Poeschla M, Arora UP, Walne A, et al. Polygenic modifiers impact penetrance and expressivity in telomere biology disorders. The Journal of clinical investigation. 2025. doi:10.1172/JCI191107DOIGoogle ScholarPubMed
Publications
Klemm N, Schimmer RR, Konrad NK, et al. The Prolonged Half-Life of the p53 Missense Variant R248Q Promotes Accumulation and Heterotetramer Formation with Wild-Type p53 to Exert the Dominant-Negative Effect. Cancer research. 2025;85(11):1978-1996. doi:10.1158/0008-5472.CAN-24-1136DOIGoogle ScholarPubMed
Flores AM, Ruan Y, Misra A, et al. Polygenic Prediction of Peripheral Artery Disease and Major Adverse Limb Events. JAMA cardiology. 2025. doi:10.1001/jamacardio.2025.1182DOIGoogle ScholarPubMed
Sim ES, Rhoades J, Xiong K, et al. Early Postoperative Minimal Residual Disease Detection with MAESTRO Is Associated with Recurrence and Worse Survival in Patients with Head and Neck Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2025:OF1-OF9. doi:10.1158/1078-0432.CCR-25-0307DOIGoogle ScholarPubMed
Bryan ME, Aye L, Das D, et al. Direct Comparison of Alternative Blood-Based Approaches for Early Detection and Diagnosis of HPV-Associated Head and Neck Cancers. Clinical cancer research : an official journal of the American Association for Cancer Research. 2025:OF1-OF11. doi:10.1158/1078-0432.CCR-24-2525DOIGoogle ScholarPubMed
Beck A, Gabler-Pamer L, Cruzeiro GAV, et al. Cellular hierarchies of embryonal tumors with multilayered rosettes are shaped by oncogenic microRNAs and receptor-ligand interactions. Nature cancer. 2025. doi:10.1038/s43018-025-00964-9DOIGoogle ScholarPubMed
Musunuru K, Grandinette S, Wang X, et al. Patient-Specific In Vivo Gene Editing to Treat a Rare Genetic Disease. The New England journal of medicine. 2025. doi:10.1056/NEJMoa2504747DOIGoogle ScholarPubMed
Geady C, Bannon JJ, Reza S, et al. Measured intrapatient radiomic variability as a predictor of treatment response in multi-metastatic soft tissue sarcoma patients. medRxiv : the preprint server for health sciences. 2025. doi:10.1101/2025.04.11.25325700DOIGoogle ScholarPubMed
Matuszek Żaneta, Arbab M, Kesavan M, et al. Base editing of trinucleotide repeats that cause Huntington’s disease and Friedreich’s ataxia reduces somatic repeat expansions in patient cells and in mice. Nature genetics. 2025. doi:10.1038/s41588-025-02172-8DOIGoogle ScholarPubMed
Nandy A, Petralia F, Porter CK, et al. Epstein-Barr Virus Exposure Precedes Crohn’s Disease Development. Gastroenterology. 2025. doi:10.1053/j.gastro.2025.01.247DOIGoogle ScholarPubMed