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2015
The DNA-binding network of Mycobacterium tuberculosis.Minch, KJ, Rustad TR, Peterson EJ, Winkler J., Reiss DJ, Ma S., Hickey M., Brabant W., Morrison B., Turkarslan S., Mawhinney C., Galagan JE, Price ND, Baliga NS, and Sherman DR Nature communications, 2015/01/12, Volume 6, p.5829, (2015) Read More / View Supplemental Materials
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Gene expression analysis identifies global gene dosage sensitivity in cancer.Fehrmann, RS, Karjalainen JM, Krajewska M., Westra HJ, Maloney D., Simeonov A., Pers TH, Hirschhorn JN, Jansen RC, Schultes EA, van Haagen HH, de Vries EG, Te Meerman GJ, Wijmenga C., van Vugt MA, and Franke L. Nature genetics, 2015/01/12, (2015) Read More / View Supplemental Materials
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A Mechanism for Asymmetric Cell Division Resulting in Proliferative Asynchronicity.Dey-Guha, I., Alves CP, Yeh AC, Salony, Sole X., Darp R., and Ramaswamy S. Molecular cancer research : MCR, 2015/01/12, (2015) Read More / View Supplemental Materials
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No evidence that selection has been less effective at removing deleterious mutations in Europeans than in Africans.Do, R., Balick D., Li H., Adzhubei I., Sunyaev S., and Reich D. Nature genetics, 2015/01/12, (2015) Read More / View Supplemental Materials
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Pluripotency transcription factor Oct4 mediates stepwise nucleosome demethylation and depletion.Shakya, A., Callister C., Goren A., Yosef N., Garg N., Khoddami V., Nix D., Regev A., and Tantin D. Molecular and cellular biology, 2015/01/12, (2015) Read More / View Supplemental Materials
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Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1.Wang, S., Tsun ZY, Wolfson RL, Shen K., Wyant GA, Plovanich ME, Yuan ED, Jones TD, Chantranupong L., Comb W., Wang T., Bar-Peled L., Zoncu R., Straub C., Kim C., Park J., Sabatini BL, and Sabatini DM Science (New York, N.Y.), 2015/01/09, Volume 347, Issue 6218, p.188-94, (2015) Read More / View Supplemental Materials
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Htt CAG repeat expansion confers pleiotropic gains of mutant huntingtin function in chromatin regulation.Biagioli, M., Ferrari F., Mendenhall EM, Zhang Y., Erdin S., Vijayvargia R., Vallabh SM, Solomos N., Manavalan P., Ragavendran A., Ozsolak F., Lee JM, Talkowski ME, Gusella JF, Macdonald ME, Park PJ, and Seong IS Human molecular genetics, 2015/01/08, (2015) Read More / View Supplemental Materials
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Metabolite Profiling and Cardiovascular Event Risk: A Prospective Study of Three Population-Based Cohorts.Würtz, P., Havulinna AS, Soininen P., Tynkkynen T., Prieto-Merino D., Tillin T., Ghorbani A., Artati A., Wang Q., Tiainen M., Kangas AJ, Kettunen J., Kaikkonen J., Mikkilä V., Jula A., Kähönen M., Lehtimäki T., Lawlor DA, Gaunt TR, Hughes AD, et al. Circulation, 2015/01/08, (2015) Read More / View Supplemental Materials
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Synthesis of Oxazocenones via Gold(I)-Catalyzed 8-Endo-Dig Hydroalkoxylation of Alkynamides.Scully, SS, Zheng SL, Wagner BK, and Schreiber SL Organic letters, 2015/01/08, (2015) Read More / View Supplemental Materials
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Using cross-classified multilevel models to disentangle school and neighborhood effects: An example focusing on smoking behaviors among adolescents in the United States.Dunn, EC, Richmond TK, Milliren CE, and Subramanian SV Health & place, 2015/01/08, Volume 31C, p.224-232, (2015) Read More / View Supplemental Materials
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Cell lineage analysis in human brain using endogenous retroelements.Evrony, GD, Lee E., Mehta BK, Benjamini Y., Johnson RM, Cai X., Yang L., Haseley P., Lehmann HS, Park PJ, and Walsh CA Neuron, 2015/01/07, Volume 85, Issue 1, p.49-59, (2015) Read More / View Supplemental Materials
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Developmental Control of Polycomb Subunit Composition by GATA Factors Mediates a Switch to Non-Canonical Functions.Xu, J., Shao Z., Li D., Xie H., Kim W., Huang J., Taylor JE, Pinello L., Glass K., Jaffe JD, Yuan GC, and Orkin SH Molecular cell, 2015/01/07, (2015) Read More / View Supplemental Materials
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Discovery and annotation of long noncoding RNAs.Mattick, JS, and Rinn JL Nature structural & molecular biology, 2015/01/07, Volume 22, Issue 1, p.5-7, (2015) Read More / View Supplemental Materials
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Copy number variation in bipolar disorder.Green, EK, Rees E., Walters JT, Smith KG, Forty L., Grozeva D., Moran JL, Sklar P., Ripke S., Chambert KD, Genovese G., McCarroll SA, Jones I., Jones L., Owen MJ, O'Donovan MC, Craddock N., and Kirov G. Molecular psychiatry, 2015/01/06, (2015) Read More / View Supplemental Materials
