Broad research

  • Dog research featured on TV's NOVA

    Leah Eisenstadt, November 18th, 2010 | Filed under

    A recent episode of PBS's NOVA series features the Broad Institute and researcher Elinor Karlsson. The program, Dogs Decoded, offers a scientific view of how dogs evolved from wolves, how their species is uniquely connected to ours, and what researchers are learning about human disease by studying dog genomes.

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  • A cast of 1000 genomes

    Nicole Davis, October 27th, 2010 | Filed under

    Nearly every week, new genomes are welcomed into the vast annals of modern science. Indeed, genomic research is moving at an ever-increasing pace, as the machines that decode — or “sequence” — DNA churn out data faster and more cheaply than ever before.

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  • Dan Neafsey takes aim at Anopheles mosquitoes and their partner parasites

    Haley Bridger, October 21st, 2010 | Filed under

    After studying the evolution of genome size in puffer fish for his doctoral thesis, Dan Neafsey was ready for a change. A population geneticist by training, Dan wanted to study an organism or system with a larger impact on human welfare. As he was finishing his thesis in the Hartl lab at Harvard, Dan began to teach himself Perl programming – just enough to perform an initial comparative analysis on malaria genomes and begin learning about the disease with Dyann Wirth’s partner lab at Harvard School of Public Health.

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  • The cell's march to malignancy

    Ellen Clegg, October 19th, 2010 | Filed under

    By the time a cancerous tumor makes itself known, it has probably lived several lifetimes, developing on a twisted evolutionary path that seems to mock the entire process of cell division and growth. Although there is no dearth of promising research, cancer remains a mute and uncooperative subject. More than 40 years into the nation’s “war on cancer,” much remains unknown.

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  • Lights, camera, lincRNA

    Haley Bridger, October 13th, 2010 | Filed under

    Broad associate member John Rinn recently stopped by our office to drop off copies of the August 6 edition of Cell – his paper on how the tumor suppressor p53 “orchestrates” the actions of noncoding RNAs to turn genes off appeared in the issue and on its cover. John also told us about his brief stint as a video star. Cell Press, which publishes several journals including Cell, allows researchers to submit video abstracts about their papers.

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  • This too, too solid flesh...

    Ellen Clegg, October 12th, 2010 | Filed under

    Food and nutrition writer M.E. Malone broke one of the last taboos of marriage on Sunday: she dished about the size of her husband’s waistline in public. Happily, her marriage seems to have survived the public disclosure, as well as the rigors of her husband’s diet regimen and weight loss, and she leaves us with a broad-brush lesson on the power of genetics. She observes that she is able to eat just about anything and remain thin, like her own father.

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  • Completing a disease mosquito genome trifecta

    Alice McCarthy, September 30th, 2010 | Filed under

    In a paper describing the genomic sequence of the Culex quinquefasciatus mosquito, researchers have completed a remarkable sequencing trifecta. The Culex mosquito is one of three kinds of mosquitoes, along with Anopheles and Aedes, known to transmit clinically important human diseases, like malaria, Dengue fever, West Nile virus, and elephantiasis.

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  • Broad epigenetics research makes a big splash

    Leah Eisenstadt, September 29th, 2010 | Filed under

    According to some, epigenomics is the next frontier for genome researchers. Literally meaning “on top of” the genome, the epigenome refers to chemical tags that attach to DNA and the protein scaffold that supports it, together known as “chromatin.” Those tags help turn genes on and off, and therefore they can have huge biological implications.

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  • ‘Nice, friendly yeast’ prompts a new approach

    Haley Bridger, July 27th, 2010 | Filed under

    Yeast is as common in the lab as it is in a bakery. It’s a very useful organism because it grows quickly, is easy to culture, and its genetics have been studied extensively. But its very simplicity means it is also has limits – and those limits prompted Broad core member Aviv Regev and her colleagues to think about developing another model for studying cell circuitry.

    Regev’s work, which she outlined in a recent talk at the Functional Genomics Data Society in Boston, focuses in part on our cells’ ability to respond to changes.

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  • Capturing Fish Faster

    Anne Buboltz, July 19th, 2010 | Filed under

    The zebrafish has emerged as one of the most commonly used organisms in scientific research. They are genetically malleable, have transparent embryonic bodies, develop rapidly and are the most complex vertebrate that can be used for large-scale screening –a combination that makes zebrafish a relatively easy-to-screen model for human disease. Recent research has upgraded the zebrafish model’s status to really-fast-and-easy-to-screen.

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