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MIA Talks

New imaging data types and computational challenges at the optical profiling platform (Note: Auditorium)

October 23, 2019
Regev Lab, Broad Institute

The Optical Profiling Platform (OPP) at the Broad Institute aims to translate promising imaging methods from their inventors’ labs to the broader biological research community. The initial technique portfolio includes highly-multiplexed antigen detection, spatially resolved transcriptomics, and all-optical electrophysiology, each to be implemented in a variety of model systems. These tools offer unique, high-throughput portraits of cell identity and functional state but require advances in hardware capabilities; wetlab and measurement protocols; and, crucially, in computational infrastructure. I will discuss our progress on the experimental front while highlighting the analysis and engineering challenges involved in processing, interpreting, and integrating the resulting data.