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High-throughput luminescent reporter of insulin secretion for discovering regulators of pancreatic Beta-cell function.Burns, SM, Vetere A., Walpita D., Dančík V., Khodier C., Perez J., Clemons PA, Wagner BK, and Altshuler D. Cell metabolism, 2015/01/06, Volume 21, Issue 1, p.126-37, (2015) Read More / View Supplemental Materials
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An in-tumor genetic screen reveals that the BET bromodomain protein, BRD4, is a potential therapeutic target in ovarian carcinoma.Baratta, MG, Schinzel AC, Zwang Y., Bandopadhayay P., Bowman-Colin C., Kutt J., Curtis J., Piao H., Wong LC, Kung AL, Beroukhim R., Bradner JE, Drapkin R., Hahn WC, Liu JF, and Livingston DM Proceedings of the National Academy of Sciences of the United States of America, 2015/01/06, Volume 112, Issue 1, p.232-7, (2015) Read More / View Supplemental Materials
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Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages.Palsson-McDermott, EM, Curtis AM, Goel G., Lauterbach MA, Sheedy FJ, Gleeson LE, van den Bosch MW, Quinn SR, Domingo-Fernandez R., Johnson DG, Jiang JK, Israelsen WJ, Keane J., Thomas C., Clish C., Vanden Heiden M., Xavier RJ, and O'Neill LA Cell metabolism, 2015/01/06, Volume 21, Issue 1, p.65-80, (2015) Read More / View Supplemental Materials
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Synthetic lethal screening in the mammalian central nervous system identifies Gpx6 as a modulator of Huntington's disease.Shema, R., Kulicke R., Cowley GS, Stein R., Root DE, and Heiman M. Proceedings of the National Academy of Sciences of the United States of America, 2015/01/06, Volume 112, Issue 1, p.268-72, (2015) Read More / View Supplemental Materials
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Comparative proteomic analysis reveals activation of mucosal innate immune signaling pathways during cholera.Ellis, CN, LaRocque RC, Uddin T., Krastins B., Mayo-Smith L., Sarracino D., Karlsson E., Rahman A., Shirin T., Bhuiyan TR, Chowdhury F., Kahn AI, Ryan ET, Calderwood SB, Qadri F., and Harris JB Infection and immunity, 2015/01/05, (2015) Read More / View Supplemental Materials
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Extracardiac control of embryonic cardiomyocyte proliferation and ventricular wall expansion.Shen, H., Cavallero S., Estrada KD, Sandovici I., Kumar SR, Makita T., Lien CL, Constancia M., and Sucov HM Cardiovascular research, 2015/01/05, (2015) Read More / View Supplemental Materials
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High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis.Goyette, P., Boucher G., Mallon D., Ellinghaus E., Jostins L., Huang H., Ripke S., Gusareva ES, Annese V., Hauser SL, Oksenberg JR, Thomsen I., Leslie S., International Inflammatory Bowel Disease Genetics Consortium, Australia and New Zealand IBDGC, Belgium IBD Genetics Consortium, Italian Group for IBD Genetic Consortium, NIDDK Inflammatory Bowel Disease Genetics Consortium, United Kingdom IBDGC, Wellcome Trust Case Control Consortium, et al. Nature genetics, 2015/01/05, (2015) Read More / View Supplemental Materials
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Using CellProfiler for Automatic Identification and Measurement of Biological Objects in Images.Bray, MA, Vokes MS, and Carpenter AE Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.], 2015/01/05, Volume 109, p.14.17.1-14.17.13, (2015) Read More / View Supplemental Materials
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Mosquito genomics. Highly evolvable malaria vectors: the genomes of 16 Anopheles mosquitoes.Neafsey, DE, Waterhouse RM, Abai MR, Aganezov SS, Alekseyev MA, Allen JE, Amon J., Arcà B., Arensburger P., Artemov G., Assour LA, Basseri H., Berlin A., Birren BW, Blandin SA, Brockman AI, Burkot TR, Burt A., Chan CS, Chauve C., et al. Science (New York, N.Y.), 2015/01/02, Volume 347, Issue 6217, p.1258522, (2015) Read More / View Supplemental Materials
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Analysis of Gene-Gene Interactions among Common Variants in Candidate Cardiovascular Genes in Coronary Artery Disease.Musameh, MD, Wang WY, Nelson CP, Lluís-Ganella C., Debiec R., Subirana I., Elosua R., Balmforth AJ, Ball SG, Hall AS, Kathiresan S., Thompson JR, Lucas G., Samani NJ, and Tomaszewski M. PloS one, 2015/01/01, Volume 10, Issue 2, p.e0117684, (2015) Read More / View Supplemental Materials
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CCAAT/Enhancer Binding Protein β Is Dispensable for Development of Lung Adenocarcinoma.Cai, Y., Hirata A., Nakayama S., VanderLaan PA, Levantini E., Yamamoto M., Hirai H., Wong KK, Costa DB, Watanabe H., and Kobayashi SS PloS one, 2015/01/01, Volume 10, Issue 3, p.e0120647, (2015) Read More / View Supplemental Materials
