Molecular determinants of disordered protein function
Washington University School of Medicine
Biography:
Alex Holehouse is an Associate Professor in the Department of Biochemistry & Molecular Biophysics at Washington University School of Medicine. He holds a Ph.D. in Computational Biophysics from Washington University in St. Louis, an MSc. in Computer Science from Imperial College London, and an MBioch. in Biochemistry from the University of Oxford. His research group integrates physics-based models, bioinformatics, deep learning, and quantitative cell biology to investigate how biological function is encoded into intrinsically disordered regions (IDRs) and how their dysfunction drives disease. His group is particularly interested in how IDRs regulate transcription, the molecular and functional determinants of IDR evolution, and applying insights gleaned from nature towards designing synthetic IDRs for bespoke molecular function.