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Submitted
Synthesis, cellular evaluation and mechanism-of-action of piperlongumine analogsAdams, DJ, Dai M., Pellegrino G., Wagner BK, Stern AM, Shamji AF, and Schreiber SL, (Submitted) Read More / View Supplemental Materials
2016
Prostate Cancer Susceptibility in Men of African Ancestry at 8q24.Han, Y., Rand KA, Hazelett DJ, Ingles SA, Kittles RA, Strom SS, Rybicki BA, Nemesure B., Isaacs WB, Stanford JL, Zheng W., Schumacher FR, Berndt SI, Wang Z., Xu J., Rohland N., Reich D., Tandon A., Pasaniuc B., Allen A., et al. Journal of the National Cancer Institute, 2016/07/01, Volume 108, Issue 7, (2016) Read More / View Supplemental Materials
Abstract
Blood metabolomics analysis identifies abnormalities in the citric acid cycle, urea cycle, and amino acid metabolism in bipolar disorder.Yoshimi, N., Futamura T., Kakumoto K., Salehi AM, Sellgren CM, Holmén-Larsson J., Jakobsson J., Pålsson E., Landén M., and Hashimoto K. BBA clinical, 2016/06/01, Volume 5, p.151-8, (2016) Read More / View Supplemental Materials
Abstract
Circulating Metabolites and Survival Among Patients With Pancreatic Cancer.Yuan, C., Clish CB, Wu C., Mayers JR, Kraft P., Townsend MK, Zhang M., Tworoger SS, Bao Y., Qian ZR, Rubinson DA, Ng K., Giovannucci EL, Ogino S., Stampfer MJ, Gaziano JM, Ma J., Sesso HD, Anderson GL, Cochrane BB, et al. Journal of the National Cancer Institute, 2016/06/01, Volume 108, Issue 6, (2016) Read More / View Supplemental Materials
Abstract
Comparison of Cas9 activators in multiple species.Chavez, A., Tuttle M., Pruitt BW, Ewen-Campen B., Chari R., Ter-Ovanesyan D., Haque SJ, Cecchi RJ, Kowal EJ, Buchthal J., Housden BE, Perrimon N., Collins JJ, and Church G. Nature methods, 2016/05/23, (2016) Read More / View Supplemental Materials
Abstract
Clonal evolution in patients with chronic lymphocytic leukaemia developing resistance to BTK inhibition.Burger, JA, Landau DA, Taylor-Weiner A., Bozic I., Zhang H., Sarosiek K., Wang L., Stewart C., Fan J., Hoellenriegel J., Sivina M., Dubuc AM, Fraser C., Han Y., Li S., Livak KJ, Zou L., Wan Y., Konoplev S., Sougnez C., et al. Nature communications, 2016/05/20, Volume 7, p.11589, (2016) Read More / View Supplemental Materials
Abstract
Mechanisms of Pediatric Inflammatory Bowel Disease.Peloquin, JM, Goel G., Villablanca EJ, and Xavier RJ Annual review of immunology, 2016/05/20, Volume 34, p.31-64, (2016) Read More / View Supplemental Materials
Abstract
Persistence of Plasmodium falciparum parasitemia after artemisinin combination therapy: evidence from a randomized trial in Uganda.Chang, HH, Meibalan E., Zelin J., Daniels R., Eziefula AC, Meyer EC, Tadesse F., Grignard L., Joice RC, Drakeley C., Wirth DF, Volkman SK, Buckee C., Bousema T., and Marti M. Scientific reports, 2016/05/20, Volume 6, p.26330, (2016) Read More / View Supplemental Materials
Abstract
Mapping adipose and muscle tissue expression quantitative trait loci in African Americans to identify genes for type 2 diabetes and obesity.Sajuthi, SP, Sharma NK, Chou JW, Palmer ND, McWilliams DR, Beal J., Comeau ME, Ma L., Calles-Escandon J., Demons J., Rogers S., Cherry K., Menon L., Kouba E., Davis D., Burris M., Byerly SJ, Ng MC, Maruthur NM, Patel SR, et al. Human genetics, 2016/05/19, (2016) Read More / View Supplemental Materials
Abstract
PCSK9 Inhibitors.Natarajan, P., and Kathiresan S. Cell, 2016/05/19, Volume 165, Issue 5, p.1037, (2016) Read More / View Supplemental Materials
Abstract
Simultaneous Pathway Activity Inference and Gene Expression Analysis Using RNA Sequencing.O'Connell, DJ, Kolde R., Sooknah M., Graham DB, Sundberg TB, Latorre IJ, Mikkelsen TS, and Xavier RJ Cell systems, 2016/05/19, (2016) Read More / View Supplemental Materials
Abstract
The impact of the MYB-NFIB fusion protooncogene in vivo.Mikse, OR, Tchaicha JH, Akbay EA, Chen L., Bronson RT, Hammerman PS, and Wong KK Oncotarget, 2016/05/18, (2016) Read More / View Supplemental Materials
Abstract
Intracellular Action of a Secreted Peptide Required for Fungal Virulence.Homer, CM, Summers DK, Goranov AI, Clarke SC, Wiesner DL, Diedrich JK, Moresco JJ, Toffaletti D., Upadhya R., Caradonna I., Petnic S., Pessino V., Cuomo CA, Lodge JK, Perfect J., Yates JR 3rd, Nielsen K., Craik CS, and Madhani HD Cell host & microbe, 2016/05/18, (2016) Read More / View Supplemental Materials
Abstract