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Center Variation in Intestinal Microbiota Prior to Late-Onset Sepsis in Preterm Infants.Taft, DH, Ambalavanan N., Schibler KR, Yu Z., Newburg DS, Deshmukh H., Ward DV, and Morrow AL PloS one, 2015/01/01, Volume 10, Issue 6, p.e0130604, (2015) Read More / View Supplemental Materials
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Copy Number Variation at the APOL1 Locus.Ruchi, R., Genovese G., Lee J., Charoonratana VT, Bernhardy AJ, Alper SL, Kopp JB, Thadhani R., Friedman DJ, and Pollak MR PloS one, 2015/01/01, Volume 10, Issue 5, p.e0125410, (2015) Read More / View Supplemental Materials
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Dialogue: A blissful future for lupus nephritis: harnessing repeat kidney biopsies to identify meaningful biomarkers of disease.Schober, FP, and Pendergraft WF 3rd Lupus science & medicine, 2015/01/01, Volume 2, Issue 1, p.e000083, (2015) Read More / View Supplemental Materials
Diverse Phenotypes and Specific Transcription Patterns in Twenty Mouse Lines with Ablated LincRNAs.Lai, KM, Gong G., Atanasio A., Rojas J., Quispe J., Posca J., White D., Huang M., Fedorova D., Grant C., Miloscio L., Droguett G., Poueymirou WT, Auerbach W., Yancopoulos GD, Frendewey D., Rinn J., and Valenzuela DM PloS one, 2015/01/01, Volume 10, Issue 4, p.e0125522, (2015) Read More / View Supplemental Materials
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Effects of sodium benzoate, a widely used food preservative, on glucose homeostasis and metabolic profiles in humans.Lennerz, BS, Vafai SB, Delaney NF, Clish CB, Deik AA, Pierce KA, Ludwig DS, and Mootha VK Molecular genetics and metabolism, 2015/01/01, Volume 114, Issue 1, p.73-9, (2015) Read More / View Supplemental Materials
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Efficient Differentiation of Steroidogenic and Germ-Like Cells from Epigenetically-Related iPSCs Derived from Ovarian Granulosa Cells.Anchan, R., Gerami-Naini B., Lindsey JS, Ho JW, Kiezun A., Lipskind S., Ng N., LiCausi JA, Kim CS, Brezina P., Tuschl T., Maas R., Kearns WG, and Williams Z. PloS one, 2015/01/01, Volume 10, Issue 3, p.e0119275, (2015) Read More / View Supplemental Materials
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Environmental mold and mycotoxin exposures elicit specific cytokine and chemokine responses.Rosenblum Lichtenstein, JH, Hsu YH, Gavin IM, Donaghey TC, Molina RM, Thompson KJ, Chi CL, Gillis BS, and Brain JD PloS one, 2015/01/01, Volume 10, Issue 5, p.e0126926, (2015) Read More / View Supplemental Materials
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An epitope tag alters phosphoglycerate dehydrogenase structure and impairs ability to support cell proliferation.Mattaini, KR, Brignole EJ, Kini M., Davidson SM, Fiske BP, Drennan CL, and Vander Heiden MG Cancer & metabolism, 2015/01/01, Volume 3, p.5, (2015) Read More / View Supplemental Materials
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Fructose ingestion acutely stimulates circulating FGF21 levels in humans.Dushay, JR, Toschi E., Mitten EK, Fisher FM, Herman MA, and Maratos-Flier E. Molecular metabolism, 2015/01/01, Volume 4, Issue 1, p.51-7, (2015) Read More / View Supplemental Materials
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Genome Engineering Using CRISPR-Cas9 System.Cong, L., and Zhang F. Methods in molecular biology (Clifton, N.J.), 2015/01/01, Volume 1239, p.197-217, (2015) Read More / View Supplemental Materials
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Genome-Wide Analyses Suggest Mechanisms Involving Early B-Cell Development in Canine IgA Deficiency.Olsson, M., Tengvall K., Frankowiack M., Kierczak M., Bergvall K., Axelsson E., Tintle L., Marti E., Roosje P., Leeb T., Hedhammar Å., Hammarström L., and Lindblad-Toh K. PloS one, 2015/01/01, Volume 10, Issue 7, p.e0133844, (2015) Read More / View Supplemental Materials
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A Genome-Wide siRNA Screen in Mammalian Cells for Regulators of S6 Phosphorylation.Papageorgiou, A., Rapley J., Mesirov J. P., Tamayo P., and Avruch J. PloS one, 2015/01/01, Volume 10, Issue 3, p.e0116096, (2015) Read More / View Supplemental Materials
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Haplotype phasing and inheritance of copy number variants in nuclear families.Palta, P., Kaplinski L., Nagirnaja L., Veidenberg A., Möls M., Nelis M., Esko T., Metspalu A., Laan M., and Remm M. PloS one, 2015/01/01, Volume 10, Issue 4, p.e0122713, (2015) Read More / View Supplemental Materials
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HdhQ111 Mice Exhibit Tissue Specific Metabolite Profiles that Include Striatal Lipid Accumulation.Carroll, JB, Deik A., Fossale E., Weston RM, Guide JR, Arjomand J., Kwak S., Clish CB, and Macdonald ME PloS one, 2015/01/01, Volume 10, Issue 8, p.e0134465, (2015) Read More / View Supplemental Materials
