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2012
Complete viral RNA genome sequencing of ultra-low copy samples by sequence-independent amplification.Malboeuf, CM, Yang X., Charlebois P., Qu J., Berlin AM, Casali M., Pesko KN, Boutwell CL, Devincenzo JP, Ebel GD, Allen TM, Zody MC, Henn MR, and Levin JZ Nucleic acids research, 2012/09/08, (2012) Read More / View Supplemental Materials
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Mechanisms and evolution of virulence in oomycetes.Jiang, RH, and Tyler BM Annual review of phytopathology, 2012/09/08, Volume 50, p.295-318, (2012) Read More / View Supplemental Materials
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Ancient Admixture in Human History.Patterson, NJ, Moorjani P., Luo Y., Mallick S., Rohland N., Zhan Y., Genschoreck T., Webster T., and Reich D. Genetics, 2012/09/07, (2012) Read More / View Supplemental Materials
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Burden of rare sarcomere gene variants in the framingham and jackson heart study cohorts.Bick, AG, Flannick J., Ito K., Cheng S., Vasan RS, Parfenov MG, Herman DS, Depalma SR, Gupta N., Gabriel SB, Funke BH, Rehm HL, Benjamin EJ, Aragam J., Taylor HA Jr, Fox ER, Newton-Cheh C., Kathiresan S., O'Donnell CJ, Wilson JG, et al. American journal of human genetics, 2012/09/07, Volume 91, Issue 3, p.513-9, (2012) Read More / View Supplemental Materials
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The first synthesis of an epidiselenodiketopiperazine.McMahon, TC, Stanley S., Kazyanskaya E., Hung D., and Wood JL Organic letters, 2012/09/07, Volume 14, Issue 17, p.4534-6, (2012) Read More / View Supplemental Materials
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Thinking inside the box: how T cell inhibitory receptors signal.Haining, WN Nature medicine, 2012/09/07, Volume 18, Issue 9, p.1338-9, (2012) Read More / View Supplemental Materials
Transcription Factor-mediated Epigenetic Reprogramming.Sindhu, C., Samavarchi-Tehrani P., and Meissner A. The Journal of biological chemistry, 2012/09/07, Volume 287, Issue 37, p.30922-31, (2012) Read More / View Supplemental Materials
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Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2.Greulich, H., Kaplan B., Mertins P., Chen TH, Tanaka KE, Yun CH, Zhang X., Lee SH, Cho J., Ambrogio L., Liao R., Imielinski M., Banerji S., Berger AH, Lawrence MS, Zhang J., Pho NH, Walker SR, Winckler W., Getz G., et al. Proceedings of the National Academy of Sciences of the United States of America, 2012/09/04, Volume 109, Issue 36, p.14476-81, (2012) Read More / View Supplemental Materials
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The malaria parasite Plasmodium vivax exhibits greater genetic diversity than Plasmodium falciparum.Neafsey, DE, Galinsky K., Jiang RH, Young L., Sykes SM, Saif S., Gujja S., Goldberg JM, Young S., Zeng Q., Chapman SB, Dash AP, Anvikar AR, Sutton PL, Birren BW, Escalante AA, Barnwell JW, and Carlton JM Nature genetics, 2012/09/01, Volume 44, Issue 9, p.1046-50, (2012) Read More / View Supplemental Materials
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Mouse ooplasm confers context-specific reprogramming capacity.Chan, MM, Smith ZD, Egli D., Regev A., and Meissner A. Nature genetics, 2012/09/01, Volume 44, Issue 9, p.978-80, (2012) Read More / View Supplemental Materials
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Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.Lundby, A., Lage K., Weinert BT, Bekker-Jensen DB, Secher A., Skovgaard T., Kelstrup CD, Dmytriyev A., Choudhary C., Lundby C., and Olsen JV Cell reports, 2012/08/30, Volume 2, Issue 2, p.419-31, (2012) Read More / View Supplemental Materials
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Novel Microcephalic Primordial Dwarfism Disorder Associated with Variants in the Centrosomal Protein Ninein.Dauber, A., Lafranchi SH, Maliga Z., Lui JC, Moon JE, McDeed C., Henke K., Zonana J., Kingman GA, Pers TH, Baron J., Rosenfeld RG, Hirschhorn JN, Harris MP, and Hwa V. The Journal of clinical endocrinology and metabolism, 2012/08/29, (2012) Read More / View Supplemental Materials
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Target practice: HDAC inhibitors for schizophrenia.Hyman, SE Nature neuroscience, 2012/08/28, Volume 15, Issue 9, p.1180-1, (2012) Read More / View Supplemental Materials
