jankipersadsing SA, Joossens M., Cenit MC, Deelen P., Swertz MA, study LifeLines Cohort, Weersma RK, et al. Science (New York, N.Y.), 2016/04/29, Volume 352, Issue 6285, p.565-9, (2016) Read More / View Supplemental Materials
Abstract
CEL-Seq2: sensitive highly-multiplexed single-cell RNA-Seq.Hashimshony, T., Senderovich N., Avital G., Klochendler A., de Leeuw Y., Anavy L., Gennert D., Li S., Livak KJ, Rozenblatt-Rosen O., Dor Y., Regev A., and Yanai I. Genome biology, 2016/04/28, Volume 17, Issue 1, p.77, (2016) Read More / View Supplemental Materials
Abstract
Clinical, Molecular, and Immune Analysis of Dabrafenib-Trametinib Combination Treatment for BRAF Inhibitor-Refractory Metastatic Melanoma: A Phase 2 Clinical Trial.Chen, G., McQuade JL, Panka DJ, Hudgens CW, Amin-Mansour A., Mu XJ, Bahl S., Jané-Valbuena J., Wani KM, Reuben A., Creasy CA, Jiang H., Cooper ZA, Roszik J., Bassett RL Jr, Joon AY, Simpson LM, Mouton RD, Glitza IC, Patel SP, et al. JAMA oncology, 2016/04/28, (2016) Read More / View Supplemental Materials
Abstract
A Clinician's perspective on clinical exome sequencing.O'Donnell-Luria, AH, and Miller DT Human genetics, 2016/04/28, (2016) Read More / View Supplemental Materials
Abstract
Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma.Dayton, TL, Gocheva V., Miller KM, Israelsen WJ, Bhutkar A., Clish CB, Davidson SM, Luengo A., Bronson RT, Jacks T., and Vander Heiden MG Genes & development, 2016/04/28, (2016) Read More / View Supplemental Materials
Abstract
Exome Sequencing of Familial Bipolar Disorder.Goes, FS, Pirooznia M., Parla JS, Kramer M., Ghiban E., Mavruk S., Chen YC, Monson ET, Willour VL, Karchin R., Flickinger M., Locke AE, Levy SE, Scott LJ, Boehnke M., Stahl E., Moran JL, Hultman CM, Landén M., Purcell SM, et al. JAMA psychiatry, 2016/04/27, (2016) Read More / View Supplemental Materials
Abstract
The healthy human microbiome.Lloyd-Price, J., Abu-Ali G., and Huttenhower C. Genome medicine, 2016/04/27, Volume 8, Issue 1, p.51, (2016) Read More / View Supplemental Materials
Abstract
IRF7 inhibition prevents destructive innate immunity-A target for nonantibiotic therapy of bacterial infections.Puthia, M., Ambite I., Cafaro C., Butler D., Huang Y., Lutay N., Rydström G., Gullstrand B., Swaminathan B., Nadeem A., Nilsson B., and Svanborg C. Science translational medicine, 2016/04/27, Volume 8, Issue 336, p.336ra59, (2016) Read More / View Supplemental Materials
Abstract
Neurobiology of social behavior abnormalities in autism and Williams syndrome.Barak, B., and Feng G. Nature neuroscience, 2016/04/26, Volume 19, Issue 6, p.647-55, (2016) Read More / View Supplemental Materials
Abstract
A Spectrum of CodY Activities Drives Metabolic Reorganization and Virulence Gene Expression in Staphylococcus aureus.Waters, NR, Samuels DJ, Behera RK, Livny J., Rhee KY, Sadykov MR, and Brinsmade SR Molecular microbiology, 2016/04/26, (2016) Read More / View Supplemental Materials
Abstract
A genetic basis for the variation in the vulnerability of cancer to DNA damage.Yard, BD, Adams DJ, Chie EK, Tamayo P., Battaglia JS, Gopal P., Rogacki K., Pearson BE, Phillips J., Raymond DP, Pennell NA, Almeida F., Cheah JH, Clemons PA, Shamji A., Peacock CD, Schreiber SL, Hammerman PS, and Abazeed ME Nature communications, 2016/04/25, Volume 7, p.11428, (2016) Read More / View Supplemental Materials
Abstract
A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.Pacold, ME, Brimacombe KR, Chan SH, Rohde JM, Lewis CA, Swier LJ, Possemato R., Chen WW, Sullivan LB, Fiske BP, Cho S., Freinkman E., Birsoy K., Abu-Remaileh M., Shaul YD, Liu CM, Zhou M., Koh MJ, Chung H., Davidson SM, et al. Nature chemical biology, 2016/04/25, (2016) Read More / View Supplemental Materials
Abstract
Punctuated bursts in human male demography inferred from 1,244 worldwide Y-chromosome sequences.Poznik, GD, Xue Y., Mendez FL, Willems TF, Massaia A., Wilson Sayres MA, Ayub Q., McCarthy SA, Narechania A., Kashin S., Chen Y., Banerjee R., Rodriguez-Flores JL, Cerezo M., Shao H., Gymrek M., Malhotra A., Louzada S., Desalle R., Ritchie GR, et al. Nature genetics, 2016/04/25, (2016) Read More / View Supplemental Materials