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High-quality draft genome sequences of five anaerobic oral bacteria and description of Peptoanaerobacter stomatis gen. nov., sp. nov., a new member of the family Peptostreptococcaceae.Sizova, MV, Chilaka A., Earl AM, Doerfert SN, Muller PA, Torralba M., McCorrison JM, Durkin AS, Nelson KE, and Epstein SS Standards in genomic sciences, 2015/01/01, Volume 10, p.37, (2015) Read More / View Supplemental Materials
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High-Throughput Single-Cell Labeling (Hi-SCL) for RNA-Seq Using Drop-Based Microfluidics.Rotem, A., Ram O., Shoresh N., Sperling RA, Schnall-Levin M., Zhang H., Basu A., Bernstein BE, and Weitz DA PloS one, 2015/01/01, Volume 10, Issue 5, p.e0116328, (2015) Read More / View Supplemental Materials
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Identification and Functional Characterization of G6PC2 Coding Variants Influencing Glycemic Traits Define an Effector Transcript at the G6PC2-ABCB11 Locus.Mahajan, A., Sim X., Ng HJ, Manning A., Rivas MA, Highland HM, Locke AE, Grarup N., Im HK, Cingolani P., Flannick J., Fontanillas P., Fuchsberger C., Gaulton KJ, Teslovich TM, Rayner NW, Robertson NR, Beer NL, Rundle JK, Bork-Jensen J., et al. PLoS genetics, 2015/01/01, Volume 11, Issue 1, p.e1004876, (2015) Read More / View Supplemental Materials
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Impact of autoimmune risk alleles on the immune system.Ray, JP, and Hacohen N. Genome medicine, 2015/01/01, Volume 7, Issue 1, p.57, (2015) Read More / View Supplemental Materials
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ISCB Ebola Award for Important Future Research on the Computational Biology of Ebola Virus.Karp, PD, Berger B., Kovats D., Lengauer T., Linial M., Sabeti P., Hide W., and Rost B. PLoS computational biology, 2015/01/01, Volume 11, Issue 1, p.e1004087, (2015) Read More / View Supplemental Materials
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ISCB Ebola Award for Important Future Research on the Computational Biology of Ebola Virus.Karp, PD, Berger B., Kovats D., Lengauer T., Linial M., Sabeti P., Hide W., and Rost B. F1000Research, 2015/01/01, Volume 4, p.12, (2015) Read More / View Supplemental Materials
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Kinetically Selective Inhibitors of Histone Deacetylase 2 (HDAC2) as Cognition Enhancers.Wagner, FF, Zhang YL, Fass DM, Joseph N., Gale JP, Weïwer M., McCarren P., Fisher SL, Kaya T., Zhao WN, Reis SA, Hennig KM, Thomas M., Lemercier BC, Lewis MC, Guan JS, Moyer MP, Scolnick E., Haggarty SJ, Tsai LH, et al. Chemical science (Royal Society of Chemistry : 2010), 2015/01/01, Volume 6, Issue 1, p.804-815, (2015) Read More / View Supplemental Materials
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A longitudinal twin study of the association between childhood autistic traits and psychotic experiences in adolescence.Taylor, MJ, Robinson EB, Happé F., Bolton P., Freeman D., and Ronald A. Molecular autism, 2015/01/01, Volume 6, p.44, (2015) Read More / View Supplemental Materials
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A Maltose-Binding Protein Fusion Construct Yields a Robust Crystallography Platform for MCL1.Clifton, MC, Dranow DM, Leed A., Fulroth B., Fairman JW, Abendroth J., Atkins KA, Wallace E., Fan D., Xu G., Ni ZJ, Daniels D., Van Drie J., Wei G., Burgin AB, Golub T. R., Hubbard BK, and Serrano-Wu MH PloS one, 2015/01/01, Volume 10, Issue 4, p.e0125010, (2015) Read More / View Supplemental Materials
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Modulation of genetic associations with serum urate levels by body-mass-index in humans.Huffman, JE, Albrecht E., Teumer A., Mangino M., Kapur K., Johnson T., Kutalik Z., Pirastu N., Pistis G., Lopez LM, Haller T., Salo P., Goel A., Li M., Tanaka T., Dehghan A., Ruggiero D., Malerba G., Smith AV, Nolte IM, et al. PloS one, 2015/01/01, Volume 10, Issue 3, p.e0119752, (2015) Read More / View Supplemental Materials
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Modulators of hepatic lipoprotein metabolism identified in a search for small-molecule inducers of tribbles pseudokinase 1 expression.Nagiec, MM, Skepner AP, Negri J., Eichhorn M., Kuperwasser N., Comer E., Muncipinto G., Subramanian A., Clish C., Musunuru K., Duvall JR, Foley M., Perez JR, and Palmer MA PloS one, 2015/01/01, Volume 10, Issue 3, p.e0120295, (2015) Read More / View Supplemental Materials
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Morphological Profiles of RNAi-Induced Gene Knockdown Are Highly Reproducible but Dominated by Seed Effects.Singh, S., Wu X., Ljosa V., Bray MA, Piccioni F., Root DE, Doench JG, Boehm JS, and Carpenter AE PloS one, 2015/01/01, Volume 10, Issue 7, p.e0131370, (2015) Read More / View Supplemental Materials
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mTOR Inhibitors in Cancer: What Can We Learn from Exceptional Responses?Kwiatkowski, DJ, and Wagle N. EBioMedicine, 2015/01/01, Volume 2, Issue 1, p.2-4, (2015) Read More / View Supplemental Materials
