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Synthesis, cellular evaluation and mechanism-of-action of piperlongumine analogsAdams, DJ, Dai M., Pellegrino G., Wagner BK, Stern AM, Shamji AF, and Schreiber SL, (Submitted) Read More / View Supplemental Materials
2015
High-throughput functional genomics using CRISPR-Cas9.Shalem, O., Sanjana NE, and Zhang F. Nature reviews. Genetics, 2015/05/01, Volume 16, Issue 5, p.299-311, (2015) Read More / View Supplemental Materials
Abstract
Developing Medicines That Mimic the Natural Successes of the Human Genome: Lessons From NPC1L1, HMGCR, PCSK9, APOC3, and CETP.Kathiresan, S. Journal of the American College of Cardiology, 2015/04/21, Volume 65, Issue 15, p.1562-6, (2015) Read More / View Supplemental Materials
Calibrating genomic and allelic coverage bias in single-cell sequencing.Zhang, CZ, Adalsteinsson VA, Francis J., Cornils H., Jung J., Maire C., Ligon KL, Meyerson M., and Love JC Nature communications, 2015/04/16, Volume 6, p.6822, (2015) Read More / View Supplemental Materials
Abstract
Integrative genomic analysis reveals widespread enhancer regulation by p53 in response to DNA damage.Younger, ST, Kenzelmann-Broz D., Jung H., Attardi LD, and Rinn JL Nucleic acids research, 2015/04/16, (2015) Read More / View Supplemental Materials
Abstract
Pugh et al. reply.Pugh, TJ, Banerji S., and Meyerson M. Nature, 2015/04/16, Volume 520, Issue 7547, p.E12-4, (2015) Read More / View Supplemental Materials
SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance.Kim, D., Fiske BP, Birsoy K., Freinkman E., Kami K., Possemato RL, Chudnovsky Y., Pacold ME, Chen WW, Cantor JR, Shelton LM, Gui DY, Kwon M., Ramkissoon SH, Ligon KL, Kang SW, Snuderl M., Vander Heiden MG, and Sabatini DM Nature, 2015/04/16, Volume 520, Issue 7547, p.363-7, (2015) Read More / View Supplemental Materials
Abstract
Live Cell Multi-Photon Fluorescence Correlation Spectroscopy with an Improved Large Stokes Shift Fluorescent Protein.Guan, Y., Meurer M., Raghavan S., Rebane A., Lindquist JR, Santos S., Kats I., Davidson MW, Mazitschek R., Hughes TE, Drobizhev M., Knop M., and Shah JV Molecular biology of the cell, 2015/04/15, (2015) Read More / View Supplemental Materials
Abstract
Cases of Ebola virus disease predicted to rise from hundreds to thousands per week unless control measures improve.Andersen, KG Evidence-based nursing, 2015/04/14, (2015) Read More / View Supplemental Materials
Distinct metabolomic signatures are associated with longevity in humans.Cheng, S., Larson MG, McCabe EL, Murabito JM, Rhee EP, Ho JE, Jacques PF, Ghorbani A., Magnusson M., Souza AL, Deik AA, Pierce KA, Bullock K., O'Donnell CJ, Melander O., Clish CB, Vasan RS, Gerszten RE, and Wang TJ Nature communications, 2015/04/13, Volume 6, p.6791, (2015) Read More / View Supplemental Materials
Abstract
Spatial reconstruction of single-cell gene expression data.Satija, R., Farrell JA, Gennert D., Schier AF, and Regev A. Nature biotechnology, 2015/04/13, (2015) Read More / View Supplemental Materials
Abstract
Genome-wide association studies of late-onset cardiovascular disease.Gustav Smith, J., and Newton-Cheh C. Journal of molecular and cellular cardiology, 2015/04/11, (2015) Read More / View Supplemental Materials
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DNA copy number analysis of metastatic urothelial carcinoma with comparison to primary tumors.Bambury, RM, Bhatt AS, Riester M., Pedamallu CS, Duke F., Bellmunt J., Stack EC, Werner L., Park R., Iyer G., Loda M., Kantoff PW, Michor F., Meyerson M., and Rosenberg JE BMC cancer, 2015/04/09, Volume 15, Issue 1, p.242, (2015) Read More / View Supplemental Materials
Abstract
In vivo genome editing using Staphylococcus aureus Cas9.Ran, FA, Cong L., Yan WX, Scott DA, Gootenberg JS, Kriz AJ, Zetsche B., Shalem O., Wu X., Makarova KS, Koonin EV, Sharp PA, and Zhang F. Nature, 2015/04/09, Volume 520, Issue 7546, p.186-91, (2015) Read More / View Supplemental Materials
Abstract
Associations between host gene expression, the mucosal microbiome, and clinical outcome in the pelvic pouch of patients with inflammatory bowel disease.Morgan, XC, Kabakchiev B., Waldron L., Tyler AD, Tickle TL, Milgrom R., Stempak JM, Gevers D., Xavier RJ, Silverberg MS, and Huttenhower C. Genome biology, 2015/04/08, Volume 16, Issue 1, p.67, (2015) Read More / View Supplemental Materials
Abstract
