Hemangiosarcoma (HSA) are rapidly growing and highly invasive, blood-fed tumors. Blood vessels grow from the tumor and often cause death through excessive blood loss due to rupturing of the tumor.

Latest Research Update: After comparing the genomes of ~100 healthy dogs with ~100 dogs with HSA we were able to identify several regions of the genome that are associated with HSA risk. These regions are currently being searched for mutations. Once the mutations have been identified and their presence in different breeds assessed, this will allow for rapid development of genetic tests for carriers of HSA.

Breeds: Boxer, German Shepherd, Golden Retrievers, Labrador Retriever, Leonberger, Irish Wolfhound

Main collaborator: Chieko Azuma (Tufts University), Jamie Modiano (University of Minnesota), Mathew Breen (NCSU) and David Sargan (University of Manchester)

Main contact: Noriko Tonomura, Tonomura@broadinstitute.org