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MIA Talks

Judging the importance of human mutations using evolutionary models

February 3, 2016
Dept. of Biomedical Informatics, Harvard University; Brigham and Women's Hospital; Broad Institute

Many forces influence the fate of alleles in populations, and the detailed quantitative description of the allelic dynamics is complex. However, some applications allow for simplifications making the evolutionary models useful in the context of human genetics. The examples include comparative genomics and the analysis of large scale sequencing datasets.