Determinants of the CmoB carboxymethyl transferase utilized for selective tRNA wobble modification.Kim, J., Xiao H., Koh J., Wang Y., Bonanno JB, Thomas K., Babbitt PC, Brown S., Lee YS, and Almo SC Nucleic acids research, 2015/04/08, (2015) Read More / View Supplemental Materials
Abstract
Genome-wide Analysis of Body Proportion Classifies Height-Associated Variants by Mechanism of Action and Implicates Genes Important for Skeletal Development.Chan, Y., Salem RM, Hsu YH, McMahon G., Pers TH, Vedantam S., Esko T., Guo MH, Lim ET, GIANT Consortium, Franke L., Smith GD, Strachan DP, and Hirschhorn JN American journal of human genetics, 2015/04/08, (2015) Read More / View Supplemental Materials
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Mutations in PYCR2, Encoding Pyrroline-5-Carboxylate Reductase 2, Cause Microcephaly and Hypomyelination.Nakayama, T., Al-Maawali A., El-Quessny M., Rajab A., Khalil S., Stoler JM, Tan WH, Nasir R., Schmitz-Abe K., Hill RS, Partlow JN, Al-Saffar M., Servattalab S., LaCoursiere CM, Tambunan DE, Coulter ME, Elhosary PC, Gorski G., Barkovich AJ, Markianos K., et al. American journal of human genetics, 2015/04/08, (2015) Read More / View Supplemental Materials
Abstract
Criteria for biological reproducibility: What does "n" mean?Naegle, K., Gough NR, and Yaffe MB Science signaling, 2015/04/07, Volume 8, Issue 371, p.fs7, (2015) Read More / View Supplemental Materials
Abstract
Flavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis.Miao, J., Ling AV, Manthena PV, Gearing ME, Graham MJ, Crooke RM, Croce KJ, Esquejo RM, Clish CB, Morbid Obesity Study Group, Vicent D., and Biddinger SB Nature communications, 2015/04/07, Volume 6, p.6498, (2015) Read More / View Supplemental Materials
Abstract
IGF2BP2/IMP2-Deficient Mice Resist Obesity through Enhanced Translation of Ucp1 mRNA and Other mRNAs Encoding Mitochondrial Proteins.Dai, N., Zhao L., Wrighting D., Krämer D., Majithia A., Wang Y., Cracan V., Borges-Rivera D., Mootha VK, Nahrendorf M., Thorburn DR, Minichiello L., Altshuler D., and Avruch J. Cell metabolism, 2015/04/07, Volume 21, Issue 4, p.609-21, (2015) Read More / View Supplemental Materials
Abstract
Reproducibility in science.Yaffe, MB Science signaling, 2015/04/07, Volume 8, Issue 371, p.eg5, (2015) Read More / View Supplemental Materials
Abstract
Biallelic mutations in SNX14 cause a syndromic form of cerebellar atrophy and lysosome-autophagosome dysfunction.Akizu, N., Cantagrel V., Zaki MS, Al-Gazali L., Wang X., Rosti RO, Dikoglu E., Gelot AB, Rosti B., Vaux KK, Scott EM, Silhavy JL, Schroth J., Copeland B., Schaffer AE, Gordts PL, Esko JD, Buschman MD, Field SJ, Napolitano G., et al. Nature genetics, 2015/04/06, (2015) Read More / View Supplemental Materials
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The lure of zebrafish in liver research: regulation of hepatic growth in development and regeneration.Cox, AG, and Goessling W. Current opinion in genetics & development, 2015/04/06, Volume 32, p.153-161, (2015) Read More / View Supplemental Materials
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The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity.Ramirez-Ortiz, ZG, Prasad A., Griffith JW, Pendergraft WF 3rd, Cowley GS, Root DE, Tai M., Luster AD, El Khoury J., Hacohen N., and Means TK Nature immunology, 2015/04/06, (2015) Read More / View Supplemental Materials
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Cancer and the microbiota.Garrett, WS Science (New York, N.Y.), 2015/04/03, Volume 348, Issue 6230, p.80-6, (2015) Read More / View Supplemental Materials
Abstract
Myocardial Infarction-Associated SNP at 6p24 Interferes With MEF2 Binding and Associates With PHACTR1 Expression Levels in Human Coronary Arteries.Beaudoin, M., Gupta RM, Won HH, Lo KS, Do R., Henderson CA, Lavoie-St-Amour C., Langlois S., Rivas D., Lehoux S., Kathiresan S., Tardif JC, Musunuru K., and Lettre G. Arteriosclerosis, thrombosis, and vascular biology, 2015/04/02, (2015) Read More / View Supplemental Materials
Abstract
Association of a brain methylation site with clinical outcomes in depression does not replicate across populations.Uher, R., Ripke S., Müller-Myhsok B., Lewis CM, and Perlis RH The American journal of psychiatry, 2015/04/01, Volume 172, Issue 4, p.395-7, (2015) Read More / View Supplemental Materials
