Selected Recent Publications

Stanley Center publications 2013-2014

Hyman and Scolnick: psychiatric disease perspectives and therapeutics

Hyman SE. Revitalizing psychiatric therapeutics. Neuropsychopharmacology 2014 Jan;39(1):220-9. doi: 10.1038/npp.2013.181.

Casey BJ, Craddock N, Cuthbert BN, Hyman SE, Lee FS, Ressler KJ. DSM-5 and RDoC: progress in psychiatry research? Nat Rev Neurosci. 2013 Nov;14(11):810-4. doi: 10.1038/nrn3621.

Plenge RM, Scolnick EM, Altshuler D. Validating therapeutic targets through human genetics. Nat Rev Drug Discov. 2013 Aug;12(8):581-94.

Hyman SE. Psychiatric drug development: diagnosing a crisis. Cerebrum. 2013 Apr 2;2013:5. 

doi: 10.1038/nrd4051. Epub 2013 Jul 19.


Genetics

Ruderfer DM, Fanous AH, Ripke S, McQuillin A, Amdur RL, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Cross-Disorder Working Group of the Psychiatric Genomics Consortium, et al. Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia. Mol Psychiatry, 26 November 2013.| doi:10.1038/mp.2013.138. 

Rees E, Kirov G, Sanders A, Walters JT, Chambert KD, Shi J, Szatkiewicz J, O'Dushlaine C, Richards AL, Green EK, Jones I, Davies G, Legge SE, Moran JL, Pato C, Pato M, Genovese G, Levinson D, Duan J, Moy W, Göring HH, Morris D, Cormican P, Kendler KS, O'Neill FA, et al. Evidence that duplications of 22q11.2 protect against schizophrenia. Mol Psychiatry. 2013 Nov 12. [Epub ahead of print.]

Macosko EZ, McCarroll SA. Genetics. Our fallen genomes. Science. 2013 Nov 1;342(6158):564-5. No abstract available.

McCarroll SA and Hyman SE. Progress in the genetics of polygenic brain disorders: significant new challenges for neurobiology. Neuron. 2013 Oct 30;80(3):578-87. doi: 10.1016/j.Neuron.2013.10.046.

Davis LK, Yu D, Keenan CL, Gamazon ER, Konkashbaev AI, Derks EM, Neale BM, Yang J, Lee SH, Evans P, Barr CL, Bellodi L, Benarroch F, Berrio GB, Bienvenu OJ, Bloch MH, Blom RM, Bruun RD, Budman CL, Camarena B, Campbell D, Cappi C, Cardona Silgado JC, Cath DC, et al. Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture. PLoS Genet. 2013 Oct;9(10):e1003864. [Epub 2013 Oct 24.]

Robinson EB, Howrigan D, Yang J, Ripke S, Anttila V, Duncan LE, Jostins L, Barrett JC, Medland SE, Macarthur DG, Breen G, O'Donovan MC, Wray NR, Devlin B, Daly MJ, Visscher PM, Sullivan PF, Neale BM. Response to ‘Predicting the diagnosis of autism spectrum disorder using gene pathway analysis’. Mol Psychiatry. 2013 Oct 22. doi: 10.1038/mp.2013.125. [Epub ahead of print.]

Ripke S, O'Dushlaine C, Chambert K, Moran JL, Kähler A, Akterin S, Bergen S, Collins AL, Crowley J, Fromer M, Kim Y, Lee SH, Magnusson PK, Sanchez N, Stahl EA, Williams S, Wray N, Xia K, Bettella F, Børglum AD, Bulik-Sullivan BK, Cormican P, Craddock N, de Leeuw C, et al. Genome-wide association analysis identifies 14 new risk loci for schizophrenia. Nat Genet. 2013 Oct;45(10):1150-9. doi: 10.1038/ng.2742. [Epub 2013 Aug 25.]

Kirov G, Rees E, Walters JT, Escott-Price V, Georgieva L, Richards AL, Chambert KD, Davies G, Legge SE, Moran JL, McCarroll SA, O'Donovan MC, Owen MJ. The penetrance of copy number variations for schizophrenia and developmental delay. Biol Psychiatry. 2013 Aug 27. doi:pii: S0006-3223(13)00676-8. 10.1016/j.biopsych.2013.07.022. [Epub ahead of print.]

Szatkiewicz JP, Neale BM, O'Dushlaine C, Fromer M, Goldstein JI, Moran JL, Chambert K, Kähler A, Magnusson PK, Hultman CM, Sklar P, Purcell S, McCarroll SA, Sullivan PF. Detecting large copy number variants using exome genotyping arrays in a large Swedish schizophrenia sample. Mol Psychiatry. 2013 Aug 13. [Epub ahead of print.]

Cross-Disorder Group of the Psychiatric Genomics Consortium. Genetic relationship among five psychiatric disorders estimated from genome-wide SNPS. Nat Genet. 2013 Sep;45(9):984-94. doi: 10.1038/ng.2711. [Epub 2013 Aug 11.]

Solovieff N, Cotsapas C, Lee PH, Purcell SM, Smoller JW. Pleiotropy in complex traits: challenges and strategies. Nat Rev Genet. 2013 Jul;14(7):483-95. [Epub 2013 Jun 11. Review.]

