Broad research

  • Revisiting our festive science images

    Leah Eisenstadt, December 27th, 2011 | Filed under

    Last year during the holiday season, we invited Broad researchers to submit scientific images with a seasonal flair. We thought it would be fun to revisit those images, resembling holiday lights, cracked ice, and tinsel. Enjoy this slideshow of festive imagery from the world of science as we count down to the new year!

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  • Behind the Scenes: Building the Broad’s cloud

    Leah Eisenstadt, December 8th, 2011 | Filed under

    Broadies are pros at sharing. They share ideas, data, equipment, and even bikes. So it may be no surprise to learn that behind the scenes of the Broad’s fast-paced research computing network for data collection and analysis, servers have been quietly getting in the sharing game, too, going “virtual” to save the Broad money, energy, and space and to keep pace with the growing demand for efficient computing by large and diverse research projects throughout the institute.

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  • Stifling a statin side effect

    Haley Bridger, October 6th, 2011 | Filed under

    In the tiny, pinhead-sized wells of a microplate, cultured muscle cells begin to twitch. These mouse cells can grow into long, hearty strands in culture. But when these tendril-like cells are exposed to statins – a drug taken by millions of people to lower cholesterol levels –they start to wither away, mirroring what may be happening in the muscles of some patients.

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  • Diving deep into mitochondrial diseases

    Haley Bridger, September 15th, 2011 | Filed under

    When mitochondria fail, the results can be devastating. Mitochondria are found in almost every cell in the human body (except for red blood cells) and are responsible for producing 90 percent of the ATP (energy units) we need to grow and survive. If mitochondria are compromised, the parts of the body that need energy the most – the heart, brain, liver, muscles, and lungs – can become damaged. Mitochondrial diseases mainly affect children, and for many, the disease is an inherited condition.

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  • Breaking open the lizard egg proteome

    Haley Bridger, September 7th, 2011 | Filed under

    About 340 million years ago, a diminutive vertebrate did something unprecedented: she laid her eggs on dry land. Today, not having to rely on the water to produce offspring may not seem like such a big deal – mammals carry their embryos to term and birds and other reptiles lay their eggs on land – but before organisms evolved the amniote egg, four-legged life was water-bound. Laying eggs on terra firma has allowed reptiles and mammals to thrive in new environments across the world.

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  • Behind the scenes of The Cancer Genome Atlas: part 2

    Leah Eisenstadt, August 11th, 2011 | Filed under

    Yesterday on the blog, we introduced you to some of the Broad researchers who built tools, teams, and resources to generate and analyze a massive flood of data and analytical code for The Cancer Genome Atlas (TCGA). Today we give you a look at the system they built to manage data analysis for the project: Firehose.

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  • Behind the scenes of The Cancer Genome Atlas: part 1

    Leah Eisenstadt, August 10th, 2011 | Filed under

    In this two-part series, we’ll give you a look at some of the tools, teams, and resources built by Broad Institute scientists to support the large-scale cancer sequencing project known as The Cancer Genome Atlas (TCGA).

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  • Getting the cover story

    Leah Eisenstadt, July 19th, 2011 | Filed under

    Back in May, we told you on the blog about Trinity, a suite of tools that assembles transcripts, or bits of RNA that have been copied from a cell’s genome, into a “transcriptome,” even without a reference genome handy.

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  • Mystery of the mitochondria

    Haley Bridger, June 22nd, 2011 | Filed under

    Postdoctoral scholar Fabiana Perocchi remembers her Ph.D. advisor once telling her that if you want to go from a million candidates to a few thousand, you need to find something that does not agree with the pattern.

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  • Molecule makers

    Haley Bridger, June 21st, 2011 | Filed under

    Damian Young’s laboratory at Harvard is a fun place to visit – if you can find it. The lab is housed in the depths of one of the interconnected buildings on Oxford Street, and getting to it requires navigating the twists and turns of many hallways. The lab itself is filled with all kinds of equipment for synthesizing chemical compounds – including an apparatus called a solvent dispensing system, which a chemist can use to decant aliquots of reagents the way a bartender might pour whatever is on tap.

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