Publications

Degradation of GSPT1 causes TP53-independent cell death in leukemia whilst sparing normal hematopoietic stem cells.

Sellar RS, Sperling AS, Słabicki M, et al. Degradation of GSPT1 causes TP53-independent cell death in leukemia whilst sparing normal hematopoietic stem cells. J Clin Invest. 2022. doi:10.1172/JCI153514.DOI Google Scholar PubMed

The 22q11.2 region regulates presynaptic gene-products linked to schizophrenia.

Nehme R, Pietilainen O, Artomov M, et al. The 22q11.2 region regulates presynaptic gene-products linked to schizophrenia. Nat Commun. 2022;13(1):3690. doi:10.1038/s41467-022-31436-8.DOI Google Scholar PubMed

Selenoprotein TXNRD3 supports male fertility via the redox regulation of spermatogenesis.

Dou Q, Turanov AA, Mariotti M, et al. Selenoprotein TXNRD3 supports male fertility via the redox regulation of spermatogenesis. J Biol Chem. 2022:102183. doi:10.1016/j.jbc.2022.102183.DOI Google Scholar PubMed

Single-nucleus profiling of human dilated and hypertrophic cardiomyopathy.

Chaffin M, Papangeli I, Simonson B, et al. Single-nucleus profiling of human dilated and hypertrophic cardiomyopathy. Nature. 2022. doi:10.1038/s41586-022-04817-8.DOI Google Scholar PubMed

Host protease activity classifies pneumonia etiology.

Anahtar M, Chan LW, Ko H, et al. Host protease activity classifies pneumonia etiology. Proc Natl Acad Sci U S A. 2022;119(25):e2121778119. doi:10.1073/pnas.2121778119.DOI Google Scholar PubMed

Genome-wide mapping of somatic mutation rates uncovers drivers of cancer.

Sherman MA, Yaari AU, Priebe O, Dietlein F, Loh P-R, Berger B. Genome-wide mapping of somatic mutation rates uncovers drivers of cancer. Nat Biotechnol. 2022. doi:10.1038/s41587-022-01353-8.DOI Google Scholar PubMed

Genetic subtypes of smoldering multiple myeloma are associated with distinct pathogenic phenotypes and clinical outcomes.

Bustoros M, Anand S, Sklavenitis-Pistofidis R, et al. Genetic subtypes of smoldering multiple myeloma are associated with distinct pathogenic phenotypes and clinical outcomes. Nat Commun. 2022;13(1):3449. doi:10.1038/s41467-022-30694-w.DOI Google Scholar PubMed

Granzyme K CD8 T cells form a core population in inflamed human tissue.

Jonsson H, Zhang F, Dunlap G, et al. Granzyme K CD8 T cells form a core population in inflamed human tissue. Sci Transl Med. 2022;14(649):eabo0686. doi:10.1126/scitranslmed.abo0686.DOI Google Scholar PubMed

YAP1 maintains active chromatin state in head and neck squamous cell carcinomas that promotes tumorigenesis through cooperation with BRD4.

Chen N, Golczer G, Ghose S, et al. YAP1 maintains active chromatin state in head and neck squamous cell carcinomas that promotes tumorigenesis through cooperation with BRD4. Cell Rep. 2022;39(11):110970. doi:10.1016/j.celrep.2022.110970.DOI Google Scholar PubMed

The Parkinson's disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability.

Hallacli E, Kayatekin C, Nazeen S, et al. The Parkinson's disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability. Cell. 2022;185(12):2035-2056.e33. doi:10.1016/j.cell.2022.05.008.DOI Google Scholar PubMed