Clinical Acquired Resistance to RAF Inhibitor Combinations in BRAF-Mutant Colorectal Cancer through MAPK Pathway Alterations.Ahronian, LG, Sennott EM, Van Allen EM, Wagle N., Kwak EL, Faris JE, Godfrey JT, Nishimura K., Lynch KD, Mermel CH, Lockerman EL, Kalsy A., Gurski JM Jr, Bahl S., Anderka K., Green LM, Lennon NJ, Huynh TG, Mino-Kenudson M., Getz G., et al. Cancer discovery, 2015/04/01, Volume 5, Issue 4, p.358-67, (2015) Read More / View Supplemental Materials
Abstract
Dynamic epigenetic regulation by menin during pancreatic islet tumor formation.Lin, W., Watanabe H., Peng S., Francis JM, Kaplan N., Pedamallu CS, Ramachandran A., Agoston A., Bass AJ, and Meyerson M. Molecular cancer research : MCR, 2015/04/01, Volume 13, Issue 4, p.689-98, (2015) Read More / View Supplemental Materials
Abstract
Frozen Encapsulated Stool in Recurrent Clostridium difficile: Exploring the Role of Pills in the Treatment Hierarchy of Fecal Microbiota Transplant Nonresponders.Stollman, N., Smith M., Giovanelli A., Mendolia G., Burns L., Didyk E., Burgess J., Noh A., Edelstein C., Alm E., and Kassam Z. The American journal of gastroenterology, 2015/04/01, Volume 110, Issue 4, p.600-1, (2015) Read More / View Supplemental Materials
Haematological malignancies: at the forefront of immunotherapeutic innovation.Bachireddy, P., Burkhardt UE, Rajasagi M., and Wu CJ Nature reviews. Cancer, 2015/04/01, Volume 15, Issue 4, p.201-15, (2015) Read More / View Supplemental Materials
Abstract
HDAC3 inhibition improves glycemia and insulin secretion in obese diabetic rats.Lundh, M., Galbo T., Poulsen SS, and Mandrup-Poulsen T. Diabetes, obesity & metabolism, 2015/04/01, (2015) Read More / View Supplemental Materials
Abstract
Loss of PCLO function underlies pontocerebellar hypoplasia type III.Ahmed, MY, Chioza BA, Rajab A., Schmitz-Abe K., Al-Khayat A., Al-Turki S., Baple EL, Patton MA, Al-Memar AY, Hurles ME, Partlow JN, Hill RS, Evrony GD, Servattalab S., Markianos K., Walsh CA, Crosby AH, and Mochida GH Neurology, 2015/04/01, (2015) Read More / View Supplemental Materials
Abstract
A microbiological revolution meets an ancient disease: improving the management of tuberculosis with genomics.Wlodarska, M., Johnston JC, Gardy JL, and Tang P. Clinical microbiology reviews, 2015/04/01, Volume 28, Issue 2, p.523-39, (2015) Read More / View Supplemental Materials
Abstract
miR-182 integrates apoptosis, growth, and differentiation programs in glioblastoma.Kouri, FM, Hurley LA, Daniel WL, Day ES, Hua Y., Hao L., Peng CY, Merkel TJ, Queisser MA, Ritner C., Zhang H., James CD, Sznajder JI, Chin L., Giljohann DA, Kessler JA, Peter ME, Mirkin CA, and Stegh AH Genes & development, 2015/04/01, Volume 29, Issue 7, p.732-45, (2015) Read More / View Supplemental Materials
Abstract
Polygenic Risk Score, Parental Socioeconomic Status, Family History of Psychiatric Disorders, and the Risk for Schizophrenia: A Danish Population-Based Study and Meta-analysis.Agerbo, E., Sullivan PF, Vilhjálmsson BJ, Pedersen CB, Mors O., Børglum AD, Hougaard DM, Hollegaard MV, Meier S., Mattheisen M., Ripke S., Wray NR, and Mortensen PB JAMA psychiatry, 2015/04/01, (2015) Read More / View Supplemental Materials
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Precision medicine in breast cancer: genes, genomes, and the future of genomically driven treatments.Stover, DG, and Wagle N. Current oncology reports, 2015/04/01, Volume 17, Issue 4, p.15, (2015) Read More / View Supplemental Materials
Abstract
Simultaneous measurement of genome-wide transcription elongation speeds and rates of RNA polymerase II transition into active elongation with 4sUDRB-seq.Fuchs, G., Voichek Y., Rabani M., Benjamin S., Gilad S., Amit I., and Oren M. Nature protocols, 2015/04/01, Volume 10, Issue 4, p.605-18, (2015) Read More / View Supplemental Materials
Abstract
The tumor virus landscape of AIDS-related lymphomas.Arvey, A., Ojesina A., Pedamallu CS, Ballon G., Jung J., Duke F., Leoncini L., De Falco G., Bressman E., Tam W., Chadburn A., Meyerson M., and Cesarman E. Blood, 2015/03/31, (2015) Read More / View Supplemental Materials
Abstract
DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia.Chen, CW, Koche RP, Sinha AU, Deshpande AJ, Zhu N., Eng R., Doench JG, Xu H., Chu SH, Qi J., Wang X., Delaney C., Bernt KM, Root DE, Hahn WC, Bradner JE, and Armstrong SA Nature medicine, 2015/03/30, (2015) Read More / View Supplemental Materials
Abstract
Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells.Liao, J., Karnik R., Gu H., Ziller MJ, Clement K., Tsankov AM, Akopian V., Gifford CA, Donaghey J., Galonska C., Pop R., Reyon D., Tsai SQ, Mallard W., Joung JK, Rinn JL, Gnirke A., and Meissner A. Nature genetics, 2015/03/30, (2015) Read More / View Supplemental Materials
Abstract
Expression profiles of 151 pediatric low-grade gliomas reveal molecular differences associated with location and histological subtype.Bergthold, G., Bandopadhayay P., Hoshida Y., Ramkissoon S., Ramkissoon L., Rich B., Maire CL, Paolella BR, Schumacher SE, Tabak B., Ferrer-Luna R., Ozek M., Sav A., Santagata S., Wen PY, Goumnerova LC, Ligon AH, Stiles C., Segal R., Golub T., et al. Neuro-oncology, 2015/03/29, (2015) Read More / View Supplemental Materials
Abstract
Unique patterns of transcript and miRNA expression in the South American strong voltage electric eel (Electrophorus electricus).Traeger, LL, Volkening JD, Moffett H., Gallant JR, Chen PH, Novina CD, Phillips GN Jr, Anand R., Wells GB, Pinch M., Güth R., Unguez GA, Albert JS, Zakon H., Sussman MR, and Samanta MP BMC genomics, 2015/03/26, Volume 16, Issue 1, p.243, (2015) Read More / View Supplemental Materials
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ImmVar project: Insights and design considerations for future studies of "healthy" immune variation.De Jager, PL, Hacohen N., Mathis D., Regev A., Stranger BE, and Benoist C. Seminars in immunology, 2015/03/25, (2015) Read More / View Supplemental Materials
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Non-crossover gene conversions show strong GC bias and unexpected clustering in humans.Williams, AL, Genovese G., Dyer T., Altemose N., Truax K., Jun G., Patterson N., Myers SR, Curran JE, Duggirala R., Blangero J., Reich D., and Przeworski M. eLife, 2015/03/25, Volume 4, (2015) Read More / View Supplemental Materials
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PLZF, a Tumor Suppressor Genetically Lost in Metastatic Castration Resistant Prostate Cancer, is a Mediator of Resistance to Androgen Deprivation Therapy.Hsieh, CL, Botta G., Gao S., Li T., Van Allen EM, Treacy DJ, Cai C., He HH, Sweeney CJ, Brown M., Balk SP, Nelson PS, Garraway LA, and Kantoff PW Cancer research, 2015/03/25, (2015) Read More / View Supplemental Materials
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Association of a 62 Variant Type 2 Diabetes Genetic Risk Score with Markers of Subclinical Atherosclerosis: A Transethnic, Multicenter Study.Dauriz, M., Porneala BC, Guo X., Bielak LF, Peyser PA, Durant NH, Carnethon MR, Bonadonna RC, Bonora E., Bowden DW, Florez JC, Fornage M., Hivert MF, Jacobs DR Jr, Kabagambe EK, Lewis CE, Murabito JM, Rasmussen-Torvik LJ, Rich SS, Vassy JL, et al. Circulation. Cardiovascular genetics, 2015/03/24, (2015) Read More / View Supplemental Materials
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Analysing human neural stem cell ontogeny by consecutive isolation of Notch active neural progenitors.Edri, R., Yaffe Y., Ziller MJ, Mutukula N., Volkman R., David E., Jacob-Hirsch J., Malcov H., Levy C., Rechavi G., Gat-Viks I., Meissner A., and Elkabetz Y. Nature communications, 2015/03/23, Volume 6, p.6500, (2015) Read More / View Supplemental Materials
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Inactivation of HDAC1 or HDAC2 induces gamma globin expression without altering cell cycle or proliferation.Esrick, EB, McConkey M., Lin K., Frisbee A., and Ebert BL American journal of hematology, 2015/03/23, (2015) Read More / View Supplemental Materials
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Dimethylglycine Deficiency and the Development of Diabetes mellitus.Magnusson, M., Wang TJ, Clish C., Engström G., Nilsson P., Gerszten RE, and Melander O. Diabetes, 2015/03/20, (2015) Read More / View Supplemental Materials
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Rare Genetic Variants in the CFI Gene are Associated with Advanced Age-Related Macular Degeneration and Commonly Result in Reduced Serum Factor I Levels.Kavanagh, D., Yu Y., Schramm EC, Triebwasser M., Wagner E., Raychaudhuri S., Daly M. J., Atkinson JP, and Seddon JM Human molecular genetics, 2015/03/18, (2015) Read More / View Supplemental Materials
