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2015
A role for HLA-DRB1*1101 and DRB1*0801 in cognitive ability and its decline with age.Payton, A., Dawes P., Platt H., Morton CC, Moore DR, Massey J., Horan M., Ollier W., Munro KJ, and Pendleton N. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2015/10/16, (2015) Read More / View Supplemental Materials
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Some of the most interesting CASP11 targets through the eyes of their authors.Kryshtafovych, A., Moult J., Baslé A., Burgin A., Craig TK, Edwards RA, Fass D., Hartmann MD, Korycinski M., Lewis RJ, Lorimer D., Lupas AN, Newman J., Peat TS, Piepenbrink KH, Prahlad J., van Raaij MJ, Rohwer F., Segall AM, Seguritan V., et al. Proteins, 2015/10/16, (2015) Read More / View Supplemental Materials
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Stable inhibitory activity of regulatory T cells requires the transcription factor Helios.Kim, HJ, Barnitz RA, Kreslavsky T., Brown FD, Moffett H., Lemieux ME, Kaygusuz Y., Meissner T., Holderried TA, Chan S., Kastner P., Haining WN, and Cantor H. Science (New York, N.Y.), 2015/10/16, Volume 350, Issue 6258, p.334-9, (2015) Read More / View Supplemental Materials
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Building the foundation for genomics in precision medicine.Aronson, SJ, and Rehm HL Nature, 2015/10/15, Volume 526, Issue 7573, p.336-42, (2015) Read More / View Supplemental Materials
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Identification and characterization of essential genes in the human genome.Wang, T., Birsoy K., Hughes NW, Krupczak KM, Post Y., Wei JJ, Lander E. S., and Sabatini DM Science (New York, N.Y.), 2015/10/15, (2015) Read More / View Supplemental Materials
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Invasive Bladder Cancer: Genomic Insights and Therapeutic Promise.Kim, J., Akbani R., Creighton CJ, Lerner SP, Weinstein J. N., Getz G., and Kwiatkowski DJ Clinical cancer research : an official journal of the American Association for Cancer Research, 2015/10/15, Volume 21, Issue 20, p.4514-24, (2015) Read More / View Supplemental Materials
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Responses to Bacteria, Virus and Malaria Distinguish the Etiology of Pediatric Clinical Pneumonia.Valim, C., Ahmad R., Lanaspa M., Tan Y., Acácio S., Gillette MA, Almendinger KD, Milner DA Jr, Madrid L., Pellé K., Harezlak J., Silterra J., Alonso PL, Carr SA, Mesirov J. P., Wirth DF, Wiegand RC, and Bassat Q. American journal of respiratory and critical care medicine, 2015/10/15, (2015) Read More / View Supplemental Materials
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Reduced Sleep Spindles in Schizophrenia: A Treatable Endophenotype That Links Risk Genes to Impaired Cognition?Manoach, DS, Pan JQ, Purcell SM, and Stickgold R. Biological psychiatry, 2015/10/14, (2015) Read More / View Supplemental Materials
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Common Variants in DRD2 are Associated with Sleep Duration: The CARe Consortium.Cade, BE, Gottlieb DJ, Lauderdale DS, Bennett DA, Buchman AS, Buxbaum SG, De Jager PL, Evans DS, Fülöp T., Gharib SA, Johnson WC, Im HK, Larkin EK, Lee SK, Lim AS, Punjabi NM, Shin C., Stone KL, Tranah GJ, Weng J., et al. Human molecular genetics, 2015/10/13, (2015) Read More / View Supplemental Materials
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Hitting the Target in BRAF-Mutant Colorectal Cancer.Nagaraja, AK, and Bass AJ Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2015/10/12, (2015) Read More / View Supplemental Materials
Single-cell ChIP-seq reveals cell subpopulations defined by chromatin state.Rotem, A., Ram O., Shoresh N., Sperling RA, Goren A., Weitz DA, and Bernstein BE Nature biotechnology, 2015/10/12, (2015) Read More / View Supplemental Materials
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Genomic correlates of response to CTLA-4 blockade in metastatic melanoma.Van Allen, EM, Miao D., Schilling B., Shukla SA, Blank C., Zimmer L., Sucker A., Hillen U., Foppen MH, Goldinger SM, Utikal J., Hassel JC, Weide B., Kaehler KC, Loquai C., Mohr P., Gutzmer R., Dummer R., Gabriel S., Wu CJ, et al. Science (New York, N.Y.), 2015/10/09, Volume 350, Issue 6257, p.207-11, (2015) Read More / View Supplemental Materials
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Addressing the burden of mental, neurological, and substance use disorders: key messages from Disease Control Priorities, 3rd edition.Patel, V., Chisholm D., Parikh R., Charlson FJ, Degenhardt L., Dua T., Ferrari AJ, Hyman S., Laxminarayan R., Levin C., Lund C., Medina Mora ME, Petersen I., Scott J., Shidhaye R., Vijayakumar L., Thornicroft G., Whiteford H., and DCP MNS Author Group Lancet (London, England), 2015/10/08, (2015) Read More / View Supplemental Materials
