Publications

Single-cell profiling of environmental enteropathy reveals signatures of epithelial remodeling and immune activation.

Kummerlowe C, Mwakamui S, Hughes TK, et al. Single-cell profiling of environmental enteropathy reveals signatures of epithelial remodeling and immune activation. Sci Transl Med. 2022;14(660):eabi8633. doi:10.1126/scitranslmed.abi8633.DOI Google Scholar PubMed

High-resolution profiling of lung adenocarcinoma identifies expression subtypes with specific biomarkers and clinically relevant vulnerabilities.

Roh W, Geffen Y, Cha H, et al. High-resolution profiling of lung adenocarcinoma identifies expression subtypes with specific biomarkers and clinically relevant vulnerabilities. Cancer Res. 2022. doi:10.1158/0008-5472.CAN-22-0432.DOI Google Scholar PubMed

Large-scale sequencing identifies multiple genes and rare variants associated with Crohn's disease susceptibility.

Sazonovs A, Stevens CR, Venkataraman GR, et al. Large-scale sequencing identifies multiple genes and rare variants associated with Crohn's disease susceptibility. Nat Genet. 2022. doi:10.1038/s41588-022-01156-2.DOI Google Scholar PubMed

Elucidating the path to Plasmodium prolyl-tRNA synthetase inhibitors that overcome halofuginone resistance.

Tye MA, Payne C, Johansson C, et al. Elucidating the path to Plasmodium prolyl-tRNA synthetase inhibitors that overcome halofuginone resistance. Nat Commun. 2022;13(1):4976. doi:10.1038/s41467-022-32630-4.DOI Google Scholar PubMed

Rare coding variation provides insight into the genetic architecture and phenotypic context of autism.

Fu JM, Satterstrom K, Peng M, et al. Rare coding variation provides insight into the genetic architecture and phenotypic context of autism. Nat Genet. 2022. doi:10.1038/s41588-022-01104-0.DOI Google Scholar PubMed

Chromatin-bound RB targets promoters, enhancers, and CTCF-bound loci and is redistributed by cell-cycle progression.

Sanidas I, Lee H, Rumde PH, et al. Chromatin-bound RB targets promoters, enhancers, and CTCF-bound loci and is redistributed by cell-cycle progression. Mol Cell. 2022. doi:10.1016/j.molcel.2022.07.014.DOI Google Scholar PubMed

Reactive metabolic byproducts contribute to antibiotic lethality under anaerobic conditions.

Wong F, Stokes JM, Bening SC, Vidoudez C, Trauger SA, Collins JJ. Reactive metabolic byproducts contribute to antibiotic lethality under anaerobic conditions. Mol Cell. 2022. doi:10.1016/j.molcel.2022.07.009.DOI Google Scholar PubMed

Pyramidal neuron subtype diversity governs microglia states in the neocortex.

Stogsdill JA, Kim K, Binan L, Farhi SL, Levin JZ, Arlotta P. Pyramidal neuron subtype diversity governs microglia states in the neocortex. Nature. 2022. doi:10.1038/s41586-022-05056-7.DOI Google Scholar PubMed

A lab-on-a-chip for the concurrent electrochemical detection of SARS-CoV-2 RNA and anti-SARS-CoV-2 antibodies in saliva and plasma.

Najjar D, Rainbow J, Timilsina SS, et al. A lab-on-a-chip for the concurrent electrochemical detection of SARS-CoV-2 RNA and anti-SARS-CoV-2 antibodies in saliva and plasma. Nat Biomed Eng. 2022. doi:10.1038/s41551-022-00919-w.DOI Google Scholar PubMed

Pan-cancer integrative histology-genomic analysis via multimodal deep learning.

Chen RJ, Lu MY, Williamson DFK, et al. Pan-cancer integrative histology-genomic analysis via multimodal deep learning. Cancer Cell. 2022;40(8):865-878.e6. doi:10.1016/j.ccell.2022.07.004.DOI Google Scholar PubMed