Abstract
Somatic ERCC2 mutations are associated with a distinct genomic signature in urothelial tumors.Kim, J., Mouw KW, Polak P., Braunstein LZ, Kamburov A., Tiao G., Kwiatkowski DJ, Rosenberg JE, Van Allen EM, D'Andrea AD, and Getz G. Nature genetics, 2016/04/25, (2016) Read More / View Supplemental Materials
Abstract
Targeted erythropoietin selectively stimulates red blood cell expansion in vivo.Burrill, DR, Vernet A., Collins JJ, Silver PA, and Way JC Proceedings of the National Academy of Sciences of the United States of America, 2016/04/25, (2016) Read More / View Supplemental Materials
Abstract
An open-source computational tool to automatically quantify immunolabeled retinal ganglion cells.Dordea, AC, Bray MA, Allen K., Logan D., Fei F., Malhotra R., Gregory M., Carpenter AE, and Buys ES Experimental eye research, 2016/04/24, (2016) Read More / View Supplemental Materials
Abstract
Population-Scale Sequencing Data Enable Precise Estimates of Y-STR Mutation Rates.Willems, T., Gymrek M., Poznik GD, Tyler-Smith C., 1000 Genomes Project Chromosome Y Group, and Erlich Y. American journal of human genetics, 2016/04/22, (2016) Read More / View Supplemental Materials
Abstract
Trained immunity: A program of innate immune memory in health and disease.Netea, MG, Joosten LA, Latz E., Mills KH, Natoli G., Stunnenberg HG, O'Neill LA, and Xavier RJ Science (New York, N.Y.), 2016/04/22, Volume 352, Issue 6284, p.aaf1098, (2016) Read More / View Supplemental Materials
Abstract
Crystal Structure of Cpf1 in Complex with Guide RNA and Target DNA.Yamano, T., Nishimasu H., Zetsche B., Hirano H., Slaymaker IM, Li Y., Fedorova I., Nakane T., Makarova KS, Koonin EV, Ishitani R., Zhang F., and Nureki O. Cell, 2016/04/21, (2016) Read More / View Supplemental Materials
Abstract
Engineering Models to Scale.Dy, AJ, and Collins JJ Cell, 2016/04/21, Volume 165, Issue 3, p.516-7, (2016) Read More / View Supplemental Materials
Abstract
The influence of a short-term gluten-free diet on the human gut microbiome.Bonder, MJ, Tigchelaar EF, Cai X., Trynka G., Cenit MC, Hrdlickova B., Zhong H., Vatanen T., Gevers D., Wijmenga C., Wang Y., and Zhernakova A. Genome medicine, 2016/04/21, Volume 8, Issue 1, p.45, (2016) Read More / View Supplemental Materials
Abstract
High fat diet and stem cells: Linking diet to intestinal tumor formation.Cangelosi, AL, and Yilmaz Ö. H. Cell cycle (Georgetown, Tex.), 2016/04/20, (2016) Read More / View Supplemental Materials
Abstract
Plasma acylcarnitines and risk of cardiovascular disease: effect of Mediterranean diet interventions.Guasch-Ferré, M., Zheng Y., Ruiz-Canela M., Hruby A., Martínez-González MA, Clish CB, Corella D., Estruch R., Ros E., Fitó M., Dennis C., Morales-Gil IM, Arós F., Fiol M., Lapetra J., Serra-Majem L., Hu FB, and Salas-Salvadó J. The American journal of clinical nutrition, 2016/04/20, (2016) Read More / View Supplemental Materials
Abstract
Characterizing genomic alterations in cancer by complementary functional associations.Kim, JW, Botvinnik OB, Abudayyeh O., Birger C., Rosenbluh J., Shrestha Y., Abazeed ME, Hammerman PS, Dicara D., Konieczkowski DJ, Johannessen CM, Liberzon A., Alizad-Rahvar AR, Alexe G., Aguirre A., Ghandi M., Greulich H., Vazquez F., Weir BA, Van Allen EM, et al. Nature biotechnology, 2016/04/18, (2016) Read More / View Supplemental Materials
Abstract
Circadian gene variants influence sleep and the sleep electroencephalogram in humans.Chang, AM, Bjonnes AC, Aeschbach D., Buxton OM, Gooley JJ, Anderson C., Reen EV, Cain SW, Czeisler CA, Duffy JF, Lockley SW, Shea SA, Scheer FA, and Saxena R. Chronobiology international, 2016/04/18, p.1-13, (2016) Read More / View Supplemental Materials
Abstract
Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.Okbay, A., Baselmans BM, De Neve JE, Turley P., Nivard MG, Fontana MA, Meddens SF, Linnér RK, Rietveld CA, Derringer J., Gratten J., Lee JJ, Liu JZ, de Vlaming R., Ahluwalia TS, Buchwald J., Cavadino A., Frazier-Wood AC, Furlotte NA, Garfield V., et al. Nature genetics, 2016/04/18, (2016) Read More / View Supplemental Materials
Abstract