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Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer.Ciriello, G., Gatza ML, Beck AH, Wilkerson MD, Rhie SK, Pastore A., Zhang H., McLellan M., Yau C., Kandoth C., Bowlby R., Shen H., Hayat S., Fieldhouse R., Lester SC, Tse GM, Factor RE, Collins LC, Allison KH, Chen YY, et al. Cell, 2015/10/08, Volume 163, Issue 2, p.506-19, (2015) Read More / View Supplemental Materials
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Post-traumatic stress disorder.Yehuda, R., Hoge CW, McFarlane AC, Vermetten E., Lanius RA, Nievergelt CM, Hobfoll SE, Koenen KC, Neylan TC, and Hyman SE Nature reviews. Disease primers, 2015/10/08, Volume 1, p.15057, (2015) Read More / View Supplemental Materials
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Sestrin2 is a leucine sensor for the mTORC1 pathway.Wolfson, RL, Chantranupong L., Saxton RA, Shen K., Scaria SM, Cantor JR, and Sabatini DM Science (New York, N.Y.), 2015/10/08, (2015) Read More / View Supplemental Materials
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Evolution of regulatory networks in Candida glabrata: learning to live with the human host.Roy, S., and Thompson D. FEMS yeast research, 2015/10/07, (2015) Read More / View Supplemental Materials
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Identification of and Molecular Basis for SIRT6 Loss-of-Function Point Mutations in Cancer.Kugel, S., Feldman JL, Klein MA, Silberman DM, Sebastián C., Mermel C., Dobersch S., Clark AR, Getz G., Denu JM, and Mostoslavsky R. Cell reports, 2015/10/07, (2015) Read More / View Supplemental Materials
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MitoCarta2.0: an updated inventory of mammalian mitochondrial proteins.Calvo, SE, Clauser KR, and Mootha VK Nucleic acids research, 2015/10/07, (2015) Read More / View Supplemental Materials
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Chromothripsis: A New Mechanism for Rapid Karyotype Evolution.Leibowitz, ML, Zhang CZ, and Pellman D. Annual review of genetics, 2015/10/06, (2015) Read More / View Supplemental Materials
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Comprehensive assessment of cancer missense mutation clustering in protein structures.Kamburov, A., Lawrence MS, Polak P., Leshchiner I., Lage K., Golub T. R., Lander E. S., and Getz G. Proceedings of the National Academy of Sciences of the United States of America, 2015/10/06, Volume 112, Issue 40, p.E5486-95, (2015) Read More / View Supplemental Materials
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Functional, chemical genomic, and super-enhancer screening identify sensitivity to cyclin D1/CDK4 pathway inhibition in Ewing sarcoma.Kennedy, AL, Vallurupalli M., Chen L., Crompton B., Cowley G., Vazquez F., Weir BA, Tsherniak A., Parasuraman S., Kim S., Alexe G., and Stegmaier K. Oncotarget, 2015/10/06, Volume 6, Issue 30, p.30178-93, (2015) Read More / View Supplemental Materials
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Interpreting de novo Variation in Human Disease Using denovolyzeR.Ware, JS, Samocha KE, Homsy J., and Daly M. J. Current protocols in human genetics / editorial board, Jonathan L. Haines ... [et al.], 2015/10/06, Volume 87, p.7.25.1-7.25.15, (2015) Read More / View Supplemental Materials
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Making Biological Sense of GWAS Data: Lessons from the FTO Locus.Herman, MA, and Rosen ED Cell metabolism, 2015/10/06, Volume 22, Issue 4, p.538-9, (2015) Read More / View Supplemental Materials
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Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis.Mancias, JD, Pontano Vaites L., Nissim S., Biancur DE, Kim AJ, Wang X., Liu Y., Goessling W., Kimmelman AC, and Harper JW eLife, 2015/10/05, Volume 4, (2015) Read More / View Supplemental Materials
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The novel mechanism of lenalidomide activity.Fink, EC, and Ebert BL Blood, 2015/10/05, (2015) Read More / View Supplemental Materials
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Orthogonal gene knockout and activation with a catalytically active Cas9 nuclease.Dahlman, JE, Abudayyeh OO, Joung J., Gootenberg JS, Zhang F., and Konermann S. Nature biotechnology, 2015/10/05, (2015) Read More / View Supplemental Materials