A Multi-Breed Genome-Wide Association Analysis for Canine Hypothyroidism Identifies a Shared Major Risk Locus on CFA12.Bianchi, M., Dahlgren S., Massey J., Dietschi E., Kierczak M., Lund-Ziener M., Sundberg K., Thoresen SI, Kämpe O., Andersson G., Ollier WE, Hedhammar Å., Leeb T., Lindblad-Toh K., Kennedy LJ, Lingaas F., and Rosengren Pielberg G. PloS one, 2015/01/01, Volume 10, Issue 8, p.e0134720, (2015) Read More / View Supplemental Materials
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Multilocus heterozygosity and coronary heart disease: nested case-control studies in men and women.Mukamal, KJ, Jensen MK, Pers TH, Pai JK, Kraft P., and Rimm EB PloS one, 2015/01/01, Volume 10, Issue 5, p.e0124847, (2015) Read More / View Supplemental Materials
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A New Imaging Platform for Visualizing Biological Effects of Non-Invasive Radiofrequency Electric-Field Cancer Hyperthermia.Corr, SJ, Shamsudeen S., Vergara LA, Cho J., Ware MJ, Keshishian V., Yokoi K., Savage DJ, Meraz IM, Kaluarachchi W., Cisneros BT, Raoof M., Nguyen DT, Zhang Y., Wilson LJ, Summers H., Rees P., Curley SA, and Serda RE PloS one, 2015/01/01, Volume 10, Issue 8, p.e0136382, (2015) Read More / View Supplemental Materials
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Next-generation sequencing to guide cancer therapy.Gagan, J., and Van Allen EM Genome medicine, 2015/01/01, Volume 7, Issue 1, p.80, (2015) Read More / View Supplemental Materials
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No Evidence for Association of Autism with Rare Heterozygous Point Mutations in Contactin-Associated Protein-Like 2 (CNTNAP2), or in Other Contactin-Associated Proteins or Contactins.Murdoch, JD, Gupta AR, Sanders SJ, Walker MF, Keaney J., Fernandez TV, Murtha MT, Anyanwu S., Ober GT, Raubeson MJ, DiLullo NM, Villa N., Waqar Z., Sullivan C., Gonzalez L., Willsey AJ, Choe SY, Neale BM, Daly M. J., and State MW PLoS genetics, 2015/01/01, Volume 11, Issue 1, p.e1004852, (2015) Read More / View Supplemental Materials
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A Re-Appraisal of the Early Andean Human Remains from Lauricocha in Peru.Fehren-Schmitz, L., Llamas B., Lindauer S., Tomasto-Cagigao E., Kuzminsky S., Rohland N., Santos FR, Kaulicke P., Valverde G., Richards SM, Nordenfelt S., Seidenberg V., Mallick S., Cooper A., Reich D., and Haak W. PloS one, 2015/01/01, Volume 10, Issue 6, p.e0127141, (2015) Read More / View Supplemental Materials
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A reproducible approach to high-throughput biological data acquisition and integration.Börnigen, D., Moon YS, Rahnavard G., Waldron L., McIver L., Shafquat A., Franzosa EA, Miropolsky L., Sweeney C., Morgan XC, Garrett WS, and Huttenhower C. PeerJ, 2015/01/01, Volume 3, p.e791, (2015) Read More / View Supplemental Materials
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RNA Antisense Purification (RAP) for Mapping RNA Interactions with Chromatin.Engreitz, J., Lander E. S., and Guttman M. Methods in molecular biology (Clifton, N.J.), 2015/01/01, Volume 1262, p.183-97, (2015) Read More / View Supplemental Materials
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Second-generation PLINK: rising to the challenge of larger and richer datasets.Chang, CC, Chow CC, Tellier LC, Vattikuti S., Purcell SM, and Lee JJ GigaScience, 2015/01/01, Volume 4, p.7, (2015) Read More / View Supplemental Materials
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The Shepherds' Tale: A Genome-Wide Study across 9 Dog Breeds Implicates Two Loci in the Regulation of Fructosamine Serum Concentration in Belgian Shepherds.Forsberg, SK, Kierczak M., Ljungvall I., Merveille AC, Gouni V., Wiberg M., Lundgren Willesen J., Hanås S., Lequarré AS, Mejer Sørensen L., Tiret L., McEntee K., Seppälä E., Koch J., Battaille G., Lohi H., Fredholm M., Chetboul V., Häggström J., Carlborg Ö., et al. PloS one, 2015/01/01, Volume 10, Issue 5, p.e0123173, (2015) Read More / View Supplemental Materials
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The Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans (SUGAR-MGH): Design of a pharmacogenetic Resource for Type 2 Diabetes.Walford, GA, Colomo N., Todd JN, Billings LK, Fernandez M., Chamarthi B., Warner AS, Davis J., Littleton KR, Hernandez AM, Fanelli RR, Lanier A., Barbato C., Ackerman RJ, Khan SQ, Bui R., Garber L., Stolerman ES, Moore AF, Huang C., et al. PloS one, 2015/01/01, Volume 10, Issue 3, p.e0121553, (2015) Read More / View Supplemental Materials
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Targeted resequencing of the pericentromere of chromosome 2 linked to constitutional delay of growth and puberty.Cousminer, DL, Leinonen JT, Sarin AP, Chheda H., Surakka I., Wehkalampi K., Ellonen P., Ripatti S., Dunkel L., Palotie A., and Widén E. PloS one, 2015/01/01, Volume 10, Issue 6, p.e0128524, (2015) Read More / View Supplemental Materials
