Genome Sequencing and Analysis Program

The Broad's Genome Sequencing and Analysis Program (GSAP) brings together a scientific community focused on deciphering the important information encoded in the human and other genomes. Understanding these components is fundamental to the study of human evolution and physiology.
GSAP scientists work closely with collaborators in the Genomics Platform on a variety of de novo and resequencing projects.

I. Major Scientific Areas

Microbial and Insect Vector Genomes

Microorganisms (including fungi, bacteria, and viruses) and insect vectors are both key model systems for genomics and important organisms for clinical medicine. Scientists in the Broad community are sequencing and analyzing the genomes of a wide range of insects and microorganisms to understand their genetic regulation, population variation, and specialized genomic mechanisms.

Vertebrate Genome Biology

One of the most powerful ways to understand the human genome is by directly comparing it with other mammalian and vertebrate genomes. Evolution tends to conserve the sequences of functional elements, allowing them to stand out above background. Broad scientists are leading a national program to sequence the genomes of more than 20 mammalian species, with the goal of obtaining enough comparative information to recognize those functional elements that are conserved across all mammals. Comparing these sequences also reveals information about the evolutionary constraints and innovations in the class Mammalia. In addition, artificial or natural selective pressures have shaped key vertebrate genomes, including the dog and stickleback fish, allowing important traits and disease genes to be readily identified and studied in these organisms.

II. Research and Development

Genome Annotation and Informatics

Genomic information is being collected at an unprecedented pace. A dedicated team of Broad researchers harnesses both experimental and computational approaches to analyze these data and to assign structural and functional information to key genome components.

Computational Research and Development

Sophisticated computational methods and tools enable scientists to effectively mine the data generated by genomic analyses. The Broad’s team of computational researchers develops and applies these approaches to help answer a vast array of important biological questions.

Molecular Biology Research and Develoment

Advances in DNA sequencing technologies are revolutionizing the depth, breadth and pace of biomedical research. Researchers in the Broad’s Genome Sequencing and Analysis Program use, develop and enhance these technologies for a range of laboratory applications.