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Population genomic structure and adaptation in the zoonotic malaria parasite Plasmodium knowlesi.Assefa, S., Lim C., Preston MD, Duffy CW, Nair MB, Adroub SA, Kadir KA, Goldberg JM, Neafsey DE, Divis P., Clark TG, Duraisingh MT, Conway DJ, Pain A., and Singh B. Proceedings of the National Academy of Sciences of the United States of America, 2015/10/05, (2015) Read More / View Supplemental Materials
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A respiratory chain controlled signal transduction cascade in the mitochondrial intermembrane space mediates hydrogen peroxide signaling.Patterson, HC, Gerbeth C., Thiru P., Vögtle NF, Knoll M., Shahsafaei A., Samocha KE, Huang CX, Harden MM, Song R., Chen C., Kao J., Shi J., Salmon W., Shaul YD, Stokes MP, Silva JC, Bell GW, Macarthur DG, Ruland J., et al. Proceedings of the National Academy of Sciences of the United States of America, 2015/10/05, (2015) Read More / View Supplemental Materials
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A non-synonymous single-nucleotide polymorphism associated with multiple sclerosis risk affects the EVI5 interactome.Didonna, A., Isobe N., Caillier SJ, Li KH, Burlingame AL, Hauser SL, Baranzini SE, Patsopoulos NA, and Oksenberg JR Human molecular genetics, 2015/10/03, (2015) Read More / View Supplemental Materials
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Whole exome sequencing combined with integrated variant annotation prediction identifies a causative myosin essential light chain variant in hypertrophic cardiomyopathy.Nomura, A., Tada H., Teramoto R., Konno T., Hodatsu A., Won HH, Kathiresan S., Ino H., Fujino N., Yamagishi M., and Hayashi K. Journal of cardiology, 2015/10/03, (2015) Read More / View Supplemental Materials
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Somatic mutation in single human neurons tracks developmental and transcriptional history.Lodato, MA, Woodworth MB, Lee S., Evrony GD, Mehta BK, Karger A., Lee S., Chittenden TW, D'Gama AM, Cai X., Luquette LJ, Lee E., Park PJ, and Walsh CA Science (New York, N.Y.), 2015/10/02, Volume 350, Issue 6256, p.94-8, (2015) Read More / View Supplemental Materials
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CD39 Expression Identifies Terminally Exhausted CD8+ T Cells.Gupta, PK, Godec J., Wolski D., Adland E., Yates K., Pauken KE, Cosgrove C., Ledderose C., Junger WG, Robson SC, Wherry EJ, Alter G., Goulder PJ, Klenerman P., Sharpe AH, Lauer GM, and Haining WN PLoS pathogens, 2015/10/01, Volume 11, Issue 10, p.e1005177, (2015) Read More / View Supplemental Materials
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Complete hematologic response of early T-cell progenitor acute lymphoblastic leukemia to the γ-secretase inhibitor BMS-906024: genetic and epigenetic findings in an outlier case.Knoechel, B., Bhatt A., Pan L., Pedamallu CS, Severson E., Gutierrez A., Dorfman DM, Kuo FC, Kluk M., Kung AL, Zweidler-McKay P., Meyerson M., Blacklow SC, DeAngelo DJ, and Aster J. C. Cold Spring Harbor molecular case studies, 2015/10/01, Volume 1, Issue 1, p.a000539, (2015) Read More / View Supplemental Materials
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Concept and design of a genome-wide association genotyping array tailored for transplantation-specific studies.Li, YR, van Setten J., Verma SS, Lu Y., Holmes MV, Gao H., Lek M., Nair N., Chandrupatla H., Chang B., Karczewski KJ, Wong C., Mohebnasab M., Mukhtar E., Phillips R., Tragante V., Hou C., Steel L., Lee T., Garifallou J., et al. Genome medicine, 2015/10/01, Volume 7, Issue 1, p.90, (2015) Read More / View Supplemental Materials
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Disproportionate Contributions of Select Genomic Compartments and Cell Types to Genetic Risk for Coronary Artery Disease.Won, HH, Natarajan P., Dobbyn A., Jordan DM, Roussos P., Lage K., Raychaudhuri S., Stahl E., and Do R. PLoS genetics, 2015/10/01, Volume 11, Issue 10, p.e1005622, (2015) Read More / View Supplemental Materials
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Does Atrial Fibrillation Follow Function? Ion Channel Mutations and Lone Atrial Fibrillation.Clauss, S., and Ellinor PT Circulation. Arrhythmia and electrophysiology, 2015/10/01, Volume 8, Issue 5, p.1005-6, (2015) Read More / View Supplemental Materials
The Dynamic Genome and Transcriptome of the Human Fungal Pathogen Blastomyces and Close Relative Emmonsia.Muñoz, JF, Gauthier GM, Desjardins CA, Gallo JE, Holder J., Sullivan TD, Marty AJ, Carmen JC, Chen Z., Ding L., Gujja S., Magrini V., Misas E., Mitreva M., Priest M., Saif S., Whiston EA, Young S., Zeng Q., Goldman WE, et al. PLoS genetics, 2015/10/01, Volume 11, Issue 10, p.e1005493, (2015) Read More / View Supplemental Materials
