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2011
PAK1 is a breast cancer oncogene that coordinately activates MAPK and MET signaling.Shrestha, Y., Schafer EJ, Boehm JS, Thomas SR, He F., Du J., Wang S., Barretina J., Weir BA, Zhao JJ, Polyak K., Golub T. R., Beroukhim R., and Hahn WC Oncogene, 2011/11/21, (2011) Read More / View Supplemental Materials
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GenomeView: a next-generation genome browser.Abeel, T., Van Parys T., Saeys Y., Galagan J., and Van de Peer Y. Nucleic acids research, 2011/11/18, (2011) Read More / View Supplemental Materials
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Strategies to discover regulatory circuits of the mammalian immune system.Amit, I., Regev A., and Hacohen N. Nature reviews. Immunology, 2011/11/18, Volume 11, Issue 12, p.873-80, (2011) Read More / View Supplemental Materials
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Common DISC1 Polymorphisms Disrupt Wnt/GSK3β Signaling and Brain Development.Singh, KK, De Rienzo G., Drane L., Mao Y., Flood Z., Madison J., Ferreira M., Bergen S., King C., Sklar P., Sive H., and Tsai LH Neuron, 2011/11/17, Volume 72, Issue 4, p.545-58, (2011) Read More / View Supplemental Materials
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Systematic discovery of TLR signaling components delineates viral-sensing circuits.Chevrier, N., Mertins P., Artyomov MN, Shalek AK, Iannacone M., Ciaccio MF, Gat-Viks I., Tonti E., Degrace MM, Clauser KR, Garber M., Eisenhaure TM, Yosef N., Robinson J., Sutton A., Andersen MS, Root DE, von Andrian U., Jones RB, Park H., et al. Cell, 2011/11/11, Volume 147, Issue 4, p.853-67, (2011) Read More / View Supplemental Materials
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RAS Mutations Are Associated With the Development of Cutaneous Squamous Cell Tumors in Patients Treated With RAF Inhibitors.Oberholzer, PA, Kee D., Dziunycz P., Sucker A., Kamsukom N., Jones R., Roden C., Chalk CJ, Ardlie K., Palescandolo E., Piris A., Macconaill LE, Robert C., Hofbauer GF, McArthur GA, Schadendorf D., and Garraway LA Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2011/11/07, (2011) Read More / View Supplemental Materials
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Comprehensive proteomic study identifies serpin and cystatin antiproteases as novel correlates of HIV-1 resistance in the cervicovaginal mucosa of female sex workers.Burgener, A., Rahman S., Ahmad R., Lajoie J., Ramdahin S., Mesa C., Brunet S., Wachihi C., Kimani J., Fowke K., Carr S., Plummer F., and Ball TB Journal of proteome research, 2011/11/04, Volume 10, Issue 11, p.5139-49, (2011) Read More / View Supplemental Materials
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Guiding DNA methylation.Meissner, A. Cell stem cell, 2011/11/04, Volume 9, Issue 5, p.388-90, (2011) Read More / View Supplemental Materials
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A genome-wide scan for common variants affecting the rate of age-related cognitive decline.De Jager, PL, Shulman JM, Chibnik LB, Keenan BT, Raj T., Wilson RS, Yu L., Leurgans SE, Tran D., Aubin C., Anderson CD, Biffi A., Corneveaux JJ, Huentelman MJ, Alzheimer's Disease Neuroimaging Initiative, Rosand J., Daly M. J., Myers AJ, Reiman EM, Bennett DA, et al. Neurobiology of aging, 2011/11/03, (2011) Read More / View Supplemental Materials
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Synaptic Deficits Are Rescued in the p25/Cdk5 Model of Neurodegeneration by the Reduction of β-Secretase (BACE1).Giusti-Rodríguez, P., Gao J., Gräff J., Rei D., Soda T., and Tsai LH The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011/11/02, Volume 31, Issue 44, p.15751-6, (2011) Read More / View Supplemental Materials
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Unfolding neurodevelopmental disorders: found in translation.Ting, JT, and Feng G. Nature medicine, 2011/11/02, Volume 17, Issue 11, p.1352-3, (2011) Read More / View Supplemental Materials
Distribution Pattern of Plasmodium falciparum Chloroquine Transporter (pfcrt) Gene Haplotypes in Sri Lanka 1996-2006.Zhang, JJ, Senaratne TN, Daniels R., Valim C., Alifrangis M., Amerasinghe P., Konradsen F., Rajakaruna R., Wirth DF, and Karunaweera ND The American journal of tropical medicine and hygiene, 2011/11/01, Volume 85, Issue 5, p.811-4, (2011) Read More / View Supplemental Materials
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Evolutionary divergence of intrinsic and trans-regulated nucleosome positioning sequences reveals plastic rules for chromatin organization.Tsankov, A., Yanagisawa Y., Rhind N., Regev A., and Rando OJ Genome research, 2011/11/01, Volume 21, Issue 11, p.1851-62, (2011) Read More / View Supplemental Materials
