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Proteomics

The Mission:

  • Apply advanced proteomics methods to further our knowledge of disease, pathways, targets, and drug effects

  • Develop and optimize advanced proteomics experimental and computational techniques to support basic and clinical research needs

  • Collaborate with scientists in the greater Broad community (Harvard, MIT, and Harvard-affiliated hospitals) and external researchers on projects of exceptional merit

Proteomics has been an integral part of research at the Broad since the Institute’s inception in 2004. Members of the Broad’s Proteomics Platform lead research efforts in this area, collaborating with scientists across the institution and beyond to develop and optimize advanced proteomic experimental and computational techniques to support basic and clinical research needs. These scientists apply these cutting-edge methods to further our knowledge of disease, pathways, targets, and drug effects.

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Areas of Focus

  • Complexes: membership, stoichiometry and dynamics
  • Epigenetics: Histone PTMs
  • Disease biomarker discovery and verification
  • Drug mechanism of action and target ID
  • HLA peptide analysis
  • Proteogenomics
  • Posttranslational modification analysis
  • Rare cell and biopsy-scale analyses
  • Spatial Localization and micro-environment
  • Signaling
  • Targeted, quantitative assays in biology and medicine