Physical and neurobehavioral determinants of reproductive onset and success.Day, FR, Helgason H., Chasman DI, Rose LM, Loh PR, Scott RA, Helgason A., Kong A., Masson G., Magnusson OT, Gudbjartsson D., Thorsteinsdottir U., Buring JE, Ridker PM, Sulem P., Stefansson K., Ong KK, and Perry JR Nature genetics, 2016/04/18, (2016) Read More / View Supplemental Materials
Abstract
Recurrent Clostridium difficile infection associates with distinct bile acid and microbiome profiles.Allegretti, JR, Kearney S., Li N., Bogart E., Bullock K., Gerber GK, Bry L., Clish CB, Alm E., and Korzenik JR Alimentary pharmacology & therapeutics, 2016/04/18, (2016) Read More / View Supplemental Materials
Abstract
The reproductive tracts of two malaria vectors are populated by a core microbiome and by gender- and swarm-enriched microbial biomarkers.Segata, N., Baldini F., Pompon J., Garrett WS, Truong DT, Dabiré RK, Diabaté A., Levashina EA, and Catteruccia F. Scientific reports, 2016/04/18, Volume 6, p.24207, (2016) Read More / View Supplemental Materials
Abstract
Sequential Infection with Common Pathogens Promotes Human-like Immune Gene Expression and Altered Vaccine Response.Reese, TA, Bi K., Kambal A., Filali-Mouhim A., Beura LK, Bürger MC, Pulendran B., Sekaly RP, Jameson SC, Masopust D., Haining WN, and Virgin HW Cell host & microbe, 2016/04/18, (2016) Read More / View Supplemental Materials
Abstract
Synthetic biology platform technologies for antimicrobial applications.Braff, D., Shis D., and Collins JJ Advanced drug delivery reviews, 2016/04/18, (2016) Read More / View Supplemental Materials
Abstract
Applications in image-based profiling of perturbations.Caicedo, JC, Singh S., and Carpenter AE Current opinion in biotechnology, 2016/04/15, Volume 39, p.134-142, (2016) Read More / View Supplemental Materials
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Common and rare forms of diabetes mellitus: towards a continuum of diabetes subtypes.Flannick, J., Johansson S., and Njølstad PR Nature reviews. Endocrinology, 2016/04/15, (2016) Read More / View Supplemental Materials
Abstract
A distant trophoblast-specific enhancer controls HLA-G expression at the maternal-fetal interface.Ferreira, LM, Meissner TB, Mikkelsen TS, Mallard W., O'Donnell CW, Tilburgs T., Gomes HA, Camahort R., Sherwood RI, Gifford DK, Rinn JL, Cowan CA, and Strominger JL Proceedings of the National Academy of Sciences of the United States of America, 2016/04/13, (2016) Read More / View Supplemental Materials
Abstract
The Human Vaccines Project: A roadmap for cancer vaccine development.Romero, P., Banchereau J., Bhardwaj N., Cockett M., Disis ML, Dranoff G., Gilboa E., Hammond SA, Hershberg R., Korman AJ, Kvistborg P., Melief C., Mellman I., Palucka AK, Redchenko I., Robins H., Sallusto F., Schenkelberg T., Schoenberger S., Sosman J., et al. Science translational medicine, 2016/04/13, Volume 8, Issue 334, p.334ps9, (2016) Read More / View Supplemental Materials
Abstract
A Method to Exploit the Structure of Genetic Ancestry Space to Enhance Case-Control Studies.Bodea, CA, Neale BM, Ripke S., International IBD Genetics Consortium, Daly M. J., Devlin B., and Roeder K. American journal of human genetics, 2016/04/13, (2016) Read More / View Supplemental Materials
Abstract
Vinca alkaloid drugs promote stress-induced translational repression and stress granule formation.Szaflarski, W., Fay MM, Kedersha N., Zabel M., Anderson P., and Ivanov P. Oncotarget, 2016/04/13, (2016) Read More / View Supplemental Materials
Abstract
Wisteria Floribunda Agglutinin-Labeled Perineuronal Nets in the Mouse Inferior Colliculus, Thalamic Reticular Nucleus and Auditory Cortex.Fader, SM, Imaizumi K., Yanagawa Y., and Lee CC Brain sciences, 2016/04/13, Volume 6, Issue 2, (2016) Read More / View Supplemental Materials
Abstract
Genome-wide analysis of over 106 000 individuals identifies 9 neuroticism-associated loci.Smith, DJ, Escott-Price V., Davies G., Bailey ME, Colodro-Conde L., Ward J., Vedernikov A., Marioni R., Cullen B., Lyall D., Hagenaars SP, Liewald DC, Luciano M., Gale CR, Ritchie SJ, Hayward C., Nicholl B., Bulik-Sullivan B., Adams M., Couvy-Duchesne B., et al. Molecular psychiatry, 2016/04/12, (2016) Read More / View Supplemental Materials
