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#HowWeScience

At the Broad Institute, researchers are revealing deep biological insights about the causes of disease, which are leading to new ways to monitor, diagnose, and treat patients with greater precision. These include new tools that help predict diseases well before symptoms appear, and more effective therapeutics that reduce the chance of relapse or drug resistance.

Illuminating human disease

Cancer dependency map
Cataloging the genetic adaptations that cancer cells rely on and leveraging them to develop new treatments
Food allergies
Understanding why the body sometimes overreacts to certain types of food
Genomic epidemiology
Using genomics to understand and track the spread of pathogens, and bring them under control.
Inflammatory bowel disease
Exploring the genetic origins of Crohn’s disease, ulcerative colitis, and related diseases to better prevent and treat them
Psychiatric Diseases
Charting a path to new therapies by unraveling the genes and mechanisms that drive psychiatric disease
Single-cell genomics
Revealing the inner life of cells, one cell at a time
Machine Learning
Developing and using computational tools to detect subtle patterns in biomedical data.

Reading and editing genomes

Connecting Variants to Function
Discovering how thousands of tiny genetic alterations lead to disease
Gene Editing
Harnessing a natural system to precisely edit the DNA of living things
Genomics Platform
Creating foundational genomics resources and capabilities to understand health and disease
Human Cell Atlas
A comprehensive reference map of all human cells as a basis for understanding human health and disease

Developing diagnostics and treatments

Blood Biopsies
Enabling clinicians to monitor the progress of a patient’s cancer through blood samples, rather than invasive procedures
Drug Repurposing Hub
Finding new opportunities for old drugs to treat common diseases
SHERLOCK
Ensuring the SHERLOCK diagnostic platform is easily accessible, especially in the developing world, where the need for inexpensive, reliable, field-based diagnostics is the most urgent
Understanding Kidney Disease
Uncovering a genetic culprit, MUC1
Using genomics to predict disease risk
Predicting a person’s genetic risk for many common diseases by scanning subtle variants across the genome

Sharing data and tools to enable discovery

Aggregating and harmonizing data
Uniting sequencing data from large-scale projects and making it available to the scientific community
Cloud computing
Partnering with technology leaders to make Broad data and tools available to researchers across the globe on secure, cloud storage platforms
Creating tools to generate data insights
Building open and scalable data-science tools to advance biomedical research
Human Cell Atlas: Data Coordination Platform
Data generated from studying trillions of cells are open and accessible to researchers worldwide.
Licensing data, tools, and technologies
Making science available to the world to maximize public benefit

Building communities

Global Alliance for Genomics and Health
Collaborating internationally to create standards to effectively store, share, analyze, and protect genomic and clinical data
Human Cell Atlas: International collaboration
A global consortium of thousands of scientists is building a complete reference map of all human cells.
Patients as partners
Working with patients with cancer, rare diseases, and other conditions to accelerate the pace of discovery and find better treatments

Collaborating, innovating, and empowering

Our Culture
Creating a diverse, cross-disciplinary, and collaborative community
Partner Institutions and Community
Bringing together some of the most talented physicians, biomedical researchers, data scientists, software engineers, and more to address the most urgent and ambitious scientific challenges in human health.
Philanthropic partnerships
Advancing a common vision of science in the service of human health
Industrial partnerships
Bridging academia and industry to translate discoveries into therapeutics that benefit patients
Become a Broadie
Search our Career Center for current openings.