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Emerging Roles of tRNA-derived Fragments in Viral Infections: The Case of Respiratory Syncytial Virus.Ivanov, P. Molecular therapy : the journal of the American Society of Gene Therapy, 2015/10/01, Volume 23, Issue 10, p.1557-8, (2015) Read More / View Supplemental Materials
The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.Winkler, TW, Justice AE, Graff M., Barata L., Feitosa MF, Chu S., Czajkowski J., Esko T., Fall T., Kilpeläinen TO, Lu Y., Mägi R., Mihailov E., Pers TH, Rüeger S., Teumer A., Ehret GB, Ferreira T., Heard-Costa NL, Karjalainen J., et al. PLoS genetics, 2015/10/01, Volume 11, Issue 10, p.e1005378, (2015) Read More / View Supplemental Materials
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Insights into the Genetic Susceptibility to Type 2 Diabetes from Genome-Wide Association Studies of Obesity-Related Traits.Karaderi, T., Drong AW, and Lindgren CM Current diabetes reports, 2015/10/01, Volume 15, Issue 10, p.83, (2015) Read More / View Supplemental Materials
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An integrated map of structural variation in 2,504 human genomes.Sudmant, PH, Rausch T., Gardner EJ, Handsaker RE, Abyzov A., Huddleston J., Zhang Y., Ye K., Jun G., Hsi-Yang Fritz M., Konkel MK, Malhotra A., Stütz AM, Shi X., Paolo Casale F., Chen J., Hormozdiari F., Dayama G., Chen K., Malig M., et al. Nature, 2015/10/01, Volume 526, Issue 7571, p.75-81, (2015) Read More / View Supplemental Materials
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Large Scale Genetic Research on Neuropsychiatric Disorders in African Populations is Needed.Dalvie, S., Koen N., Duncan L., Abbo C., Akena D., Atwoli L., Chiliza B., Donald KA, Kinyanda E., Lochner C., Mall S., Nakasujja N., Newton CR, Ramesar R., Sibeko G., Teferra S., Stein DJ, and Koenen KC EBioMedicine, 2015/10/01, Volume 2, Issue 10, p.1259-61, (2015) Read More / View Supplemental Materials
Linking RNA biology to lncRNAs.Goff, LA, and Rinn JL Genome research, 2015/10/01, Volume 25, Issue 10, p.1456-65, (2015) Read More / View Supplemental Materials
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Metabolomics: an emerging but powerful tool for precision medicine.Clish, CB Cold Spring Harbor molecular case studies, 2015/10/01, Volume 1, Issue 1, p.a000588, (2015) Read More / View Supplemental Materials
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Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores.Vilhjálmsson, BJ, Yang J., Finucane HK, Gusev A., Lindström S., Ripke S., Genovese G., Loh PR, Bhatia G., Do R., Hayeck T., Won HH, and of in study Schizophrenia Working Group of the Psychiatric Genomics Consortium, Discovery Biology Risk Inherited Variants Breast Cancer(DRIVE), Kathiresan S., Pato M., Pato C., Tamimi R., Stahl E., Zaitlen N., Pasaniuc B., et al. American journal of human genetics, 2015/10/01, Volume 97, Issue 4, p.576-92, (2015) Read More / View Supplemental Materials
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A Novel Approach to High-Quality Postmortem Tissue Procurement: The GTEx Project.Carithers, LJ, Ardlie K., Barcus M., Branton PA, Britton A., Buia SA, Compton CC, Deluca DS, Peter-Demchok J., Gelfand ET, Guan P., Korzeniewski GE, Lockhart NC, Rabiner CA, Rao AK, Robinson KL, Roche NV, Sawyer SJ, Segrè AV, Shive CE, et al. Biopreservation and biobanking, 2015/10/01, Volume 13, Issue 5, p.311-9, (2015) Read More / View Supplemental Materials
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Quantitative proteomics suggests decrease in the secretogranin-1 cerebrospinal fluid levels during the disease course of multiple sclerosis.Kroksveen, AC, Jaffe JD, Aasebø E., Barsnes H., Bjørlykke Y., Franciotta D., Keshishian H., Myhr KM, Opsahl JA, van Pesch V., Teunissen CE, Torkildsen Ø., Ulvik RJ, Vethe H., Carr SA, and Berven FS Proteomics, 2015/10/01, Volume 15, Issue 19, p.3361-9, (2015) Read More / View Supplemental Materials
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Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture.Zheng, HF, Forgetta V., Hsu YH, Estrada K., Rosello-Diez A., Leo PJ, Dahia CL, Park-Min KH, Tobias JH, Kooperberg C., Kleinman A., Styrkarsdottir U., Liu CT, Uggla C., Evans DS, Nielson CM, Walter K., Pettersson-Kymmer U., McCarthy S., Eriksson J., et al. Nature, 2015/10/01, Volume 526, Issue 7571, p.112-7, (2015) Read More / View Supplemental Materials
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Ethanol Enhances TGF-β Activity by Recruiting TGF-β Receptors from Intracellular Vesicles/Lipid Rafts/Caveolae to Non-lipid Raft Microdomains.Huang, SS, Chen CL, Huang FW, Johnson FE, and Huang JS Journal of cellular biochemistry, 2015/09/30, (2015) Read More / View Supplemental Materials
