MitoCarta2.0 is an inventory of 1158 human and mouse genes encoding proteins with strong support of mitochondrial localization. To generate this inventory, we performed mass spectrometry of mitochondria isolated from fourteen tissues, assessed protein localization through large-scale GFP tagging/microscopy, and integrated these results with six other genome-scale datasets of mitochondrial localization, using a Bayesian approach. MitoCarta2.0, released 2015, is an update from the MitoCarta1.0 inventory published in Cell, 2008.
Calvo, S.E., Klauser, C.R., Mootha, V.K. MitoCarta2.0: an updated inventory of mammalian mitochondrial proteins (2015). Nucleic Acids Research [doi: 10.1093/nar/gkv1003]
Pagliarini, D.J., Calvo, S.E., Chang, B., Sheth, S.A., Vafai, S.B., Ong, S.E., Walford, G.A., Sugiana, C., Boneh, A., Chen, W.K., et al. (2008). A mitochondrial protein compendium elucidates complex I disease biology. Cell 134, 112-123. [Pubmed: 18614015]
Excel database containing detailed information on the 1158 mitochondrial human genes, as well as integrated scores of mitochondrial localization for all ~20,000 human genes with well-defined mouse homologs from HomoloGene