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MIA Talks

Studying cell and tissue physiology with random composite experiments

October 24, 2018
Regev Lab, Lander Lab, Broad Institute

In this talk I describe how compressed sensing can be applied to greatly accelerate the study of cell physiology. Specifically, it has the potential to transform work in two distinct fields, histology and genetics, using a common approach: composite experiments. With these approaches, methods that can today image 10-100 genes in a sample will be leveraged to measure thousands of genes, and genetic perturbation studies can be scaled by 1,000-10,000 fold. I will describe both the theoretical underpinnings of these approaches, as well as the status of ongoing efforts to implement composite experiments in the lab.