2010 research highlights

Validated a set of small molecules that may serve as radio-ligands for PET imaging to report neuronal activity.

Showed Interferon response genes are essential for microenvironment-induced metastatic breast cancer and that Tubacin can inhibit this metastatic behavior in vitro.

Developed a general methodology for predicting the effectiveness of cancer treatments based on genomic markers.

Studied patterns of evolution of Sko1 and MSN2/4, downstream regulators of the HOG-1 activated osmotic stress response pathway in eight Ascomycota yeasts.

Utilized HDACi and other chromatin modulators to induce expression of drug metabolizing enzyme genes in liver cell lines with the goal in mind of creating a more efficient and cost-effective human liver model for drug toxicity screening.

Studied the relationship between structure and activity in transcription factor binding compounds.

Improved experimental and analytical approaches for using high throughput sequencing to define the transcriptomes of diverse bacteria.