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MIA Talks

DNA microscopy and the sequence-to-image inverse problem

April 20, 2016
Zhang Lab, Broad Institute

Technologies that jointly resolve both gene sequences and the spatial relationships of the cells that express them are playing an increasing role in deepening our understanding of tissue biology. In this talk, I will describe an experimental technique, called DNA microscopy, which encodes the physical structure and genetic composition of a biological sample directly into a library of DNA sequences. I will then discuss and demonstrate the application of N-body optimization to the inverse problem of inferring positions from real data.