The lncRNA SLNCR1 Mediates Melanoma Invasion through a Conserved SRA1-like Region.Schmidt, K., Joyce CE, Buquicchio F., Brown A., Ritz J., Distel RJ, Yoon CH, and Novina CD Cell reports, 2016/05/18, (2016) Read More / View Supplemental Materials
Abstract
Role of Plasmodium vivax Duffy-binding protein 1 in invasion of Duffy-null Africans.Gunalan, K., Lo E., Hostetler JB, Yewhalaw D., Mu J., Neafsey DE, Yan G., and Miller LH Proceedings of the National Academy of Sciences of the United States of America, 2016/05/17, (2016) Read More / View Supplemental Materials
Abstract
Divergent modes of clonal spread and intraperitoneal mixing in high-grade serous ovarian cancer.McPherson, A., Roth A., Laks E., Masud T., Bashashati A., Zhang AW, Ha G., Biele J., Yap D., Wan A., Prentice LM, Khattra J., Smith MA, Nielsen CB, Mullaly SC, Kalloger S., Karnezis A., Shumansky K., Siu C., Rosner J., et al. Nature genetics, 2016/05/16, (2016) Read More / View Supplemental Materials
Abstract
A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases.Han, B., Pouget JG, Slowikowski K., Stahl E., Lee CH, Diogo D., Hu X., Park YR, Kim E., Gregersen PK, Dahlqvist SR, Worthington J., Martin J., Eyre S., Klareskog L., Huizinga T., Chen WM, Onengut-Gumuscu S., Rich SS, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, et al. Nature genetics, 2016/05/16, (2016) Read More / View Supplemental Materials
Abstract
Novel microRNA regulators of atrial natriuretic peptide production.Wu, C., Arora P., Agha O., Hurst LA, Allen K., Nathan DI, Hu D., Jiramongkolchai P., Smith JG, Melander O., Trenson S., Janssens SP, Domian I., Wang TJ, Bloch KD, Buys ES, Bloch DB, and Newton-Cheh C. Molecular and cellular biology, 2016/05/16, (2016) Read More / View Supplemental Materials
Abstract
Variants within the SP110 nuclear body protein modify risk of canine degenerative myelopathy.Ivansson, EL, Megquier K., Kozyrev SV, Murén E., Körberg IB, Swofford R., Koltookian M., Tonomura N., Zeng R., Kolicheski AL, Hansen L., Katz ML, Johnson GC, Johnson GS, Coates JR, and Lindblad-Toh K. Proceedings of the National Academy of Sciences of the United States of America, 2016/05/16, (2016) Read More / View Supplemental Materials
Abstract
Hematopoietic Age at Onset of Triple-Negative Breast Cancer Dictates Disease Aggressiveness and Progression.Marsh, T., Wong I., Sceneay J., Barakat A., Qin Y., Sjödin A., Alspach E., Nilsson B., Stewart SA, and McAllister SS Cancer research, 2016/05/15, Volume 76, Issue 10, p.2932-43, (2016) Read More / View Supplemental Materials
Abstract
The leak channel NALCN controls tonic firing and glycolytic sensitivity of substantia nigra pars reticulata neurons.Lutas, A., Lahmann C., Soumillon M., and Yellen G. eLife, 2016/05/13, Volume 5, (2016) Read More / View Supplemental Materials
Abstract
Metabolomics of Chronic Kidney Disease Progression: A Case-Control Analysis in the Chronic Renal Insufficiency Cohort Study.Rhee, EP, Clish CB, Wenger J., Roy J., Elmariah S., Pierce KA, Bullock K., Anderson AH, Gerszten RE, and Feldman HI American journal of nephrology, 2016/05/13, Volume 43, Issue 5, p.366-374, (2016) Read More / View Supplemental Materials
Abstract
Associations of Trauma Exposure and Posttraumatic Stress Symptoms With Venous Thromboembolism Over 22 Years in Women.Sumner, JA, Kubzansky LD, Kabrhel C., Roberts AL, Chen Q., Winning A., Gilsanz P., Rimm EB, Glymour MM, and Koenen KC Journal of the American Heart Association, 2016/05/12, Volume 5, Issue 5, (2016) Read More / View Supplemental Materials
Abstract
Clinical Sequencing Exploratory Research Consortium: Accelerating Evidence-Based Practice of Genomic Medicine.Green, RC, Goddard KA, Jarvik GP, Amendola LM, Appelbaum PS, Berg JS, Bernhardt BA, Biesecker LG, Biswas S., Blout CL, Bowling KM, Brothers KB, Burke W., Caga-Anan CF, Chinnaiyan AM, Chung WK, Clayton EW, Cooper GM, East K., Evans JP, et al. American journal of human genetics, 2016/05/12, (2016) Read More / View Supplemental Materials
Abstract
YB-1 regulates tiRNA-induced Stress Granule formation but not translational repression.Lyons, SM, Achorn C., Kedersha NL, Anderson PJ, and Ivanov P. Nucleic acids research, 2016/05/12, (2016) Read More / View Supplemental Materials
Abstract
Genome-wide Association Studies of Posttraumatic Stress Disorder in 2 Cohorts of US Army Soldiers.Stein, MB, Chen CY, Ursano RJ, Cai T., Gelernter J., Heeringa SG, Jain S., Jensen KP, Maihofer AX, Mitchell C., Nievergelt CM, Nock MK, Neale BM, Polimanti R., Ripke S., Sun X., Thomas ML, Wang Q., Ware EB, Borja S., et al. JAMA psychiatry, 2016/05/11, (2016) Read More / View Supplemental Materials
