NF1 and RAF inhibitor resistance
Using whole-genome shRNA screening, this work identifies functional loss of NF1 as a mediator of resistance to RAF inhibitors in B-RAFV600E-mutant cancers. Furthermore, we nominate new therapeutic modalities to treat this mechanism of resistance.
A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition
Steven R. Whittaker, Jean-Philippe Theurillat, Eliezer Van Allen, Nikhil Wagle, Jessica Hsiao, Glenn S. Cowley, Dirk Schadendorf, David E. Root and Levi A. Garraway. A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition. Cancer Discovery. OnlineFirst January 3, 2013.