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News from the Broad

The Broad Institute is committed to open sharing not only of its scientific data and tools, but also information and news about our progress towards achieving our mission. Below are just a few highlights from the Broad scientific community.

    Reading the rules of gene regulation with CRISPR

    September 29th, 2016
    We have barely begun to crack open the rulebook for the vast noncoding regions of the genome. Two new methods, building on CRISPR advances, may help reveal some of the pages.
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    Licensing CRISPR for Agriculture: Policy considerations

    September 22nd, 2016
    Broad researchers and their collaborators have pioneered the development and sharing of new genome editing tools, such as CRISPR-Cas9, which are revolutionizing and accelerating nearly every aspect of disease research and drug discovery around the world. In addition to making these genome editing tools and techniques freely available to the academic and non-profit communities, the Broad Institute has since 2013 issued more than a dozen...
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    Unraveling tangled transcriptional webs reveals a dysfunction program in T cells

    September 12th, 2016
    By identifying a unique gene signature for T cell dysfunction, Broad researchers have uncovered a potential path to help the immune system get back in the game against cancer.
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    • Screens of the Broad’s entire DOS (Diversity Oriented Synthesis) library
      of over 100,000 small molecules on the malaria parasite P. falciparum
      have identified compounds that act on a novel malaria target during all
      three stages of the disease.
      Image by Susanna Hamilton, Broad Communications

    Chemistry-based approach reveals new target in fight against malaria

    September 7th, 2016
    Systematic screening identified potential antimalarials with new mechanism of action
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    • The ExAC resource contains data on the exome sequences (protein-
      coding portions of the genome) from 60,706 people from diverse
      ethnic backgrounds.
      Image by Broad Communications/iStockphoto

    Largest collection of human exome sequence data yields unprecedented tool for diagnosing rare disease

    August 17th, 2016
    Deep genetic catalog powers studies of disease and DNA variation
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