Pato MT, Sobell JL, Medeiros H, Abbott C, Skar B, Buckley PF, Bromet EJ, Escamilla MA, Fanous AH, Lehrer DS, Macciardi F, Malaspina D, McCarroll SA, Marder SR, Moran J, Morley CP, Nicolini H, Perkins DO, Purcell SM, Rapaport MH, Sklar P, Smoller JW, Knowles JA, The Genomic Psychiatry Cohort Consortium, Pato CN. The Genomic Psychiatry Cohort: Partners in discovery. Am J Med Genet B Neuropsychiatr Genet. 2013 May 3.  [Epub ahead of print.]

Genovese G, Handsaker RE, Li H, Altemose N, Lindgren AM, Chambert K, Pasaniuc B, Price AL, Reich D, Morton CC, Pollak MR, Wilson JG, McCarroll SA. Using population admixture to help complete maps of the human genome. Nat Genet. 2013 Apr;45(4):406-14, 414e1-2. [Epub 2013 Feb 24.]

Cross-Disorder Group of the Psychiatric Genomics Consortium. Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. The Lancet. 2013. [Epub: February 28, 2013.]


Neurobiology

Ting JT, Feng G. Development of transgenic animals for optogenetic manipulation of mammalian nervous system function: progress and prospects for behavioral neuroscience. Behav Brain Res. 2013 Oct 15;255:3-18. [Epub 2013 Mar 6.]

Burguière E, Monteiro P, Feng G, Graybiel AM. Optogenetic stimulation of lateral orbitofronto-striatal pathway suppresses compulsive behaviors. Science. 2013:340:1243-6.

Pinto L, Goard MJ, Estandian D, Xu M, Kwan AC, Lee S-H, Harrison TC, Feng G, and Dan Y. Fast modulation of visual perception by basal forebrain cholinergic neurons. Nat. Neurosci. 2013:16:1857-63.
 

Stem Cells

Eggan, K. Picking the lock on pluripotency. N Engl J Med. 2013; November 28, 2013;369:2150-2151. doi: 10.1056


Clinical and Therapeutics

Ostacher MJ, Iosifescu DV, Hay A, Blumenthal SR, Sklar P, Perlis RH. Pilot investigation of isradipine in the treatment of bipolar depression motivated by genome-wide association. Bipolar Disord. 2013 Dec 27. doi: 10.1111/bdi.12143. [Epub ahead of print.]

Wang C, Eassalu TE, Barth VN, Mitch CH, Wagner FF, Hong Y, Neelemegam R, Schroeder FA, Holson EB, Haggarty SJ, Hooker JM. Design, synthesis, and evaluation of hydroxamic acid-based molecular probes for in vivo imaging of histone deacetylase (HDAC) in brain. Am J Nucl Med Mol Imaging. 2013 Dec 15:4(1):29-38.

Wagner FF, Weїwer M, Lewis MC, Holson EB. Small molecule inhibitors of zinc-dependent histone deacetylases. Neurotherapeutics. 2013 Oct;10(4):589-604. 

Weïwer M, Lewis MC, Wagner FF, Holson EB. Therapeutic potential of isoform selective HDAC inhibitors for the treatment of schizophrenia. Future Med Chem. 2013 Sep;5(13):1491-508. doi: 10.4155/fmc.13.141.

Schroeder FA, Chonde DB, Riley MM, Moseley CK, Granda ML, Wilson CM, Wagner FF, Zhang YL, Gale J, Holson EB, Haggarty SJ, Hooker JM. FDG-PET imaging reveals local brain glucose utilization is altered by class I histone deacetylase inhibitors. Neurosci Lett. 2013 Aug 29;550:119-24. [doi: 10.1016/j.neulet.2013.06.016.Epub 2013 Jun 25.]

Schroeder FA, Lewis MC, Fass DM, Wagner FF, Zhang YL, Hennig KM, Gale J, Zhao WN, Reis S, Barker DD, Berry-Scott E, Kim SW, Clore EL, Hooker JM, Holson EB, Haggarty SJ, Petryshen TL. A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and alters mouse behavior in two mood-related tests. PLoS One. 2013 Aug 14;8(8):e71323. [eCollection 2013.]

Haggarty SJ, Perlis RH. Translation: Screening for novel therapeutics with disease-relevant cell types derived from human stem cell models. Biol Psychiatry. 2013 Jul 19. pii: S0006-3223(13)00503-9. doi: 10.1016/j.biopsych.2013.05.028. [Epub ahead of print.]

Olson DE, Wagner FF, Kaya T, Gale JP, Aidoud N, Davoine EL, Lazzaro F, Weïwer M, Zhang YL, Holson EB. Discovery of the first histone deacetylase 6/8 dual inhibitors. J Med Chem. 2013 Jun 13;56(11):4816-20. [ doi: 10.1021/jm400390r. Epub 2013 May 29.]


Tool development

Shalem O, Sanjana NE, Hartenian E, Shi X, Scott DA, Mikkelson T, Heckl D, Ebert BL, Root DE, Doench JG, Zhang F. Genome-scale CRISPR-Cas9 knockout screening in human cells. Science. 2014 Jan 3;343(6166):84-7. doi: 10.1126/science. 1247005.