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Selected Publications

  1. "A Receptor for the Immuno­sup­pressant FK506 is a cis-trans Peptidyl-Prolyl Isomerase" M. W. Harding, A. Galat, D. E. Uehling, and S. L. Schreiber, Nature, 1989, 341, 758.
  2. "Probing Immunosuppressant Action with a Nonnatural Immunophilin Ligand, 506BD" B. E. Bierer, P. K. Somers, T. J. Wandless, S. J. Burakoff, S. L. Schreiber, Science, 1990, 250, 556.
  3. "Calcineurin is a Common Target of Cyclophilin-Cyclosporin A and FKBP-FK506 Complexes" J. Liu, J. D. Farmer, W. S. Lane, J. Friedman, I. Weissman, S. L. Schreiber, Cell 1991, 66, 807.
  4. “Controlling Signal Transduction with Synthetic Ligands” D. Spencer, T. J. Wandless, S. L. Schreiber, G. R. Crabtree, Science 1993, 262, 1019-1024.
  5. "A Mammalian Protein mTOR Targeted by G1-Arresting Rapamycin-Receptor Complex" E. J. Brown, M. W. Albers, T. B. Shin, K Ichikawa, C. T. Keith, W Lane, S. L. Schreiber, Nature 1994, 369, 756-758.
  6. "Neuritogenic Agent Lactacystin: Subunit-Specific Inhibitor of Multiple Proteasome Activities" G. Fenteany, R F Standaert, W Lane, S. Choi, E. J. Corey, S. L. Schreiber, Science 1995, 268, 726.
  7. "Control of p70 S6 Kinase by Kinase Activity of mTOR in vivo" Eric J. Brown, Peter Beal, Curtis T. Keith, Jie Chen, Tae Bum Shin, Stuart L. Schreiber Nature 1995, 377, 441-446.
  8. "A Mammalian Histone Deacetylase Related to the Yeast Transcriptional Repressor RPD3" Jack Taunton, Christian A. Hassig, Stuart L. Schreiber, Science 1996, 272, 408-411.
  9. "Functional Analysis of Fas Signaling in vivo Using Synthetic Dimerizers" D. Spencer, P. J. Belshaw, L. Chen, S. Ho, F. Randazzo, G. R. Crabtree and S. L. Schreiber, Curr Biol, 1996, 6, 839-848.
  10. “An HDAC-associated, ATP-Dependent Nucleosome Remodeling Factor is Required for Deacetyla­tion of Chromatinized Structures” Jeffrey K. Tong, Christian A. Hassig, Gavin R. Schnitzler, Robert E. Kingston, Stuart L. Schreiber, Nature 1998, 395, 917-921.
  11. "Printing proteins as microarrays for high-throughput function determination" Gavin MacBeath, and Stuart L. Schreiber Science 2000, 289, 1760-1762. 
  12. "Small-molecule developmental screens reveal the logic and timing of vertebrate development" Randall T. Peterson, Brian A. Link, John E. Dowling, Stuart L. Schreiber, Proc Natl. Acad. Sci., U.S.A. 2000, 97, 12965-12969. 
  13. "Dissection of a glucose-sensitive pathway of the nutrient-response network using diversity-oriented synthesis and small-molecule microarrays" F. G. Kuruvilla, A. F. Shamji, S. M. Sternson, P. J. Hergenrother, S. L. Schreiber, Nature, 2002, 416, 653-656.
  14. "Signaling network model of chromatin”, S L Schreiber and B E Bernstein, Cell, 2002, 111, 771-778.
  15. “Diversity-oriented synthesis using the build/couple/pair strategy” Thomas E. Nielsen and Stuart L. Schreiber, Angewandte Chemie, 2008, 47, 48-56.  
  16. “Organic synthesis towards small-molecule probes and drugs”, Stuart L. Schreiber, Proc. Natl. Acad. Sci., U.S.A., 2011, 108, 6699-6702.
