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2016
From Mutational Mechanisms in Single Cells to Mutational Patterns in Cancer Genomes.Zhang, CZ, and Pellman D. Cold Spring Harbor symposia on quantitative biology, 2016/03/11, (2016) Read More / View Supplemental Materials
Abstract
Illumina error profiles: resolving fine-scale variation in metagenomic sequencing data.Schirmer, M., D'Amore R., Ijaz UZ, Hall N., and Quince C. BMC bioinformatics, 2016/03/11, Volume 17, Issue 1, p.125, (2016) Read More / View Supplemental Materials
Abstract
Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease.Zanoni, P., Khetarpal SA, Larach DB, Hancock-Cerutti WF, Millar JS, Cuchel M., DerOhannessian S., Kontush A., Surendran P., Saleheen D., Trompet S., Jukema JW, De Craen A., Deloukas P., Sattar N., Ford I., Packard C., Majumder Aa, Alam DS, Di Angelantonio E., et al. Science (New York, N.Y.), 2016/03/11, Volume 351, Issue 6278, p.1166-71, (2016) Read More / View Supplemental Materials
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Use of the MS2 aptamer and coat protein for RNA localization in yeast: A response to "MS2 coat proteins bound to yeast mRNAs block 5' to 3' degradation and trap mRNA decay products: implications for the localization of mRNAs by MS2-MCP system".Haimovich, G., Zabezhinsky D., Haas B., Slobodin B., Purushothaman P., Fan L., Levin JZ, Nusbaum C., and Gerst JE RNA (New York, N.Y.), 2016/03/11, (2016) Read More / View Supplemental Materials
Abstract
Genome-wide association analysis identifies novel loci for chronotype in 100,420 individuals from the UK Biobank.Lane, JM, Vlasac I., Anderson SG, Kyle SD, Dixon WG, Bechtold DA, Gill S., Little MA, Luik A., Loudon A., Emsley R., Scheer FA, Lawlor DA, Redline S., Ray DW, Rutter MK, and Saxena R. Nature communications, 2016/03/09, Volume 7, p.10889, (2016) Read More / View Supplemental Materials
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Protective Effects of the Mediterranean Diet on Type 2 Diabetes and Metabolic Syndrome.Salas-Salvadó, J., Guasch-Ferré M., Lee CH, Estruch R., Clish CB, and Ros E. The Journal of nutrition, 2016/03/09, (2016) Read More / View Supplemental Materials
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Regulation of the fetal hemoglobin silencing factor BCL11A.Basak, A., and Sankaran VG Annals of the New York Academy of Sciences, 2016/03/09, (2016) Read More / View Supplemental Materials
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The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway.Chantranupong, L., Scaria SM, Saxton RA, Gygi MP, Shen K., Wyant GA, Wang T., Harper JW, Gygi SP, and Sabatini DM Cell, 2016/03/08, (2016) Read More / View Supplemental Materials
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Height, body mass index, and socioeconomic status: mendelian randomisation study in UK Biobank.Tyrrell, J., Jones SE, Beaumont R., Astley CM, Lovell R., Yaghootkar H., Tuke M., Ruth KS, Freathy RM, Hirschhorn JN, Wood AR, Murray A., Weedon MN, and Frayling TM BMJ (Clinical research ed.), 2016/03/08, Volume 352, p.i582, (2016) Read More / View Supplemental Materials
Abstract
System-wide Analysis of the T Cell Response.Covacu, R., Philip H., Jaronen M., Almeida J., Kenison JE, Darko S., Chao CC, Yaari G., Louzoun Y., Carmel L., Douek DC, Efroni S., and Quintana FJ Cell reports, 2016/03/08, (2016) Read More / View Supplemental Materials
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Twenty-eight genetic loci associated with ST-T wave amplitudes of the electrocardiogram.Verweij, N., Mateo Leach I., Isaacs A., Arking DE, Bis JC, Pers TH, van den Berg ME, Lyytikäinen LP, Barnett P., Wang X., study LifeLines Cohort, Soliman EZ, van Duijn CM, Kähönen M., van Veldhuisen DJ, Kors JA, Raitakari OT, Silva CT, Lehtimäki T., Hillege HL, et al. Human molecular genetics, 2016/03/08, (2016) Read More / View Supplemental Materials
Abstract
Impaired antibacterial autophagy links granulomatous intestinal inflammation in Niemann-Pick disease type C1 and XIAP deficiency with NOD2 variants in Crohn's disease.Schwerd, T., Pandey S., Yang HT, Bagola K., Jameson E., Jung J., Lachmann RH, Shah N., Patel SY, Booth C., Runz H., Düker G., Bettels R., Rohrbach M., Kugathasan S., Chapel H., Keshav S., Elkadri A., Platt N., Muise AM, et al. Gut, 2016/03/07, (2016) Read More / View Supplemental Materials
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The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons.Braasch, I., Gehrke AR, Smith JJ, Kawasaki K., Manousaki T., Pasquier J., Amores A., Desvignes T., Batzel P., Catchen J., Berlin AM, Campbell MS, Barrell D., Martin KJ, Mulley JF, Ravi V., Lee AP, Nakamura T., Chalopin D., Fan S., et al. Nature genetics, 2016/03/07, (2016) Read More / View Supplemental Materials