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CHD2 variants are a risk factor for photosensitivity in epilepsy.Galizia, EC, Myers CT, Leu C., de Kovel CG, Afrikanova T., Cordero-Maldonado ML, Martins TG, Jacmin M., Drury S., Krishna Chinthapalli V., Muhle H., Pendziwiat M., Sander T., Ruppert AK, Møller RS, Thiele H., Krause R., Schubert J., Lehesjoki AE, Nürnberg P., et al. Brain : a journal of neurology, 2015/03/17, (2015) Read More / View Supplemental Materials
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Contribution of common non-synonymous variants in PCSK1 to body-mass index variation and risk of obesity: a systematic review and meta-analysis with evidence from up to 331,175 individuals.Nead, KT, Li A., Wehner MR, Neupane B., Gustafsson S., Butterworth A., Engert JC, Davis AD, Hegele RA, Miller R., den Hoed M., Khaw KT, Kilpeläinen TO, Wareham N., Edwards TL, Hallmans G., Varga TV, Kardia SL, Smith JA, Zhao W., et al. Human molecular genetics, 2015/03/17, (2015) Read More / View Supplemental Materials
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A novel Alzheimer disease locus located near the gene encoding tau protein.Jun, G., Ibrahim-Verbaas CA, Vronskaya M., Lambert JC, Chung J., Naj AC, Kunkle BW, Wang LS, Bis JC, Bellenguez C., Harold D., Lunetta KL, Destefano AL, Grenier-Boley B., Sims R., Beecham GW, Smith AV, Chouraki V., Hamilton-Nelson KL, Ikram MA, et al. Molecular psychiatry, 2015/03/17, (2015) Read More / View Supplemental Materials
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Temporal trends in the incidence and prognosis of aortic stenosis: a nationwide study of the Swedish population.Martinsson, A., Li X., Andersson C., Nilsson J., Smith JG, and Sundquist K. Circulation, 2015/03/17, Volume 131, Issue 11, p.988-94, (2015) Read More / View Supplemental Materials
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Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as a novel autophagy regulator by high content shRNA screening.Strohecker, AM, Joshi S., Possemato R., Abraham RT, Sabatini DM, and White E. Oncogene, 2015/03/16, (2015) Read More / View Supplemental Materials
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Transformation of the intestinal epithelium by the MSI2 RNA-binding protein.Wang, S., Li N., Yousefi M., Nakauka-Ddamba A., Li F., Parada K., Rao S., Minuesa G., Katz Y., Gregory BD, Kharas MG, Yu Z., and Lengner CJ Nature communications, 2015/03/16, Volume 6, p.6517, (2015) Read More / View Supplemental Materials
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Constitutive asymmetric dimerization drives oncogenic activation of epidermal growth factor receptor carboxyl-terminal deletion mutants.Park, AK, Francis JM, Park WY, Park JO, and Cho J. Oncotarget, 2015/03/12, (2015) Read More / View Supplemental Materials
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Genome-wide CRISPR Screen in a Mouse Model of Tumor Growth and Metastasis.Chen, S., Sanjana NE, Zheng K., Shalem O., Lee K., Shi X., Scott DA, Song J., Pan JQ, Weissleder R., Lee H., Zhang F., and Sharp PA Cell, 2015/03/12, Volume 160, Issue 6, p.1246-60, (2015) Read More / View Supplemental Materials
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RB loss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer.Niederst, MJ, Sequist LV, Poirier JT, Mermel CH, Lockerman EL, Garcia AR, Katayama R., Costa C., Ross KN, Moran T., Howe E., Fulton LE, Mulvey HE, Bernardo LA, Mohamoud F., Miyoshi N., VanderLaan PA, Costa DB, Jänne PA, Borger DR, et al. Nature communications, 2015/03/11, Volume 6, p.6377, (2015) Read More / View Supplemental Materials
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Clinical implementation of integrated whole-genome copy number and mutation profiling for glioblastoma.Ramkissoon, SH, Bi WL, Schumacher SE, Ramkissoon LA, Haidar S., Knoff D., Dubuc A., Brown L., Burns M., Cryan JB, Abedalthagafi M., Kang YJ, Schultz N., Reardon DA, Lee EQ, Rinne ML, Norden AD, Nayak L., Ruland S., Doherty LM, et al. Neuro-oncology, 2015/03/09, (2015) Read More / View Supplemental Materials
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Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers.Onengut-Gumuscu, S., Chen WM, Burren O., Cooper NJ, Quinlan AR, Mychaleckyj JC, Farber E., Bonnie JK, Szpak M., Schofield E., Achuthan P., Guo H., Fortune MD, Stevens H., Walker NM, Ward LD, Kundaje A., Kellis M., Daly M. J., Barrett JC, et al. Nature genetics, 2015/03/09, (2015) Read More / View Supplemental Materials