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Master Data Management: Getting your House in Order.Seiler, KP, Bodycombe NE, Hawkins T., Shell R., Lemon A., Souza A., and Clemons PA Combinatorial chemistry & high throughput screening, 2011/11/01, Volume 14, Issue 9, p.749-56, (2011) Read More / View Supplemental Materials
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A statistical framework for SNP calling, mutation discovery, association mapping and population genetical parameter estimation from sequencing data.Li, H. Bioinformatics (Oxford, England), 2011/11/01, Volume 27, Issue 21, p.2987-93, (2011) Read More / View Supplemental Materials
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The two-component sensor kinase KinB acts as a non-canonical switch between acute and chronic infection.Chand, NS, and Hung DT Virulence, 2011/11/01, Volume 2, Issue 6, p.553-8, (2011) Read More / View Supplemental Materials
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Reply to "More on color blindness".Wong, B. Nature methods, 2011/10/28, Volume 8, Issue 11, p.891-2, (2011) Read More / View Supplemental Materials
ANAT: a tool for constructing and analyzing functional protein networks.Yosef, N., Zalckvar E., Rubinstein AD, Homilius M., Atias N., Vardi L., Berman I., Zur H., Kimchi A., Ruppin E., and Sharan R. Science signaling, 2011/10/25, Volume 4, Issue 196, p.pl1, (2011) Read More / View Supplemental Materials
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A rare penetrant mutation in CFH confers high risk of age-related macular degeneration.Raychaudhuri, S., Iartchouk O., Chin K., Tan PL, Tai AK, Ripke S., Gowrisankar S., Vemuri S., Montgomery K., Yu Y., Reynolds R., Zack DJ, Campochiaro B., Campochiaro P., Katsanis N., Daly M. J., and Seddon JM Nature genetics, 2011/10/23, Volume 43, Issue 12, p.1232-6, (2011) Read More / View Supplemental Materials
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Diastereoselective control of intramolecular aza-Michael reactions using achiral catalysts.Zhong, C., Wang Y., Hung AW, Schreiber SL, and Young DW Organic letters, 2011/10/21, Volume 13, Issue 20, p.5556-9, (2011) Read More / View Supplemental Materials
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Genomic analysis identifies association of Fusobacterium with colorectal carcinoma.Kostic, AD, Gevers D., Pedamallu CS, Michaud M., Duke F., Earl AM, Ojesina AI, Jung J., Bass AJ, Tabernero J., Baselga J., Liu C., Shivdasani RA, Ogino S., Birren BW, Huttenhower C., Garrett WS, and Meyerson M. Genome research, 2011/10/18, (2011) Read More / View Supplemental Materials
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A high-resolution map of human evolutionary constraint using 29 mammals.Lindblad-Toh, K., Garber M., Zuk O., Lin MF, Parker BJ, Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward LD, Lowe CB, Holloway AK, Clamp M., Gnerre S., Alföldi J., Beal K., Chang J., Clawson H., Cuff J., et al. Nature, 2011/10/12, Volume 478, Issue 7370, p.476-82, (2011) Read More / View Supplemental Materials
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Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease.Rivas, MA, Beaudoin M., Gardet A., Stevens C., Sharma Y., Zhang CK, Boucher G., Ripke S., Ellinghaus D., Burtt N., Fennell T., Kirby A., Latiano A., Goyette P., Green T., Halfvarson J., Haritunians T., Korn JM, Kuruvilla F., Lagacé C., et al. Nature genetics, 2011/10/09, Volume 43, Issue 11, p.1066-73, (2011) Read More / View Supplemental Materials
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Diversity-oriented synthesis of 13- to 18-membered macrolactams via ring-closing metathesis.Dandapani, S., Lowe JT, Comer E., and Marcaurelle LA The Journal of organic chemistry, 2011/10/07, Volume 76, Issue 19, p.8042-8, (2011) Read More / View Supplemental Materials
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Approaches to Fungal Genome Annotation.Haas, BJ, Zeng Q., Pearson MD, Cuomo CA, and Wortman JR Mycology, 2011/10/03, Volume 2, Issue 3, p.118-141, (2011) Read More / View Supplemental Materials
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Comparative genomic analysis of human fungal pathogens causing paracoccidioidomycosis.Desjardins, CA, Champion MD, Holder JW, Muszewska A., Goldberg J., Bailão AM, Brigido MM, Ferreira ME, Garcia AM, Grynberg M., Gujja S., Heiman DI, Henn MR, Kodira CD, León-Narváez H., Longo LV, Ma LJ, Malavazi I., Matsuo AL, Morais FV, et al. PLoS genetics, 2011/10/01, Volume 7, Issue 10, p.e1002345, (2011) Read More / View Supplemental Materials
