Gene Set Enrichment Analysis (GSEA)

GSEA is a computational method that determines whether an a priori defined set of genes shows statistically significant, concordant differences between two biological states (e.g. phenotypes).

Contact: 
Arthur Liberzon (liberzon@broadinstitute.org), gsea@broadinstitute.org
Publication Info: 
Date: 
6/15/2003
Notes: 
Mootha, et al. PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet. 2003 Jul;34(3):267-73.
Date: 
8/2/2005
Notes: 
Subramanian, et al. Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50. Epub 2005 Sep 30.
Tool Info: 
Description: 

GSEA is also available on the public GenePattern server at http://genepattern.broadinstitute.org