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Eye disease

Broad associate member Eric Pierce studies the molecular mechanisms of inherited retinal degenerations (IRDs), with a focus on improving therapeutic interventions for these conditions. IRDs are a leading cause of blindness worldwide, and are characterized by progressive dysfunction and death of retinal photoreceptor cells. Pierce's research program is focused on identifying new IRD disease genes, investigating the mechanism by which mutations in the identified genes lead to blindness, and using this information about disease pathogenesis to develop rational therapies to prevent vision loss.