Esther Uduehi

Accessing Skeletal Diversity Using Catalytic Control: Synthesis of a Macrocyclic Triazole Library

Mentor: Ann Rowley Kelly

Society is beset by many untreatable or incurable diseases. Current drug discovery methods are not measuring up to the social demands for new and more effective treatments. The Broad Institute is committed to developing small-molecule probes to find new treatments for these incurable diseases -- and dedicated to making this information available to the public. The goal of Esther's research project this summer was to create skeletally diverse macrocycles -- molecules with a certain structure -- for a future small-molecule library design.

The preparation of small molecules libraries using diversity-oriented synthesis (DOS) is one approach for the discovery of biological probes and pharmaceutical agents that could illuminate pathways to potential new drug therapies.

Esther Uduehi

"I have learned so much from this summer research experience. Apart from different chemical techniques and mechanisms, I have been able to become a better scientist, overall. My mentor taught me how to balance science and other aspects of my life, which I find very important as I want to pursue graduate school."

Esther Uduehi is a biochemistry and mathematics junior at Indiana University in Bloomington.

Other students

Samuel Ares Christel Chehoud
Eric Delgado Kunle Demuren
Peter Cruz Gordillo Seanna Pieper Jordan
Michael Melgar Amalchi Castillo Rodriguez
Kristen Rose Esther Uduehi