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Tissue-specific regulatory circuits reveal variable modular perturbations across complex diseases.Marbach, D., Lamparter D., Quon G., Kellis M., Kutalik Z., and Bergmann S. Nature methods, 2016/03/07, (2016) Read More / View Supplemental Materials
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Genome sequencing of the phytoseiid predatory mite Metaseiulus occidentalis reveals completely atomised Hox genes and super-dynamic intron evolution.Hoy, MA, Waterhouse RM, Wu K., Estep AS, Ioannidis P., Palmer WJ, Pomerantz AF, Simão FA, Thomas J., Jiggins FM, Murphy TD, Pritham EJ, Robertson HM, Zdobnov EM, Gibbs RA, and Richards S. Genome biology and evolution, 2016/03/06, (2016) Read More / View Supplemental Materials
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Comparative genomics and prediction of conditionally dispensable sequences in legume-infecting Fusarium oxysporum formae speciales facilitates identification of candidate effectors.Williams, AH, Sharma M., Thatcher LF, Azam S., Hane JK, Sperschneider J., Kidd BN, Anderson JP, Ghosh R., Garg G., Lichtenzveig J., Kistler HC, Shea T., Young S., Buck SA, Kamphuis LG, Saxena R., Pande S., Ma LJ, Varshney RK, et al. BMC genomics, 2016/03/05, Volume 17, Issue 1, p.191, (2016) Read More / View Supplemental Materials
Abstract
Evaluation of DISCOVAR de novo using a mosquito sample for cost-effective short-read genome assembly.Love, RR, Weisenfeld NI, Jaffe DB, Besansky NJ, and Neafsey DE BMC genomics, 2016/03/05, Volume 17, Issue 1, p.187, (2016) Read More / View Supplemental Materials
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Reproducibility of Differential Proteomic Technologies in CPTAC Fractionated Xenografts.Tabb, DL, Wang X., Carr SA, Clauser KR, Mertins P., Chambers MC, Holman JD, Wang J., Zhang B., Zimmerman LJ, Chen X., Gunawardena HP, Davies SR, Ellis MJ, Li S., Townsend RR, Boja ES, Ketchum KA, Kinsinger CR, Mesri M., et al. Journal of proteome research, 2016/03/04, Volume 15, Issue 3, p.691-706, (2016) Read More / View Supplemental Materials
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Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade.McGranahan, N., Furness AJ, Rosenthal R., Ramskov S., Lyngaa R., Saini SK, Jamal-Hanjani M., Wilson GA, Birkbak NJ, Hiley CT, Watkins TB, Shafi S., Murugaesu N., Mitter R., Akarca AU, Linares J., Marafioti T., Henry JY, Van Allen EM, Miao D., et al. Science (New York, N.Y.), 2016/03/03, (2016) Read More / View Supplemental Materials
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CRISPR-Cas9 Targeting of PCSK9 in Human Hepatocytes In Vivo.Wang, X., Raghavan A., Chen T., Qiao L., Zhang Y., Ding Q., and Musunuru K. Arteriosclerosis, thrombosis, and vascular biology, 2016/03/03, (2016) Read More / View Supplemental Materials
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Draft Genome Sequences of Two Extensively Drug-Resistant Strains of Mycobacterium tuberculosis Belonging to the Euro-American S Lineage.Malinga, LA, Abeel T., Desjardins CA, Dlamini TC, Cassell G., Chapman SB, Birren BW, Earl AM, and van der Walt M. Genome announcements, 2016/03/03, Volume 4, Issue 2, (2016) Read More / View Supplemental Materials
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Fast Principal-Component Analysis Reveals Convergent Evolution of ADH1B in Europe and East Asia.Galinsky, KJ, Bhatia G., Loh PR, Georgiev S., Mukherjee S., Patterson NJ, and Price AL American journal of human genetics, 2016/03/03, Volume 98, Issue 3, p.456-72, (2016) Read More / View Supplemental Materials
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Health and population effects of rare gene knockouts in adult humans with related parents.Narasimhan, VM, Hunt KA, Mason D., Baker CL, Karczewski KJ, Barnes MR, Barnett AH, Bates C., Bellary S., Bockett NA, Giorda K., Griffiths CJ, Hemingway H., Jia Z., Kelly MA, Khawaja HA, Lek M., McCarthy S., McEachan R., O'Donnell-Luria A., et al. Science (New York, N.Y.), 2016/03/03, (2016) Read More / View Supplemental Materials
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High-fat diet enhances stemness and tumorigenicity of intestinal progenitors.Beyaz, S., Mana MD, Roper J., Kedrin D., Saadatpour A., Hong SJ, Bauer-Rowe KE, Xifaras ME, Akkad A., Arias E., Pinello L., Katz Y., Shinagare S., Abu-Remaileh M., Mihaylova MM, Lamming DW, Dogum R., Guo G., Bell GW, Selig M., et al. Nature, 2016/03/03, Volume 531, Issue 7592, p.53-8, (2016) Read More / View Supplemental Materials