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The statistical properties of gene-set analysis.de Leeuw, CA, Neale BM, Heskes T., and Posthuma D. Nature reviews. Genetics, 2016/04/12, (2016) Read More / View Supplemental Materials
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Crowdsourced estimation of cognitive decline and resilience in Alzheimer's disease.Allen, GI, Amoroso N., Anghel C., Balagurusamy V., Bare CJ, Beaton D., Bellotti R., Bennett DA, Boehme K., Boutros PC, Caberlotto L., Caloian C., Campbell F., Neto EC, Chang YC, Chen B., Chen CY, Chien TY, Clark T., Das S., et al. Alzheimer's & dementia : the journal of the Alzheimer's Association, 2016/04/11, (2016) Read More / View Supplemental Materials
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Genomic and functional analyses of Mycobacterium tuberculosis strains implicate ald in D-cycloserine resistance.Desjardins, CA, Cohen KA, Munsamy V., Abeel T., Maharaj K., Walker BJ, Shea TP, Almeida DV, Manson AL, Salazar A., Padayatchi N., O'Donnell MR, Mlisana KP, Wortman J., Birren BW, Grosset J., Earl AM, and Pym AS Nature genetics, 2016/04/11, (2016) Read More / View Supplemental Materials
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The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice.Townsend, EC, Murakami MA, Christodoulou A., Christie AL, Köster J., DeSouza TA, Morgan EA, Kallgren SP, Liu H., Wu SC, Plana O., Montero J., Stevenson KE, Rao P., Vadhi R., Andreeff M., Armand P., Ballen KK, Barzaghi-Rinaudo P., Cahill S., et al. Cancer cell, 2016/04/11, Volume 29, Issue 4, p.574-86, (2016) Read More / View Supplemental Materials
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Superheroes of disease resistance.Macarthur, D. Nature biotechnology, 2016/04/11, (2016) Read More / View Supplemental Materials
The Chthonomonas calidirosea genome is highly conserved across geography and distinct chemical and microbial environments in the Taupō Volcanic Zone, New Zealand.Lee, KC, Stott MB, Dunfield PF, Huttenhower C., McDonald IR, and Morgan XC Applied and environmental microbiology, 2016/04/08, (2016) Read More / View Supplemental Materials
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Complementation of mitochondrial electron transport chain by manipulation of the NAD+/NADH ratio.Titov, DV, Cracan V., Goodman RP, Peng J., Grabarek Z., and Mootha VK Science (New York, N.Y.), 2016/04/08, Volume 352, Issue 6282, p.231-5, (2016) Read More / View Supplemental Materials
Abstract
Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq.Tirosh, I., Izar B., Prakadan SM, Wadsworth MH 2nd, Treacy D., Trombetta JJ, Rotem A., Rodman C., Lian C., Murphy G., Fallahi-Sichani M., Dutton-Regester K., Lin JR, Cohen O., Shah P., Lu D., Genshaft AS, Hughes TK, Ziegler CG, Kazer SW, et al. Science (New York, N.Y.), 2016/04/08, Volume 352, Issue 6282, p.189-96, (2016) Read More / View Supplemental Materials
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Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation.Gusev, A., Shi H., Kichaev G., Pomerantz M., Li F., Long HW, Ingles SA, Kittles RA, Strom SS, Rybicki BA, Nemesure B., Isaacs WB, Zheng W., Pettaway CA, Yeboah ED, Tettey Y., Biritwum RB, Adjei AA, Tay E., Truelove A., et al. Nature communications, 2016/04/07, Volume 7, p.10979, (2016) Read More / View Supplemental Materials
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Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML.Puram, RV, Kowalczyk MS, de Boer CG, Schneider RK, Miller PG, McConkey M., Tothova Z., Tejero H., Heckl D., Järås M., Chen MC, Li H., Tamayo A., Cowley GS, Rozenblatt-Rosen O., Al-Shahrour F., Regev A., and Ebert BL Cell, 2016/04/07, Volume 165, Issue 2, p.303-16, (2016) Read More / View Supplemental Materials
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Polymorphic tandem repeats within gene promoters act as modifiers of gene expression and DNA methylation in humans.Quilez, J., Guilmatre A., Garg P., Highnam G., Gymrek M., Erlich Y., Joshi RS, Mittelman D., and Sharp AJ Nucleic acids research, 2016/04/07, (2016) Read More / View Supplemental Materials