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A Functional Landscape of Resistance to ALK Inhibition in Lung Cancer.Wilson, FH, Johannessen CM, Piccioni F., Tamayo P., Kim JW, Van Allen EM, Corsello SM, Capelletti M., Calles A., Butaney M., Sharifnia T., Gabriel SB, Mesirov J. P., Hahn WC, Engelman JA, Meyerson M., Root DE, Jänne PA, and Garraway LA Cancer cell, 2015/03/09, Volume 27, Issue 3, p.397-408, (2015) Read More / View Supplemental Materials
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Immunogenetics. Dynamic profiling of the protein life cycle in response to pathogens.Jovanovic, M., Rooney MS, Mertins P., Przybylski D., Chevrier N., Satija R., Rodriguez EH, Fields AP, Schwartz S., Raychowdhury R., Mumbach MR, Eisenhaure T., Rabani M., Gennert D., Lu D., Delorey T., Weissman JS, Carr SA, Hacohen N., and Regev A. Science (New York, N.Y.), 2015/03/06, Volume 347, Issue 6226, p.1259038, (2015) Read More / View Supplemental Materials
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Notch-mediated expansion of cord blood progenitors: maintenance of transcriptional and epigenetic fidelity.Dahlberg, A., Woo S., Delaney C., Boyle P., Gnirke A., Bock C., Bernstein BE, Meissner A., Gottardo R., and Bernstein ID Leukemia, 2015/03/06, (2015) Read More / View Supplemental Materials
2014 curt stern award introduction: mark daly.Palotie, A. American journal of human genetics, 2015/03/05, Volume 96, Issue 3, p.367-8, (2015) Read More / View Supplemental Materials
2014 curt stern award: a tryst with genetics.Daly, M. J. American journal of human genetics, 2015/03/05, Volume 96, Issue 3, p.369-71, (2015) Read More / View Supplemental Materials
Anemia: progress in molecular mechanisms and therapies.Sankaran, VG, and Weiss MJ Nature medicine, 2015/03/05, Volume 21, Issue 3, p.221-230, (2015) Read More / View Supplemental Materials
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Characterization of large structural genetic mosaicism in human autosomes.Machiela, MJ, Zhou W., Sampson JN, Dean MC, Jacobs KB, Black A., Brinton LA, Chang IS, Chen C., Chen C., Chen K., Cook LS, Crous Bou M., De Vivo I., Doherty J., Friedenreich CM, Gaudet MM, Haiman CA, Hankinson SE, Hartge P., et al. American journal of human genetics, 2015/03/05, Volume 96, Issue 3, p.487-97, (2015) Read More / View Supplemental Materials
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Remodelling of a homeobox gene cluster by multiple independent gene reunions in Drosophila.Chan, C., Jayasekera S., Kao B., Páramo M., von Grotthuss M., and Ranz JM Nature communications, 2015/03/05, Volume 6, p.6509, (2015) Read More / View Supplemental Materials
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Characterization of bipolar disorder patient-specific induced pluripotent stem cells from a family reveals neurodevelopmental and mRNA expression abnormalities.Madison, JM, Zhou F., Nigam A., Hussain A., Barker DD, Nehme R., van der Ven K., Hsu J., Wolf P., Fleishman M., O'Dushlaine C., Rose S., Chambert K., Lau FH, Ahfeldt T., Rueckert EH, Sheridan SD, Fass DM, Nemesh J., Mullen TE, et al. Molecular psychiatry, 2015/03/03, (2015) Read More / View Supplemental Materials
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Single-cell analysis reveals transcriptional heterogeneity of neural progenitors in human cortex.Johnson, MB, Wang PP, Atabay KD, Murphy EA, Doan RN, Hecht JL, and Walsh CA Nature neuroscience, 2015/03/03, (2015) Read More / View Supplemental Materials
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Highly efficient Cas9-mediated transcriptional programming.Chavez, A., Scheiman J., Vora S., Pruitt BW, Tuttle M., P R Iyer E., Lin S., Kiani S., Guzman CD, Wiegand DJ, Ter-Ovanesyan D., Braff JL, Davidsohn N., Housden BE, Perrimon N., Weiss R., Aach J., Collins JJ, and Church GM Nature methods, 2015/03/02, (2015) Read More / View Supplemental Materials
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Massive migration from the steppe was a source for Indo-European languages in Europe.Haak, W., Lazaridis I., Patterson N., Rohland N., Mallick S., Llamas B., Brandt G., Nordenfelt S., Harney E., Stewardson K., Fu Q., Mittnik A., Bánffy E., Economou C., Francken M., Friederich S., Pena RG, Hallgren F., Khartanovich V., Khokhlov A., et al. Nature, 2015/03/02, (2015) Read More / View Supplemental Materials
