Novo Nordisk Foundation Center for Genomic Mechanisms of Disease

The Novo Nordisk Foundation Center generates systematic datasets that will help researchers around the world understand how human genetic variants affect risk for common complex diseases. All datasets are shared freely with the research community. A key activity of the Center is to launch and facilitate close collaborations between the Broad Institute and researchers at Danish universities, with initial focus on understanding type 2 diabetes and obesity, and mapping human gene regulation.

The Center aligns with existing international efforts, sharing data, methodology, and tools to contribute to the roadmap of the International Common Disease Alliance, working in common cause with investigators from other large-scale efforts such as the Accelerating Medicines Partnership in Common Metabolic Diseases and the Impact of Genomic Variation on Function consortia. 

Research collaborations at the Center aim to advance patient-centered research and precision medicine. The Center facilitates an exchange program to provide opportunities for Danish scientists to study genomic technologies at the Broad Institute.

Research at the Center is carried out at the Broad Institute and at Danish institutions, with exchange of scientists and dedicated training programmes for Danish researchers.

The Center is led by Broad Institute associate member Kasper Lage, who is also an associate professor of surgery at Harvard Medical School and director of bioinformatics of the Massachusetts General Hospital Department of Surgery.

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