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BroadE: Fragment-based Drug Discovery 101

This presentation was filmed during the March 2015 Fragment-based Drug Discovery 101 workshop, part of the BroadE Workshop series.

This seminar highlighted key concepts relevant for implementing Fragment Based Drug Discovery (FBDD) and Structure-Based Drug Design (SBD), approaches to efficient discovery and optimization of drugs for newly identified and challenging targets.

Major topics include:

  • Key factors that motivate FBDD and SBD
  • Physicochemical properties and chemical space
  • NMR methods for screening and structure-based design
  • Other biophysical methods for screening and structure-based design
  • Examples of success in the clinic