DNA Methylation Dynamics during In Vivo Differentiation of Blood and Skin Stem Cells.Bock, C., Beerman I., Lien WH, Smith ZD, Gu H., Boyle P., Gnirke A., Fuchs E., Rossi DJ, and Meissner A. Molecular cell, 2012/08/24, Volume 47, Issue 4, p.633-47, (2012) Read More / View Supplemental Materials
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Epigenetic obstacles encountered by transcription factors: reprogramming against all odds.Gifford, CA, and Meissner A. Current opinion in genetics & development, 2012/08/23, (2012) Read More / View Supplemental Materials
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Evidence of widespread selection on standing variation in Europe at height-associated SNPs.Turchin, MC, Chiang CW, Palmer CD, Sankararaman S., Reich D., Genetic Investigation of ANthropometric Traits(GIANT) Consortium, and Hirschhorn JN Nature genetics, 2012/08/19, Volume 44, Issue 9, p.1015-9, (2012) Read More / View Supplemental Materials
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Cancer vulnerabilities unveiled by genomic loss.Nijhawan, D., Zack TI, Ren Y., Strickland MR, Lamothe R., Schumacher SE, Tsherniak A., Besche HC, Rosenbluh J., Shehata S., Cowley GS, Weir BA, Goldberg AL, Mesirov J. P., Root DE, Bhatia SN, Beroukhim R., and Hahn WC Cell, 2012/08/17, Volume 150, Issue 4, p.842-54, (2012) Read More / View Supplemental Materials
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Candida albicans infection affords protection against reinfection via functional reprogramming of monocytes.Quintin, J., Saeed S., Martens JH, Giamarellos-Bourboulis EJ, Ifrim DC, Logie C., Jacobs L., Jansen T., Kullberg BJ, Wijmenga C., Joosten LA, Xavier RJ, van der Meer JW, Stunnenberg HG, and Netea MG Cell host & microbe, 2012/08/16, Volume 12, Issue 2, p.223-32, (2012) Read More / View Supplemental Materials
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Mild paroxysmal kinesigenic dyskinesia caused by PRRT2 missense mutation with reduced penetrance.Friedman, J., Olvera J., Silhavy JL, Gabriel SB, and Gleeson JG Neurology, 2012/08/15, (2012) Read More / View Supplemental Materials
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Targeted Tumor-Penetrating siRNA Nanocomplexes for Credentialing the Ovarian Cancer Oncogene ID4.Ren, Y., Cheung HW, von Maltzhan G., Agrawal A., Cowley GS, Weir BA, Boehm JS, Tamayo P., Karst AM, Liu JF, Hirsch MS, Mesirov J. P., Drapkin R., Root DE, Lo J., Fogal V., Ruoslahti E., Hahn WC, and Bhatia SN Science translational medicine, 2012/08/15, Volume 4, Issue 147, p.147ra112, (2012) Read More / View Supplemental Materials
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ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression.Abdel-Wahab, O., Adli M., LaFave LM, Gao J., Hricik T., Shih AH, Pandey S., Patel JP, Chung YR, Koche R., Perna F., Zhao X., Taylor JE, Park CY, Carroll M., Melnick A., Nimer SD, Jaffe JD, Aifantis I., Bernstein BE, et al. Cancer cell, 2012/08/14, Volume 22, Issue 2, p.180-93, (2012) Read More / View Supplemental Materials
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Genome-wide association study of Tourette's syndrome.Scharf, JM, Yu D., Mathews CA, Neale BM, Stewart SE, Fagerness JA, Evans P., Gamazon E., Edlund CK, Service SK, Tikhomirov A., Osiecki L., Illmann C., Pluzhnikov A., Konkashbaev A., Davis LK, Han B., Crane J., Moorjani P., Crenshaw AT, et al. Molecular psychiatry, 2012/08/14, (2012) Read More / View Supplemental Materials
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Phasing of many thousands of genotyped samples.Williams, AL, Patterson N., Glessner J., Hakonarson H., and Reich D. American journal of human genetics, 2012/08/10, Volume 91, Issue 2, p.238-51, (2012) Read More / View Supplemental Materials
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Synthesis and Profiling of a Diverse Collection of Azetidine-Based Scaffolds for the Development of CNS-Focused Lead-like Libraries.Lowe, JT, Lee MD 4th, Akella LB, Davoine E., Donckele EJ, Durak L., Duvall JR, Gerard B., Holson EB, Joliton A., Kesavan S., Lemercier BC, Liu H., Marié JC, Mulrooney CA, Muncipinto G., Welzel-O'Shea M., Panko LM, Rowley A., Suh BC, et al. The Journal of organic chemistry, 2012/08/10, (2012) Read More / View Supplemental Materials