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Steady-state and dynamic gene expression programs in Saccharomyces cerevisiae in response to variation in environmental nitrogen.Airoldi, EM, Miller D., Athanasiadou R., Brandt N., Abdul-Rhaman F., Neymotin B., Hashimoto T., Bahmani T., and Gresham D. Molecular biology of the cell, 2016/03/03, (2016) Read More / View Supplemental Materials
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Glioma Genomics and Epigenomics: Arriving at the Start and Knowing it for the First Time.Filbin, MG, and Suvà ML Annual review of pathology, 2016/03/02, (2016) Read More / View Supplemental Materials
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A homozygous nonsense mutation in SGCA is a common cause of LGMD in Assiut, Egypt.Reddy, HM, Hamed SA, Lek M., Mitsuhashi S., Estrella E., Jones MD, Mahoney LJ, Duncan AR, Cho K., Macarthur DG, Kunkel LM, and Kang PB Muscle & nerve, 2016/03/02, (2016) Read More / View Supplemental Materials
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Multilevel Genomics-Based Taxonomy of Renal Cell Carcinoma.Chen, F., Zhang Y., Şenbabaoğlu Y., Ciriello G., Yang L., Reznik E., Shuch B., Micevic G., De Velasco G., Shinbrot E., Noble MS, Lu Y., Covington KR, Xi L., Drummond JA, Muzny D., Kang H., Lee J., Tamboli P., Reuter V., et al. Cell reports, 2016/03/02, (2016) Read More / View Supplemental Materials
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An Analysis of the Sensitivity of Proteogenomic Mapping of Somatic Mutations and Novel Splicing Events in Cancer.Ruggles, KV, Tang Z., Wang X., Grover H., Askenazi M., Teubl J., Cao S., McLellan MD, Clauser KR, Tabb DL, Mertins P., Slebos R., Erdmann-Gilmore P., Li S., Gunawardena HP, Xie L., Liu T., Zhou JY, Sun S., Hoadley KA, et al. Molecular & cellular proteomics : MCP, 2016/03/01, Volume 15, Issue 3, p.1060-71, (2016) Read More / View Supplemental Materials
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Autoimmune diseases - connecting risk alleles with molecular traits of the immune system.Gutierrez-Arcelus, M., Rich SS, and Raychaudhuri S. Nature reviews. Genetics, 2016/03/01, Volume 17, Issue 3, p.160-74, (2016) Read More / View Supplemental Materials
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Bridging the gap between real-life data and simulated data by providing a highly realistic fall dataset for evaluating camera-based fall detection algorithms.Baldewijns, G., Debard G., Mertes G., Vanrumste B., and Croonenborghs T. Healthcare technology letters, 2016/03/01, Volume 3, Issue 1, p.6-11, (2016) Read More / View Supplemental Materials
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Exome arrays capture polygenic rare variant contributions to schizophrenia.Richards, AL, Leonenko G., Walters JT, Kavanagh DH, Rees EG, Evans A., Chambert KD, Moran JL, Goldstein J., Neale BM, McCarroll SA, Pocklington AJ, Holmans PA, Owen MJ, and O'Donovan MC Human molecular genetics, 2016/03/01, Volume 25, Issue 5, p.1001-7, (2016) Read More / View Supplemental Materials
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Found in Translation: A Type 1 Diabetes Genetic Risk Score Applied to Clinical Diagnosis.Florez, JC Diabetes care, 2016/03/01, Volume 39, Issue 3, p.330-2, (2016) Read More / View Supplemental Materials
Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept.Franke, B., Stein JL, Ripke S., Anttila V., Hibar DP, van Hulzen KJ, Arias-Vasquez A., Smoller JW, Nichols TE, Neale MC, McIntosh AM, Lee P., McMahon FJ, Meyer-Lindenberg A., Mattheisen M., Andreassen OA, Gruber O., Sachdev PS, Roiz-Santiañez R., Saykin AJ, et al. Nature neuroscience, 2016/03/01, Volume 19, Issue 3, p.420-31, (2016) Read More / View Supplemental Materials
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Large-Scale Single Guide RNA Library Construction and Use for CRISPR-Cas9-Based Genetic Screens.Wang, T., Lander E. S., and Sabatini DM Cold Spring Harbor protocols, 2016/03/01, Volume 2016, Issue 3, p.pdb.top086892, (2016) Read More / View Supplemental Materials
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O-011 Paneth Cell Phenotypes Define a Subtype of Pediatric Crohn's Disease Through Alterations in Host-Microbial Interactions.Liu, TC, Gurram B., Baldridge M., Head R., Lam V., Luo C., Cao Y., Simpson P., Hayward M., Holtz M., Noe J., Lerner D., Cabrera J., Biank V., Stephens M., Huttenhower C., McGovern D., Xavier R., Stappenbeck T., and Salzman N. Inflammatory bowel diseases, 2016/03/01, Volume 22 Suppl 1, p.S4, (2016) Read More / View Supplemental Materials
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Populations of latent Mycobacterium tuberculosis lack a cell wall: Isolation, visualization, and whole-genome characterization.Velayati, AA, Abeel T., Shea T., Konstantinovich Zhavnerko G., Birren B., Cassell GH, Earl AM, Hoffner S., and Farnia P. International journal of mycobacteriology, 2016/03/01, Volume 5, Issue 1, p.66-73, (2016) Read More / View Supplemental Materials