Abstract
Loss of MAFB Function in Humans and Mice Causes Duane Syndrome, Aberrant Extraocular Muscle Innervation, and Inner-Ear Defects.Park, JG, Tischfield MA, Nugent AA, Cheng L., Di Gioia SA, Chan WM, Maconachie G., Bosley TM, Summers CG, Hunter DG, Robson CD, Gottlob I., and Engle EC American journal of human genetics, 2016/05/11, (2016) Read More / View Supplemental Materials
Abstract
Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation.Dominguez-Brauer, C., Hao Z., Elia AJ, Fortin JM, Nechanitzky R., Brauer PM, Sheng Y., Mana MD, Chio II, Haight J., Pollett A., Cairns R., Tworzyanski L., Inoue S., Reardon C., Marques A., Silvester J., Cox MA, Wakeham A., Yilmaz OH, et al. Cell stem cell, 2016/05/11, (2016) Read More / View Supplemental Materials
Abstract
Performance of ACMG-AMP Variant-Interpretation Guidelines among Nine Laboratories in the Clinical Sequencing Exploratory Research Consortium.Amendola, LM, Jarvik GP, Leo MC, McLaughlin HM, Akkari Y., Amaral MD, Berg JS, Biswas S., Bowling KM, Conlin LK, Cooper GM, Dorschner MO, Dulik MC, Ghazani AA, Ghosh R., Green RC, Hart R., Horton C., Johnston JJ, Lebo MS, et al. American journal of human genetics, 2016/05/11, (2016) Read More / View Supplemental Materials
Abstract
The RNA Binding Protein IMP2 Preserves Glioblastoma Stem Cells by Preventing let-7 Target Gene Silencing.Degrauwe, N., Schlumpf TB, Janiszewska M., Martin P., Cauderay A., Provero P., Riggi N., Suvà ML, Paro R., and Stamenkovic I. Cell reports, 2016/05/11, (2016) Read More / View Supplemental Materials
Abstract
SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b.Kugel, S., Sebastián C., Fitamant J., Ross KN, Saha SK, Jain E., Gladden A., Arora KS, Kato Y., Rivera MN, Ramaswamy S., Sadreyev RI, Goren A., Deshpande V., Bardeesy N., and Mostoslavsky R. Cell, 2016/05/11, (2016) Read More / View Supplemental Materials
Abstract
Discovery and validation of sub-threshold genome-wide association study loci using epigenomic signatures.Wang, X., Tucker NR, Rizki G., Mills R., Krijger PH, de Wit E., Subramanian V., Bartell E., Nguyen XX, Ye J., Leyton-Mange J., Dolmatova EV, van der Harst P., de Laat W., Ellinor PT, Newton-Cheh C., Milan DJ, Kellis M., and Boyer LA eLife, 2016/05/10, Volume 5, (2016) Read More / View Supplemental Materials
Abstract
Massive contribution of transposable elements to mammalian regulatory sequences.Rayan, NA, Del Rosario RC, and Prabhakar S. Seminars in cell & developmental biology, 2016/05/10, (2016) Read More / View Supplemental Materials
Abstract
Most neutralizing human monoclonal antibodies target novel epitopes requiring both Lassa virus glycoprotein subunits.Robinson, JE, Hastie KM, Cross RW, Yenni RE, Elliott DH, Rouelle JA, Kannadka CB, Smira AA, Garry CE, Bradley BT, Yu H., Shaffer JG, Boisen ML, Hartnett JN, Zandonatti MA, Rowland MM, Heinrich ML, Martínez-Sobrido L., Cheng B., de la Torre JC, et al. Nature communications, 2016/05/10, Volume 7, p.11544, (2016) Read More / View Supplemental Materials
Abstract
Recurrent hormone-binding domain truncated ESR1 amplifications in primary endometrial cancers suggest their implication in hormone independent growth.Holst, F., Hoivik EA, Gibson WJ, Taylor-Weiner A., Schumacher SE, Asmann YW, Grossmann P., Trovik J., Necela BM, Thompson EA, Meyerson M., Beroukhim R., Salvesen HB, and Cherniack AD Scientific reports, 2016/05/10, Volume 6, p.25521, (2016) Read More / View Supplemental Materials
Abstract
Adult axolotls can regenerate original neuronal diversity in response to brain injury.Amamoto, R., Huerta VG, Takahashi E., Dai G., Grant AK, Fu Z., and Arlotta P. eLife, 2016/05/09, Volume 5, (2016) Read More / View Supplemental Materials
Abstract
CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands.Lamas, B., Richard ML, Leducq V., Pham HP, Michel ML, Da Costa G., Bridonneau C., Jegou S., Hoffmann TW, Natividad JM, Brot L., Taleb S., Couturier-Maillard A., Nion-Larmurier I., Merabtene F., Seksik P., Bourrier A., Cosnes J., Ryffel B., Beaugerie L., et al. Nature medicine, 2016/05/09, (2016) Read More / View Supplemental Materials
Abstract
Comprehensive Pan-Genomic Characterization of Adrenocortical Carcinoma.Zheng, S., Cherniack AD, Dewal N., Moffitt RA, Danilova L., Murray BA, Lerario AM, Else T., Knijnenburg TA, Ciriello G., Kim S., Assie G., Morozova O., Akbani R., Shih J., Hoadley KA, Choueiri TK, Waldmann J., Mete O., Robertson AG, et al. Cancer cell, 2016/05/09, Volume 29, Issue 5, p.723-36, (2016) Read More / View Supplemental Materials
