News and insights

Researchers have developed a machine learning model that connects images of DNA structure to gene regulation.

A suite of new machine learning models can estimate the safety of potential new drugs

New study shows how leveraging unsupervised learning can decode DCIS progression from chromatin images.

The method could accelerate the development of more effective adeno-associated viruses (AAVs).

A new method allows precise activation or repression of genes in specific cells and tissues.

Broad and Denmark-based scientists are collaborating to scale up their efforts to turn genetic insights into the fundamental biological mechanisms underlying metabolic disease.

The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease is forging connections between Danish and Broad scientists. Here are two of their stories.

The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease brings together Danish and Broad scientists. Managing director Kasper Lage shares the center’s origin story, its achievements so far, and what the future holds.

By studying a diversity of participants, scientists find nearly 150 new locations in the genome linked to type 2 diabetes risk.

Researchers suggest diabetes exists in multiple forms on a spectrum of varying genetic factors and symptoms.

The clusters point to a range of biological processes that likely contribute to the development of type 2 diabetes.

Specific species and strains of bacteria linked to changes in the functioning of the gut microbiome and a person's risk of type 2 diabetes

Scientists have engineered an adeno-associated virus (AAV) that efficiently crosses the blood-brain barrier in human cell models and delivers genes throughout the brain in humanized mice.

Scientists have engineered long lasting mRNAs that increased therapeutic protein production in cells and animals.

The LEGO framework could help scientists create mRNA therapies that last longer and require smaller doses.

BRD-810 inhibits the MCL1 protein and reactivates apoptosis in tumor cells, displaying therapeutic potential in animal models.

Tightly synchronized genetic changes in two types of brain cells may underlie cognitive impairment in both conditions, offering potential therapeutic clues.

Ralda Nehme, director of Broad’s stem cell program, talks about how stem cells can be a model for disease in a dish and what scientists can learn from these experiments.

Researchers examined scat from hundreds of animals around the world and pinpointed genes that could fuel drug-resistant infections.

The microbes control the growth of harmful bacteria in mice, promoting a healthier intestinal microbiome.

A low-cost CRISPR-based paper strip test distinguishes between influenza types and can be reprogrammed to recognize different viruses including the H5N1 bird flu virus.

Scientists from the US and West Africa have teamed up to build a better public health network that can quickly detect and respond to emerging viral threats.

In a pilot study with patient samples, the technology performed as well as the current gold-standard methods, yielding accurate results within hours instead of days.

Researchers find four coordinated gene expression programs in immune cells from glioma tumors, including two that could lead to immunotherapy resistance.

Targeting the PELO gene could be a way to kill tumor cells in cancers with one of two common genetic mutations.

Slow-growing glioma tumors become more aggressive when their cells shift identities and acquire new genetic mutations.

Myocarditis is driven by a different immune response than the anti-tumor one, suggesting that the serious complication could one day be managed without halting cancer therapy.

The team compared different single-cell and spatial profiling methods to explore the diversity of cells in metastatic breast cancer biopsies.