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Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by S100A8 and S100A9.Schneider, RK, Schenone M., Ferreira MV, Kramann R., Joyce CE, Hartigan C., Beier F., Brümmendorf TH, Germing U., Platzbecker U., Büsche G., Knüchel R., Chen MC, Waters CS, Chen E., Chu LP, Novina CD, Lindsley RC, Carr SA, and Ebert BL Nature medicine, 2016/03/01, Volume 22, Issue 3, p.288-97, (2016) Read More / View Supplemental Materials
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Single Guide RNA Library Design and Construction.Wang, T., Lander E. S., and Sabatini DM Cold Spring Harbor protocols, 2016/03/01, Volume 2016, Issue 3, p.pdb.prot090803, (2016) Read More / View Supplemental Materials
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Spatially resolved proteomic mapping in living cells with the engineered peroxidase APEX2.Hung, V., Udeshi ND, Lam SS, Loh KH, Cox KJ, Pedram K., Carr SA, and Ting AY Nature protocols, 2016/03/01, Volume 11, Issue 3, p.456-75, (2016) Read More / View Supplemental Materials
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Transforming Clinical Data into Actionable Prognosis Models: Machine-Learning Framework and Field-Deployable App to Predict Outcome of Ebola Patients.Colubri, A., Silver T., Fradet T., Retzepi K., Fry B., and Sabeti P. PLoS neglected tropical diseases, 2016/03/01, Volume 10, Issue 3, p.e0004549, (2016) Read More / View Supplemental Materials
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Viral Packaging and Cell Culture for CRISPR-Based Screens.Wang, T., Lander E. S., and Sabatini DM Cold Spring Harbor protocols, 2016/03/01, Volume 2016, Issue 3, p.pdb.prot090811, (2016) Read More / View Supplemental Materials
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Electroconvulsive therapy suppresses the neurotoxic branch of the kynurenine pathway in treatment-resistant depressed patients.Schwieler, L., Samuelsson M., Frye MA, Bhat M., Schuppe-Koistinen I., Jungholm O., Johansson AG, Landén M., Sellgren CM, and Erhardt S. Journal of neuroinflammation, 2016/02/29, Volume 13, Issue 1, p.51, (2016) Read More / View Supplemental Materials
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High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines.Yu, C., Mannan AM, Yvone GM, Ross KN, Zhang YL, Marton MA, Taylor BR, Crenshaw A., Gould JZ, Tamayo P., Weir BA, Tsherniak A., Wong B., Garraway LA, Shamji AF, Palmer MA, Foley MA, Winckler W., Schreiber SL, Kung AL, et al. Nature biotechnology, 2016/02/29, (2016) Read More / View Supplemental Materials
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New Regulatory Roles of Galectin-3 in the High-affinity IgE Receptor Signaling.Bambouskova, M., Polakovicova I., Halova I., Goel G., Draberova L., Bugajev V., Doan A., Utekal P., Gardet A., Xavier RJ, and Draber P. Molecular and cellular biology, 2016/02/29, (2016) Read More / View Supplemental Materials
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Strictly co-isogenic C57BL/6J-Prnp-/- mice: A rigorous resource for prion science.Nuvolone, M., Hermann M., Sorce S., Russo G., Tiberi C., Schwarz P., Minikel E., Sanoudou D., Pelczar P., and Aguzzi A. The Journal of experimental medicine, 2016/02/29, (2016) Read More / View Supplemental Materials
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Fibroblast growth factor receptor 2 expression, but not its genetic amplification, is associated with tumor growth and worse survival in esophagogastric junction adenocarcinoma.Tokunaga, R., Imamura Y., Nakamura K., Ishimoto T., Nakagawa S., Miyake K., Nakaji Y., Tsuda Y., Iwatsuki M., Baba Y., Sakamoto Y., Miyamoto Y., Saeki H., Yoshida N., Oki E., Watanabe M., Oda Y., Bass AJ, Maehara Y., and Baba H. Oncotarget, 2016/02/27, (2016) Read More / View Supplemental Materials
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MicroRNA and gene expression changes in unruptured human cerebral aneurysms.Bekelis, K., Kerley-Hamilton JS, Teegarden A., Tomlinson CR, Kuintzle R., Simmons N., Singer RJ, Roberts DW, Kellis M., and Hendrix DA Journal of neurosurgery, 2016/02/26, p.1-10, (2016) Read More / View Supplemental Materials
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A polyalanine peptide derived from polar fish with anti-infectious activities.Cardoso, MH, Ribeiro SM, Nolasco DO, de la Fuente-Núñez C., Felício MR, Gonçalves S., Matos CO, Liao LM, Santos NC, Hancock RE, Franco OL, and Migliolo L. Scientific reports, 2016/02/26, Volume 6, p.21385, (2016) Read More / View Supplemental Materials