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TRAF1/C5 but Not PTPRC Variants Are Potential Predictors of Rheumatoid Arthritis Response to Anti-Tumor Necrosis Factor Therapy.Canhão, H., Rodrigues AM, Santos MJ, Carmona-Fernandes D., Bettencourt BF, Cui J., Rocha FL, Canas Silva J., Polido-Pereira J., Pereira Silva JA, Costa JA, Araujo D., Silva C., Santos H., Duarte C., Cáliz R., Filipescu I., Pimentel-Santos F., Branco J., Sainz J., et al. BioMed research international, 2015/01/01, Volume 2015, p.490295, (2015) Read More / View Supplemental Materials
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Transcriptional profiling defines dynamics of parasite tissue sequestration during malaria infection.Pelle, KG, Oh K., Buchholz K., Narasimhan V., Joice R., Milner DA, Brancucci NM, Ma S., Voss TS, Ketman K., Seydel KB, Taylor TE, Barteneva NS, Huttenhower C., and Marti M. Genome medicine, 2015/01/01, Volume 7, Issue 1, p.19, (2015) Read More / View Supplemental Materials
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TYK2 Protein-Coding Variants Protect against Rheumatoid Arthritis and Autoimmunity, with No Evidence of Major Pleiotropic Effects on Non-Autoimmune Complex Traits.Diogo, D., Bastarache L., Liao KP, Graham RR, Fulton RS, Greenberg JD, Eyre S., Bowes J., Cui J., Lee A., Pappas DA, Kremer JM, Barton A., Coenen MJ, Franke B., Kiemeney LA, Mariette X., Richard-Miceli C., Canhão H., Fonseca JE, et al. PloS one, 2015/01/01, Volume 10, Issue 4, p.e0122271, (2015) Read More / View Supplemental Materials
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Using modelling to disentangle the relative contributions of zoonotic and anthroponotic transmission: the case of lassa Fever.Lo Iacono, G., Cunningham AA, Fichet-Calvet E., Garry RF, Grant DS, Khan SH, Leach M., Moses LM, Schieffelin JS, Shaffer JG, Webb CT, and Wood JL PLoS neglected tropical diseases, 2015/01/01, Volume 9, Issue 1, p.e3398, (2015) Read More / View Supplemental Materials
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Within-trait heterogeneity in age group differences in personality domains and facets: implications for the development and coherence of personality traits.Mõttus, R., Realo A., Allik J., Esko T., Metspalu A., and Johnson W. PloS one, 2015/01/01, Volume 10, Issue 3, p.e0119667, (2015) Read More / View Supplemental Materials
Abstract
2014
Increased expression of the immune modulatory molecule PD-L1 (CD274) in anaplastic meningioma.Du, Z., Abedalthagafi M., Aizer AA, McHenry AR, Sun HH, Bray MA, Viramontes O., Machaidze R., Brastianos PK, Reardon DA, Dunn IF, Freeman GJ, Ligon KL, Carpenter AE, Alexander BM, Agar NY, Rodig SJ, Bradshaw EM, and Santagata S. Oncotarget, 2014/12/31, (2014) Read More / View Supplemental Materials
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DeCoN: Genome-wide Analysis of In Vivo Transcriptional Dynamics during Pyramidal Neuron Fate Selection in Neocortex.Molyneaux, BJ, Goff LA, Brettler AC, Chen H., Brown JR, Hrvatin S., Rinn JL, and Arlotta P. Neuron, 2014/12/30, (2014) Read More / View Supplemental Materials
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Genetic Architecture of White Matter Hyperintensities Differs in Hypertensive and Nonhypertensive Ischemic Stroke.Adib-Samii, P., Devan W., Traylor M., Lanfranconi S., Zhang CR, Cloonan L., Falcone GJ, Radmanesh F., Fitzpatrick K., Kanakis A., Rothwell PM, Sudlow C., Boncoraglio GB, Meschia JF, Levi C., Dichgans M., Bevan S., Rosand J., Rost NS, and Markus HS Stroke; a journal of cerebral circulation, 2014/12/30, (2014) Read More / View Supplemental Materials
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Target-Based Identification of Whole-Cell Active Inhibitors of Biotin Biosynthesis in Mycobacterium tuberculosis.Park, SW, Casalena DE, Wilson DJ, Dai R., Nag PP, Liu F., Boyce JP, Bittker JA, Schreiber SL, Finzel BC, Schnappinger D., and Aldrich CC Chemistry & biology, 2014/12/30, (2014) Read More / View Supplemental Materials
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Inducible RNAi in vivo reveals that the transcription factor BATF is required to initiate but not maintain CD8+ T-cell effector differentiation.Godec, J., Cowley GS, Barnitz RA, Root DE, Sharpe AH, and Haining WN Proceedings of the National Academy of Sciences of the United States of America, 2014/12/29, (2014) Read More / View Supplemental Materials
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Title (78 characters): A TREM1 variant alters the accumulation of Alzheimer-related amyloid pathology.Replogle, JM, Chan G., White CC, Raj T., Winn PA, Evans DA, Sperling RA, Chibnik LB, Bradshaw EM, Schneider JA, Bennett DA, and De Jager PL Annals of neurology, 2014/12/26, (2014) Read More / View Supplemental Materials
