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MIA Talks

How to make a picture worth a thousand numbers: Models and methods in biological image analysis

May 2, 2018
Carpenter Lab, Imaging Platform, Broad Institute
Carpenter Lab, Imaging Platform, Broad Institute
Carpenter Lab, Imaging Platform, Broad Institute
Carpenter Lab, Imaging Platform, Broad Institute

Our group (Carpenter lab / Imaging Platform) develops CellProfiler – a widely-used bioimage analysis software, and has pioneered image-based profiling – an approach to create signatures of cell populations using high-throughput microscopy imaging. In this talk, we will present approaches we've been developing to create a new generation of these tools and methods. This talk will include four quick vignettes:

  • A deep learning-based tool and library for cell detection, applied to nucleus detection and malaria stage classification.An extensive evaluation of two convnet models for nucleus segmentation, as well as a sneak peak into the results of the 2018 Kaggle Data Science Bowl challenge we organized.
  • new approach for creating morphological profiles by training convnets using weak labels.
  • A new approach for creating cell population profiles which capture single-cell heterogeneity.