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Polyploidy can drive rapid adaptation in yeast.Selmecki, AM, Maruvka YE, Richmond PA, Guillet M., Shoresh N., Sorenson AL, De S., Kishony R., Michor F., Dowell R., and Pellman D. Nature, 2015/03/02, (2015) Read More / View Supplemental Materials
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Simultaneous generation of many RNA-seq libraries in a single reaction.Shishkin, AA, Giannoukos G., Kucukural A., Ciulla D., Busby M., Surka C., Chen J., Bhattacharyya RP, Rudy RF, Patel MM, Novod N., Hung DT, Gnirke A., Garber M., Guttman M., and Livny J. Nature methods, 2015/03/02, (2015) Read More / View Supplemental Materials
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Antimicrobial-induced DNA damage and genomic instability in microbial pathogens.Shapiro, RS PLoS pathogens, 2015/03/01, Volume 11, Issue 3, p.e1004678, (2015) Read More / View Supplemental Materials
Chromatin regulation at the frontier of synthetic biology.Keung, AJ, Joung JK, Khalil AS, and Collins JJ Nature reviews. Genetics, 2015/03/01, Volume 16, Issue 3, p.159-71, (2015) Read More / View Supplemental Materials
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Commentary: Insights from across diagnostic boundaries: ADHD in the RDoC era - a commentary on Scerif and Baker ().Doyle, AE Journal of child psychology and psychiatry, and allied disciplines, 2015/03/01, Volume 56, Issue 3, p.274-7, (2015) Read More / View Supplemental Materials
Abstract
Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt.Murn, J., Zarnack K., Yang YJ, Durak O., Murphy EA, Cheloufi S., Gonzalez DM, Teplova M., Curk T., Zuber J., Patel DJ, Ule J., Luscombe NM, Tsai LH, Walsh CA, and Shi Y. Genes & development, 2015/03/01, Volume 29, Issue 5, p.501-12, (2015) Read More / View Supplemental Materials
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Development of a Single Nucleotide Polymorphism Barcode to Genotype Plasmodium vivax Infections.Baniecki, ML, Faust AL, Schaffner SF, Park DJ, Galinsky K., Daniels RF, Hamilton E., Ferreira MU, Karunaweera ND, Serre D., Zimmerman PA, Sá JM, Wellems TE, Musset L., Legrand E., Melnikov A., Neafsey DE, Volkman SK, Wirth DF, and Sabeti PC PLoS neglected tropical diseases, 2015/03/01, Volume 9, Issue 3, p.e0003539, (2015) Read More / View Supplemental Materials
Abstract
Discovery of novel rhabdoviruses in the blood of healthy individuals from west Africa.Stremlau, MH, Andersen KG, Folarin OA, Grove JN, Odia I., Ehiane PE, Omoniwa O., Omoregie O., Jiang PP, Yozwiak NL, Matranga CB, Yang X., Gire SK, Winnicki S., Tariyal R., Schaffner SF, Okokhere PO, Okogbenin S., Akpede GO, Asogun DA, et al. PLoS neglected tropical diseases, 2015/03/01, Volume 9, Issue 3, p.e0003631, (2015) Read More / View Supplemental Materials
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A Meta-analysis of Gene Expression Signatures of Blood Pressure and Hypertension.Huan, T., Esko T., Peters MJ, Pilling LC, Schramm K., Schurmann C., Chen BH, Liu C., Joehanes R., Johnson AD, Yao C., Ying SX, Courchesne P., Milani L., Raghavachari N., Wang R., Liu P., Reinmaa E., Dehghan A., Hofman A., et al. PLoS genetics, 2015/03/01, Volume 11, Issue 3, p.e1005035, (2015) Read More / View Supplemental Materials
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Mosquito biology. Evolution of sexual traits influencing vectorial capacity in anopheline mosquitoes.Mitchell, SN, Kakani EG, South A., Howell PI, Waterhouse RM, and Catteruccia F. Science (New York, N.Y.), 2015/02/27, Volume 347, Issue 6225, p.985-8, (2015) Read More / View Supplemental Materials
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Multiplexed, Quantitative Workflow for Sensitive Biomarker Discovery in Plasma Yields Novel Candidates for Early Myocardial Injury.Keshishian, H., Burgess MW, Gillette MA, Mertins P., Clauser KR, Mani D. R., Kuhn EW, Farrell LA, Gerszten RE, and Carr SA Molecular & cellular proteomics : MCP, 2015/02/27, (2015) Read More / View Supplemental Materials
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Predicting clinical response to anticancer drugs using an ex vivo platform that captures tumour heterogeneity.Majumder, B., Baraneedharan U., Thiyagarajan S., Radhakrishnan P., Narasimhan H., Dhandapani M., Brijwani N., Pinto DD, Prasath A., Shanthappa BU, Thayakumar A., Surendran R., Babu GK, Shenoy AM, Kuriakose MA, Bergthold G., Horowitz P., Loda M., Beroukhim R., Agarwal S., et al. Nature communications, 2015/02/27, Volume 6, p.6169, (2015) Read More / View Supplemental Materials
