Cancer is among the most-common causes of death in Mexico, and incidence of the disease is on the rise worldwide. The SIGMA project aims to develop novel biomedical approaches to treat this devastating disease by applying powerful sequencing technologies to discover the genes and key pathways underlying common varieties of cancer. In first phase of the project, SIGMA researchers identified new genetic drivers of breast cancer, cervical cancer – both with special emphasis on patients in Mexico – lymphoma, head and neck cancer, sarcoma and several types of pediatric cancers. Today, in addition to continued genomic efforts, SIGMA researchers are translating those initial discoveries into therapeutic “roadmaps” of the disease, which will help speed the development of new cancer therapies to benefit patients in Mexico and beyond.

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