Equity in Biomedicine past talks

2023

Need for increased genetic diversity in cell line models and CRISPR experimental tools

November 30, 2023

Join Broad’s Lindy Barrett, Ralda Nehme, Sean Misek and MIT's Jesse Boehm as they present on the ways that genetic ancestry can limit scientific understanding and impact equity in downstream translational benefits. Lindy Barrett and Ralda Nehme will discuss why increasing genetic diversity of pluripotent stem cell models is critical for ensuring equitable and broadly useful scientific insights and translational benefits. Sean Misek and Jesse Boehm will discuss their work showing how genetic ancestry-based CRISPR guide bias can lead to false negatives in cell-based screens.

The format for the session will be short presentations by each team, followed by a panel discussion focused on challenges and opportunities in this area, and ending with a Q&A from the audience.

Speakers

Sean Misek
Cancer Program
Broad Institute

Jesse Boehm
Break Through Cancer

Ralda Nehme
Stanley Center for Psychiatric Research

Stem Cell Program
Broad Institute

Lindy Barrett
Stanley Center for Psychiatric Research
Broad Institute

Visiting Scholar
Harvard University

Moderator

Anne Carpenter
Broad Institute

Thoughtful Use of "Population Descriptors" in Genetics & Genomic Research

June 15, 2023

“Population descriptors” — including race, ethnicity, and genetic ancestry — can broadly be thought of as describing “descent-associated” groups, whose members are thought to share some characteristic that derives from their common origin. These descriptors are used ubiquitously across genetics and genomics research. However, inappropriate use of these terms, without proper contextualization, can make problematic essentialist links to biology and propagate incorrect and racist notions that discrete genetic groups exist. In an effort to address these problems, the NASEM formed a working group to create guidance about the use of population descriptors as well as an opportunity to implement substantive changes to the ways they are used. Join Katrina Claw (University of Colorado Anschutz Medical Campus), Genevieve L. Wojcik (Johns Hopkins Bloomberg School of Public Health), and Anna Lewis (Edmond and Lily Safra Center for Ethics, Harvard University and Broad Institute) for a panel discussion on why using group descriptors thoughtfully is important for science and society and what researchers should consider when making these decisions in their own work.

Speakers

Katrina G. Claw
University of Colorado Anschutz Medical Campus

Anna Lewis
Edmond and Lily Safra Center for Ethics, Harvard University
Brigham and Women's Hospital
Broad Institute

Genevieve Wojcik
Johns Hopkins University

Opening remarks

Todd Golub
Director
Broad Institute

Sex and gender minority inclusion in research

March 16, 2023

Sexual and gender minority (SGM) people—including members of the lesbian, gay, bisexual, transgender, intersex, and queer communities—are understudied and underrepresented in precision medicine research. In addition to lack of funding and barriers to participation driven by medical mistrust, there are numerous limitations to standard reporting practices which create additional challenges in identifying and serving these individuals. These challenges include failing to ask individuals in surveys and the clinic about their sexual orientation and gender; focusing family studies on biological family structures; varying behavioral and identity relationships across ethnicities and cultures; and differentiating and reconciling multiple definitions of sex and gender. We further need more community driven selection and recruitment efforts for individuals holding multiple marginalized identities, particularly queer and trans* people of color (QTPOC). Looking forward, thoughtfully including SGM people in research and improving our oversimplified understanding of sex and gender and can help reduce SGM health disparities.

Speaker

Nasa Sinnott-Armstrong
Assistant Professor, Herbold Computational Biology Program Public Health Sciences Division, Fred Hutch Cancer Center

Opening remarks

Alham Saadat
Associate Director, Scientific Equity, IDEA Office
Broad Institute