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Sequence-based association and selection scans identify drug resistance loci in the Plasmodium falciparum malaria parasite.Park, DJ, Lukens AK, Neafsey DE, Schaffner SF, Chang HH, Valim C., Ribacke U., Van Tyne D., Galinsky K., Galligan M., Becker JS, Ndiaye D., Mboup S., Wiegand RC, Hartl DL, Sabeti PC, Wirth DF, and Volkman SK Proceedings of the National Academy of Sciences of the United States of America, 2012/08/07, Volume 109, Issue 32, p.13052-7, (2012) Read More / View Supplemental Materials
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Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL.Wen, Q., Goldenson B., Silver SJ, Schenone M., Dancik V., Huang Z., Wang LZ, Lewis TA, An WF, Li X., Bray MA, Thiollier C., Diebold L., Gilles L., Vokes MS, Moore CB, Bliss-Moreau M., VerPlank L., Tolliday NJ, Mishra R., et al. Cell, 2012/08/03, Volume 150, Issue 3, p.575-89, (2012) Read More / View Supplemental Materials
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Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations.Pugh, TJ, Weeraratne SD, Archer TC, Pomeranz Krummel DA, Auclair D., Bochicchio J., Carneiro MO, Carter SL, Cibulskis K., Erlich RL, Greulich H., Lawrence MS, Lennon NJ, McKenna A., Meldrim J., Ramos AH, Ross MG, Russ C., Shefler E., Sivachenko A., et al. Nature, 2012/08/02, Volume 488, Issue 7409, p.106-10, (2012) Read More / View Supplemental Materials
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The human microbiome project: a community resource for the healthy human microbiome.Gevers, D., Knight R., Petrosino JF, Huang K., McGuire AL, Birren BW, Nelson KE, White O., Methé BA, and Huttenhower C. PLoS biology, 2012/08/01, Volume 10, Issue 8, p.e1001377, (2012) Read More / View Supplemental Materials
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The metabochip, a custom genotyping array for genetic studies of metabolic, cardiovascular, and anthropometric traits.Voight, BF, Kang HM, Ding J., Palmer CD, Sidore C., Chines PS, Burtt NP, Fuchsberger C., Li Y., Erdmann J., Frayling TM, Heid IM, Jackson AU, Johnson T., Kilpeläinen TO, Lindgren CM, Morris AP, Prokopenko I., Randall JC, Saxena R., et al. PLoS genetics, 2012/08/01, Volume 8, Issue 8, p.e1002793, (2012) Read More / View Supplemental Materials
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Cis-acting regulation of brain-specific ANK3 gene expression by a genetic variant associated with bipolar disorder.Rueckert, EH, Barker D., Ruderfer D., Bergen SE, O'Dushlaine C., Luce CJ, Sheridan SD, Theriault KM, Chambert K., Moran J., Purcell SM, Madison JM, Haggarty SJ, and Sklar P. Molecular psychiatry, 2012/07/31, (2012) Read More / View Supplemental Materials
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Novel, panzootic and hybrid genotypes of amphibian chytridiomycosis associated with the bullfrog trade.Schloegel, LM, Toledo LF, Longcore JE, Greenspan SE, Vieira CA, Lee M., Zhao S., Wangen C., Ferreira CM, Hipolito M., Davies AJ, Cuomo CA, Daszak P., and James TY Molecular ecology, 2012/07/31, (2012) Read More / View Supplemental Materials
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Resistance to EGFR blockade in colorectal cancer: liquid biopsies and latent subclones.Konieczkowski, DJ, and Garraway LA Cell research, 2012/07/31, (2012) Read More / View Supplemental Materials
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New mechanisms of 5-nitrofuran toxicity.Peterson, RT Chemistry & biology, 2012/07/27, Volume 19, Issue 7, p.789-90, (2012) Read More / View Supplemental Materials
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zCall: A Rare Variant Caller for Array-based Genotyping.Goldstein, JI, Crenshaw A., Carey J., Grant G., Maguire J., Fromer M., O'Dushlaine C., Moran JL, Chambert K., Stevens C., Swedish Schizophrenia Consortium, ARRA Autism Sequencing Consortium, Sklar P., Hultman CM, Purcell S., McCarroll S., Sullivan PF, Daly M. J., and Neale BM Bioinformatics (Oxford, England), 2012/07/27, (2012) Read More / View Supplemental Materials
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Comprehensive interrogation of natural TALE DNA-binding modules and transcriptional repressor domains.Cong, L., Zhou R., Kuo YC, Cunniff M., and Zhang F. Nature communications, 2012/07/24, Volume 3, p.968, (2012) Read More / View Supplemental Materials
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Eradication of bacterial persisters with antibiotic-generated hydroxyl radicals.Grant, SS, Kaufmann BB, Chand NS, Haseley N., and Hung DT Proceedings of the National Academy of Sciences of the United States of America, 2012/07/24, Volume 109, Issue 30, p.12147-52, (2012) Read More / View Supplemental Materials
