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MIA Talks

Primer: The multiple testing problem

February 26, 2020
Neale Lab, Lander Lab, Broad Institute; Analytic and Translational Genetics Unit, Massachusetts General Hospital

How do we control false positives when testing multiple hypotheses simultaneously? I will review the family-wise error rate (FWER), the false discovery rate (FDR) and related quantities, and discuss some classical and recent methods to control them. Highlights will include the (in)famous genome-wide significance threshold for association studies and Stephens's "New Deal."