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Whole exome sequencing of urachal adenocarcinoma reveals recurrent NF1 mutations.Singh, H., Liu Y., Xiao X., Lin L., Kim J., Van Hummelen P., Wu CL, Bass AJ, and Saylor PJ Oncotarget, 2016/04/07, (2016) Read More / View Supplemental Materials
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Enhanced CLIP Uncovers IMP Protein-RNA Targets in Human Pluripotent Stem Cells Important for Cell Adhesion and Survival.Conway, AE, Van Nostrand EL, Pratt GA, Aigner S., Wilbert ML, Sundararaman B., Freese P., Lambert NJ, Sathe S., Liang TY, Essex A., Landais S., Burge CB, Jones DL, and Yeo GW Cell reports, 2016/04/05, (2016) Read More / View Supplemental Materials
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Novel diversity-oriented synthesis-derived respiratory syncytial virus inhibitors identified via a high throughput replicon-based screen.Duvall, JR, VerPlank L., Ludeke B., McLeod SM, Lee MD 4th, Vishwanathan K., Mulrooney CA, le Quement S., Yu Q., Palmer MA, Fleming P., Fearns R., Foley MA, and Scherer CA Antiviral research, 2016/04/05, (2016) Read More / View Supplemental Materials
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Insight into GATA1 transcriptional activity through interrogation of cis elements disrupted in human erythroid disorders.Wakabayashi, A., Ulirsch JC, Ludwig LS, Fiorini C., Yasuda M., Choudhuri A., McDonel P., Zon LI, and Sankaran VG Proceedings of the National Academy of Sciences of the United States of America, 2016/04/04, (2016) Read More / View Supplemental Materials
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Ancient mitochondrial DNA provides high-resolution time scale of the peopling of the Americas.Llamas, B., Fehren-Schmitz L., Valverde G., Soubrier J., Mallick S., Rohland N., Nordenfelt S., Valdiosera C., Richards SM, Rohrlach A., Romero MI, Espinoza IF, Cagigao ET, Jiménez LW, Makowski K., Reyna IS, Lory JM, Torrez JA, Rivera MA, Burger RL, et al. Science advances, 2016/04/01, Volume 2, Issue 4, p.e1501385, (2016) Read More / View Supplemental Materials
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Comparison of Heritability Estimation and Linkage Analysis for Multiple Traits Using Principal Component Analyses.Liang, J., Cade BE, Wang H., Chen H., Gleason KJ, Larkin EK, Saxena R., Lin X., Redline S., and Zhu X. Genetic epidemiology, 2016/04/01, Volume 40, Issue 3, p.222-32, (2016) Read More / View Supplemental Materials
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Computational Reconstruction of NFκB Pathway Interaction Mechanisms during Prostate Cancer.Börnigen, D., Tyekucheva S., Wang X., Rider JR, Lee GS, Mucci LA, Sweeney C., and Huttenhower C. PLoS computational biology, 2016/04/01, Volume 12, Issue 4, p.e1004820, (2016) Read More / View Supplemental Materials
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GENOME-WIDE ASSOCIATION STUDY (GWAS) AND GENOME-WIDE BY ENVIRONMENT INTERACTION STUDY (GWEIS) OF DEPRESSIVE SYMPTOMS IN AFRICAN AMERICAN AND HISPANIC/LATINA WOMEN.Dunn, EC, Wiste A., Radmanesh F., Almli LM, Gogarten SM, Sofer T., Faul JD, Kardia SL, Smith JA, Weir DR, Zhao W., Soare TW, Mirza SS, Hek K., Tiemeier H., Goveas JS, Sarto GE, Snively BM, Cornelis M., Koenen KC, et al. Depression and anxiety, 2016/04/01, Volume 33, Issue 4, p.265-80, (2016) Read More / View Supplemental Materials
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Homozygous deletion in MICU1 presenting with fatigue and lethargy in childhood.Lewis-Smith, D., Kamer KJ, Griffin H., Childs AM, Pysden K., Titov D., Duff J., Pyle A., Taylor RW, Yu-Wai-Man P., Ramesh V., Horvath R., Mootha VK, and Chinnery PF Neurology. Genetics, 2016/04/01, Volume 2, Issue 2, p.e59, (2016) Read More / View Supplemental Materials
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Lifting Up the HAT: Synthetic Lethal Screening Reveals a Novel Vulnerability at the CBP-p300 Axis.Kadoch, C. Cancer discovery, 2016/04/01, Volume 6, Issue 4, p.350-2, (2016) Read More / View Supplemental Materials
