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Susanna M. Hamilton, Broad Communications
News / 01.19.17
A genomic analysis of more than 5,000 clinical Mycobacterium tuberculosis strains from around the world sheds light on early signs of antibiotic resistance and suggests potential strategies to slow its progression. Read more
Lauren Solomon & Maria Nemchuck, Broad Communications; Sam Ogden, DFCI
Blog / 01.17.17
A cancer cell can also harbor thousands of structural variants — large-scale losses (deletions), duplications, swaps (translocations), and other changes — in its DNA. Matthew Meyerson and Rameen Beroukhim of the Broad Cancer Program and Dana-Farber Cancer Institute discuss the challenges to studying structural variations in cancer, why it is important to do so, and what researchers are learning that could benefit patients today and in the future. Read more
Susanna M. Hamilton
News / 01.17.17
The study of structural variation — large-scale changes in DNA that can, in some cases, refashion entire chromosomes — in the genomic era has lagged behind that of sequence variation. But there’s a growing appreciation of how important structural variants are to human biology and disease. What makes these variants more challenging to study, and what is being done to overcome those challenges? Read more
Susanna M. Hamilton, Broad Communications
Blog / 01.17.17
Steve McCarroll, an institute member at the Broad Institute, director of genetics for the Stanley Center for Psychiatric Genetics, and an associate professor at Harvard Medical School, takes us beyond single base-pair deletions and misspellings to explore variations in the human genome on a structural level. With the analytical tools available today to examine huge lengths of DNA, McCarroll and others are linking these structural differences to human health and our risk of developing diseases such as schizophrenia and cancer. Read more
Image courtesy of Broad Communications, iStockphoto/somersault1824
News / 01.12.17
Noncoding mutations in lineage-defining genes could represent a new mutational process in cancer Read more