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A roadmap for interpreting 13C metabolite labeling patterns from cells.Buescher, JM, Antoniewicz MR, Boros LG, Burgess SC, Brunengraber H., Clish CB, DeBerardinis RJ, Feron O., Frezza C., Ghesquiere B., Gottlieb E., Hiller K., Jones RG, Kamphorst JJ, Kibbey RG, Kimmelman AC, Locasale JW, Lunt SY, Maddocks OD, Malloy C., et al. Current opinion in biotechnology, 2015/02/27, Volume 34C, p.189-201, (2015) Read More / View Supplemental Materials
Abstract
Data sharing: Make outbreak research open access.Yozwiak, NL, Schaffner SF, and Sabeti PC Nature, 2015/02/26, Volume 518, Issue 7540, p.477-9, (2015) Read More / View Supplemental Materials
Draft Genome Sequence of the Cellulolytic Fungus Chaetomium globosum.Cuomo, CA, Untereiner WA, Ma LJ, Grabherr M., and Birren BW Genome announcements, 2015/02/26, Volume 3, Issue 1, (2015) Read More / View Supplemental Materials
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A genomic data viewer for iPad.Thorvaldsdóttir, H., Robinson JT, Turner D., and Mesirov J. P. Genome biology, 2015/02/26, Volume 16, p.46, (2015) Read More / View Supplemental Materials
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Biogeography of the Intestinal Mucosal and Lumenal Microbiome in the Rhesus Macaque.Yasuda, K., Oh K., Ren B., Tickle TL, Franzosa EA, Wachtman LM, Miller AD, Westmoreland SV, Mansfield KG, Vallender EJ, Miller GM, Rowlett JK, Gevers D., Huttenhower C., and Morgan XC Cell host & microbe, 2015/02/25, (2015) Read More / View Supplemental Materials
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Glucokinase regulatory protein: complexity at the crossroads of triglyceride and glucose metabolism.Raimondo, A., Rees MG, and Gloyn AL Current opinion in lipidology, 2015/02/24, (2015) Read More / View Supplemental Materials
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Searching for a minimal set of behaviors for autism detection through feature selection-based machine learning.Kosmicki, JA, Sochat V., Duda M., and Wall DP Translational psychiatry, 2015/02/24, Volume 5, p.e514, (2015) Read More / View Supplemental Materials
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Age- and Sex-Specific Causal Effects of Adiposity on Cardiovascular Risk Factors.Fall, T., Hägg S., Ploner A., Mägi R., Fischer K., Draisma HH, Sarin AP, Benyamin B., Ladenvall C., Åkerlund M., Kals M., Esko T., Nelson CP, Kaakinen M., Huikari V., Mangino M., Meirhaeghe A., Kristiansson K., Nuotio ML, Kobl M., et al. Diabetes, 2015/02/23, (2015) Read More / View Supplemental Materials
Abstract
Oncotator: Cancer Variant Annotation Tool.Ramos, AH, Lichtenstein L., Gupta M., Lawrence MS, Pugh TJ, Saksena G., Meyerson M., and Getz G. Human mutation, 2015/02/23, (2015) Read More / View Supplemental Materials
Abstract
BRCA1 Recruitment to Transcriptional Pause Sites Is Required for R-Loop-Driven DNA Damage Repair.Hatchi, E., Skourti-Stathaki K., Ventz S., Pinello L., Yen A., Kamieniarz-Gdula K., Dimitrov S., Pathania S., McKinney KM, Eaton ML, Kellis M., Hill SJ, Parmigiani G., Proudfoot NJ, and Livingston DM Molecular cell, 2015/02/19, Volume 57, Issue 4, p.636-47, (2015) Read More / View Supplemental Materials
Abstract
Cell-of-origin chromatin organization shapes the mutational landscape of cancer.Polak, P., Karlić R., Koren A., Thurman R., Sandstrom R., Lawrence MS, Reynolds A., Rynes E., Vlahoviček K., Stamatoyannopoulos JA, and Sunyaev SR Nature, 2015/02/19, Volume 518, Issue 7539, p.360-4, (2015) Read More / View Supplemental Materials
Abstract
Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer's disease.Gjoneska, E., Pfenning AR, Mathys H., Quon G., Kundaje A., Tsai LH, and Kellis M. Nature, 2015/02/19, Volume 518, Issue 7539, p.365-9, (2015) Read More / View Supplemental Materials
Abstract
Integrative analysis of 111 reference human epigenomes.Roadmap Epigenomics, Consortium, Kundaje A., Meuleman W., Ernst J., Bilenky M., Yen A., Heravi-Moussavi A., Kheradpour P., Zhang Z., Wang J., Ziller MJ, Amin V., Whitaker JW, Schultz MD, Ward LD, Sarkar A., Quon G., Sandstrom RS, Eaton ML, Wu YC, et al. Nature, 2015/02/19, Volume 518, Issue 7539, p.317-30, (2015) Read More / View Supplemental Materials
Abstract
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