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Finished bacterial genomes from shotgun sequence data.Ribeiro, F., Przybylski D., Yin S., Sharpe T., Gnerre S., Abouelleil A., Berlin AM, Montmayeur A., Shea TP, Walker BJ, Young SK, Russ C., Maccallum I., Nusbaum C., and Jaffe DB Genome research, 2012/07/24, (2012) Read More / View Supplemental Materials
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Concordance and Discordance in Tumor Genomic Profiling.Garraway, LA Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2012/07/23, (2012) Read More / View Supplemental Materials
A landscape of driver mutations in melanoma.Hodis, E., Watson IR, Kryukov GV, Arold ST, Imielinski M., Theurillat JP, Nickerson E., Auclair D., Li L., Place C., Dicara D., Ramos AH, Lawrence MS, Cibulskis K., Sivachenko A., Voet D., Saksena G., Stransky N., Onofrio RC, Winckler W., et al. Cell, 2012/07/20, Volume 150, Issue 2, p.251-63, (2012) Read More / View Supplemental Materials
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Microsporidian genome analysis reveals evolutionary strategies for obligate intracellular growth.Cuomo, CA, Desjardins CA, Bakowski MA, Goldberg J., Ma AT, Becnel JJ, Didier ES, Fan L., Heiman DI, Levin JZ, Young S., Zeng Q., and Troemel ER Genome research, 2012/07/18, (2012) Read More / View Supplemental Materials
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Paired-end sequencing of Fosmid libraries by Illumina.Williams, LJ, Tabbaa DG, Li N., Berlin AM, Shea TP, Maccallum I., Lawrence MS, Drier Y., Getz G., Young SK, Jaffe DB, Nusbaum C., and Gnirke A. Genome research, 2012/07/17, (2012) Read More / View Supplemental Materials
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A remarkably simple genome underlies highly malignant pediatric rhabdoid cancers.Lee, RS, Stewart C., Carter SL, Ambrogio L., Cibulskis K., Sougnez C., Lawrence MS, Auclair D., Mora J., Golub T. R., Biegel JA, Getz G., and Roberts CW The Journal of clinical investigation, 2012/07/16, (2012) Read More / View Supplemental Materials
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Wisdom of crowds for robust gene network inference.Marbach, D., Costello JC, Küffner R., Vega NM, Prill RJ, Camacho DM, Allison KR, The DREAM5 Consortium, Aderhold A., Allison KR, Bonneau R., Camacho DM, Chen Y., Collins JJ, Cordero F., Costello JC, Crane M., Dondelinger F., Drton M., Esposito R., et al. Nature methods, 2012/07/15, (2012) Read More / View Supplemental Materials
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Reconstructing Native American population history.Reich, D., Patterson N., Campbell D., Tandon A., Mazieres S., Ray N., Parra MV, Rojas W., Duque C., Mesa N., García LF, Triana O., Blair S., Maestre A., Dib JC, Bravi CM, Bailliet G., Corach D., Hünemeier T., Bortolini MC, et al. Nature, 2012/07/11, (2012) Read More / View Supplemental Materials
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Untuning the tumor metabolic machine: Targeting cancer metabolism: a bedside lesson.Birsoy, K., Sabatini DM, and Possemato R. Nature medicine, 2012/07/06, Volume 18, Issue 7, p.1022-3, (2012) Read More / View Supplemental Materials
Crebinostat: A novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity.Fass, DM, Reis SA, Ghosh B., Hennig KM, Joseph NF, Zhao WN, Nieland TJ, Guan JS, Groves Kuhnle CE, Tang W., Barker DD, Mazitschek R., Schreiber SL, Tsai LH, and Haggarty SJ Neuropharmacology, 2012/07/04, (2012) Read More / View Supplemental Materials
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Strain-Specific Regulation of Striatal Phenotype in Drd2-eGFP BAC Transgenic Mice.Chan, CS, Peterson JD, Gertler TS, Glajch KE, Quintana RE, Cui Q., Sebel LE, Plotkin JL, Shen W., Heiman M., Heintz N., Greengard P., and Surmeier DJ The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012/07/04, Volume 32, Issue 27, p.9124-9132, (2012) Read More / View Supplemental Materials
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Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion.Straussman, R., Morikawa T., Shee K., Barzily-Rokni M., Qian ZR, Du J., Davis A., Mongare MM, Gould J., Frederick DT, Cooper ZA, Chapman PB, Solit DB, Ribas A., Lo RS, Flaherty KT, Ogino S., Wargo JA, and Golub T. R. Nature, 2012/07/04, (2012) Read More / View Supplemental Materials
