Cardiovascular disease

In the lab of institute member Christine Seidman, researchers harness and integrate clinical medicine and molecular technologies to define disease-causing gene mutations and genetic variations that increase disease risk. The Seidman laboratory also develops and interrogates genetically engineered mouse models and human iPS cells to elucidate pathogenetic mechanisms for disease. Major research projects focus on discovery of the genetic contributions to cardiovascular disease, including dilated and hypertrophic cardiomyopathy and congenital heart disease.