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American Diabetes Association and JDRF Research Symposium: Diabetes and the Microbiome.Semenkovich, CF, Danska J., Darsow T., Dunne JL, Huttenhower C., Insel RA, McElvaine AT, Ratner RE, Shuldiner AR, and Blaser MJ Diabetes, 2015/09/29, (2015) Read More / View Supplemental Materials
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Cell Surface Proteomic Map of HIV Infection Reveals Antagonism of Amino Acid Metabolism by Vpu and Nef.Matheson, NJ, Sumner J., Wals K., Rapiteanu R., Weekes MP, Vigan R., Weinelt J., Schindler M., Antrobus R., Costa AS, Frezza C., Clish CB, Neil SJ, and Lehner PJ Cell host & microbe, 2015/09/29, (2015) Read More / View Supplemental Materials
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The Genetic Modifiers of Motor OnsetAge (GeM MOA) Website: Genome-wide Association Analysis for Genetic Modifiers of Huntington's Disease.Correia, K., Harold D., Kim KH, Holmans P., Jones L., Orth M., Myers RH, Kwak S., Wheeler VC, Macdonald ME, Gusella JF, and Lee JM Journal of Huntington's disease, 2015/09/29, Volume 4, Issue 3, p.279-84, (2015) Read More / View Supplemental Materials
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MetaPhlAn2 for enhanced metagenomic taxonomic profiling.Truong, DT, Franzosa EA, Tickle TL, Scholz M., Weingart G., Pasolli E., Tett A., Huttenhower C., and Segata N. Nature methods, 2015/09/29, Volume 12, Issue 10, p.902-3, (2015) Read More / View Supplemental Materials
Proteomic mapping in live Drosophila tissues using an engineered ascorbate peroxidase.Chen, CL, Hu Y., Udeshi ND, Lau TY, Wirtz-Peitz F., He L., Ting AY, Carr SA, and Perrimon N. Proceedings of the National Academy of Sciences of the United States of America, 2015/09/29, Volume 112, Issue 39, p.12093-8, (2015) Read More / View Supplemental Materials
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RDTs as a source of DNA to study Plasmodium falciparum drug resistance in isolates from Senegal and the Comoros Islands.Papa Mze, N., Ndiaye YD, Diedhiou CK, Rahamatou S., Dieye B., Daniels RF, Hamilton EJ, Diallo M., Bei AK, Wirth DF, Mboup S., Volkman SK, Ahouidi AD, and Ndiaye D. Malaria journal, 2015/09/29, Volume 14, Issue 1, p.373, (2015) Read More / View Supplemental Materials
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Association of APOE with tau-tangle pathology with and without β-amyloid.Farfel, JM, Yu L., De Jager PL, Schneider JA, and Bennett DA Neurobiology of aging, 2015/09/28, (2015) Read More / View Supplemental Materials
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An atlas of genetic correlations across human diseases and traits.Bulik-Sullivan, B., Finucane HK, Anttila V., Gusev A., Day FR, Loh PR, ReproGen Consortium, Psychiatric Genomics Consortium, Genetic Consortium for Anorexia Nervosa of the Wellcome Trust Case Control Consortium 3, Duncan L., Perry JR, Patterson N., Robinson EB, Daly M. J., Price AL, and Neale BM Nature genetics, 2015/09/28, (2015) Read More / View Supplemental Materials
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CD33 modulates TREM2: convergence of Alzheimer loci.Chan, G., White CC, Winn PA, Cimpean M., Replogle JM, Glick LR, Cuerdon NE, Ryan KJ, Johnson KA, Schneider JA, Bennett DA, Chibnik LB, Sperling RA, Bradshaw EM, and De Jager PL Nature neuroscience, 2015/09/28, (2015) Read More / View Supplemental Materials
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Extending the 'cross-disorder' relevance of executive functions to dimensional neuropsychiatric traits in youth.McGrath, LM, Braaten EB, Doty ND, Willoughby BL, Wilson HK, O'Donnell EH, Colvin MK, Ditmars HL, Blais JE, Hill EN, Metzger A., Perlis RH, Willcutt EG, Smoller JW, Waldman ID, Faraone SV, Seidman LJ, and Doyle AE Journal of child psychology and psychiatry, and allied disciplines, 2015/09/28, (2015) Read More / View Supplemental Materials
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Partitioning heritability by functional annotation using genome-wide association summary statistics.Finucane, HK, Bulik-Sullivan B., Gusev A., Trynka G., Reshef Y., Loh PR, Anttila V., Xu H., Zang C., Farh K., Ripke S., Day FR, ReproGen Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium, RACI Consortium, Purcell S., Stahl E., Lindstrom S., Perry JR, Okada Y., et al. Nature genetics, 2015/09/28, (2015) Read More / View Supplemental Materials