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Exome sequencing identifies GATA1 mutations resulting in Diamond-Blackfan anemia.Sankaran, VG, Ghazvinian R., Do R., Thiru P., Vergilio JA, Beggs AH, Sieff CA, Orkin SH, Nathan DG, Lander E. S., and Gazda HT The Journal of clinical investigation, 2012/07/02, Volume 122, Issue 7, p.2439-43, (2012) Read More / View Supplemental Materials
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Efficiency and power as a function of sequence coverage, SNP array density, and imputation.Flannick, J., Korn JM, Fontanillas P., Grant GB, Banks E., DePristo MA, and Altshuler D. PLoS computational biology, 2012/07/01, Volume 8, Issue 7, p.e1002604, (2012) Read More / View Supplemental Materials
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Structural haplotypes and recent evolution of the human 17q21.31 region.Boettger, LM, Handsaker RE, Zody MC, and McCarroll SA Nature genetics, 2012/07/01, (2012) Read More / View Supplemental Materials
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The uncertain road towards genomic medicine.Macarthur, DG, and Lek M. Trends in genetics : TIG, 2012/07/01, Volume 28, Issue 7, p.303-5, (2012) Read More / View Supplemental Materials
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Annotated high-throughput microscopy image sets for validation.Ljosa, V., Sokolnicki KL, and Carpenter AE Nature methods, 2012/06/28, Volume 9, Issue 7, p.637, (2012) Read More / View Supplemental Materials
A call for bioimaging software usability.Carpenter, AE, Kamentsky L., and Eliceiri KW Nature methods, 2012/06/28, Volume 9, Issue 7, p.666-70, (2012) Read More / View Supplemental Materials
Amino acids and mTORC1: from lysosomes to disease.Efeyan, A., Zoncu R., and Sabatini DM Trends in molecular medicine, 2012/06/27, (2012) Read More / View Supplemental Materials
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Iterative capped assembly: rapid and scalable synthesis of repeat-module DNA such as TAL effectors from individual monomers.Briggs, AW, Rios X., Chari R., Yang L., Zhang F., Mali P., and Church GM Nucleic acids research, 2012/06/26, (2012) Read More / View Supplemental Materials
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Genomic sequencing of Plasmodium falciparum malaria parasites from Senegal reveals the demographic history of the population.Chang, HH, Park DJ, Galinsky KJ, Schaffner SF, Ndiaye D., Ndir O., Mboup S., Wiegand RC, Volkman SK, Sabeti PC, Wirth DF, Neafsey DE, and Hartl DL Molecular biology and evolution, 2012/06/24, (2012) Read More / View Supplemental Materials
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Inhibition of histone deacetylase 3 protects Beta cells from cytokine-induced apoptosis.Chou, DH, Holson EB, Wagner FF, Tang AJ, Maglathlin RL, Lewis TA, Schreiber SL, and Wagner BK Chemistry & biology, 2012/06/22, Volume 19, Issue 6, p.669-73, (2012) Read More / View Supplemental Materials
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Sequence analysis of mutations and translocations across breast cancer subtypes.Banerji, S., Cibulskis K., Rangel-Escareno C., Brown KK, Carter SL, Frederick AM, Lawrence MS, Sivachenko AY, Sougnez C., Zou L., Cortes ML, Fernandez-Lopez JC, Peng S., Ardlie KG, Auclair D., Bautista-Piña V., Duke F., Francis J., Jung J., Maffuz-Aziz A., et al. Nature, 2012/06/20, Volume 486, Issue 7403, p.405-9, (2012) Read More / View Supplemental Materials
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Activity-dependent A-to-I RNA Editing in Rat Cortical Neurons.Sanjana, NE, Levanon EY, Hueske EA, Ambrose JM, and Li JB Genetics, 2012/06/19, (2012) Read More / View Supplemental Materials
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Efficient algorithms for the reconciliation problem with gene duplication, horizontal transfer and loss.Bansal, MS, Alm EJ, and Kellis M. Bioinformatics (Oxford, England), 2012/06/15, Volume 28, Issue 12, p.i283-i291, (2012) Read More / View Supplemental Materials
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The promise and perils of stem cell therapeutics.Daley, GQ Cell stem cell, 2012/06/14, Volume 10, Issue 6, p.740-9, (2012) Read More / View Supplemental Materials
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Integrative Genomic Analysis Implicates Gain of PIK3CA at 3q26 and MYC at 8q24 in Chronic Lymphocytic Leukemia.Brown, JR, Hanna M., Tesar B., Werner L., Pochet N., Asara JM, Wang YE, Dal Cin P., Fernandes SM, Thompson C., MacConaill L., Wu CJ, Van de Peer Y., Correll M., Regev A., Neuberg D., and Freedman AS Clinical cancer research : an official journal of the American Association for Cancer Research, 2012/06/13, (2012) Read More / View Supplemental Materials
