The genome of the domesticated dog, a close evolutionary relation to human, is a powerful new tool for understanding the human genome. Comparison of the dog with human and other mammals reveals key information about the structure and evolution of genes and genomes. The unique breeding history of dogs, with their extraordinary behavioral and physical diversity, offers the opportunity to find important genes underlying diseases shared between dogs and humans, such as cancer, diabetes, and epilepsy.
The Canine Genome Sequencing Project produced a high-quality draft sequence of a female boxer named Tasha. By comparing Tasha with many other breeds, the project also compiled a comprehensive set of SNPs (single nucleotide polymorphisms) useful in all dog breeds. These closely spaced genomic landmarks are critical for disease mapping. By comparing the dog, rodent, and human lineages, researchers at the Broad Institute uncovered exciting new information about human genes, their evolution, and the regulatory mechanisms governing their expression. Using SNPs, researchers describe the strikingly different haplotype structure in dog breeds compared with the entire dog population. In addition, they show that by understanding the patterns of variation in dog breeds, scientists can design powerful gene mapping experiments for complex diseases that are difficult to map in human populations.
- Dog Genome Paper & supplemental information
- Dog disease research
- UCSC Canine Annotation Track Hub
- Sending dog DNA samples
- Information about canine SNP arrays
|Shotgun Sequence||7.6X complete|
|Genome Assembly||High-quality draft assembly, released|
|Genome Coverage||> 98% of euchromatic genome|
CanFam1.0 - 2,551,617 SNPs
CanFam2.0 - 2,544,508 SNPs
|Data release summary|
|Initial Assembly||CanFam1.0, released July 2004|
|Current Assembly||CanFam3.1, released September 2011|
|SNP Collection||Mapped on CanFam1.0 & CanFam2.0|
Participate in dog disease research
Questions or comments, please email firstname.lastname@example.org .