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Reply to Lee: Downward bias in heritability estimation is not due to simplified linkage equilibrium SNP simulation.Golan, D., Rosset S., and Lander E. S. Proceedings of the National Academy of Sciences of the United States of America, 2015/09/28, (2015) Read More / View Supplemental Materials
A Src inhibitor regulates the cell cycle of human pluripotent stem cells and improves directed differentiation.Chetty, S., Engquist EN, Mehanna E., Lui KO, Tsankov AM, and Melton DA The Journal of cell biology, 2015/09/28, Volume 210, Issue 7, p.1257-68, (2015) Read More / View Supplemental Materials
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Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets.Brastianos, PK, Carter SL, Santagata S., Cahill DP, Taylor-Weiner A., Jones RT, Van Allen EM, Lawrence MS, Horowitz PM, Cibulskis K., Ligon KL, Tabernero J., Seoane J., Martinez-Saez E., Curry WT, Dunn IF, Paek SH, Park SH, McKenna A., Chevalier A., et al. Cancer discovery, 2015/09/26, (2015) Read More / View Supplemental Materials
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How Y-Family DNA polymerase IV is more accurate than Dpo4 at dCTP insertion opposite an N2-dG adduct of benzo a pyrene.Sholder, G., Creech A., and Loechler EL DNA repair, 2015/09/26, Volume 35, p.144-153, (2015) Read More / View Supplemental Materials
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Characterization of DDR2 Inhibitors for the Treatment of DDR2 Mutated Nonsmall Cell Lung Cancer.Terai, H., Tan L., Beauchamp EM, Hatcher JM, Liu Q., Meyerson M., Gray NS, and Hammerman PS ACS chemical biology, 2015/09/25, (2015) Read More / View Supplemental Materials
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High-throughput approaches to unravel hepatitis C virus-host interactions.Colpitts, CC, El-Saghire H., Pochet N., Schuster C., and Baumert TF Virus research, 2015/09/24, (2015) Read More / View Supplemental Materials
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CAUSEL: an epigenome- and genome-editing pipeline for establishing function of noncoding GWAS variants.Spisák, S., Lawrenson K., Fu Y., Csabai I., Cottman RT, Seo JH, Haiman C., Han Y., Lenci R., Li Q., Tisza V., Szállási Z., Herbert ZT, Chabot M., Pomerantz M., Solymosi N., GAME-ON/ELLIPSE Consortium, Gayther SA, Joung JK, and Freedman ML Nature medicine, 2015/09/23, (2015) Read More / View Supplemental Materials
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Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System.Zetsche, B., Gootenberg JS, Abudayyeh OO, Slaymaker IM, Makarova KS, Essletzbichler P., Volz SE, Joung J., van der Oost J., Regev A., Koonin EV, and Zhang F. Cell, 2015/09/23, (2015) Read More / View Supplemental Materials
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Insights into Autism Spectrum Disorder Genomic Architecture and Biology from 71 Risk Loci.Sanders, SJ, He X., Willsey AJ, Ercan-Sencicek AG, Samocha KE, Cicek AE, Murtha MT, Bal VH, Bishop SL, Dong S., Goldberg AP, Jinlu C., Keaney JF 3rd, Klei L., Mandell JD, Moreno-De-Luca D., Poultney CS, Robinson EB, Smith L., Solli-Nowlan T., et al. Neuron, 2015/09/23, Volume 87, Issue 6, p.1215-33, (2015) Read More / View Supplemental Materials
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Common alleles contribute to schizophrenia in CNV carriers.Tansey, KE, Rees E., Linden DE, Ripke S., Chambert KD, Moran JL, McCarroll SA, Holmans P., Kirov G., Walters J., Owen MJ, and O'Donovan MC Molecular psychiatry, 2015/09/22, (2015) Read More / View Supplemental Materials
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Genome-wide autozygosity is associated with lower general cognitive ability.Howrigan, DP, Simonson MA, Davies G., Harris SE, Tenesa A., Starr JM, Liewald DC, Deary IJ, McRae A., Wright MJ, Montgomery GW, Hansell N., Martin NG, Payton A., Horan M., Ollier WE, Abdellaoui A., Boomsma DI, DeRosse P., Knowles EE, et al. Molecular psychiatry, 2015/09/22, (2015) Read More / View Supplemental Materials
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Massively parallel sequencing of single cells by epicPCR links functional genes with phylogenetic markers.Spencer, SJ, Tamminen MV, Preheim SP, Guo MT, Briggs AW, Brito IL, Weitz DA, Pitkänen LK, Vigneault F., Virta MP, and Alm EJ The ISME journal, 2015/09/22, (2015) Read More / View Supplemental Materials
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DNA sense-and-respond protein modules for mammalian cells.Slomovic, S., and Collins JJ Nature methods, 2015/09/21, (2015) Read More / View Supplemental Materials