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Genomic risk of hepatitis C-related hepatocellular carcinoma.Hoshida, Y., Fuchs BC, and Tanabe KK Journal of hepatology, 2011/09/29, (2011) Read More / View Supplemental Materials
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Whole-genome chromatin profiling from limited numbers of cells using nano-ChIP-seq.Adli, M., and Bernstein BE Nature protocols, 2011/09/29, Volume 6, Issue 10, p.1656-68, (2011) Read More / View Supplemental Materials
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Corridors of migrating neurons in the human brain and their decline during infancy.Sanai, N., Nguyen T., Ihrie RA, Mirzadeh Z., Tsai HH, Wong M., Gupta N., Berger MS, Huang E., Garcia-Verdugo JM, Rowitch DH, and Alvarez-Buylla A. Nature, 2011/09/28, Volume 478, Issue 7369, p.382-6, (2011) Read More / View Supplemental Materials
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Workflow and Metrics for Image Quality Control in Large-Scale High-Content Screens.Bray, MA, Fraser AN, Hasaka TP, and Carpenter AE Journal of biomolecular screening, 2011/09/28, (2011) Read More / View Supplemental Materials
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ContEst: estimating cross-contamination of human samples in next-generation sequencing data.Cibulskis, K., McKenna A., Fennell T., Banks E., DePristo M., and Getz G. Bioinformatics (Oxford, England), 2011/09/15, Volume 27, Issue 18, p.2601-2, (2011) Read More / View Supplemental Materials
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The DNA damage mark pH2AX differentiates the cytotoxic effects of small molecule HDAC inhibitors in ovarian cancer cells.Wilson, AJ, Holson E., Wagner F., Zhang YL, Fass DM, Haggarty SJ, Bhaskara S., Hiebert SW, Schreiber SL, and Khabele D. Cancer biology & therapy, 2011/09/15, Volume 12, Issue 6, p.484-93, (2011) Read More / View Supplemental Materials
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The genome of th17 cell-inducing segmented filamentous bacteria reveals extensive auxotrophy and adaptations to the intestinal environment.Sczesnak, A., Segata N., Qin X., Gevers D., Petrosino JF, Huttenhower C., Littman DR, and Ivanov II Cell host & microbe, 2011/09/15, Volume 10, Issue 3, p.260-72, (2011) Read More / View Supplemental Materials
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Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses.Cabili, MN, Trapnell C., Goff L., Koziol M., Tazon-Vega B., Regev A., and Rinn JL Genes & development, 2011/09/15, Volume 25, Issue 18, p.1915-27, (2011) Read More / View Supplemental Materials
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Piperazinyl quinolines as chemosensitizers to increase fluconazole susceptibility of Candida albicans clinical isolates.Youngsaye, W., Vincent B., Hartland CL, Morgan BJ, Buhrlage SJ, Johnston S., Bittker JA, Macpherson L., Dandapani S., Palmer M., Whitesell L., Lindquist S., Schreiber SL, and Munoz B. Bioorganic & medicinal chemistry letters, 2011/09/15, Volume 21, Issue 18, p.5502-5, (2011) Read More / View Supplemental Materials
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Computational and statistical approaches to analyzing variants identified by exome sequencing.Stitziel, NO, Kiezun A., and Sunyaev S. Genome biology, 2011/09/14, Volume 12, Issue 9, p.227, (2011) Read More / View Supplemental Materials
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Synthesis of a novel suppressor of beta-cell apoptosis via diversity-oriented synthesis.Chou, DH, Duvall JR, Gerard B., Liu H., Pandya BA, Suh BC, Forbeck EM, Faloon P., Wagner BK, and Marcaurelle LA ACS medicinal chemistry letters, 2011/09/08, Volume 2, Issue 9, p.698-702, (2011) Read More / View Supplemental Materials
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Mutations in MTFMT underlie a human disorder of formylation causing impaired mitochondrial translation.Tucker, EJ, Hershman SG, Köhrer C., Belcher-Timme CA, Patel J., Goldberger OA, Christodoulou J., Silberstein JM, McKenzie M., Ryan MT, Compton AG, Jaffe JD, Carr SA, Calvo SE, RajBhandary UL, Thorburn DR, and Mootha VK Cell metabolism, 2011/09/07, Volume 14, Issue 3, p.428-34, (2011) Read More / View Supplemental Materials
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Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion.Bass, AJ, Lawrence MS, Brace LE, Ramos AH, Drier Y., Cibulskis K., Sougnez C., Voet D., Saksena G., Sivachenko A., Jing R., Parkin M., Pugh T., Verhaak RG, Stransky N., Boutin AT, Barretina J., Solit DB, Vakiani E., Shao W., et al. Nature genetics, 2011/09/04, Volume 43, Issue 10, p.964-8, (2011) Read More / View Supplemental Materials