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VariantBam: filtering and profiling of next-generational sequencing data using region-specific rules.Wala, J., Zhang CZ, Meyerson M., and Beroukhim R. Bioinformatics (Oxford, England), 2016/02/26, (2016) Read More / View Supplemental Materials
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EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection.Olenchock, BA, Moslehi J., Baik AH, Davidson SM, Williams J., Gibson WJ, Pierce KA, Miller CM, Hanse EA, Kelekar A., Sullivan LB, Wagers AJ, Clish CB, Vander Heiden MG, and Kaelin WG Jr Cell, 2016/02/25, Volume 164, Issue 5, p.884-95, (2016) Read More / View Supplemental Materials
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Hypoxia as a therapy for mitochondrial disease.Jain, IH, Zazzeron L., Goli R., Alexa K., Schatzman-Bone S., Dhillon H., Goldberger O., Peng J., Shalem O., Sanjana NE, Zhang F., Goessling W., Zapol WM, and Mootha VK Science (New York, N.Y.), 2016/02/25, (2016) Read More / View Supplemental Materials
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Reducing Cardiovascular Risk Using Genomic Information in the Era of Precision Medicine.Natarajan, P., and O'Donnell CJ Circulation, 2016/02/25, (2016) Read More / View Supplemental Materials
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Buying cures versus renting health: Financing health care with consumer loans.Montazerhodjat, V., Weinstock DM, and Lo AW Science translational medicine, 2016/02/24, Volume 8, Issue 327, p.327ps6, (2016) Read More / View Supplemental Materials
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Acute Metabolic Influences on the Natriuretic Peptide System in Humans.Arora, P., Wu C., Hamid T., Arora G., Agha O., Allen K., Tainsh RE, Hu D., Ryan RA, Domian IJ, Buys ES, Bloch DB, Prabhu SD, Bloch KD, Newton-Cheh C., and Wang TJ Journal of the American College of Cardiology, 2016/02/23, Volume 67, Issue 7, p.804-12, (2016) Read More / View Supplemental Materials
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Polygenic risk for type 2 diabetes mellitus among individuals with psychosis and their relatives.Padmanabhan, JL, Nanda P., Tandon N., Mothi SS, Bolo N., McCarroll S., Clementz BA, Gershon ES, Pearlson GD, Sweeney JA, Tamminga CA, and Keshavan MS Journal of psychiatric research, 2016/02/23, Volume 77, p.52-58, (2016) Read More / View Supplemental Materials
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Precision medicine for advanced prostate cancer.Mullane, SA, and Van Allen EM Current opinion in urology, 2016/02/23, (2016) Read More / View Supplemental Materials
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Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms.Horikoshi, M., Pasquali L., Wiltshire S., Huyghe JR, Mahajan A., Asimit JL, Ferreira T., Locke AE, Robertson NR, Wang X., Sim X., Fujita H., Hara K., Young R., Zhang W., Choi S., Chen H., Kaur I., Takeuchi F., Fontanillas P., et al. Human molecular genetics, 2016/02/23, (2016) Read More / View Supplemental Materials
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Chemoproteomic profiling of host and pathogen enzymes active in cholera.Hatzios, SK, Abel S., Martell J., Hubbard T., Sasabe J., Munera D., Clark L., Bachovchin DA, Qadri F., Ryan ET, Davis BM, Weerapana E., and Waldor MK Nature chemical biology, 2016/02/22, (2016) Read More / View Supplemental Materials
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Gene co-expression analysis identifies brain regions and cell types involved in migraine pathophysiology: a GWAS-based study using the Allen Human Brain Atlas.Eising, E., Huisman SM, Mahfouz A., Vijfhuizen LS, Anttila V., Winsvold BS, Kurth T., Ikram MA, Freilinger T., Kaprio J., Boomsma DI, van Duijn CM, Järvelin MR, Zwart JA, Quaye L., Strachan DP, Kubisch C., Dichgans M., Davey Smith G., Stefansson K., et al. Human genetics, 2016/02/22, (2016) Read More / View Supplemental Materials
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Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.Ma, L., Chen Z., Huang da W., Kutty G., Ishihara M., Wang H., Abouelleil A., Bishop L., Davey E., Deng R., Deng X., Fan L., Fantoni G., FitzGerald M., Gogineni E., Goldberg JM, Handley G., Hu X., Huber C., Jiao X., et al. Nature communications, 2016/02/22, Volume 7, p.10740, (2016) Read More / View Supplemental Materials
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Natural variation in non-coding regions underlying phenotypic diversity in budding yeast.Salinas, F., de Boer CG, Abarca V., García V., Cuevas M., Araos S., Larrondo LF, Martínez C., and Cubillos FA Scientific reports, 2016/02/22, Volume 6, p.21849, (2016) Read More / View Supplemental Materials
