Publications

Reference-based chemical-genetic interaction profiling to elucidate small molecule mechanism of action in Mycobacterium tuberculosis.

Bond AN, Orzechowski M, Zhang S, et al. Reference-based chemical-genetic interaction profiling to elucidate small molecule mechanism of action in Mycobacterium tuberculosis. Nature communications. 2025;16(1):9673. doi:10.1038/s41467-025-64662-xGoogle Scholar DOI PubMed

Mutant p53 protein accumulation is selectively targetable by proximity-inducing drugs.

Sadagopan A, Carson M, Zamurs EJ, et al. Mutant p53 protein accumulation is selectively targetable by proximity-inducing drugs. Nature chemical biology. 2025. doi:10.1038/s41589-025-02051-7Google Scholar DOI PubMed

Molecular Characterization Informs Prognosis in Patients With Localized Ewing Sarcoma: A Report From the Children's Oncology Group.

Gillani R, Shulman DS, DelRocco NJ, et al. Molecular Characterization Informs Prognosis in Patients With Localized Ewing Sarcoma: A Report From the Children’s Oncology Group. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2025:JCO2500157. doi:10.1200/JCO-25-00157Google Scholar DOI PubMed

Allosteric modulation of the solute carrier transporter SLC39A8 potentiates manganese and cadmium uptake.

Damm-Ganamet KL, Moon C, Wickenden AD, et al. Allosteric modulation of the solute carrier transporter SLC39A8 potentiates manganese and cadmium uptake. The Journal of clinical investigation. 2025;135(21). doi:10.1172/JCI191096Google Scholar DOI PubMed

Brain dynamics reflecting an intra-network brain state is associated with increased posttraumatic stress symptoms in the early aftermath of trauma.

Sendi MS, Fu Z, Harnett NG, et al. Brain dynamics reflecting an intra-network brain state is associated with increased posttraumatic stress symptoms in the early aftermath of trauma. Nature. Mental health. 2025;3(2):185-198. doi:10.1038/s44220-024-00377-0PubMed Central Google Scholar DOI PubMed

PMCID

PMC12574611

Genetic Downregulation of Interleukin-6 Signaling and Arteriolosclerotic Cerebral Small Vessel Disease: A Drug Target Mendelian Randomization Analysis.

Tchuisseu-Kwangoua LA, Omarov M, Shatunov A, Markus HS, Kamtchum-Tatuene J, Georgakis MK. Genetic Downregulation of Interleukin-6 Signaling and Arteriolosclerotic Cerebral Small Vessel Disease: A Drug Target Mendelian Randomization Analysis. Journal of the American Heart Association. 2025:e041814. doi:10.1161/JAHA.124.041814Google Scholar DOI PubMed

Burden of Central Nervous System Cancer in the United States, 1990-2021.

Han HJ, Kim YS, Park S, et al. Burden of Central Nervous System Cancer in the United States, 1990-2021. JAMA neurology. 2025. doi:10.1001/jamaneurol.2025.4286Google Scholar DOI PubMed

Off-pore Nucleoporin sPOM121 Transcriptionally Propels β-Catenin-driven Tumor Progression and Immune Escape in Prostate Cancer.

Kirthika P, Jawalagatti V, Li P, et al. Off-pore Nucleoporin sPOM121 Transcriptionally Propels β-Catenin-driven Tumor Progression and Immune Escape in Prostate Cancer. Cancer discovery. 2025;15(11):2374-2396. doi:10.1158/2159-8290.CD-25-0629Google Scholar DOI PubMed

Discovery of placental microRNAs associated with maternal insulin sensitivity during pregnancy.

Majid S, Soukar I, White F, et al. Discovery of placental microRNAs associated with maternal insulin sensitivity during pregnancy. Placenta. 2025;172:104-113. doi:10.1016/j.placenta.2025.10.021Google Scholar DOI PubMed

Clinical pathway-aware large language models for reliable and transparent medical dialogue.

Wu J, Wu X, Zheng Y, Yang J. Clinical pathway-aware large language models for reliable and transparent medical dialogue. Journal of biomedical informatics. 2025:104942. doi:10.1016/j.jbi.2025.104942Google Scholar DOI PubMed