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Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation.Kato, N., Loh M., Takeuchi F., Verweij N., Wang X., Zhang W., Kelly TN, Saleheen D., Lehne B., Leach IM, Drong AW, Abbott J., Wahl S., Tan ST, Scott WR, Campanella G., Chadeau-Hyam M., Afzal U., Ahluwalia TS, Bonder MJ, et al. Nature genetics, 2015/09/21, (2015) Read More / View Supplemental Materials
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Risk prediction by genetic risk scores for coronary heart disease is independent of self-reported family history.Tada, H., Melander O., Louie JZ, Catanese JJ, Rowland CM, Devlin JJ, Kathiresan S., and Shiffman D. European heart journal, 2015/09/20, (2015) Read More / View Supplemental Materials
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Genetic research in autism spectrum disorders.Robinson, EB, Neale BM, and Hyman SE Current opinion in pediatrics, 2015/09/18, (2015) Read More / View Supplemental Materials
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In vivo Monitoring of Transcriptional Dynamics After Lower-Limb Muscle Injury Enables Quantitative Classification of Healing.Aguilar, CA, Shcherbina A., Ricke DO, Pop R., Carrigan CT, Gifford CA, Urso ML, Kottke MA, and Meissner A. Scientific reports, 2015/09/18, Volume 5, p.13885, (2015) Read More / View Supplemental Materials
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Genetic influences on the neural and physiological bases of acute threat: A research domain criteria (RDoC) perspective.Sumner, JA, Powers A., Jovanovic T., and Koenen KC American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2015/09/17, (2015) Read More / View Supplemental Materials
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Loci associated with N-glycosylation of human IgG are not associated with rheumatoid arthritis: a Mendelian randomisation study.Yarwood, A., Viatte S., Okada Y., Plenge R., Yamamoto K., BRAGGSS RACI, Barton A., Symmons D., Raychaudhuri S., Klareskog L., Gregersen P., Worthington J., and Eyre S. Annals of the rheumatic diseases, 2015/09/17, (2015) Read More / View Supplemental Materials
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Tools and best practices for data processing in allelic expression analysis.Castel, SE, Levy-Moonshine A., Mohammadi P., Banks E., and Lappalainen T. Genome biology, 2015/09/17, Volume 16, Issue 1, p.195, (2015) Read More / View Supplemental Materials
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BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis.Canver, MC, Smith EC, Sher F., Pinello L., Sanjana NE, Shalem O., Chen DD, Schupp PG, Vinjamur DS, Garcia SP, Luc S., Kurita R., Nakamura Y., Fujiwara Y., Maeda T., Yuan GC, Zhang F., Orkin SH, and Bauer DE Nature, 2015/09/16, (2015) Read More / View Supplemental Materials
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De novo mutations in ARID1B associated with both syndromic and non-syndromic short stature.Yu, Y., Yao R., Wang L., Fan Y., Huang X., Hirschhorn J., Dauber A., and Shen Y. BMC genomics, 2015/09/16, Volume 16, Issue 1, p.701, (2015) Read More / View Supplemental Materials
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Gene-Based Meta-Analysis of Genome-Wide Association Studies Implicates New Loci Involved in Obesity.Hägg, S., Ganna A., van der Laan SW, Esko T., Pers TH, Locke AE, Berndt SI, Justice AE, Kahali B., Siemelink MA, Pasterkamp G., GIANT Consortium, Strachan DP, Speliotes EK, North KE, Loos RJ, Hirschhorn JN, Pawitan Y., and Ingelsson E. Human molecular genetics, 2015/09/16, (2015) Read More / View Supplemental Materials
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Adaptive evolution of malaria parasites in French Guiana: Reversal of chloroquine resistance by acquisition of a mutation in pfcrt.Pelleau, S., Moss EL, Dhingra SK, Volney B., Casteras J., Gabryszewski SJ, Volkman SK, Wirth DF, Legrand E., Fidock DA, Neafsey DE, and Musset L. Proceedings of the National Academy of Sciences of the United States of America, 2015/09/15, Volume 112, Issue 37, p.11672-7, (2015) Read More / View Supplemental Materials
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Comprehensive analysis of cancer-associated somatic mutations in class I HLA genes.Shukla, SA, Rooney MS, Rajasagi M., Tiao G., Dixon PM, Lawrence MS, Lane WJ, Steelman S., Sougnez C., Cibulskis K., Kiezun A., Hacohen N., Brusic V., Wu CJ, and Getz G. Nature biotechnology, 2015/09/15, (2015) Read More / View Supplemental Materials
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Host genetic variation impacts microbiome composition across human body sites.Blekhman, R., Goodrich JK, Huang K., Sun Q., Bukowski R., Bell JT, Spector TD, Keinan A., Ley RE, Gevers D., and Clark AG Genome biology, 2015/09/15, Volume 16, p.191, (2015) Read More / View Supplemental Materials