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Comparative and functional genomics of Rhodococcus opacus PD630 for biofuels development.Holder, JW, Ulrich JC, DeBono AC, Godfrey PA, Desjardins CA, Zucker J., Zeng Q., Leach AL, Ghiviriga I., Dancel C., Abeel T., Gevers D., Kodira CD, Desany B., Affourtit JP, Birren BW, and Sinskey AJ PLoS genetics, 2011/09/01, Volume 7, Issue 9, p.e1002219, (2011) Read More / View Supplemental Materials
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Leucine-rich repeat (LRR) proteins: integrators of pattern recognition and signaling in immunity.Ng, A., and Xavier RJ Autophagy, 2011/09/01, Volume 7, Issue 9, p.1082-4, (2011) Read More / View Supplemental Materials
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Molecular signatures and prognosis of hepatocellular carcinoma.Hoshida, Y. Minerva gastroenterologica e dietologica, 2011/09/01, Volume 57, Issue 3, p.311-22, (2011) Read More / View Supplemental Materials
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Points of view: arrows.Wong, B. Nature methods, 2011/09/01, Volume 8, Issue 9, p.701, (2011) Read More / View Supplemental Materials
STK33 kinase activity is nonessential in KRAS-dependent cancer cells.Babij, C., Zhang Y., Kurzeja RJ, Munzli A., Shehabeldin A., Fernando M., Quon K., Kassner PD, Ruefli-Brasse AA, Watson VJ, Fajardo F., Jackson A., Zondlo J., Sun Y., Ellison AR, Plewa CA, San MT, Robinson J., McCarter J., Schwandner R., et al. Cancer research, 2011/09/01, Volume 71, Issue 17, p.5818-26, (2011) Read More / View Supplemental Materials
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Clustering with position-specific constraints on variance: applying redescending M-estimators to label-free LC-MS data analysis.Frühwirth, R., Mani D. R., and Pyne S. BMC bioinformatics, 2011/08/31, Volume 12, p.358, (2011) Read More / View Supplemental Materials
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The genome of the green anole lizard and a comparative analysis with birds and mammals.Alföldi, J., Di Palma F., Grabherr M., Williams C., Kong L., Mauceli E., Russell P., Lowe CB, Glor RE, Jaffe JD, Ray DA, Boissinot S., Shedlock AM, Botka C., Castoe TA, Colbourne JK, Fujita MK, Moreno RG, ten Hallers BF, Haussler D., et al. Nature, 2011/08/31, Volume 477, Issue 7366, p.587-91, (2011) Read More / View Supplemental Materials
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lincRNAs act in the circuitry controlling pluripotency and differentiation.Guttman, M., Donaghey J., Carey BW, Garber M., Grenier JK, Munson G., Young G., Lucas AB, Ach R., Bruhn L., Yang X., Amit I., Meissner A., Regev A., Rinn JL, Root DE, and Lander E. S. Nature, 2011/08/28, Volume 477, Issue 7364, p.295-300, (2011) Read More / View Supplemental Materials
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Stem cell gene expression programs influence clinical outcome in human leukemia.Eppert, K., Takenaka K., Lechman ER, Waldron L., Nilsson B., van Galen P., Metzeler KH, Poeppl A., Ling V., Beyene J., Canty AJ, Danska JS, Bohlander SK, Buske C., Minden MD, Golub T. R., Jurisica I., Ebert BL, and Dick JE Nature medicine, 2011/08/28, Volume 17, Issue 9, p.1086-93, (2011) Read More / View Supplemental Materials
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The mutational landscape of head and neck squamous cell carcinoma.Stransky, N., Egloff AM, Tward AD, Kostic AD, Cibulskis K., Sivachenko A., Kryukov GV, Lawrence MS, Sougnez C., McKenna A., Shefler E., Ramos AH, Stojanov P., Carter SL, Voet D., Cortés ML, Auclair D., Berger MF, Saksena G., Guiducci C., et al. Science (New York, N.Y.), 2011/08/26, Volume 333, Issue 6046, p.1157-60, (2011) Read More / View Supplemental Materials
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Practical asymmetric synthesis of β-hydroxy γ-amino acids via complimentary aldol reactions.Pandya, BA, Dandapani S., Duvall JR, Rowley A., Mulrooney CA, Ryba T., Dombrowski M., Harton M., Young DW, and Marcaurelle LA Tetrahedron, 2011/08/26, Volume 67, Issue 34, p.6131-6137, (2011) Read More / View Supplemental Materials
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Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells.Gupta, PB, Fillmore CM, Jiang G., Shapira SD, Tao K., Kuperwasser C., and Lander E. S. Cell, 2011/08/19, Volume 146, Issue 4, p.633-44, (2011) Read More / View Supplemental Materials
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Ceestatin, a novel small molecule inhibitor of hepatitis C virus replication, inhibits 3-hydroxy-3-methylglutaryl-coenzyme A synthase.Peng, LF, Schaefer EA, Maloof N., Skaff A., Berical A., Belon CA, Heck JA, Lin W., Frick DN, Allen TM, Miziorko HM, Schreiber SL, and Chung RT The Journal of infectious diseases, 2011/08/15, Volume 204, Issue 4, p.609-16, (2011) Read More / View Supplemental Materials