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Polygenic overlap between schizophrenia risk and antipsychotic response: a genomic medicine approach.Ruderfer, DM, Charney AW, Readhead B., Kidd BA, Kähler AK, Kenny PJ, Keiser MJ, Moran JL, Hultman CM, Scott SA, Sullivan PF, Purcell SM, Dudley JT, and Sklar P. The lancet. Psychiatry, 2016/04/01, Volume 3, Issue 4, p.350-7, (2016) Read More / View Supplemental Materials
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Rare loss-of-function variants in SETD1A are associated with schizophrenia and developmental disorders.Singh, T., Kurki MI, Curtis D., Purcell SM, Crooks L., McRae J., Suvisaari J., Chheda H., Blackwood D., Breen G., Pietiläinen O., Gerety SS, Ayub M., Blyth M., Cole T., Collier D., Coomber EL, Craddock N., Daly M. J., Danesh J., et al. Nature neuroscience, 2016/04/01, Volume 19, Issue 4, p.571-7, (2016) Read More / View Supplemental Materials
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Complement and microglia mediate early synapse loss in Alzheimer mouse models.Hong, S., Beja-Glasser VF, Nfonoyim BM, Frouin A., Li S., Ramakrishnan S., Merry KM, Shi Q., Rosenthal A., Barres BA, Lemere CA, Selkoe DJ, and Stevens B. Science (New York, N.Y.), 2016/03/31, (2016) Read More / View Supplemental Materials
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Variants near CHRNA3/5 and APOE have age- and sex-related effects on human lifespan.Joshi, PK, Fischer K., Schraut KE, Campbell H., Esko T., and Wilson JF Nature communications, 2016/03/31, Volume 7, p.11174, (2016) Read More / View Supplemental Materials
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Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1.Chouchani, ET, Kazak L., Jedrychowski MP, Lu GZ, Erickson BK, Szpyt J., Pierce KA, Laznik-Bogoslavski D., Vetrivelan R., Clish CB, Robinson AJ, Gygi SP, and Spiegelman BM Nature, 2016/03/30, (2016) Read More / View Supplemental Materials
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Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium.Stringer, S., Minică CC, Verweij KJ, Mbarek H., Bernard M., Derringer J., van Eijk KR, Isen JD, Loukola A., Maciejewski DF, Mihailov E., van der Most PJ, Sánchez-Mora C., Roos L., Sherva R., Walters R., Ware JJ, Abdellaoui A., Bigdeli TB, Branje SJ, et al. Translational psychiatry, 2016/03/29, Volume 6, p.e769, (2016) Read More / View Supplemental Materials
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Genome-wide interaction study of brain beta-amyloid burden and cognitive impairment in Alzheimer's disease.Roostaei, T., Nazeri A., Felsky D., De Jager PL, Schneider JA, Pollock BG, Bennett DA, Voineskos AN, and Alzheimer’s Disease Neuroimaging Initiative(ADNI) Molecular psychiatry, 2016/03/29, (2016) Read More / View Supplemental Materials
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Leveraging signaling research to understand and treat disease.Yaffe, MB, and Gough NR Science signaling, 2016/03/29, Volume 9, Issue 421, p.eg4, (2016) Read More / View Supplemental Materials
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18F CFA as a clinically translatable probe for PET imaging of deoxycytidine kinase activity.Kim, W., Le TM, Wei L., Poddar S., Bazzy J., Wang X., Uong NT, Abt ER, Capri JR, Austin WR, Van Valkenburgh JS, Steele D., Gipson RM, Slavik R., Cabebe AE, Taechariyakul T., Yaghoubi SS, Lee JT, Sadeghi S., Lavie A., et al. Proceedings of the National Academy of Sciences of the United States of America, 2016/03/28, (2016) Read More / View Supplemental Materials
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Diagnostic Yield of Sequencing Familial Hypercholesterolemia Genes in Patients with Severe Hypercholesterolemia.Khera, AV, Won HH, Peloso GM, Lawson KS, Bartz TM, Deng X., van Leeuwen EM, Natarajan P., Emdin CA, Bick AG, Morrison AC, Brody JA, Gupta N., Nomura A., Kessler T., Duga S., Bis JC, van Duijn CM, Cupples LA, Psaty B., et al. Journal of the American College of Cardiology, 2016/03/28, (2016) Read More / View Supplemental Materials
Abstract