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Dissecting neural differentiation regulatory networks through epigenetic footprinting.Ziller, MJ, Edri R., Yaffe Y., Donaghey J., Pop R., Mallard W., Issner R., Gifford CA, Goren A., Xing J., Gu H., Cacchiarelli D., Tsankov AM, Epstein C., Rinn JL, Mikkelsen TS, Kohlbacher O., Gnirke A., Bernstein BE, Elkabetz Y., et al. Nature, 2014/12/24, (2014) Read More / View Supplemental Materials
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Genetic analysis of schizophrenia and bipolar disorder reveals polygenicity but also suggests new directions for molecular interrogation.Neale, BM, and Sklar P. Current opinion in neurobiology, 2014/12/24, Volume 30C, p.131-138, (2014) Read More / View Supplemental Materials
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The HLA-DRβ1 amino acid positions 11-13-26 explain the majority of SLE-MHC associations.Kim, K., Bang SY, Lee HS, Okada Y., Han B., Saw WY, Teo YY, and Bae SC Nature communications, 2014/12/23, Volume 5, p.5902, (2014) Read More / View Supplemental Materials
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Systematic identification of signaling pathways with potential to confer anticancer drug resistance.Martz, CA, Ottina KA, Singleton KR, Jasper JS, Wardell SE, Peraza-Penton A., Anderson GR, Winter PS, Wang T., Alley HM, Kwong LN, Cooper ZA, Tetzlaff M., Chen PL, Rathmell JC, Flaherty KT, Wargo JA, McDonnell DP, Sabatini DM, and Wood KC Science signaling, 2014/12/23, Volume 7, Issue 357, p.ra121, (2014) Read More / View Supplemental Materials
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The Genetic Ancestry of African Americans, Latinos, and European Americans across the United States.Bryc, K., Durand EY, Macpherson JM, Reich D., and Mountain JL American journal of human genetics, 2014/12/18, (2014) Read More / View Supplemental Materials
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Genetic Variants Associated with Quantitative Glucose Homeostasis Traits Translate to Type 2 Diabetes in Mexican Americans: The GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium.Palmer, ND, Goodarzi MO, Langefeld CD, Wang N., Guo X., Taylor KD, Fingerlin TE, Norris JM, Buchanan TA, Xiang AH, Haritunians T., Ziegler JT, Williams AH, Stefansovski D., Cui J., Mackay AW, Henkin LF, Bergman RN, Gao X., Gauderman J., et al. Diabetes, 2014/12/18, (2014) Read More / View Supplemental Materials
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High-resolution sequencing and modeling identifies distinct dynamic RNA regulatory strategies.Rabani, M., Raychowdhury R., Jovanovic M., Rooney M., Stumpo DJ, Pauli A., Hacohen N., Schier AF, Blackshear PJ, Friedman N., Amit I., and Regev A. Cell, 2014/12/18, Volume 159, Issue 7, p.1698-710, (2014) Read More / View Supplemental Materials
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X chromosome reactivation dynamics reveal stages of reprogramming to pluripotency.Pasque, V., Tchieu J., Karnik R., Uyeda M., Sadhu Dimashkie A., Case D., Papp B., Bonora G., Patel S., Ho R., Schmidt R., McKee R., Sado T., Tada T., Meissner A., and Plath K. Cell, 2014/12/18, Volume 159, Issue 7, p.1681-97, (2014) Read More / View Supplemental Materials
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Genetic Predisposition to Dyslipidemia and Risk of Preeclampsia.Spracklen, CN, Saftlas AF, Triche EW, Bjonnes A., Keating B., Saxena R., Breheny PJ, Dewan AT, Robinson JG, Hoh J., and Ryckman KK American journal of hypertension, 2014/12/17, (2014) Read More / View Supplemental Materials
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Katanin p80 Regulates Human Cortical Development by Limiting Centriole and Cilia Number.Hu, WF, Pomp O., Ben-Omran T., Kodani A., Henke K., Mochida GH, Yu TW, Woodworth MB, Bonnard C., Raj GS, Tan TT, Hamamy H., Masri A., Shboul M., Al Saffar M., Partlow JN, Al-Dosari M., Alazami A., Alowain M., Alkuraya FS, et al. Neuron, 2014/12/17, Volume 84, Issue 6, p.1240-57, (2014) Read More / View Supplemental Materials
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The study of psychiatric disease genes and drugs in zebrafish.Haesemeyer, M., and Schier AF Current opinion in neurobiology, 2014/12/16, Volume 30C, p.122-130, (2014) Read More / View Supplemental Materials
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Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma.Perry, JA, Kiezun A., Tonzi P., Van Allen EM, Carter SL, Baca SC, Cowley GS, Bhatt AS, Rheinbay E., Pedamallu CS, Helman E., Taylor-Weiner A., McKenna A., Deluca DS, Lawrence MS, Ambrogio L., Sougnez C., Sivachenko A., Walensky LD, Wagle N., et al. Proceedings of the National Academy of Sciences of the United States of America, 2014/12/15, (2014) Read More / View Supplemental Materials
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Computational Modeling Predicts IL-10 Control of Lesion Sterilization by Balancing Early Host Immunity-Mediated Antimicrobial Responses with Caseation during Mycobacterium tuberculosis Infection.Cilfone, NA, Ford CB, Marino S., Mattila JT, Gideon HP, Flynn JL, Kirschner DE, and Linderman JJ Journal of immunology (Baltimore, Md. : 1950), 2014/12/15, (2014) Read More / View Supplemental Materials