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Molecular evolution of West Nile virus in a northern temperate region: Connecticut, USA 1999-2008.Armstrong, PM, Vossbrinck CR, Andreadis TG, Anderson JF, Pesko KN, Newman RM, Lennon NJ, Birren BW, Ebel GD, and Henn MR Virology, 2011/08/15, Volume 417, Issue 1, p.203-10, (2011) Read More / View Supplemental Materials
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Hybrid selection for sequencing pathogen genomes from clinical samples.Melnikov, A., Galinsky K., Rogov P., Fennell T., Van Tyne D., Russ C., Daniels R., Barnes KG, Bochicchio J., Ndiaye D., Sene PD, Wirth DF, Nusbaum C., Volkman SK, Birren BW, Gnirke A., and Neafsey DE Genome biology, 2011/08/11, Volume 12, Issue 8, p.R73, (2011) Read More / View Supplemental Materials
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Status and prospects for discovery and verification of new biomarkers of cardiovascular disease by proteomics.Gerszten, RE, Asnani A., and Carr SA Circulation research, 2011/08/05, Volume 109, Issue 4, p.463-74, (2011) Read More / View Supplemental Materials
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Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling.Wagle, N., Emery C., Berger MF, Davis MJ, Sawyer A., Pochanard P., Kehoe SM, Johannessen CM, Macconaill LE, Hahn WC, Meyerson M., and Garraway LA Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2011/08/01, Volume 29, Issue 22, p.3085-96, (2011) Read More / View Supplemental Materials
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Genomic analysis of the necrotrophic fungal pathogens Sclerotinia sclerotiorum and Botrytis cinerea.Amselem, J., Cuomo CA, van Kan JA, Viaud M., Benito EP, Couloux A., Coutinho PM, de Vries RP, Dyer PS, Fillinger S., Fournier E., Gout L., Hahn M., Wincker P., Anthouard V., Chen Z., Danchin EG, Dasilva C., Güldener U., Henrissat B., et al. PLoS genetics, 2011/08/01, Volume 7, Issue 8, p.e1002230, (2011) Read More / View Supplemental Materials
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Quantification of proteins using peptide immunoaffinity enrichment coupled with mass spectrometry.Zhao, L., Whiteaker JR, Pope ME, Kuhn E., Jackson A., Anderson NL, Pearson TW, Carr SA, and Paulovich AG Journal of visualized experiments : JoVE, 2011/07/31, Issue 53, (2011) Read More / View Supplemental Materials
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AAK1 identified as an inhibitor of neuregulin-1/ErbB4-dependent neurotrophic factor signaling using integrative chemical genomics and proteomics.Kuai, L., Ong SE, Madison JM, Wang X., Duvall JR, Lewis TA, Luce CJ, Conner SD, Pearlman DA, Wood JL, Schreiber SL, Carr SA, Scolnick EM, and Haggarty SJ Chemistry & biology, 2011/07/29, Volume 18, Issue 7, p.891-906, (2011) Read More / View Supplemental Materials
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Exoplasmic cysteine Cys384 of the HDL receptor SR-BI is critical for its sensitivity to a small-molecule inhibitor and normal lipid transport activity.Yu, M., Romer KA, Nieland TJ, Xu S., Saenz-Vash V., Penman M., Yesilaltay A., Carr SA, and Krieger M. Proceedings of the National Academy of Sciences of the United States of America, 2011/07/26, Volume 108, Issue 30, p.12243-8, (2011) Read More / View Supplemental Materials
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Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer.Cheung, HW, Cowley GS, Weir BA, Boehm JS, Rusin S., Scott JA, East A., Ali LD, Lizotte PH, Wong TC, Jiang G., Hsiao J., Mermel CH, Getz G., Barretina J., Gopal S., Tamayo P., Gould J., Tsherniak A., Stransky N., et al. Proceedings of the National Academy of Sciences of the United States of America, 2011/07/26, Volume 108, Issue 30, p.12372-7, (2011) Read More / View Supplemental Materials
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Comparing strategies to fine-map the association of common SNPs at chromosome 9p21 with type 2 diabetes and myocardial infarction.Shea, J., Agarwala V., Philippakis AA, Maguire J., Banks E., DePristo M., Thomson B., Guiducci C., Onofrio RC, Kathiresan S., Gabriel S., Burtt NP, Daly M. J., Groop L., Altshuler D., and Myocardial Infarction Genetics Consortium Nature genetics, 2011/07/24, Volume 43, Issue 8, p.801-5, (2011) Read More / View Supplemental Materials
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Extracellular movement of signaling molecules.Müller, P., and Schier AF Developmental cell, 2011/07/19, Volume 21, Issue 1, p.145-58, (2011) Read More / View Supplemental Materials