Abstract
Diagnosis and aetiology of congenital muscular dystrophy: we are halfway there.O'Grady, GL, Lek M., Lamande SR, Waddell L., Oates EC, Punetha J., Ghaoui R., Sandaradura SA, Best H., Kaur S., Davis M., Laing NG, Muntoni F., Hoffman E., Macarthur DG, Clarke NF, Cooper S., and North K. Annals of neurology, 2016/05/09, (2016) Read More / View Supplemental Materials
Abstract
Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas.Campbell, JD, Alexandrov A., Kim J., Wala J., Berger AH, Pedamallu CS, Shukla SA, Guo G., Brooks AN, Murray BA, Imielinski M., Hu X., Ling S., Akbani R., Rosenberg M., Cibulskis C., Ramachandran A., Collisson EA, Kwiatkowski DJ, Lawrence MS, et al. Nature genetics, 2016/05/09, (2016) Read More / View Supplemental Materials
Abstract
Genome-wide association study of generalized anxiety symptoms in the Hispanic Community Health Study/Study of Latinos.Dunn, EC, Sofer T., Gallo LC, Gogarten SM, Kerr KF, Chen CY, Stein MB, Ursano RJ, Guo X., Jia Y., Qi Q., Rotter JI, Argos M., Cai J., Penedo FJ, Perreira K., Wassertheil-Smoller S., and Smoller JW American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2016/05/09, (2016) Read More / View Supplemental Materials
Abstract
MAPK activation and HRAS mutation identified in pituitary spindle cell oncocytoma.Miller, MB, Bi WL, Ramkissoon LA, Kang YJ, Abedalthagafi M., Knoff DS, Agarwalla PK, Wen PY, Reardon DA, Alexander BM, Laws ER Jr, Dunn IF, Beroukhim R., Ligon KL, and Ramkissoon SH Oncotarget, 2016/05/09, (2016) Read More / View Supplemental Materials
Abstract
ROR1 is essential for proper innervation of auditory hair cells and hearing in humans and mice.Diaz-Horta, O., Abad C., Sennaroglu L., Foster J 2nd, DeSmidt A., Bademci G., Tokgoz-Yilmaz S., Duman D., Cengiz FB, Grati M., Fitoz S., Liu XZ, Farooq A., Imtiaz F., Currall BB, Morton CC, Nishita M., Minami Y., Lu Z., Walz K., et al. Proceedings of the National Academy of Sciences of the United States of America, 2016/05/09, (2016) Read More / View Supplemental Materials
Abstract
Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor.Rothhammer, V., Mascanfroni ID, Bunse L., Takenaka MC, Kenison JE, Mayo L., Chao CC, Patel B., Yan R., Blain M., Alvarez JI, Kébir H., Anandasabapathy N., Izquierdo G., Jung S., Obholzer N., Pochet N., Clish CB, Prinz M., Prat A., et al. Nature medicine, 2016/05/09, (2016) Read More / View Supplemental Materials
Abstract
Comparative transcriptomics across the prokaryotic tree of life.Cohen, O., Doron S., Wurtzel O., Dar D., Edelheit S., Karunker I., Mick E., and Sorek R. Nucleic acids research, 2016/05/06, (2016) Read More / View Supplemental Materials
Abstract
Rapid, Low-Cost Detection of Zika Virus Using Programmable Biomolecular Components.Pardee, K., Green AA, Takahashi MK, Braff D., Lambert G., Lee JW, Ferrante T., Ma D., Donghia N., Fan M., Daringer NM, Bosch I., Dudley DM, O'Connor DH, Gehrke L., and Collins JJ Cell, 2016/05/06, (2016) Read More / View Supplemental Materials
Abstract
Single-molecule decoding of combinatorially modified nucleosomes.Shema, E., Jones D., Shoresh N., Donohue L., Ram O., and Bernstein BE Science (New York, N.Y.), 2016/05/06, Volume 352, Issue 6286, p.717-21, (2016) Read More / View Supplemental Materials
Abstract
An ancient yet flexible cis-regulatory architecture allows localized Hedgehog tuning by patched/Ptch1.Lorberbaum, DS, Ramos AI, Peterson KA, Carpenter BS, Parker DS, De S., Hillers LE, Blake VM, Nishi Y., McFarlane MR, Chiang AC, Kassis JA, Allen BL, McMahon AP, and Barolo S. eLife, 2016/05/05, Volume 5, (2016) Read More / View Supplemental Materials
Abstract
A comparative assessment of clinical whole exome and transcriptome profiling across sequencing centers: Implications for precision cancer medicine.Allen, EM, Robinson D., Morrissey C., Pritchard C., Imamovic A., Carter S., Rosenberg M., McKenna A., Wu YM, Cao X., Chinnaiyan A., Garraway L., and Nelson PS Oncotarget, 2016/05/05, (2016) Read More / View Supplemental Materials
Abstract
CSF1R mosaicism in a family with hereditary diffuse leukoencephalopathy with spheroids.Eichler, FS, Li J., Guo Y., Caruso PA, Bjonnes AC, Pan J., Booker JK, Lane JM, Tare A., Vlasac I., Hakonarson H., Gusella JF, Zhang J., Keating BJ, and Saxena R. Brain : a journal of neurology, 2016/05/05, (2016) Read More / View Supplemental Materials