  17. "An interactive resource to identify cancer genetic and lineage dependencies targeted by small molecules", Amrita Basu, Nicole E. Bodycombe, Jaime H. Cheah, Edmund V. Price, Ke Liu, Giannina I. Schaefer, Richard Y. Ebright, Michelle L. Stewart, Daisuke Ito, Stephanie Wang, Abigail L. Bracha, Ted Liefeld, Mathias Wawer, Joshua C. Gilbert, Andrew J. Wilson, Nicolas Stransky, Gregory V. Kryukov, Vlado Dancik, Jordi Barretina, Levi A. Garraway, C. Suk-Yee Hon, Benito Munoz, Joshua A. Bittker, Brent R. Stockwell, Dineo Khabele, Andrew M. Stern, Paul A. Clemons, Alykhan F. Shamji, Stuart L. Schreiber, Cell, 2013, 154, 1151-1161.
  18. "Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes”, Stuart L. Schreiber, Joanne D. Kotz, Min Li, Jeffrey Aubé, Christopher P. Austin, John C. Reed, Hugh Rosen, E. Lucile White, Larry A. Sklar, Craig W. Lindsley, Joshua Bittker, Andrea De Souza, Michael A. Foley, Michelle Palmer, Paul A. Clemons, Owen McManus, Meng Wu, Beiyan Zou, Haibo Yu, Jennifer E. Golden, Frank J. Schoenen, Anton Simeonov, Ajit Jadhav, Michael R. Jackson, Anthony B. Pinkerton, Thomas D.Y. Chung, Patrick R. Griffin, Benjamin F. Cravatt, Dong-Hoon Chung, Colleen B. Jonsson, James W. Noah, William E. Severson, Subramaniam Ananthan, Bruce Edwards, Tudor I. Oprea, P. Jeffrey Conn, Corey R. Hopkins, Michael R. Wood, Shaun R. Stauffer, Kyle A. Emmitte, Cell, 2015, 161, 1252-1265.
  19. "Correlating chemical sensitivity and basal gene expression reveals mechanism of action”, Matthew G. Rees, Brinton Seashore-Ludlow, Jaime H. Cheah, Drew J. Adams, Edmund V. Price, Shubhroz Gill, Sarah Javaid, Matthew E. Coletti, Victor L. Jones, Nicole E. Bodycombe, Christian K. Soule, Benjamin Alexander, Ava Li, Philip Montgomery, Joanne D. Kotz, C. Suk-Yee Hon, Benito Munoz, Ted Liefeld, Vlado Dančík, Daniel A. Haber, Clary B. Clish, Joshua A. Bittker, Michelle Palmer, Bridget K. Wagner, Paul A. Clemons, Alykhan F. Shamji, Stuart L. Schreiber, Nature Chem. Biol., 2016, 12, 109-116.
  20. "Diversity-oriented synthesis yields novel multistage antimalarial inhibitors”, Nobutaka Kato, Eamon Comer, Tomoyo Sakata-Kato, Arvind Sharma, Manmohan Sharma, Micah Maetani, Jessica Bastien, Nicolas M. Brancucci, Joshua A. Bittker, Victoria Corey, David Clarke, Emily R. Derbyshire, Gillian Dornan, Sandra Duffy, Sean Eckley, Maurice A, Itoe, Karin MJ Koolen, Timothy A. Lewis, Ping S. Lui, Amanda K. Lukens, Emily Lund, Sandra March, Elamaran Meibalan, Bennett C. Meier, Jacob McPhail, Branko Mitasev, Eli L. Moss, Morgane Sayes, Yvonne VanGessel, Mathias J. Wawer, Takashi Yoshinaga, Anne-Marie Zeeman, Vicky M. Avery, Sangeeta N. Bhatia, John E. Burke, Flaminia Catteruccia, Jon C. Clardy, Paul A. Clemons, Koen J. Dechering, Jeremy R. Duvall, Michael A. Foley, Fabian Gusovsky, Clemens H. M. Kocken, Matthias Marti, Marshall L. Morningstar, Benito Munoz, Daniel E. Neafsey, Amit Sharma, Elizabeth A. Winzeler, Dyann F. Wirth, Christina A. Scherer, Stuart L. Schreiber, Nature, 2016, 538, 344-349.