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A haploid genetic screen identifies the major facilitator domain containing 2A (MFSD2A) transporter as a key mediator in the response to tunicamycin.Reiling, JH, Clish CB, Carette JE, Varadarajan M., Brummelkamp TR, and Sabatini DM Proceedings of the National Academy of Sciences of the United States of America, 2011/07/19, Volume 108, Issue 29, p.11756-65, (2011) Read More / View Supplemental Materials
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Humanized mice with ectopic artificial liver tissues.Chen, AA, Thomas DK, Ong LL, Schwartz RE, Golub T. R., and Bhatia SN Proceedings of the National Academy of Sciences of the United States of America, 2011/07/19, Volume 108, Issue 29, p.11842-7, (2011) Read More / View Supplemental Materials
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A novel HDAC inhibitor with a hydroxy-pyrimidine scaffold.Kemp, MM, Wang Q., Fuller JH, West N., Martinez NM, Morse EM, Weïwer M., Schreiber SL, Bradner JE, and Koehler AN Bioorganic & medicinal chemistry letters, 2011/07/15, Volume 21, Issue 14, p.4164-9, (2011) Read More / View Supplemental Materials
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Selective killing of cancer cells by a small molecule targeting the stress response to ROS.Raj, L., Ide T., Gurkar AU, Foley M., Schenone M., Li X., Tolliday NJ, Golub T. R., Carr SA, Shamji AF, Stern AM, Mandinova A., Schreiber SL, and Lee SW Nature, 2011/07/13, Volume 475, Issue 7355, p.231-4, (2011) Read More / View Supplemental Materials
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Catalytic Diastereoselective Petasis Reactions.Muncipinto, G., Moquist PN, Schreiber SL, and Schaus SE Angewandte Chemie (International ed. in English), 2011/07/12, (2011) Read More / View Supplemental Materials
QnAs with Eric S. Lander. Interview by Prashant Nair.Lander, E. S. Proceedings of the National Academy of Sciences of the United States of America, 2011/07/12, Volume 108, Issue 28, p.11319, (2011) Read More / View Supplemental Materials
Application of a sparse matrix design strategy to the synthesis of dos libraries.Akella, LB, and Marcaurelle LA ACS combinatorial science, 2011/07/11, Volume 13, Issue 4, p.357-64, (2011) Read More / View Supplemental Materials
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Synthesis of a stereochemically diverse library of medium-sized lactams and sultams via S(N)Ar cycloetherification.Gerard, B., Duvall JR, Lowe JT, Murillo T., Wei J., Akella LB, and Marcaurelle LA ACS combinatorial science, 2011/07/11, Volume 13, Issue 4, p.365-74, (2011) Read More / View Supplemental Materials
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Genetic diversity and lineage dynamic of dengue virus serotype 1 (DENV-1) in Cambodia.Duong, V., Simmons C., Gavotte L., Viari A., Ong S., Chantha N., Lennon NJ, Birren BW, Vong S., Farrar JJ, Henn MR, Deubel V., Frutos R., and Buchy P. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 2011/07/02, (2011) Read More / View Supplemental Materials
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Comparative genomics yields insights into niche adaptation of plant vascular wilt pathogens.Klosterman, SJ, Subbarao KV, Kang S., Veronese P., Gold SE, Thomma BP, Chen Z., Henrissat B., Lee YH, Park J., Garcia-Pedrajas MD, Barbara DJ, Anchieta A., de Jonge R., Santhanam P., Maruthachalam K., Atallah Z., Amyotte SG, Paz Z., Inderbitzin P., et al. PLoS pathogens, 2011/07/01, Volume 7, Issue 7, p.e1002137, (2011) Read More / View Supplemental Materials
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A hypoxia-induced positive feedback loop promotes hypoxia-inducible factor 1alpha stability through miR-210 suppression of glycerol-3-phosphate dehydrogenase 1-like.Kelly, TJ, Souza AL, Clish CB, and Puigserver P. Molecular and cellular biology, 2011/07/01, Volume 31, Issue 13, p.2696-706, (2011) Read More / View Supplemental Materials
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Points of view: Avoiding color.Wong, B. Nature methods, 2011/07/01, Volume 8, Issue 7, p.525, (2011) Read More / View Supplemental Materials
Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination.Fancy, SP, Harrington EP, Yuen TJ, Silbereis JC, Zhao C., Baranzini SE, Bruce CC, Otero JJ, Huang EJ, Nusse R., Franklin RJ, and Rowitch DH Nature neuroscience, 2011/06/26, Volume 14, Issue 8, p.1009-16, (2011) Read More / View Supplemental Materials
