Publications

Arc Requires PSD95 for Assembly into Postsynaptic Complexes Involved with Neural Dysfunction and Intelligence.

Fernández E, Collins MO, Frank RAW, et al. Arc Requires PSD95 for Assembly into Postsynaptic Complexes Involved with Neural Dysfunction and Intelligence. Cell Rep. 2017;21(3):679-691. doi:10.1016/j.celrep.2017.09.045.

Prolonged IKKβ Inhibition Improves Ongoing CTL Antitumor Responses by Incapacitating Regulatory T Cells.

Heuser C, Gotot J, Piotrowski EChristina, et al. Prolonged IKKβ Inhibition Improves Ongoing CTL Antitumor Responses by Incapacitating Regulatory T Cells. Cell Rep. 2017;21(3):578-586. doi:10.1016/j.celrep.2017.09.082.

Integrating evolutionary and regulatory information with a multispecies approach implicates genes and pathways in obsessive-compulsive disorder.

Noh HJi, Tang R, Flannick J, et al. Integrating evolutionary and regulatory information with a multispecies approach implicates genes and pathways in obsessive-compulsive disorder. Nat Commun. 2017;8(1):774. doi:10.1038/s41467-017-00831-x.

Substantial contribution of genetic variation in the expression of transcription factors to phenotypic variation revealed by eRD-GWAS.

Lin H-Y, Liu Q, Li X, et al. Substantial contribution of genetic variation in the expression of transcription factors to phenotypic variation revealed by eRD-GWAS. Genome Biol. 2017;18(1):192. doi:10.1186/s13059-017-1328-6.

Antibiotic efficacy-context matters.

Yang JH, Bening SC, Collins JJ. Antibiotic efficacy-context matters. Curr Opin Microbiol. 2017;39:73-80. doi:10.1016/j.mib.2017.09.002.

Antibodies to biotin enable large-scale detection of biotinylation sites on proteins.

Udeshi ND, Pedram K, Svinkina T, et al. Antibodies to biotin enable large-scale detection of biotinylation sites on proteins. Nat Methods. 2017. doi:10.1038/nmeth.4465.

Phage-assisted continuous evolution of proteases with altered substrate specificity.

Packer MS, Rees HA, Liu DR. Phage-assisted continuous evolution of proteases with altered substrate specificity. Nat Commun. 2017;8(1):956. doi:10.1038/s41467-017-01055-9.

A machine learning approach for predicting CRISPR-Cas9 cleavage efficiencies and patterns underlying its mechanism of action.

Abadi S, Yan WX, Amar D, Mayrose I. A machine learning approach for predicting CRISPR-Cas9 cleavage efficiencies and patterns underlying its mechanism of action. PLoS Comput Biol. 2017;13(10):e1005807. doi:10.1371/journal.pcbi.1005807.

Crystal structures reveal an elusive functional domain of pyrrolysyl-tRNA synthetase.

Suzuki T, Miller C, Guo L-T, et al. Crystal structures reveal an elusive functional domain of pyrrolysyl-tRNA synthetase. Nat Chem Biol. 2017. doi:10.1038/nchembio.2497.

Continuous directed evolution of aminoacyl-tRNA synthetases.

Bryson DI, Fan C, Guo L-T, Miller C, Söll D, Liu DR. Continuous directed evolution of aminoacyl-tRNA synthetases. Nat Chem Biol. 2017. doi:10.1038/nchembio.2474.