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Nonparametric estimation of the rediscovery rate.Lee, D., Ganna A., Pawitan Y., and Lee W. Statistics in medicine, 2016/02/22, (2016) Read More / View Supplemental Materials
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Recurring exon deletions in the HP (haptoglobin) gene contribute to lower blood cholesterol levels.Boettger, LM, Salem RM, Handsaker RE, Peloso GM, Kathiresan S., Hirschhorn JN, and McCarroll SA Nature genetics, 2016/02/22, (2016) Read More / View Supplemental Materials
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Transcriptome-scale RNase-footprinting of RNA-protein complexes.Ji, Z., Song R., Huang H., Regev A., and Struhl K. Nature biotechnology, 2016/02/22, (2016) Read More / View Supplemental Materials
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A general framework for meta-analyzing dependent studies with overlapping subjects in association mapping.Han, B., Duong D., Sul JH, de Bakker PI, Eskin E., and Raychaudhuri S. Human molecular genetics, 2016/02/21, (2016) Read More / View Supplemental Materials
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Testing the Role of Predicted Gene Knockouts in Human Anthropometric Trait Variation.Lessard, S., Manning AK, Low-Kam C., Auer PL, Giri A., Graff M., Schurmann C., Yaghootkar H., Luan J., Esko T., Karaderi T., NHLBI GO Exome Sequence Project, GOT2D, T2D-GENES, GIANT Consortium, Bottinger EP, Lu Y., Carlson C., Caulfield M., Dubé MP, et al. Human molecular genetics, 2016/02/21, (2016) Read More / View Supplemental Materials
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Developing a system that can automatically detect health changes using transfer times of older adults.Baldewijns, G., Luca S., Vanrumste B., and Croonenborghs T. BMC medical research methodology, 2016/02/20, Volume 16, Issue 1, p.23, (2016) Read More / View Supplemental Materials
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Intravenous leiomyomatosis: an unusual intermediate between benign and malignant uterine smooth muscle tumors.Ordulu, Z., Nucci MR, Dal Cin P., Hollowell ML, Otis CN, Hornick JL, Park PJ, Kim TM, Quade BJ, and Morton CC Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2016/02/19, (2016) Read More / View Supplemental Materials
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An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in β-Cell Protection.Wagner, FF, Lundh M., Kaya T., McCarren P., Zhang YL, Chattopadhyay S., Gale JP, Galbo T., Fisher SL, Meier BC, Vetere A., Richardson S., Morgan NG, Christensen DP, Gilbert TJ, Hooker JM, Leroy M., Walpita D., Mandrup-Poulsen T., Wagner BK, et al. ACS chemical biology, 2016/02/19, Volume 11, Issue 2, p.363-74, (2016) Read More / View Supplemental Materials
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Surprises From Genetic Analyses of Lipid Risk Factors for Atherosclerosis.Musunuru, K., and Kathiresan S. Circulation research, 2016/02/19, Volume 118, Issue 4, p.579-85, (2016) Read More / View Supplemental Materials
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Early-branching gut fungi possess a large, comprehensive array of biomass-degrading enzymes.Solomon, KV, Haitjema CH, Henske JK, Gilmore SP, Borges-Rivera D., Lipzen A., Brewer HM, Purvine SO, Wright AT, Theodorou MK, Grigoriev IV, Regev A., Thompson DA, and O'Malley MA Science (New York, N.Y.), 2016/02/18, (2016) Read More / View Supplemental Materials
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Visualizing antibody affinity maturation in germinal centers.Tas, JM, Mesin L., Pasqual G., Targ S., Jacobsen JT, Mano YM, Chen CS, Weill JC, Reynaud CA, Browne EP, Meyer-Hermann M., and Victora GD Science (New York, N.Y.), 2016/02/18, (2016) Read More / View Supplemental Materials
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Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints.Koyama, S., Akbay EA, Li YY, Herter-Sprie GS, Buczkowski KA, Richards W. G., Gandhi L., Redig AJ, Rodig SJ, Asahina H., Jones RE, Kulkarni MM, Kuraguchi M., Palakurthi S., Fecci PE, Johnson B. E., Janne PA, Engelman JA, Gangadharan SP, Costa DB, et al. Nature communications, 2016/02/17, Volume 7, p.10501, (2016) Read More / View Supplemental Materials
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Adult restoration of Shank3 expression rescues selective autistic-like phenotypes.Mei, Y., Monteiro P., Zhou Y., Kim JA, Gao X., Fu Z., and Feng G. Nature, 2016/02/17, (2016) Read More / View Supplemental Materials
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Impaired Dendritic Development and Memory in Sorbs2 Knock-Out Mice.Zhang, Q., Gao X., Li C., Feliciano C., Wang D., Zhou D., Mei Y., Monteiro P., Anand M., Itohara S., Dong X., Fu Z., and Feng G. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016/02/17, Volume 36, Issue 7, p.2247-60, (2016) Read More / View Supplemental Materials