Abstract
Development and Validation of a Mass Spectrometry-Based Assay for the Molecular Diagnosis of Mucin-1 Kidney Disease.Blumenstiel, B., DeFelice M., Birsoy O., Bleyer AJ, Kmoch S., Carter TA, Gnirke A., Kidd K., Rehm HL, Ronco L., Lander E. S., Gabriel S., and Lennon NJ The Journal of molecular diagnostics : JMD, 2016/05/05, (2016) Read More / View Supplemental Materials
Abstract
Population-Scale Sequencing Data Enable Precise Estimates of Y-STR Mutation Rates.Willems, T., Gymrek M., Poznik GD, Tyler-Smith C., 1000 Genomes Project Chromosome Y Group, and Erlich Y. American journal of human genetics, 2016/05/05, Volume 98, Issue 5, p.919-33, (2016) Read More / View Supplemental Materials
Abstract
Tumour CD274 (PD-L1) expression and T cells in colorectal cancer.Masugi, Y., Nishihara R., Yang J., Mima K., da Silva A., Shi Y., Inamura K., Cao Y., Song M., Nowak JA, Liao X., Nosho K., Chan AT, Giannakis M., Bass AJ, Hodi FS, Freeman GJ, Rodig S., Fuchs CS, Qian ZR, et al. Gut, 2016/05/05, (2016) Read More / View Supplemental Materials
Abstract
Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans.Vatanen, T., Kostic AD, d'Hennezel E., Siljander H., Franzosa EA, Yassour M., Kolde R., Vlamakis H., Arthur TD, Hämäläinen AM, Peet A., Tillmann V., Uibo R., Mokurov S., Dorshakova N., Ilonen J., Virtanen SM, Szabo SJ, Porter JA, Lähdesmäki H., et al. Cell, 2016/05/05, Volume 165, Issue 4, p.842-53, (2016) Read More / View Supplemental Materials
Abstract
Antidepressant-like effect of low dose ketamine and scopolamine co-treatment in mice.Petryshen, TL, Lewis MC, Dennehy KA, Garza JC, and Fava M. Neuroscience letters, 2016/05/04, Volume 620, p.70-3, (2016) Read More / View Supplemental Materials
Abstract
Enrichment of rare variants in population isolates: single AICDA mutation responsible for hyper-IgM syndrome type 2 in Finland.Trotta, L., Hautala T., Hämäläinen S., Syrjänen J., Viskari H., Almusa H., Lepisto M., Kaustio M., Porkka K., Palotie A., Seppänen M., and Saarela J. European journal of human genetics : EJHG, 2016/05/04, (2016) Read More / View Supplemental Materials
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Clinical Activity and Quality of Life Indices Are Valid Across Ulcerative Colitis But Not Crohn's Disease Phenotypes.Taleban, S., Stewart KO, Li DK, Singh P., Pardi DS, Sturgeon HC, Yajnik V., Xavier RJ, Ananthakrishnan AN, and Khalili H. Digestive diseases and sciences, 2016/05/03, (2016) Read More / View Supplemental Materials
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COMT Val158 Met genotype is associated with reward learning: A replication study and meta-analysis.Corral-Frías, NS, Pizzagalli DA, Carré J., Michalski LJ, Nikolova YS, Perlis RH, Fagerness J., Lee MR, Drabant Conley E., Lancaster TM, Haddad S., Wolf A., Smoller JW, Hariri AR, and Bogdan R. Genes, brain, and behavior, 2016/05/03, (2016) Read More / View Supplemental Materials
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A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs.Raffan, E., Dennis RJ, O'Donovan CJ, Becker JM, Scott RA, Smith SP, Withers DJ, Wood CJ, Conci E., Clements DN, Summers KM, German AJ, Mellersh CS, Arendt ML, Iyemere VP, Withers E., Söder J., Wernersson S., Andersson G., Lindblad-Toh K., et al. Cell metabolism, 2016/05/02, (2016) Read More / View Supplemental Materials
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The genetic history of Ice Age Europe.Fu, Q., Posth C., Hajdinjak M., Petr M., Mallick S., Fernandes D., Furtwängler A., Haak W., Meyer M., Mittnik A., Nickel B., Peltzer A., Rohland N., Slon V., Talamo S., Lazaridis I., Lipson M., Mathieson I., Schiffels S., Skoglund P., et al. Nature, 2016/05/02, (2016) Read More / View Supplemental Materials
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A genetic method for dating ancient genomes provides a direct estimate of human generation interval in the last 45,000 years.Moorjani, P., Sankararaman S., Fu Q., Przeworski M., Patterson N., and Reich D. Proceedings of the National Academy of Sciences of the United States of America, 2016/05/02, (2016) Read More / View Supplemental Materials
Abstract
Lower prevalence but similar fitness in a parasitic fungus at higher radiation levels near Chernobyl.Aguileta, G., Badouin H., Hood ME, Møller AP, Le Prieur S., Snirc A., Siguenza S., Mousseau TA, Shykoff JA, Cuomo CA, and Giraud T. Molecular ecology, 2016/05/02, (2016) Read More / View Supplemental Materials