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A public genome-scale lentiviral expression library of human ORFs.Yang, X., Boehm JS, Yang X., Salehi-Ashtiani K., Hao T., Shen Y., Lubonja R., Thomas SR, Alkan O., Bhimdi T., Green TM, Johannessen CM, Silver SJ, Nguyen C., Murray RR, Hieronymus H., Balcha D., Fan C., Lin C., Ghamsari L., et al. Nature methods, 2011/06/26, Volume 8, Issue 8, p.659-61, (2011) Read More / View Supplemental Materials
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Metagenomic biomarker discovery and explanation.Segata, N., Izard J., Waldron L., Gevers D., Miropolsky L., Garrett WS, and Huttenhower C. Genome biology, 2011/06/24, Volume 12, Issue 6, p.R60, (2011) Read More / View Supplemental Materials
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Control of olefin geometry in macrocyclic ring-closing metathesis using a removable silyl group.Wang, Y., Jimenez M., Hansen AS, Raiber EA, Schreiber SL, and Young DW Journal of the American Chemical Society, 2011/06/22, Volume 133, Issue 24, p.9196-9, (2011) Read More / View Supplemental Materials
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A selective inhibitor and probe of the cellular functions of Jumonji C domain-containing histone demethylases.Luo, X., Liu Y., Kubicek S., Myllyharju J., Tumber A., Ng S., Che KH, Podoll J., Heightman TD, Oppermann U., Schreiber SL, and Wang X. Journal of the American Chemical Society, 2011/06/22, Volume 133, Issue 24, p.9451-6, (2011) Read More / View Supplemental Materials
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Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter.Baughman, JM, Perocchi F., Girgis HS, Plovanich M., Belcher-Timme CA, Sancak Y., Bao XR, Strittmatter L., Goldberger O., Bogorad RL, Koteliansky V., and Mootha VK Nature, 2011/06/19, Volume 476, Issue 7360, p.341-5, (2011) Read More / View Supplemental Materials
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A pipeline that integrates the discovery and verification of plasma protein biomarkers reveals candidate markers for cardiovascular disease.Addona, TA, Shi X., Keshishian H., Mani D. R., Burgess M., Gillette MA, Clauser KR, Shen D., Lewis GD, Farrell LA, Fifer MA, Sabatine MS, Gerszten RE, and Carr SA Nature biotechnology, 2011/06/19, Volume 29, Issue 7, p.635-43, (2011) Read More / View Supplemental Materials
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Towards systematic functional characterization of cancer genomes.Boehm, JS, and Hahn WC Nature reviews. Genetics, 2011/06/17, Volume 12, Issue 7, p.487-98, (2011) Read More / View Supplemental Materials
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Genetics and pathogenesis of inflammatory bowel disease.Khor, B., Gardet A., and Xavier RJ Nature, 2011/06/15, Volume 474, Issue 7351, p.307-17, (2011) Read More / View Supplemental Materials
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Molecular signatures database (MSigDB) 3.0.Liberzon, A., Subramanian A., Pinchback R., Thorvaldsdóttir H., Tamayo P., and Mesirov J. P. Bioinformatics (Oxford, England), 2011/06/15, Volume 27, Issue 12, p.1739-40, (2011) Read More / View Supplemental Materials
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mRNA expression signature of Gleason grade predicts lethal prostate cancer.Penney, KL, Sinnott JA, Fall K., Pawitan Y., Hoshida Y., Kraft P., Stark JR, Fiorentino M., Perner S., Finn S., Calza S., Flavin R., Freedman ML, Setlur S., Sesso HD, Andersson SO, Martin N., Kantoff PW, Johansson JE, Adami HO, et al. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2011/06/10, Volume 29, Issue 17, p.2391-6, (2011) Read More / View Supplemental Materials
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Syntheses of α-pyrones using gold-catalyzed coupling reactions.Luo, T., Dai M., Zheng SL, and Schreiber SL Organic letters, 2011/06/03, Volume 13, Issue 11, p.2834-6, (2011) Read More / View Supplemental Materials
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AKT kinase activity is required for lithium to modulate mood-related behaviors in mice.Pan, JQ, Lewis MC, Ketterman JK, Clore EL, Riley M., Richards KR, Berry-Scott E., Liu X., Wagner FF, Holson EB, Neve RL, Biechele TL, Moon RT, Scolnick EM, Petryshen TL, and Haggarty SJ Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2011/06/01, Volume 36, Issue 7, p.1397-411, (2011) Read More / View Supplemental Materials
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Computational methods for transcriptome annotation and quantification using RNA-seq.Garber, M., Grabherr MG, Guttman M., and Trapnell C. Nature methods, 2011/06/01, Volume 8, Issue 6, p.469-77, (2011) Read More / View Supplemental Materials