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Molecular features of cellular reprogramming and development.Smith, ZD, Sindhu C., and Meissner A. Nature reviews. Molecular cell biology, 2016/02/17, (2016) Read More / View Supplemental Materials
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Plasma Branched-Chain Amino Acids and Incident Cardiovascular Disease in the PREDIMED Trial.Ruiz-Canela, M., Toledo E., Clish CB, Hruby A., Liang L., Salas-Salvadó J., Razquin C., Corella D., Estruch R., Ros E., Fitó M., Gómez-Gracia E., Arós F., Fiol M., Lapetra J., Serra-Majem L., Martínez-González MA, and Hu FB Clinical chemistry, 2016/02/17, (2016) Read More / View Supplemental Materials
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Reclassification of genetic-based risk predictions as GWAS data accumulate.Krier, J., Barfield R., Green RC, and Kraft P. Genome medicine, 2016/02/17, Volume 8, Issue 1, p.20, (2016) Read More / View Supplemental Materials
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Sub-clinical detection of gut microbial biomarkers of obesity and type 2 diabetes.Yassour, M., Lim MY, Yun HS, Tickle TL, Sung J., Song YM, Lee K., Franzosa EA, Morgan XC, Gevers D., Lander E. S., Xavier RJ, Birren BW, Ko G., and Huttenhower C. Genome medicine, 2016/02/17, Volume 8, Issue 1, p.17, (2016) Read More / View Supplemental Materials
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Altered drug susceptibility during host adaptation of a Plasmodium falciparum strain in a non-human primate model.Obaldía Iii, N., Dow GS, Gerena L., Kyle D., Otero W., Mantel PY, Baro N., Daniels R., Mukherjee A., Childs LM, Buckee C., Duraisingh MT, Volkman SK, Wirth DF, and Marti M. Scientific reports, 2016/02/16, Volume 6, p.21216, (2016) Read More / View Supplemental Materials
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Response to Letter Regarding Article, "Trauma Exposure and Posttraumatic Stress Disorder Symptoms Predict Onset of Cardiovascular Events in Women".Sumner, JA, Kubzansky LD, Elkind MS, Roberts AL, Agnew-Blais J., Chen Q., Cerdá M., Rexrode KM, Rich-Edwards JW, Spiegelman D., Suglia SF, Rimm EB, and Koenen KC Circulation, 2016/02/16, Volume 133, Issue 7, p.e401-2, (2016) Read More / View Supplemental Materials
Truncating PREX2 mutations activate its GEF activity and alter gene expression regulation in NRAS-mutant melanoma.Lissanu Deribe, Y., Shi Y., Rai K., Nezi L., Amin SB, Wu CC, Akdemir KC, Mahdavi M., Peng Q., Chang QE, Hornigold K., Arold ST, Welch HC, Garraway LA, and Chin L. Proceedings of the National Academy of Sciences of the United States of America, 2016/02/16, (2016) Read More / View Supplemental Materials
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Type 2 Diabetes Genetic Predisposition, Obesity, and All-Cause Mortality Risk in the U.S.: A Multiethnic Analysis.Leong, A., Porneala B., Dupuis J., Florez JC, and Meigs JB Diabetes care, 2016/02/16, (2016) Read More / View Supplemental Materials
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Widespread RNA binding by chromatin-associated proteins.Hendrickson, DG, Kelley DR, Tenen D., Bernstein B., and Rinn JL Genome biology, 2016/02/16, Volume 17, Issue 1, p.28, (2016) Read More / View Supplemental Materials
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Cannabinoid receptor signaling regulates liver development and metabolism.Liu, LY, Alexa K., Cortes M., Schatzman-Bone S., Kim AJ, Mukhopadhyay B., Cinar R., Kunos G., North TE, and Goessling W. Development (Cambridge, England), 2016/02/15, Volume 143, Issue 4, p.609-22, (2016) Read More / View Supplemental Materials
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Gene expression inference with deep learning.Chen, Y., Li Y., Narayan R., Subramanian A., and Xie X. Bioinformatics (Oxford, England), 2016/02/11, (2016) Read More / View Supplemental Materials
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Impact of common diabetes risk variant in MTNR1B on sleep, circadian and melatonin physiology.Lane, JM, Chang AM, Bjonnes AC, Aeschbach D., Anderson C., Cade BE, Cain SW, Czeisler CA, Gharib SA, Gooley JJ, Gottlieb DJ, Grant SF, Klerman EB, Lauderdale DS, Lockley SW, Munch M., Patel S., Punjabi NM, Rajaratnam SM, Rueger M., et al. Diabetes, 2016/02/11, (2016) Read More / View Supplemental Materials
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Integrated genomic approaches identify upregulation of SCRN1 as a novel mechanism associated with acquired resistance to erlotinib in PC9 cells harboring oncogenic EGFR mutation.Kim, N., Cho A., Watanabe H., Choi YL, Aziz M., Kassner M., Joung JG, Park AK, Francis JM, Bae JS, Ahn SM, Kim KM, Park JO, Park WY, Ahn MJ, Park K., Koo J., Yin HH, and Cho J. Oncotarget, 2016/02/11, (2016) Read More / View Supplemental Materials