G3BP-Caprin1-USP10 complexes mediate stress granule condensation and associate with 40S subunits.Kedersha, N., Panas MD, Achorn CA, Lyons S., Tisdale S., Hickman T., Thomas M., Lieberman J., McInerney GM, Ivanov P., and Anderson P. The Journal of cell biology, 2016/03/28, Volume 212, Issue 7, p.845-60, (2016) Read More / View Supplemental Materials
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The Combined Landscape of Denisovan and Neanderthal Ancestry in Present-Day Humans.Sankararaman, S., Mallick S., Patterson N., and Reich D. Current biology : CB, 2016/03/26, (2016) Read More / View Supplemental Materials
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CANCER. The oncogene makes its escape.Wala, J., and Beroukhim R. Science (New York, N.Y.), 2016/03/25, Volume 351, Issue 6280, p.1398-9, (2016) Read More / View Supplemental Materials
Personal Genome Sequencing in Ostensibly Healthy Individuals and the PeopleSeq Consortium.Linderman, MD, Nielsen DE, and Green RC Journal of personalized medicine, 2016/03/25, Volume 6, Issue 2, (2016) Read More / View Supplemental Materials
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Survey of variation in human transcription factors reveals prevalent DNA binding changes.Barrera, LA, Vedenko A., Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J., Mariani L., Kock KH, Inukai S., Siggers T., Shokri L., Gordân R., Sahni N., Cotsapas C., Hao T., Yi S., Kellis M., Daly M. J., Vidal M., et al. Science (New York, N.Y.), 2016/03/25, Volume 351, Issue 6280, p.1450-4, (2016) Read More / View Supplemental Materials
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Common and Rare Genetic Variation in CCR2, CCR5, or CX3CR1 and Risk of Atherosclerotic Coronary Heart Disease and Glucometabolic Traits.Golbus, JR, Stitziel NO, Zhao W., Xue C., Farrall M., McPherson R., Erdmann J., Deloukas P., Watkins H., Schunkert H., Samani NJ, Saleheen D., Kathiresan S., and Reilly MP Circulation. Cardiovascular genetics, 2016/03/24, (2016) Read More / View Supplemental Materials
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Differential dopaminergic regulation of inwardly rectifying potassium channel mediated subthreshold dynamics in striatal medium spiny neurons.Zhao, B., Zhu J., Dai D., Xing J., He J., Fu Z., Zhang L., Li Z., and Wang W. Neuropharmacology, 2016/03/24, Volume 107, p.396-410, (2016) Read More / View Supplemental Materials
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Function and evolution of local repeats in the Firre locus.Hacisuleyman, E., Shukla CJ, Weiner CL, and Rinn JL Nature communications, 2016/03/24, Volume 7, p.11021, (2016) Read More / View Supplemental Materials
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Improved Identification and Analysis of Small Open Reading Frame Encoded Polypeptides.Ma, J., Diedrich JK, Jungreis I., Donaldson C., Vaughan J., Kellis M., Yates JR 3rd, and Saghatelian A. Analytical chemistry, 2016/03/24, (2016) Read More / View Supplemental Materials
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PGC1α drives NAD biosynthesis linking oxidative metabolism to renal protection.Tran, MT, Zsengeller ZK, Berg AH, Khankin EV, Bhasin MK, Kim W., Clish CB, Stillman IE, Karumanchi SA, Rhee EP, and Parikh SM Nature, 2016/03/24, Volume 531, Issue 7595, p.528-32, (2016) Read More / View Supplemental Materials
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Imprinted genes and imprinting control regions show predominant intermediate methylation in adult somatic tissues.Pervjakova, N., Kasela S., Morris AP, Kals M., Metspalu A., Lindgren CM, Salumets A., and Mägi R. Epigenomics, 2016/03/23, (2016) Read More / View Supplemental Materials
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Methylation profiles in peripheral blood CD4+ lymphocytes versus brain: The relation to Alzheimer's disease pathology.Yu, L., Chibnik L., Yang J., McCabe C., Xu J., Schneider JA, De Jager PL, and Bennett DA Alzheimer's & dementia : the journal of the Alzheimer's Association, 2016/03/23, (2016) Read More / View Supplemental Materials
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Thalamic reticular impairment underlies attention deficit in Ptchd1Y/- mice.Wells, MF, Wimmer RD, Schmitt LI, Feng G., and Halassa MM Nature, 2016/03/23, (2016) Read More / View Supplemental Materials