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Endemic dengue associated with the co-circulation of multiple viral lineages and localized density-dependent transmission.Raghwani, J., Rambaut A., Holmes EC, Hang VT, Hien TT, Farrar J., Wills B., Lennon NJ, Birren BW, Henn MR, and Simmons CP PLoS pathogens, 2011/06/01, Volume 7, Issue 6, p.e1002064, (2011) Read More / View Supplemental Materials
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RNA-protein interactions in human health and disease.Khalil, AM, and Rinn JL Seminars in cell & developmental biology, 2011/06/01, Volume 22, Issue 4, p.359-65, (2011) Read More / View Supplemental Materials
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Summaries from the XVIII World Congress of Psychiatric Genetics, Athens, Greece, 3-7 October 2010.Bergen, SE, Balhara YP, Christoforou A., Cole J., Degenhardt F., Dempster E., Fatjó-Vilas M., Khedr Y., Lopez LM, Lysenko L., McGrath LM, Mühleisen TW, Neves FS, Nymberg C., Ozomaro U., Verweij KJ, Voineskos AN, Zai CC, O'Shea A., and DeLisi LE Psychiatric genetics, 2011/06/01, Volume 21, Issue 3, p.136-72, (2011) Read More / View Supplemental Materials
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Obligate biotrophy features unraveled by the genomic analysis of rust fungi.Duplessis, S., Cuomo CA, Lin YC, Aerts A., Tisserant E., Veneault-Fourrey C., Joly DL, Hacquard S., Amselem J., Cantarel BL, Chiu R., Coutinho PM, Feau N., Field M., Frey P., Gelhaye E., Goldberg J., Grabherr MG, Kodira CD, Kohler A., et al. Proceedings of the National Academy of Sciences of the United States of America, 2011/05/31, Volume 108, Issue 22, p.9166-71, (2011) Read More / View Supplemental Materials
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Full-length transcriptome assembly from RNA-Seq data without a reference genome.Grabherr, MG, Haas BJ, Yassour M., Levin JZ, Thompson DA, Amit I., Adiconis X., Fan L., Raychowdhury R., Zeng Q., Chen Z., Mauceli E., Hacohen N., Gnirke A., Rhind N., Di Palma F., Birren BW, Nusbaum C., Lindblad-Toh K., Friedman N., et al. Nature biotechnology, 2011/05/15, Volume 29, Issue 7, p.644-52, (2011) Read More / View Supplemental Materials
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Mapping and analysis of chromatin state dynamics in nine human cell types.Ernst, J., Kheradpour P., Mikkelsen TS, Shoresh N., Ward LD, Epstein CB, Zhang X., Wang L., Issner R., Coyne M., Ku M., Durham T., Kellis M., and Bernstein BE Nature, 2011/05/05, Volume 473, Issue 7345, p.43-9, (2011) Read More / View Supplemental Materials
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Discovery of histone deacetylase 8 selective inhibitors.Tang, W., Luo T., Greenberg EF, Bradner JE, and Schreiber SL Bioorganic & medicinal chemistry letters, 2011/05/01, Volume 21, Issue 9, p.2601-5, (2011) Read More / View Supplemental Materials
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Distinct microbiome in pouchitis compared to healthy pouches in ulcerative colitis and familial adenomatous polyposis.Zella, GC, Hait EJ, Glavan T., Gevers D., Ward DV, Kitts CL, and Korzenik JR Inflammatory bowel diseases, 2011/05/01, Volume 17, Issue 5, p.1092-100, (2011) Read More / View Supplemental Materials
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A framework for variation discovery and genotyping using next-generation DNA sequencing data.DePristo, MA, Banks E., Poplin R., Garimella KV, Maguire JR, Hartl C., Philippakis AA, del Angel G., Rivas MA, Hanna M., McKenna A., Fennell TJ, Kernytsky AM, Sivachenko AY, Cibulskis K., Gabriel SB, Altshuler D., and Daly M. J. Nature genetics, 2011/05/01, Volume 43, Issue 5, p.491-8, (2011) Read More / View Supplemental Materials
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Metabolic labeling of RNA uncovers principles of RNA production and degradation dynamics in mammalian cells.Rabani, M., Levin JZ, Fan L., Adiconis X., Raychowdhury R., Garber M., Gnirke A., Nusbaum C., Hacohen N., Friedman N., Amit I., and Regev A. Nature biotechnology, 2011/05/01, Volume 29, Issue 5, p.436-42, (2011) Read More / View Supplemental Materials
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Minimum information about a marker gene sequence (MIMARKS) and minimum information about any (x) sequence (MIxS) specifications.Yilmaz, P., Kottmann R., Field D., Knight R., Cole JR, Amaral-Zettler L., Gilbert JA, Karsch-Mizrachi I., Johnston A., Cochrane G., Vaughan R., Hunter C., Park J., Morrison N., Rocca-Serra P., Sterk P., Arumugam M., Bailey M., Baumgartner L., Birren BW, et al. Nature biotechnology, 2011/05/01, Volume 29, Issue 5, p.415-20, (2011) Read More / View Supplemental Materials
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