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Association of Long Runs of Homozygosity With Alzheimer Disease Among African American Individuals.Ghani, M., Reitz C., Cheng R., Vardarajan BN, Jun G., Sato C., Naj A., Rajbhandary R., Wang LS, Valladares O., Lin CF, Larson EB, Graff-Radford NR, Evans D., De Jager PL, Crane PK, Buxbaum JD, Murrell JR, Raj T., Ertekin-Taner N., et al. JAMA neurology, 2015/09/14, (2015) Read More / View Supplemental Materials
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Detection of low-abundance bacterial strains in metagenomic datasets by eigengenome partitioning.Cleary, B., Brito IL, Huang K., Gevers D., Shea T., Young S., and Alm EJ Nature biotechnology, 2015/09/14, (2015) Read More / View Supplemental Materials
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Population genetic differentiation of height and body mass index across Europe.Robinson, MR, Hemani G., Medina-Gomez C., Mezzavilla M., Esko T., Shakhbazov K., Powell JE, Vinkhuyzen A., Berndt SI, Gustafsson S., Justice AE, Kahali B., Locke AE, Pers TH, Vedantam S., Wood AR, van Rheenen W., Andreassen OA, Gasparini P., Metspalu A., et al. Nature genetics, 2015/09/14, (2015) Read More / View Supplemental Materials
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Zebrafish as tools for drug discovery.Macrae, CA, and Peterson RT Nature reviews. Drug discovery, 2015/09/11, (2015) Read More / View Supplemental Materials
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Pathogen Cell-to-Cell Variability Drives Heterogeneity in Host Immune Responses.Avraham, R., Haseley N., Brown D., Penaranda C., Jijon HB, Trombetta JJ, Satija R., Shalek AK, Xavier RJ, Regev A., and Hung DT Cell, 2015/09/10, Volume 162, Issue 6, p.1309-21, (2015) Read More / View Supplemental Materials
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Targeting of Fn14 Prevents Cancer-Induced Cachexia and Prolongs Survival.Johnston, AJ, Murphy KT, Jenkinson L., Laine D., Emmrich K., Faou P., Weston R., Jayatilleke KM, Schloegel J., Talbo G., Casey JL, Levina V., Wong WW, Dillon H., Sahay T., Hoogenraad J., Anderton H., Hall C., Schneider P., Tanzer M., et al. Cell, 2015/09/10, Volume 162, Issue 6, p.1365-78, (2015) Read More / View Supplemental Materials
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Mechanisms of Cancer Cell Dormancy-Another Hallmark of Cancer?Yeh, AC, and Ramaswamy S. Cancer research, 2015/09/09, (2015) Read More / View Supplemental Materials
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Phenotypic extremes in rare variant study designs.Peloso, GM, Rader DJ, Gabriel S., Kathiresan S., Daly M. J., and Neale BM European journal of human genetics : EJHG, 2015/09/09, (2015) Read More / View Supplemental Materials
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Systematic Identification of Factors for Provirus Silencing in Embryonic Stem Cells.Yang, BX, El Farran CA, Guo HC, Yu T., Fang HT, Wang HF, Schlesinger S., Seah YF, Goh GY, Neo SP, Li Y., Lorincz MC, Tergaonkar V., Lim TM, Chen L., Gunaratne J., Collins JJ, Goff SP, Daley GQ, Li H., et al. Cell, 2015/09/09, (2015) Read More / View Supplemental Materials
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Combined pan-RAF and MEK inhibition overcomes multiple resistance mechanisms to selective RAF inhibitors.Whittaker, SR, Cowley GS, Wagner S., Root DE, and Garraway LA Molecular cancer therapeutics, 2015/09/08, (2015) Read More / View Supplemental Materials
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Fossil hominin shoulders support an African ape-like last common ancestor of humans and chimpanzees.Young, NM, Capellini TD, Roach NT, and Alemseged Z. Proceedings of the National Academy of Sciences of the United States of America, 2015/09/08, (2015) Read More / View Supplemental Materials
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A Noncanonical Autophagy Pathway Restricts Toxoplasma gondii Growth in a Strain-Specific Manner in IFN-γ-Activated Human Cells.Selleck, EM, Orchard RC, Lassen KG, Beatty WL, Xavier RJ, Levine B., Virgin HW, and Sibley LD mBio, 2015/09/08, Volume 6, Issue 5, (2015) Read More / View Supplemental Materials
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Cas9 gRNA engineering for genome editing, activation and repression.Kiani, S., Chavez A., Tuttle M., Hall RN, Chari R., Ter-Ovanesyan D., Qian J., Pruitt BW, Beal J., Vora S., Buchthal J., Kowal EJ, Ebrahimkhani MR, Collins JJ, Weiss R., and Church G. Nature methods, 2015/09/07, (2015) Read More / View Supplemental Materials
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