Publications

Identification of small molecule inhibitors of PPM1D using an integrated drug discovery platform.

Shaw S, Jiang W, Rush J, et al. Identification of small molecule inhibitors of PPM1D using an integrated drug discovery platform. iScience. 2025;28(3):112069. doi:10.1016/j.isci.2025.112069PubMed Google Scholar DOI

Shifting the needle in cognitive health: urgent action on modifiable risk factors to prevent dementia in Singapore.

Tan BYQ, Tan LF, Rosand J. Shifting the needle in cognitive health: urgent action on modifiable risk factors to prevent dementia in Singapore. Singapore medical journal. 2025. doi:10.4103/singaporemedj.SMJ-2024-216PubMed Google Scholar DOI

Improving the Efficacy of Cancer mRNA Vaccines.

Kirtane AR, Traverso G. Improving the Efficacy of Cancer mRNA Vaccines. Cancer journal (Sudbury, Mass.). 2025;31(2). doi:10.1097/PPO.0000000000000764PubMed Google Scholar DOI

Large-scale combination screens reveal small-molecule sensitization of antibiotic-resistant gram-negative ESKAPE pathogens.

Tse MW, Zhu M, Peters B, et al. Large-scale combination screens reveal small-molecule sensitization of antibiotic-resistant gram-negative ESKAPE pathogens. Proceedings of the National Academy of Sciences of the United States of America. 2025;122(13):e2402017122. doi:10.1073/pnas.2402017122PubMed Google Scholar DOI

Temporal dynamics and metagenomics of phosphorothioate epigenomes in the human gut microbiome.

Byrne SR, DeMott MS, Yuan Y, et al. Temporal dynamics and metagenomics of phosphorothioate epigenomes in the human gut microbiome. Microbiome. 2025;13(1):81. doi:10.1186/s40168-025-02071-4PubMed Google Scholar DOI

Type 2 diabetes and late-onset Alzheimer's disease and related dementia: A longitudinal cohort study integrating polygenic risk score.

Jeong S, Lin L, Leone AP, Hsu YH. Type 2 diabetes and late-onset Alzheimer’s disease and related dementia: A longitudinal cohort study integrating polygenic risk score. Journal of Alzheimer’s disease : JAD. 2025:13872877251326107. doi:10.1177/13872877251326107PubMed Google Scholar DOI

base editing of Angptl3 via lipid nanoparticles to treat cardiovascular disease.

Khirallah J, Bloomer H, Wich D, et al. base editing of Angptl3 via lipid nanoparticles to treat cardiovascular disease. Molecular therapy. Nucleic acids. 2025;36(2):102486. doi:10.1016/j.omtn.2025.102486PubMed Google Scholar DOI

Large-Scale Functional Characterization of Low-Density Lipoprotein Receptor Gene Variants Improves Risk Assessment in Cardiovascular Disease.

Islam MM, Tamlander M, Hlushchenko I, Ripatti S, Pfisterer SG. Large-Scale Functional Characterization of Low-Density Lipoprotein Receptor Gene Variants Improves Risk Assessment in Cardiovascular Disease. JACC. Basic to translational science. 2025;10(2):170-183. doi:10.1016/j.jacbts.2024.10.006PubMed Google Scholar DOI

Systematic evaluation of single-cell multimodal data integration for comprehensive human reference atlas.

Acera-Mateos M, Adiconis X, Li JK, et al. Systematic evaluation of single-cell multimodal data integration for comprehensive human reference atlas. bioRxiv : the preprint server for biology. 2025. doi:10.1101/2025.03.06.637075PubMed Google Scholar DOI

Potential of synergist ablation to study mechanisms of skeletal muscle hypertrophy in rodent disease models.

Sarto F, Fry CS, Narici M V, Rubin L, Price FD. Potential of synergist ablation to study mechanisms of skeletal muscle hypertrophy in rodent disease models. American journal of physiology. Cell physiology. 2025. doi:10.1152/ajpcell.00076.2025PubMed Google Scholar DOI