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MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells.Kryukov, GV, Wilson FH, Ruth JR, Paulk J., Tsherniak A., Marlow SE, Vazquez F., Weir BA, Fitzgerald ME, Tanaka M., Bielski CM, Scott JM, Dennis C., Cowley GS, Boehm JS, Root DE, Golub T. R., Clish CB, Bradner JE, Hahn WC, et al. Science (New York, N.Y.), 2016/02/11, (2016) Read More / View Supplemental Materials
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Oncologists' and cancer patients' views on whole-exome sequencing and incidental findings: results from the CanSeq study.Gray, SW, Park ER, Najita J., Martins Y., Traeger L., Bair E., Gagne J., Garber J., Jänne PA, Lindeman N., Lowenstein C., Oliver N., Van Allen EM, Wagle N., Garraway L., and Joffe S. Genetics in medicine : official journal of the American College of Medical Genetics, 2016/02/11, (2016) Read More / View Supplemental Materials
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Schizophrenia risk from complex variation of complement component 4.Sekar, A., Bialas AR, de Rivera H., Davis A., Hammond TR, Kamitaki N., Tooley K., Presumey J., Baum M., Van Doren V., Genovese G., Rose SA, Handsaker RE, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Daly M. J., Carroll MC, Stevens B., and McCarroll SA Nature, 2016/02/11, Volume 530, Issue 7589, p.177-83, (2016) Read More / View Supplemental Materials
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Targeting BRCA1- and BRCA2-deficient cells with RAD52 small molecule inhibitors.Huang, F., Goyal N., Sullivan K., Hanamshet K., Patel M., Mazina OM, Wang CX, An WF, Spoonamore J., Metkar S., Emmitte KA, Cocklin S., Skorski T., and Mazin AV Nucleic acids research, 2016/02/11, (2016) Read More / View Supplemental Materials
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Midlife exercise blood pressure, heart rate, and fitness relate to brain volume 2 decades later.Spartano, NL, Himali JJ, Beiser AS, Lewis GD, Decarli C., Vasan RS, and Seshadri S. Neurology, 2016/02/10, (2016) Read More / View Supplemental Materials
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Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM.Wong, AS, Choi GC, Cui CH, Pregernig G., Milani P., Adam M., Perli SD, Kazer SW, Gaillard A., Hermann M., Shalek AK, Fraenkel E., and Lu TK Proceedings of the National Academy of Sciences of the United States of America, 2016/02/10, (2016) Read More / View Supplemental Materials
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Standardizing Flow Cytometry Immunophenotyping Analysis from the Human ImmunoPhenotyping Consortium.Finak, G., Langweiler M., Jaimes M., Malek M., Taghiyar J., Korin Y., Raddassi K., Devine L., Obermoser G., Pekalski ML, Pontikos N., Diaz A., Heck S., Villanova F., Terrazzini N., Kern F., Qian Y., Stanton R., Wang K., Brandes A., et al. Scientific reports, 2016/02/10, Volume 6, p.20686, (2016) Read More / View Supplemental Materials
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Structure and Engineering of Francisella novicida Cas9.Hirano, H., Gootenberg JS, Horii T., Abudayyeh OO, Kimura M., Hsu PD, Nakane T., Ishitani R., Hatada I., Zhang F., Nishimasu H., and Nureki O. Cell, 2016/02/10, (2016) Read More / View Supplemental Materials
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Association and prognostic significance of BRCA1/2-mutation status with neoantigen load, number of tumor-infiltrating lymphocytes and expression of PD-1/PD-L1 in high grade serous ovarian cancer.Strickland, KC, Howitt BE, Shukla SA, Rodig S., Ritterhouse LL, Liu JF, Garber JE, Chowdhury D., Wu CJ, D'Andrea AD, Matulonis UA, and Konstantinopoulos PA Oncotarget, 2016/02/09, (2016) Read More / View Supplemental Materials
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Genomic insights into the Ixodes scapularis tick vector of Lyme disease.Gulia-Nuss, M., Nuss AB, Meyer JM, Sonenshine DE, Roe RM, Waterhouse RM, Sattelle DB, de la Fuente J., Ribeiro JM, Megy K., Thimmapuram J., Miller JR, Walenz BP, Koren S., Hostetler JB, Thiagarajan M., Joardar VS, Hannick LI, Bidwell S., Hammond MP, et al. Nature communications, 2016/02/09, Volume 7, p.10507, (2016) Read More / View Supplemental Materials
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Metabolite profiles of diabetes incidence and intervention response in the Diabetes Prevention Program.Walford, GA, Ma Y., Clish C., Florez JC, Wang TJ, Gerszten RE, and Diabetes Prevention Program Research Group Diabetes, 2016/02/09, (2016) Read More / View Supplemental Materials
Abstract
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