Familial Shar-Pei Fever (FSF)

Familial Shar-Pei Fever (FSF) is a condition that causes recurrent episodes of unexplained fevers, which can be accompanied by swollen hocks and muzzles. Sometimes FSF can result in renal and liver failure following depositions of amyloid in the organs.

Latest Research Update: A strong genetic risk factor has been identified. The risk factor is a copy number variant that regulates the expression of the gene HAS2. We are currently working on a validation of a potential genetic test.
Publication: Olsson et al, A Novel Unstable Duplication Upstream of HAS2 Predisposes to a Breed-Defining Skin Phenotype and a Periodic Fever Syndrome in Chinese Shar-Pei Dogs, (2011) PLoS Genet. 7: e1001332.
Breeds: Shar-Pei
Main collaborators: Mia Olsson and Jennifer Meadows, (Uppsala University), Linda Tintle (Wurtsburo Veterinary Clinic), Lluis Ferrer (Universitat Autònoma de Barcelona), Elaine Remmers and Daniel Kastner (NHGRI, Bethesda)

Main contact: Mia Olsson, mia.olsson@imbim.uu.se and Linda Tintle wvc@warwick.net