News from the Broad

The Broad Institute is committed to open sharing not only of its scientific data and tools, but also information and news about our progress towards achieving our mission. Below are just a few highlights from the Broad scientific community.
  • Largest collection of human exome sequence data yields unprecedented tool for diagnosing rare disease

    August 17th, 2016
    Deep genetic catalog powers studies of disease and DNA variation
    Read Full Story
  • Better off without it: Broken gene may help protect against ulcerative colitis

    August 9th, 2016
    Loss-of-function mutation that protects against ulcerative colitis suggests possible therapeutic targets
    Read Full Story
  • Taking aim at rare cancer variants

    July 28th, 2016
    With a systematic look at function, Broad’s Target Accelerator effort proves that even rare mutations can drive cancer
    Read Full Story
  • New approach speeds chemical library screens

    July 18th, 2016

    It can take a year or more for a chemical library to be screened in cells, a delay that often slows chemists’ access to biological data that could help them plan their synthesis efforts. In the Journal of the American Chemical Society last week, a team led by Stuart Schreiber and Zarko Boskovic, of Broad’s Center for the Science of Therapeutics and Harvard University’s Department of Chemistry and Chemical Biology, shares an approach for screening newly synthesized compounds’ biological activity in near real-time. Combining chemical synthesis and cell painting, the approach could make the library design process more nimble, reveal how certain synthesis steps impact molecules’ biological activities, and accelerate drug candidate discovery.

  • Microbiome genes on the move

    July 14th, 2016
    Largest metagenomic view of the developing world uncovers “mobile genes” that reveal how culture shapes the human microbiome The word “culture” typically refers to a group’s shared heritage – such as its customs, cuisine, music, and language – that connects people in unique ways. But what if culture extended to a population’s microbiome – the collection of microorganisms that live on and...
    Read Full Story