Research highlights:
Cancer

Cancer is a disease of the genome gone awry. Across multiple types of cancer, from the common to the rare, researchers at Broad and their partners are probing the circuitry of the cell and the structure of the genome to gain insight into tumor biology, metastasis, and drug resistance. Broad researchers also seek to comprehensively identify vulnerabilities within cancers, vulnerabilities that may equal new treatment opportunities.

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Broad Press releases and news stories

Taking aim at rare cancer variants
The emerging focus on precision medicine urges a tailored approach to therapy that aims to give the right medicine to the right patient at the right time.

Direct patient engagement through social media speeds recruitment to cancer research study
A crowd-sourcing strategy aimed at accelerating research into metastatic breast cancer has connected advocacy groups, social media, and a dedicated web site to register more than 2,000 patients from all 50 states in its first seven months.

First large-scale proteogenomic study of breast cancer provides insight into potential therapeutic targets
Scientists complete the first large-scale “proteogenomic” study of breast cancer, linking DNA mutations to protein signaling and helping pinpoint the genes that drive cancer.

Newly identified pathway driving pancreatic cancer shows promise as therapeutic target
Researchers have uncovered a novel biological pathway that may be driving up to a third of pancreatic cancers.

Shining a light on bladder cancer
Researchers scrutinize patterns of mutations in bladder tumor genomes, gleaning insights into the roles of DNA repair and tobacco-related DNA damage.

Taking on melanoma, one cell at a time
Single cell melanoma sequencing study aims to address how to study cellular diversity in cell environments with heterogeneous populations.

Blog posts

Time to light the FireCloud
Announcing that FireCloud is open for public evaluation

Cancer close-up: Single-cell approach provides detailed look inside tumors
Single cell melanoma sequencing study, includes video

Broad Institute joins White House Precision Medicine Summit with researchers, initiatives to drive health research forward
Broad joins PMI; features Sonia Vallabh and Eric Minikel

Good apart, better together
Using two Broad-developed cancer data sets, Project Achilles and The Cancer Cell Line Encyclopedia (CCLE), to find cancer vulnerabilities

Enhancer hijacking means a power-up for salivary gland cancer
Brad Bernstein and Birgit Knoechel paper on gene translocations in salivary cancers