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Fifth Annual Kidney-NExT Symposium: New Horizons for Kidney Therapeutics

This annual one-day symposium, chaired by institute member of the Broad and faculty at Brigham and Women’s Hospital and Harvard Medical School, Dr. Anna Greka, will bring together leading stakeholders to discuss how we can advance the quest for novel therapeutics for kidney diseases, an area of tremendous unmet need. The Kidney-NExT Symposium is a unique forum for shared dialogue between academia and industry leaders, the FDA and patients from across the country to shape the future of kidney treatments.

Thursday April 4, 2019
Broad Institute
415 Main St., Monadnock Room
Cambridge, MA

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Symposium Program

9:00 am Welcome
Todd Golub and Anna Greka

Keynote Lecture 1

Chair: Todd Golub

9:15 am – 10:00 am Big data and health outcomes: challenges and opportunities
Robert Califf

Session 1

Toward therapies for kidney diseases

Chairs: Amy Shulman and Opeyemi Olabisi

10:00 am – 10:30 am SGLT2 inhibitors for diabetic kidney disease
Jim List
10:30 am – 11:00 am Tolvaptan for polycystic kidney disease
Vincente Torres
11:30 am – 11:30am New perspectives on endpoints and clinical trial design
Lesley Inker

Panel Discussion and Brainstorming Session: How much progress have we made in kidney therapeutics? What can be done better?

Facilitator: Anna Greka

11:30 am – 12:30 pm Panelists: Dave White, patient advocate / Nicole Jefferson, patient advocate / Kimberly Smith, FDA / Mera Tilley, Goldfinch Bio / Uptal Patel, Gilead / Melissa West, Kidney Health Initiative / Eugene Rhee, MGH / Samir Parikh, BIDMC
12:30 pm – 1:15 pm Lunch

Session 2

Frontiers: genomics, organoids and systems biology in the kidney space

Chairs: Brian Pereira and Joseph Bonventre

1:15 pm – 1:45 pm A systems biology approach to ciliopathies
Peter Jackson
1:45 pm – 2:15 pm A glomerulus on a chip: current technology and future directions
Samira Musah
2:15 pm – 2:45 pm Kidney organoids in drug development
Beno Freedman
2:45 pm – 3:15 pm A newly completed GWAS of diabetic kidney disease
Joanne Cole
3:15 pm – 3:30 pm Coffee break

Keynote Lecture 2

Chair: Krzystzof Kiryluk

3:30 pm – 4:15 pm Predicting risk for common deadly diseases from millions of genetic variants 
Sekar Kathiresan
4:15 pm Closing remarks
Anna Greka