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Genetic polymorphisms for estimating risk of atrial fibrillation: a literature-based meta-analysis.Gustav Smith, J., Almgren P., Engström G., Hedblad B., Platonov PG, Newton-Cheh C., and Melander O. Journal of internal medicine, 2012/06/12, (2012) Read More / View Supplemental Materials
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Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder.Bergen, SE, O'Dushlaine CT, Ripke S., Lee PH, Ruderfer DM, Akterin S., Moran JL, Chambert KD, Handsaker RE, Backlund L., Osby U., McCarroll S., Landen M., Scolnick EM, Magnusson PK, Lichtenstein P., Hultman CM, Purcell SM, Sklar P., and Sullivan PF Molecular psychiatry, 2012/06/12, (2012) Read More / View Supplemental Materials
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Highly efficient generation of heritable zebrafish gene mutations using homo- and heterodimeric TALENs.Cade, L., Reyon D., Hwang WY, Tsai SQ, Patel S., Khayter C., Joung JK, Sander JD, Peterson RT, and Yeh JR Nucleic acids research, 2012/06/07, (2012) Read More / View Supplemental Materials
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The Role of Genetic Markers in the Management of Prostate Cancer.Choudhury, AD, Eeles R., Freedland SJ, Isaacs WB, Pomerantz MM, Schalken JA, Tammela TL, and Visakorpi T. European urology, 2012/06/05, (2012) Read More / View Supplemental Materials
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Attenuation of notch and hedgehog signaling is required for fate specification in the spinal cord.Huang, P., Xiong F., Megason SG, and Schier AF PLoS genetics, 2012/06/01, Volume 8, Issue 6, p.e1002762, (2012) Read More / View Supplemental Materials
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Dosage and tumour suppression.Berger, AH, Knudson AG, and Pandolfi PP The Journal of pathology, 2012/06/01, Volume 227, Issue 2, p.e1, (2012) Read More / View Supplemental Materials
Identifying gnostic predictors of the vaccine response.Haining, WN, and Pulendran B. Current opinion in immunology, 2012/06/01, Volume 24, Issue 3, p.332-6, (2012) Read More / View Supplemental Materials
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RNA-SeQC: RNA-seq metrics for quality control and process optimization.Deluca, DS, Levin JZ, Sivachenko A., Fennell T., Nazaire MD, Williams C., Reich M., Winckler W., and Getz G. Bioinformatics (Oxford, England), 2012/06/01, Volume 28, Issue 11, p.1530-2, (2012) Read More / View Supplemental Materials
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Behavioral barcoding in the cloud: embracing data-intensive digital phenotyping in neuropharmacology.Kokel, D., Rennekamp AJ, Shah AH, Liebel U., and Peterson RT Trends in biotechnology, 2012/05/29, (2012) Read More / View Supplemental Materials
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Cooperative interactions of BRAFV600E kinase and CDKN2A locus deficiency in pediatric malignant astrocytoma as a basis for rational therapy.Huillard, E., Hashizume R., Phillips JJ, Griveau A., Ihrie RA, Aoki Y., Nicolaides T., Perry A., Waldman T., McMahon M., Weiss WA, Petritsch C., James CD, and Rowitch DH Proceedings of the National Academy of Sciences of the United States of America, 2012/05/29, Volume 109, Issue 22, p.8710-5, (2012) Read More / View Supplemental Materials
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Exome sequencing and the genetic basis of complex traits.Kiezun, A., Garimella K., Do R., Stitziel NO, Neale BM, McLaren PJ, Gupta N., Sklar P., Sullivan PF, Moran JL, Hultman CM, Lichtenstein P., Magnusson P., Lehner T., Shugart YY, Price AL, de Bakker PI, Purcell SM, and Sunyaev SR Nature genetics, 2012/05/29, Volume 44, Issue 6, p.623-30, (2012) Read More / View Supplemental Materials
Exploring the variation within.Macosko, EZ, and McCarroll SA Nature genetics, 2012/05/29, Volume 44, Issue 6, p.614-6, (2012) Read More / View Supplemental Materials
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A Keystone for ncRNA.Hacisuleyman, E., Cabili MN, and Rinn JL Genome biology, 2012/05/25, Volume 13, Issue 5, p.315, (2012) Read More / View Supplemental Materials
