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RNA targeting with CRISPR-Cas13.
Abudayyeh OO, Gootenberg JS, Essletzbichler P, et al. RNA targeting with CRISPR-Cas13. Nature. 2017;550(7675):280-284. doi:10.1038/nature24049.
Landscape of X chromosome inactivation across human tissues.
Tukiainen T, Villani A-C, Yen A, et al. Landscape of X chromosome inactivation across human tissues. Nature. 2017;550(7675):244-248. doi:10.1038/nature24265.
The impact of rare variation on gene expression across tissues.
Li X, Kim Y, Tsang EK, et al. The impact of rare variation on gene expression across tissues. Nature. 2017;550(7675):239-243. doi:10.1038/nature24267.
Uncoupling of Metabolic Health from Longevity through Genetic Alteration of Adipose Tissue Lipid-Binding Proteins.
Charles KN, Li M-D, Engin F, Arruda APaula, Inouye K, Hotamışlıgil GS. Uncoupling of Metabolic Health from Longevity through Genetic Alteration of Adipose Tissue Lipid-Binding Proteins. Cell Rep. 2017;21(2):393-402. doi:10.1016/j.celrep.2017.09.051.
Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution.
Mathys H, Adaikkan C, Gao F, et al. Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution. Cell Rep. 2017;21(2):366-380. doi:10.1016/j.celrep.2017.09.039.
A Scaled Framework for CRISPR Editing of Human Pluripotent Stem Cells to Study Psychiatric Disease.
Hazelbaker DZ, Beccard A, Bara AM, et al. A Scaled Framework for CRISPR Editing of Human Pluripotent Stem Cells to Study Psychiatric Disease. Stem Cell Reports. 2017;9(4):1315-1327. doi:10.1016/j.stemcr.2017.09.006.
SETD2 alterations impair DNA damage recognition and lead to resistance to chemotherapy in leukemia.
Mar BG, S Chu H, Kahn JD, et al. SETD2 alterations impair DNA damage recognition and lead to resistance to chemotherapy in leukemia. Blood. 2017. doi:10.1182/blood-2017-03-775569.
RIPK1 mediates a disease-associated microglial response in Alzheimer's disease.
Ofengeim D, Mazzitelli S, Ito Y, et al. RIPK1 mediates a disease-associated microglial response in Alzheimer's disease. Proc Natl Acad Sci U S A. 2017;114(41):E8788-E8797. doi:10.1073/pnas.1714175114.
Whole transcriptome and genomic analysis of extensively drug-resistant Mycobacterium tuberculosis clinical isolates identifies downregulation of ethA as a mechanism of ethionamide resistance.
de Welzen L, Eldholm V, Maharaj K, Manson AL, Earl AM, Pym AS. Whole transcriptome and genomic analysis of extensively drug-resistant Mycobacterium tuberculosis clinical isolates identifies downregulation of ethA as a mechanism of ethionamide resistance. Antimicrob Agents Chemother. 2017. doi:10.1128/AAC.01461-17.
Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia.
Li Z, Chen J, Yu H, et al. Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia. Nat Genet. 2017. doi:10.1038/ng.3973.