Five questions

  • Five Questions for Nir Hacohen

    Haley Bridger, November 16th, 2010 | Filed under

    Your immune system is quite clever. It can sense when bacteria, viruses, or pathogens are invading, distinguish among them, and respond accordingly. But an overactive or improperly functioning immune system can lead to a variety of problems such as auto-immune diseases like lupus or diseases related to inflammation, such as hardening of the arteries (atherosclerosis). Nir Hacohen and his colleagues at the Broad Institute and Massachusetts General Hospital want to find out more about the intricacies of how the immune system works and how it relates to these diseases.

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  • Five Questions for Soumya Raychaudhuri

    Haley Bridger, September 22nd, 2010 | Filed under

    Recent papers have suggested that duplications and deletions of large segments of DNA from patients with schizophrenia, ADHD, and other psychiatric illnesses are linked to genes involved in brain development. Soumya Raychaudhuri and his colleagues at the Broad Institute wanted to take a deeper look – to do so, they developed a statistical test in which they matched people with schizophrenia (“cases”) to people without the disease (“controls”) and compared these duplications and deletions (known as copy number variation, or CNV).

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  • Five Questions for Bang Wong

    Leah Eisenstadt, September 21st, 2010 | Filed under

    As Creative Director at the Broad, Bang Wong has helped shape the DNAtrium’s varied exhibits, created figures and cover art for many scientific papers, and collaborated with scientists on the best way to display complex data.

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  • Five Questions for Brad Bernstein

    Haley Bridger, August 23rd, 2010 | Filed under

    Earlier this month, researchers from the Broad Institute and Massachusetts General Hospital (MGH) published a paper in Nature Methods about a new approach to an established technique. The technique is called ChiP-seq, short for chromatin immunoprecipitation with high-throughput sequencing, and is used to study how protein and DNA interact. The paper's authors are postdoctoral scholars Mazhar Adli and Jiang Zhu and Broad associate member Brad Bernstein. Brad answered five of our questions about his latest paper and his field of interest.

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  • Five Questions for Visual Designer Lauren Solomon

    Ellen Clegg, August 10th, 2010 | Filed under

    Broad Visual Designer Lauren Solomon worked with Associate Member John Rinn and postdoctoral scientist Maite Huarte on a cover concept to illustrate their paper in the August 6 issue of the journal Cell describing the critical role lincRNAs play in mediating the cellular response to DNA damage. Lauren arrived at the Broad earlier this year after 19 years as senior graphic designer at Millipore Corp. in Billerica, where she designed everything from t-shirts to building signs and everything between.

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  • Five Questions for Nick Patterson

    Alice McCarthy, July 1st, 2010 | Filed under

    Nick Patterson is a man of many stories. Currently a Computational Biologist in the Broad’s Program in Medical and Population Genetics, Nick’s past lives have been as intriguing as his current research in mathematics and evolutionary biology.

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