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Atrial Fibrillation and Declining Physical Performance in Older Adults: The Health, Aging, and Body Composition Study.Magnani, JW, Wang N., Benjamin EJ, Garcia ME, Bauer DC, Butler J., Ellinor PT, Kritchevsky S., Marcus GM, Newman A., Phillips CL, Sasai H., Satterfield S., Sullivan LM, Harris TB, and and Health, Aging Body Composition Study Circulation. Arrhythmia and electrophysiology, 2016/05/01, Volume 9, Issue 5, p.e003525, (2016) Read More / View Supplemental Materials
Abstract
Differences in the Selection Bottleneck between Modes of Sexual Transmission Influence the Genetic Composition of the HIV-1 Founder Virus.Tully, DC, Ogilvie CB, Batorsky RE, Bean DJ, Power KA, Ghebremichael M., Bedard HE, Gladden AD, Seese AM, Amero MA, Lane K., McGrath G., Bazner SB, Tinsley J., Lennon NJ, Henn MR, Brumme ZL, Norris PJ, Rosenberg ES, Mayer KH, et al. PLoS pathogens, 2016/05/01, Volume 12, Issue 5, p.e1005619, (2016) Read More / View Supplemental Materials
Abstract
Discovery of Genetic Variation on Chromosome 5q22 Associated with Mortality in Heart Failure.Smith, JG, Felix JF, Morrison AC, Kalogeropoulos A., Trompet S., Wilk JB, Gidlöf O., Wang X., Morley M., Mendelson M., Joehanes R., Ligthart S., Shan X., Bis JC, Wang YA, Sjögren M., Ngwa J., Brandimarto J., Stott DJ, Aguilar D., et al. PLoS genetics, 2016/05/01, Volume 12, Issue 5, p.e1006034, (2016) Read More / View Supplemental Materials
Abstract
Genome-Wide Analysis Identifies Germ-Line Risk Factors Associated with Canine Mammary Tumours.Melin, M., Rivera P., Arendt M., Elvers I., Murén E., Gustafson U., Starkey M., Borge KS, Lingaas F., Häggström J., Saellström S., Rönnberg H., and Lindblad-Toh K. PLoS genetics, 2016/05/01, Volume 12, Issue 5, p.e1006029, (2016) Read More / View Supplemental Materials
Abstract
Metabolomics in Prediabetes and Diabetes: A Systematic Review and Meta-analysis.Guasch-Ferré, M., Hruby A., Toledo E., Clish CB, Martínez-González MA, Salas-Salvadó J., and Hu FB Diabetes care, 2016/05/01, Volume 39, Issue 5, p.833-46, (2016) Read More / View Supplemental Materials
Abstract
Reduced-representation Phosphosignatures Measured by Quantitative Targeted MS Capture Cellular States and Enable Large-scale Comparison of Drug-induced Phenotypes.Abelin, JG, Patel J., Lu X., Feeney CM, Fagbami L., Creech AL, Hu R., Lam D., Davison D., Pino L., Qiao JW, Kuhn E., Officer A., Li J., Abbatiello S., Subramanian A., Sidman R., Snyder E., Carr SA, and Jaffe JD Molecular & cellular proteomics : MCP, 2016/05/01, Volume 15, Issue 5, p.1622-41, (2016) Read More / View Supplemental Materials
Abstract
Utilizing the Dog Genome in the Search for Novel Candidate Genes Involved in Glioma Development-Genome Wide Association Mapping followed by Targeted Massive Parallel Sequencing Identifies a Strongly Associated Locus.Truvé, K., Dickinson P., Xiong A., York D., Jayashankar K., Pielberg G., Koltookian M., Murén E., Fuxelius HH, Weishaupt H., Swartling FJ, Andersson G., Hedhammar Å., Bongcam-Rudloff E., Forsberg-Nilsson K., Bannasch D., and Lindblad-Toh K. PLoS genetics, 2016/05/01, Volume 12, Issue 5, p.e1006000, (2016) Read More / View Supplemental Materials
Abstract
Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity.Zhernakova, A., Kurilshikov A., Bonder MJ, Tigchelaar EF, Schirmer M., Vatanen T., Mujagic Z., Vila AV, Falony G., Vieira-Silva S., Wang J., Imhann F., Brandsma E., Jankipersadsing SA, Joossens M., Cenit MC, Deelen P., Swertz MA, study LifeLines Cohort, Weersma RK, et al. Science (New York, N.Y.), 2016/04/29, Volume 352, Issue 6285, p.565-9, (2016) Read More / View Supplemental Materials
Abstract
Subacute decline in serum lipids precedes the occurrence of primary intracerebral hemorrhage.Phuah, CL, Raffeld MR, Ayres AM, Viswanathan A., Greenberg SM, Biffi A., Rosand J., and Anderson CD Neurology, 2016/04/29, (2016) Read More / View Supplemental Materials
Abstract
Abundant PD-L1 expression in Epstein-Barr Virus-infected gastric cancers.Derks, S., Liao X., Chiaravalli AM, Xu X., Camargo MC, Solcia E., Sessa F., Fleitas T., Freeman GJ, Rodig SJ, Rabkin CS, and Bass AJ Oncotarget, 2016/04/28, (2016) Read More / View Supplemental Materials
Abstract
CEL-Seq2: sensitive highly-multiplexed single-cell RNA-Seq.Hashimshony, T., Senderovich N., Avital G., Klochendler A., de Leeuw Y., Anavy L., Gennert D., Li S., Livak KJ, Rozenblatt-Rosen O., Dor Y., Regev A., and Yanai I. Genome biology, 2016/04/28, Volume 17, Issue 1, p.77, (2016) Read More / View Supplemental Materials
