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James Galagan By comparing four fungal genomes, a research team has described some of the dynamics of the evolution of introns, which are non-coding portions of genes that comprise a large proportion of many genomes. Introns are found in eukaryotic species, which includes all members of the fungi... Read more
Co-lead authors Michael Kamal ( left ) and Brad Bernstein The first high-resolution analysis of the key feature that controls the activation of genes on human chromosomes was reported today in the journal Cell, by researchers from the Broad Institute of MIT and Harvard and Affymetrix, Inc. The...
Left to right : David Altshuler, Wendy Winckler, and Stacey Gabriel Not pictured : Gavin McDonald, Rob Onofrio, David Reich, and Dan Richter In today's online version of the journal Science, researchers report a surprising find: Despite 99% similarity at the level of DNA sequence between humans and...
Eric S. Lander Photo by John Nikolai The American Association for the Advancement of Science (AAAS), the world's largest general scientific society, today named Eric S. Lander to receive the prestigious Public Understanding of Science and Technology Award. Lander, founding director of the newly...
In the latest issue of R&D Magazine , the Broad-developed genome browser Argo is featured as a tool for promoting genomic studies. David DeCaprio and Reinhard Engels are quoted. Argo is a Java application that is used for visualizing and manually annotating whole genomes. It provides an easy-to...
Eleven leading biomedical organizations announced today the formation of a unique $18M, three-year public-private consortium to create a comprehensive library of gene inhibitors to be made available to the entire scientific community. Based on the method of RNA interference (RNAi), this library...
First author Xiaohui Xie ( left ) and senior author Manolis Kellis Because so many genes have been conserved, or passed along from species to species throughout evolution, comparing genomes across species has emerged as a powerful tool for discovering functional elements. Comparative genomics has...
In recognition of distinguished and continuing achievements in original research, Broad associate members Daniel Hartl, Christine Seidman, David Page and Broad project member Christophe Benoist were recently named to the National Academy of Sciences. Membership of the Academy is considered one of...
Tubacin, an experimental compound created at the Broad Institute, overcomes the resistance of myeloma cells to the drug Velcade when both are administered together. In fact, the combination is more than twice as effective as either drug alone in killing resistant cells from patients' bone marrow...
Of all the chemical modifications proteins undergo, we think that acetylation — the addition of a small acetyl group — is one of the most interesting. The classic example of an acetylated protein is histone, one of the proteins that makes up the scaffolding on which DNA is held and regulates which...