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De novo CNVs in bipolar affective disorder and schizophrenia.Georgieva, L., Rees E., Moran JL, Chambert KD, Milanova V., Craddock N., Purcell S., Sklar P., McCarroll S., Holmans P., O'Donovan MC, Owen MJ, and Kirov G. Human molecular genetics, 2014/12/15, Volume 23, Issue 24, p.6677-83, (2014) Read More / View Supplemental Materials
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Dilazep analogues for the study of equilibrative nucleoside transporters 1 and 2 (ENT1 and ENT2).Playa, H., Lewis TA, Ting A., Suh BC, Muñoz B., Matuza R., Passer BJ, Schreiber SL, and Buolamwini JK Bioorganic & medicinal chemistry letters, 2014/12/15, Volume 24, Issue 24, p.5801-4, (2014) Read More / View Supplemental Materials
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Genetic modifiers of EGFR dependence in non-small cell lung cancer.Sharifnia, T., Rusu V., Piccioni F., Bagul M., Imielinski M., Cherniack AD, Pedamallu CS, Wong B., Wilson FH, Garraway LA, Altshuler D., Golub T. R., Root DE, Subramanian A., and Meyerson M. Proceedings of the National Academy of Sciences of the United States of America, 2014/12/15, (2014) Read More / View Supplemental Materials
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Identification of nuclear hormone receptor pathways causing insulin resistance by transcriptional and epigenomic analysis.Kang, S., Tsai LT, Zhou Y., Evertts A., Xu S., Griffin MJ, Issner R., Whitton HJ, Garcia BA, Epstein CB, Mikkelsen TS, and Rosen ED Nature cell biology, 2014/12/15, (2014) Read More / View Supplemental Materials
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Pan-cancer network analysis identifies combinations of rare somatic mutations across pathways and protein complexes.Leiserson, MD, Vandin F., Wu H., Dobson JR, Eldridge JV, Thomas JL, Papoutsaki A., Kim Y., Niu B., McLellan M., Lawrence MS, Gonzalez-Perez A., Tamborero D., Cheng Y., Ryslik GA, Lopez-Bigas N., Getz G., Ding L., and Raphael BJ Nature genetics, 2014/12/15, (2014) Read More / View Supplemental Materials
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Core and region-enriched networks of behaviorally regulated genes and the singing genome.Whitney, O., Pfenning AR, Howard JT, Blatti CA, Liu F., Ward JM, Wang R., Audet JN, Kellis M., Mukherjee S., Sinha S., Hartemink AJ, West AE, and Jarvis ED Science (New York, N.Y.), 2014/12/12, Volume 346, Issue 6215, p.1256780, (2014) Read More / View Supplemental Materials
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Familial aggregation of arthritis-related diseases in seropositive and seronegative rheumatoid arthritis: a register-based case-control study in Sweden.Frisell, T., Hellgren K., Alfredsson L., Raychaudhuri S., Klareskog L., and Askling J. Annals of the rheumatic diseases, 2014/12/12, (2014) Read More / View Supplemental Materials
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A 3D Map of the Human Genome at Kilobase Resolution Reveals Principles of Chromatin Looping.Rao, SS, Huntley MH, Durand NC, Stamenova EK, Bochkov ID, Robinson JT, Sanborn AL, Machol I., Omer AD, Lander E. S., and Aiden EL Cell, 2014/12/11, (2014) Read More / View Supplemental Materials
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Integrating phenotypic small-molecule profiling and human genetics: the next phase in drug discovery.Johannessen, CM, Clemons PA, and Wagner BK Trends in genetics : TIG, 2014/12/11, (2014) Read More / View Supplemental Materials
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Single Diastereomer of a Macrolactam Core Binds Specifically to Myeloid Cell Leukemia 1 (MCL1).Fang, C., D'Souza B., Thompson CF, Clifton MC, Fairman JW, Fulroth B., Leed A., McCarren P., Wang L., Wang Y., Feau C., Kaushik VK, Palmer M., Wei G., Golub T. R., Hubbard BK, and Serrano-Wu MH ACS medicinal chemistry letters, 2014/12/11, Volume 5, Issue 12, p.1308-12, (2014) Read More / View Supplemental Materials
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Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex.Konermann, S., Brigham MD, Trevino AE, Joung J., Abudayyeh OO, Barcena C., Hsu PD, Habib N., Gootenberg JS, Nishimasu H., Nureki O., and Zhang F. Nature, 2014/12/10, (2014) Read More / View Supplemental Materials
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Genome-wide association study of kidney function decline in individuals of European descent.Gorski, M., Tin A., Garnaas M., McMahon GM, Chu AY, Tayo BO, Pattaro C., Teumer A., Chasman DI, Chalmers J., Hamet P., Tremblay J., Woodward M., Aspelund T., Eiriksdottir G., Gudnason V., Harris TB, Launer LJ, Smith AV, Mitchell BD, et al. Kidney international, 2014/12/10, (2014) Read More / View Supplemental Materials
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