Abstract
Clinical, Molecular, and Immune Analysis of Dabrafenib-Trametinib Combination Treatment for BRAF Inhibitor-Refractory Metastatic Melanoma: A Phase 2 Clinical Trial.Chen, G., McQuade JL, Panka DJ, Hudgens CW, Amin-Mansour A., Mu XJ, Bahl S., Jané-Valbuena J., Wani KM, Reuben A., Creasy CA, Jiang H., Cooper ZA, Roszik J., Bassett RL Jr, Joon AY, Simpson LM, Mouton RD, Glitza IC, Patel SP, et al. JAMA oncology, 2016/04/28, (2016) Read More / View Supplemental Materials
Abstract
A Clinician's perspective on clinical exome sequencing.O'Donnell-Luria, AH, and Miller DT Human genetics, 2016/04/28, (2016) Read More / View Supplemental Materials
Abstract
Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma.Dayton, TL, Gocheva V., Miller KM, Israelsen WJ, Bhutkar A., Clish CB, Davidson SM, Luengo A., Bronson RT, Jacks T., and Vander Heiden MG Genes & development, 2016/04/28, (2016) Read More / View Supplemental Materials
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Exome Sequencing of Familial Bipolar Disorder.Goes, FS, Pirooznia M., Parla JS, Kramer M., Ghiban E., Mavruk S., Chen YC, Monson ET, Willour VL, Karchin R., Flickinger M., Locke AE, Levy SE, Scott LJ, Boehnke M., Stahl E., Moran JL, Hultman CM, Landén M., Purcell SM, et al. JAMA psychiatry, 2016/04/27, (2016) Read More / View Supplemental Materials
Abstract
The healthy human microbiome.Lloyd-Price, J., Abu-Ali G., and Huttenhower C. Genome medicine, 2016/04/27, Volume 8, Issue 1, p.51, (2016) Read More / View Supplemental Materials
Abstract
IRF7 inhibition prevents destructive innate immunity-A target for nonantibiotic therapy of bacterial infections.Puthia, M., Ambite I., Cafaro C., Butler D., Huang Y., Lutay N., Rydström G., Gullstrand B., Swaminathan B., Nadeem A., Nilsson B., and Svanborg C. Science translational medicine, 2016/04/27, Volume 8, Issue 336, p.336ra59, (2016) Read More / View Supplemental Materials
Abstract
Neurobiology of social behavior abnormalities in autism and Williams syndrome.Barak, B., and Feng G. Nature neuroscience, 2016/04/26, Volume 19, Issue 6, p.647-55, (2016) Read More / View Supplemental Materials
Abstract
A Spectrum of CodY Activities Drives Metabolic Reorganization and Virulence Gene Expression in Staphylococcus aureus.Waters, NR, Samuels DJ, Behera RK, Livny J., Rhee KY, Sadykov MR, and Brinsmade SR Molecular microbiology, 2016/04/26, (2016) Read More / View Supplemental Materials
Abstract
A genetic basis for the variation in the vulnerability of cancer to DNA damage.Yard, BD, Adams DJ, Chie EK, Tamayo P., Battaglia JS, Gopal P., Rogacki K., Pearson BE, Phillips J., Raymond DP, Pennell NA, Almeida F., Cheah JH, Clemons PA, Shamji A., Peacock CD, Schreiber SL, Hammerman PS, and Abazeed ME Nature communications, 2016/04/25, Volume 7, p.11428, (2016) Read More / View Supplemental Materials
Abstract
A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.Pacold, ME, Brimacombe KR, Chan SH, Rohde JM, Lewis CA, Swier LJ, Possemato R., Chen WW, Sullivan LB, Fiske BP, Cho S., Freinkman E., Birsoy K., Abu-Remaileh M., Shaul YD, Liu CM, Zhou M., Koh MJ, Chung H., Davidson SM, et al. Nature chemical biology, 2016/04/25, (2016) Read More / View Supplemental Materials
Abstract
Punctuated bursts in human male demography inferred from 1,244 worldwide Y-chromosome sequences.Poznik, GD, Xue Y., Mendez FL, Willems TF, Massaia A., Wilson Sayres MA, Ayub Q., McCarthy SA, Narechania A., Kashin S., Chen Y., Banerjee R., Rodriguez-Flores JL, Cerezo M., Shao H., Gymrek M., Malhotra A., Louzada S., Desalle R., Ritchie GR, et al. Nature genetics, 2016/04/25, (2016) Read More / View Supplemental Materials
Abstract
Somatic ERCC2 mutations are associated with a distinct genomic signature in urothelial tumors.Kim, J., Mouw KW, Polak P., Braunstein LZ, Kamburov A., Tiao G., Kwiatkowski DJ, Rosenberg JE, Van Allen EM, D'Andrea AD, and Getz G. Nature genetics, 2016/04/25, (2016) Read More / View Supplemental Materials
Abstract
Targeted erythropoietin selectively stimulates red blood cell expansion in vivo.Burrill, DR, Vernet A., Collins JJ, Silver PA, and Way JC Proceedings of the National Academy of Sciences of the United States of America, 2016/04/25, (2016) Read More / View Supplemental Materials
Abstract