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Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation.Jain, M., Nilsson R., Sharma S., Madhusudhan N., Kitami T., Souza AL, Kafri R., Kirschner MW, Clish CB, and Mootha VK Science (New York, N.Y.), 2012/05/25, Volume 336, Issue 6084, p.1040-4, (2012) Read More / View Supplemental Materials
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Identification of Novel Inhibitors of M. tuberculosis Growth Using Whole Cell Based High-Throughput Screening.Stanley, SA, Grant SS, Kawate T., Iwase N., Shimizu M., Wivagg C., Silvis M., Kazyanskaya E., Aquadro J., Golas A., FitzGerald M., Dai H., Zhang L., and Hung DT ACS chemical biology, 2012/05/21, (2012) Read More / View Supplemental Materials
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Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer.Barbieri, CE, Baca SC, Lawrence MS, Demichelis F., Blattner M., Theurillat JP, White TA, Stojanov P., Van Allen E., Stransky N., Nickerson E., Chae SS, Boysen G., Auclair D., Onofrio RC, Park K., Kitabayashi N., MacDonald TY, Sheikh K., Vuong T., et al. Nature genetics, 2012/05/20, Volume 44, Issue 6, p.685-9, (2012) Read More / View Supplemental Materials
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Extremely low-coverage sequencing and imputation increases power for genome-wide association studies.Pasaniuc, B., Rohland N., McLaren PJ, Garimella K., Zaitlen N., Li H., Gupta N., Neale BM, Daly M. J., Sklar P., Sullivan PF, Bergen S., Moran JL, Hultman CM, Lichtenstein P., Magnusson P., Purcell SM, Haas DW, Liang L., Sunyaev S., et al. Nature genetics, 2012/05/20, Volume 44, Issue 6, p.631-5, (2012) Read More / View Supplemental Materials
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mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake.Yilmaz, OH, Katajisto P., Lamming DW, Gültekin Y., Bauer-Rowe KE, Sengupta S., Birsoy K., Dursun A., Yilmaz VO, Selig M., Nielsen GP, Mino-Kenudson M., Zukerberg LR, Bhan AK, Deshpande V., and Sabatini DM Nature, 2012/05/20, (2012) Read More / View Supplemental Materials
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Evolutionary diversity of the mitochondrial calcium uniporter.Bick, AG, Calvo SE, and Mootha VK Science (New York, N.Y.), 2012/05/18, Volume 336, Issue 6083, p.886, (2012) Read More / View Supplemental Materials
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Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study.Voight, BF, Peloso GM, Orho-Melander M., Frikke-Schmidt R., Barbalic M., Jensen MK, Hindy G., Hólm H., Ding EL, Johnson T., Schunkert H., Samani NJ, Clarke R., Hopewell JC, Thompson JF, Li M., Thorleifsson G., Newton-Cheh C., Musunuru K., Pirruccello JP, et al. Lancet, 2012/05/17, (2012) Read More / View Supplemental Materials
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Identification of a selective small molecule inhibitor of breast cancer stem cells.Germain, AR, Carmody LC, Morgan B., Fernandez C., Forbeck E., Lewis TA, Nag PP, Ting A., VerPlank L., Feng Y., Perez JR, Dandapani S., Palmer M., Lander E. S., Gupta PB, Schreiber SL, and Munoz B. Bioorganic & medicinal chemistry letters, 2012/05/15, Volume 22, Issue 10, p.3571-4, (2012) Read More / View Supplemental Materials
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A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.Manning, AK, Hivert MF, Scott RA, Grimsby JL, Bouatia-Naji N., Chen H., Rybin D., Liu CT, Bielak LF, Prokopenko I., Amin N., Barnes D., Cadby G., Hottenga JJ, Ingelsson E., Jackson AU, Johnson T., Kanoni S., Ladenvall C., Lagou V., et al. Nature genetics, 2012/05/13, Volume 44, Issue 6, p.659-669, (2012) Read More / View Supplemental Materials
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Melanoma genome sequencing reveals frequent PREX2 mutations.Berger, MF, Hodis E., Heffernan TP, Deribe YL, Lawrence MS, Protopopov A., Ivanova E., Watson IR, Nickerson E., Ghosh P., Zhang H., Zeid R., Ren X., Cibulskis K., Sivachenko AY, Wagle N., Sucker A., Sougnez C., Onofrio R., Ambrogio L., et al. Nature, 2012/05/09, Volume 485, Issue 7399, p.502-6, (2012) Read More / View Supplemental Materials
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Apoptotic Cells Are Cleared by Directional Migration and elmo1- Dependent Macrophage Engulfment.van Ham, TJ, Kokel D., and Peterson RT Current biology : CB, 2012/05/08, Volume 22, Issue 9, p.830-6, (2012) Read More / View Supplemental Materials