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Tractography Analysis of 5 White Matter Bundles and Their Clinical and Cognitive Correlates in Early-Course Schizophrenia.Seitz, J., Zuo JX, Lyall AE, Makris N., Kikinis Z., Bouix S., Pasternak O., Fredman E., Duskin J., Goldstein JM, Petryshen TL, Mesholam-Gately RI, Wojcik J., McCarley RW, Seidman LJ, Shenton ME, Koerte IK, and Kubicki M. Schizophrenia bulletin, 2016/03/23, (2016) Read More / View Supplemental Materials
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Fatty Acid Metabolic Defects and Right Ventricular Lipotoxicity in Human Pulmonary Arterial Hypertension.Brittain, EL, Talati M., Fessel JP, Zhu H., Penner N., Calcutt MW, West J., Funke M., Lewis GD, Gerszten RE, Hamid R., Pugh ME, Austin ED, Newman JH, and Hemnes AR Circulation, 2016/03/22, (2016) Read More / View Supplemental Materials
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Variation at 2q35 (PNKD and TMBIM1) influences colorectal cancer risk and identifies a pleiotropic effect with inflammatory bowel disease.Orlando, G., Law PJ, Palin K., Tuupanen S., Gylfe A., Hänninen U., Cajuso T., Tanskanen T., Kondelin J., Kaasinen E., Sarin AP, Kaprio J., Eriksson JG, Rissanen H., Knekt P., Pukkala E., Jousilahti P., Salomaa V., Ripatti S., Palotie A., et al. Human molecular genetics, 2016/03/22, (2016) Read More / View Supplemental Materials
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Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population.Robinson, EB, St Pourcain B., Anttila V., Kosmicki JA, Bulik-Sullivan B., Grove J., Maller J., Samocha KE, Sanders SJ, Ripke S., Martin J., Hollegaard MV, Werge T., Hougaard DM, iPSYCH-SSI-Broad Autism Group, Neale BM, Evans DM, Skuse D., Mortensen PB, Børglum AD, et al. Nature genetics, 2016/03/21, (2016) Read More / View Supplemental Materials
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A role for the bacterial GATC methylome in antibiotic stress survival.Cohen, NR, Ross CA, Jain S., Shapiro RS, Gutierrez A., Belenky P., Li H., and Collins JJ Nature genetics, 2016/03/21, (2016) Read More / View Supplemental Materials
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Stem cell models of neuropsychiatric disorders.Karmacharya, R., and Haggarty SJ Molecular and cellular neurosciences, 2016/03/21, (2016) Read More / View Supplemental Materials
3D hydrogel scaffold doped with 2D graphene materials for biosensors and bioelectronics.Song, HS, Kwon OS, Kim JH, Conde J., and Artzi N. Biosensors & bioelectronics, 2016/03/19, (2016) Read More / View Supplemental Materials
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Disseminated glioneuronal tumors occurring in childhood: treatment outcomes and BRAF alterations including V600E mutation.Dodgshun, AJ, SantaCruz N., Hwang J., Ramkissoon SH, Malkin H., Bergthold G., Manley P., Chi S., MacGregor D., Goumnerova L., Sullivan M., Ligon K., Beroukhim R., Herrington B., Kieran MW, Hansford JR, and Bandopadhayay P. Journal of neuro-oncology, 2016/03/19, (2016) Read More / View Supplemental Materials
Abstract
Allele-specific transcription factor binding to common and rare variants associated with disease and gene expression.Cavalli, M., Pan G., Nord H., Wallerman O., Wallén Arzt E., Berggren O., Elvers I., Eloranta ML, Rönnblom L., Lindblad Toh K., and Wadelius C. Human genetics, 2016/03/18, (2016) Read More / View Supplemental Materials
Abstract
Genetic Association of Curative and Adverse Reactions to Tyrosine Kinase Inhibitors in Chinese advanced Non-Small Cell Lung Cancer patients.Ruan, Y., Jiang J., Guo L., Li Y., Huang H., Shen L., Luan M., Li M., Du H., Ma C., He L., Zhang X., and Qin S. Scientific reports, 2016/03/18, Volume 6, p.23368, (2016) Read More / View Supplemental Materials
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Targeting Fat: Mechanisms of Protein Localization to Lipid Droplets.Kory, N., Farese RV Jr, and Walther TC Trends in cell biology, 2016/03/16, (2016) Read More / View Supplemental Materials
Abstract
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