An open-source computational tool to automatically quantify immunolabeled retinal ganglion cells.Dordea, AC, Bray MA, Allen K., Logan D., Fei F., Malhotra R., Gregory M., Carpenter AE, and Buys ES Experimental eye research, 2016/04/24, (2016) Read More / View Supplemental Materials
Abstract
Targeted exonic sequencing of GWAS loci in the high extremes of the plasma lipids distribution.Patel, AP, Peloso GM, Pirruccello JP, Johansen CT, Dubé JB, Larach DB, Ban MR, Dallinge-Thie GM, Gupta N., Boehnke M., Abecasis GR, Kastelein JJ, Hovingh GK, Hegele RA, Rader DJ, and Kathiresan S. Atherosclerosis, 2016/04/23, Volume 250, p.63-68, (2016) Read More / View Supplemental Materials
Abstract
Trained immunity: A program of innate immune memory in health and disease.Netea, MG, Joosten LA, Latz E., Mills KH, Natoli G., Stunnenberg HG, O'Neill LA, and Xavier RJ Science (New York, N.Y.), 2016/04/22, Volume 352, Issue 6284, p.aaf1098, (2016) Read More / View Supplemental Materials
Abstract
Crystal Structure of Cpf1 in Complex with Guide RNA and Target DNA.Yamano, T., Nishimasu H., Zetsche B., Hirano H., Slaymaker IM, Li Y., Fedorova I., Nakane T., Makarova KS, Koonin EV, Ishitani R., Zhang F., and Nureki O. Cell, 2016/04/21, (2016) Read More / View Supplemental Materials
Abstract
Engineering Models to Scale.Dy, AJ, and Collins JJ Cell, 2016/04/21, Volume 165, Issue 3, p.516-7, (2016) Read More / View Supplemental Materials
Abstract
The influence of a short-term gluten-free diet on the human gut microbiome.Bonder, MJ, Tigchelaar EF, Cai X., Trynka G., Cenit MC, Hrdlickova B., Zhong H., Vatanen T., Gevers D., Wijmenga C., Wang Y., and Zhernakova A. Genome medicine, 2016/04/21, Volume 8, Issue 1, p.45, (2016) Read More / View Supplemental Materials
Abstract
PD-1 marks dysfunctional regulatory T cells in malignant gliomas.Lowther, DE, Goods BA, Lucca LE, Lerner BA, Raddassi K., van Dijk D., Hernandez AL, Duan X., Gunel M., Coric V., Krishnaswamy S., Love JC, and Hafler DA JCI insight, 2016/04/21, Volume 1, Issue 5, (2016) Read More / View Supplemental Materials
Abstract
High fat diet and stem cells: Linking diet to intestinal tumor formation.Cangelosi, AL, and Yilmaz Ö. H. Cell cycle (Georgetown, Tex.), 2016/04/20, (2016) Read More / View Supplemental Materials
Abstract
Plasma acylcarnitines and risk of cardiovascular disease: effect of Mediterranean diet interventions.Guasch-Ferré, M., Zheng Y., Ruiz-Canela M., Hruby A., Martínez-González MA, Clish CB, Corella D., Estruch R., Ros E., Fitó M., Dennis C., Morales-Gil IM, Arós F., Fiol M., Lapetra J., Serra-Majem L., Hu FB, and Salas-Salvadó J. The American journal of clinical nutrition, 2016/04/20, (2016) Read More / View Supplemental Materials
Abstract
gkmSVM: an R package for gapped-kmer SVM.Ghandi, M., Mohammad-Noori M., Ghareghani N., Lee D., Garraway L., and Beer MA Bioinformatics (Oxford, England), 2016/04/19, (2016) Read More / View Supplemental Materials
Abstract
Characterizing genomic alterations in cancer by complementary functional associations.Kim, JW, Botvinnik OB, Abudayyeh O., Birger C., Rosenbluh J., Shrestha Y., Abazeed ME, Hammerman PS, Dicara D., Konieczkowski DJ, Johannessen CM, Liberzon A., Alizad-Rahvar AR, Alexe G., Aguirre A., Ghandi M., Greulich H., Vazquez F., Weir BA, Van Allen EM, et al. Nature biotechnology, 2016/04/18, (2016) Read More / View Supplemental Materials
Abstract
Circadian gene variants influence sleep and the sleep electroencephalogram in humans.Chang, AM, Bjonnes AC, Aeschbach D., Buxton OM, Gooley JJ, Anderson C., Reen EV, Cain SW, Czeisler CA, Duffy JF, Lockley SW, Shea SA, Scheer FA, and Saxena R. Chronobiology international, 2016/04/18, p.1-13, (2016) Read More / View Supplemental Materials
Abstract
Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.Okbay, A., Baselmans BM, De Neve JE, Turley P., Nivard MG, Fontana MA, Meddens SF, Linnér RK, Rietveld CA, Derringer J., Gratten J., Lee JJ, Liu JZ, de Vlaming R., Ahluwalia TS, Buchwald J., Cavadino A., Frazier-Wood AC, Furlotte NA, Garfield V., et al. Nature genetics, 2016/04/18, (2016) Read More / View Supplemental Materials
Abstract
Physical and neurobehavioral determinants of reproductive onset and success.Day, FR, Helgason H., Chasman DI, Rose LM, Loh PR, Scott RA, Helgason A., Kong A., Masson G., Magnusson OT, Gudbjartsson D., Thorsteinsdottir U., Buring JE, Ridker PM, Sulem P., Stefansson K., Ong KK, and Perry JR Nature genetics, 2016/04/18, (2016) Read More / View Supplemental Materials
Abstract
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