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Exploring single-sample SNP and INDEL calling with whole-genome de novo assembly.Li, H. Bioinformatics (Oxford, England), 2012/05/07, (2012) Read More / View Supplemental Materials
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A Method of Moments Estimator for Random Effect Multivariate Meta-Analysis.Chen, H., Manning AK, and Dupuis J. Biometrics, 2012/05/02, (2012) Read More / View Supplemental Materials
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Expression of the p53 Target CDIP Correlates with Sensitivity to TNFα-Induced Apoptosis in Cancer Cells.Brown-Endres, L., Schoenfeld D., Tian F., Kim HG, Namba T., Muñoz-Fontela C., Mandinova A., Aaronson SA, and Lee SW Cancer research, 2012/05/01, Volume 72, Issue 9, p.2373-82, (2012) Read More / View Supplemental Materials
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Modification site localization scoring: strategies and performance.Chalkley, RJ, and Clauser KR Molecular & cellular proteomics : MCP, 2012/05/01, Volume 11, Issue 5, p.3-14, (2012) Read More / View Supplemental Materials
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Overcoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles.Youngsaye, W., Dockendorff C., Vincent B., Hartland CL, Bittker JA, Dandapani S., Palmer M., Whitesell L., Lindquist S., Schreiber SL, and Munoz B. Bioorganic & medicinal chemistry letters, 2012/05/01, Volume 22, Issue 9, p.3362-5, (2012) Read More / View Supplemental Materials
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A Small-Molecule Probe of the Histone Methyltransferase G9a Induces Cellular Senescence in Pancreatic Adenocarcinoma.Yuan, Y., Wang Q., Paulk J., Kubicek S., Kemp MM, Adams DJ, Shamji AF, Wagner BK, and Schreiber SL ACS chemical biology, 2012/04/30, (2012) Read More / View Supplemental Materials
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Absolute quantification of somatic DNA alterations in human cancer.Carter, SL, Cibulskis K., Helman E., McKenna A., Shen H., Zack T., Laird PW, Onofrio RC, Winckler W., Weir BA, Beroukhim R., Pellman D., Levine DA, Lander E. S., Meyerson M., and Getz G. Nature biotechnology, 2012/04/29, (2012) Read More / View Supplemental Materials
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Reduced Expression of Ribosomal Proteins Relieves MicroRNA-Mediated Repression.Janas, MM, Wang E., Love T., Harris AS, Stevenson K., Semmelmann K., Shaffer JM, Chen PH, Doench JG, Yerramilli SV, Neuberg DS, Iliopoulos D., Housman DE, Burge CB, and Novina CD Molecular cell, 2012/04/27, Volume 46, Issue 2, p.171-86, (2012) Read More / View Supplemental Materials
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Sequencing Chromosomal Abnormalities Reveals Neurodevelopmental Loci that Confer Risk across Diagnostic Boundaries.Talkowski, ME, Rosenfeld JA, Blumenthal I., Pillalamarri V., Chiang C., Heilbut A., Ernst C., Hanscom C., Rossin E., Lindgren AM, Pereira S., Ruderfer D., Kirby A., Ripke S., Harris DJ, Lee JH, Ha K., Kim HG, Solomon BD, Gropman AL, et al. Cell, 2012/04/27, Volume 149, Issue 3, p.525-37, (2012) Read More / View Supplemental Materials
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Apolipoprotein E Genotype Predicts Hematoma Expansion in Lobar Intracerebral Hemorrhage.Brouwers, HB, Biffi A., Ayres AM, Schwab K., Cortellini L., Romero JM, Rost NS, Viswanathan A., Greenberg SM, Rosand J., and Goldstein JN Stroke; a journal of cerebral circulation, 2012/04/24, (2012) Read More / View Supplemental Materials
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Sex-specific influence of DRD2 on ADHD-type temperament in a large population-based birth cohort.Nyman, ES, Loukola A., Varilo T., Taanila A., Hurtig T., Moilanen I., Loo S., McGough JJ, Järvelin MR, Smalley SL, Nelson SF, and Peltonen L. Psychiatric genetics, 2012/04/23, (2012) Read More / View Supplemental Materials
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An image analysis toolbox for high-throughput C. elegans assays.Wählby, C., Kamentsky L., Liu ZH, Riklin-Raviv T., Conery AL, O'Rourke EJ, Sokolnicki KL, Visvikis O., Ljosa V., Irazoqui JE, Golland P., Ruvkun G., Ausubel FM, and Carpenter AE Nature methods, 2012/04/22, (2012) Read More / View Supplemental Materials
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Not lost in translation: stepwise regulation of microRNA targets.Janas, MM, and Novina CD The EMBO journal, 2012/04/20, (2012) Read More / View Supplemental Materials