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2016
Population-Scale Sequencing Data Enable Precise Estimates of Y-STR Mutation Rates.Willems, T., Gymrek M., Poznik GD, Tyler-Smith C., 1000 Genomes Project Chromosome Y Group, and Erlich Y. American journal of human genetics, 2016/05/05, Volume 98, Issue 5, p.919-33, (2016) Read More / View Supplemental Materials
Abstract
Tumour CD274 (PD-L1) expression and T cells in colorectal cancer.Masugi, Y., Nishihara R., Yang J., Mima K., da Silva A., Shi Y., Inamura K., Cao Y., Song M., Nowak JA, Liao X., Nosho K., Chan AT, Giannakis M., Bass AJ, Hodi FS, Freeman GJ, Rodig S., Fuchs CS, Qian ZR, et al. Gut, 2016/05/05, (2016) Read More / View Supplemental Materials
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Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans.Vatanen, T., Kostic AD, d'Hennezel E., Siljander H., Franzosa EA, Yassour M., Kolde R., Vlamakis H., Arthur TD, Hämäläinen AM, Peet A., Tillmann V., Uibo R., Mokurov S., Dorshakova N., Ilonen J., Virtanen SM, Szabo SJ, Porter JA, Lähdesmäki H., et al. Cell, 2016/05/05, Volume 165, Issue 4, p.842-53, (2016) Read More / View Supplemental Materials
Abstract
Antidepressant-like effect of low dose ketamine and scopolamine co-treatment in mice.Petryshen, TL, Lewis MC, Dennehy KA, Garza JC, and Fava M. Neuroscience letters, 2016/05/04, Volume 620, p.70-3, (2016) Read More / View Supplemental Materials
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Enrichment of rare variants in population isolates: single AICDA mutation responsible for hyper-IgM syndrome type 2 in Finland.Trotta, L., Hautala T., Hämäläinen S., Syrjänen J., Viskari H., Almusa H., Lepisto M., Kaustio M., Porkka K., Palotie A., Seppänen M., and Saarela J. European journal of human genetics : EJHG, 2016/05/04, (2016) Read More / View Supplemental Materials
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Systematic functional interrogation of rare cancer variants identifies oncogenic alleles.Kim, E., Ilic N., Shrestha Y., Zou L., Kamburov A., Zhu C., Yang X., Lubonja R., Tran N., Nguyen C., Lawrence MS, Piccioni F., Bagul M., Doench JG, Chouinard CR, Wu X., Hogstrom L., Natoli T., Tamayo P., Horn H., et al. Cancer discovery, 2016/05/04, (2016) Read More / View Supplemental Materials
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Clinical Activity and Quality of Life Indices Are Valid Across Ulcerative Colitis But Not Crohn's Disease Phenotypes.Taleban, S., Stewart KO, Li DK, Singh P., Pardi DS, Sturgeon HC, Yajnik V., Xavier RJ, Ananthakrishnan AN, and Khalili H. Digestive diseases and sciences, 2016/05/03, (2016) Read More / View Supplemental Materials
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COMT Val158 Met genotype is associated with reward learning: A replication study and meta-analysis.Corral-Frías, NS, Pizzagalli DA, Carré J., Michalski LJ, Nikolova YS, Perlis RH, Fagerness J., Lee MR, Drabant Conley E., Lancaster TM, Haddad S., Wolf A., Smoller JW, Hariri AR, and Bogdan R. Genes, brain, and behavior, 2016/05/03, (2016) Read More / View Supplemental Materials
Abstract
A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs.Raffan, E., Dennis RJ, O'Donovan CJ, Becker JM, Scott RA, Smith SP, Withers DJ, Wood CJ, Conci E., Clements DN, Summers KM, German AJ, Mellersh CS, Arendt ML, Iyemere VP, Withers E., Söder J., Wernersson S., Andersson G., Lindblad-Toh K., et al. Cell metabolism, 2016/05/02, (2016) Read More / View Supplemental Materials
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The genetic history of Ice Age Europe.Fu, Q., Posth C., Hajdinjak M., Petr M., Mallick S., Fernandes D., Furtwängler A., Haak W., Meyer M., Mittnik A., Nickel B., Peltzer A., Rohland N., Slon V., Talamo S., Lazaridis I., Lipson M., Mathieson I., Schiffels S., Skoglund P., et al. Nature, 2016/05/02, (2016) Read More / View Supplemental Materials
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A genetic method for dating ancient genomes provides a direct estimate of human generation interval in the last 45,000 years.Moorjani, P., Sankararaman S., Fu Q., Przeworski M., Patterson N., and Reich D. Proceedings of the National Academy of Sciences of the United States of America, 2016/05/02, (2016) Read More / View Supplemental Materials
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Lower prevalence but similar fitness in a parasitic fungus at higher radiation levels near Chernobyl.Aguileta, G., Badouin H., Hood ME, Møller AP, Le Prieur S., Snirc A., Siguenza S., Mousseau TA, Shykoff JA, Cuomo CA, and Giraud T. Molecular ecology, 2016/05/02, (2016) Read More / View Supplemental Materials
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Atrial Fibrillation and Declining Physical Performance in Older Adults: The Health, Aging, and Body Composition Study.Magnani, JW, Wang N., Benjamin EJ, Garcia ME, Bauer DC, Butler J., Ellinor PT, Kritchevsky S., Marcus GM, Newman A., Phillips CL, Sasai H., Satterfield S., Sullivan LM, Harris TB, and and Health, Aging Body Composition Study Circulation. Arrhythmia and electrophysiology, 2016/05/01, Volume 9, Issue 5, p.e003525, (2016) Read More / View Supplemental Materials
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The Contribution of GWAS Loci in Familial Dyslipidemias.Ripatti, P., Rämö JT, Söderlund S., Surakka I., Matikainen N., Pirinen M., Pajukanta P., Sarin AP, Service SK, Laurila PP, Ehnholm C., Salomaa V., Wilson RK, Palotie A., Freimer NB, Taskinen MR, and Ripatti S. PLoS genetics, 2016/05/01, Volume 12, Issue 5, p.e1006078, (2016) Read More / View Supplemental Materials
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Differences in the Selection Bottleneck between Modes of Sexual Transmission Influence the Genetic Composition of the HIV-1 Founder Virus.Tully, DC, Ogilvie CB, Batorsky RE, Bean DJ, Power KA, Ghebremichael M., Bedard HE, Gladden AD, Seese AM, Amero MA, Lane K., McGrath G., Bazner SB, Tinsley J., Lennon NJ, Henn MR, Brumme ZL, Norris PJ, Rosenberg ES, Mayer KH, et al. PLoS pathogens, 2016/05/01, Volume 12, Issue 5, p.e1005619, (2016) Read More / View Supplemental Materials
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Discovery of Genetic Variation on Chromosome 5q22 Associated with Mortality in Heart Failure.Smith, JG, Felix JF, Morrison AC, Kalogeropoulos A., Trompet S., Wilk JB, Gidlöf O., Wang X., Morley M., Mendelson M., Joehanes R., Ligthart S., Shan X., Bis JC, Wang YA, Sjögren M., Ngwa J., Brandimarto J., Stott DJ, Aguilar D., et al. PLoS genetics, 2016/05/01, Volume 12, Issue 5, p.e1006034, (2016) Read More / View Supplemental Materials
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Genome-Wide Analysis Identifies Germ-Line Risk Factors Associated with Canine Mammary Tumours.Melin, M., Rivera P., Arendt M., Elvers I., Murén E., Gustafson U., Starkey M., Borge KS, Lingaas F., Häggström J., Saellström S., Rönnberg H., and Lindblad-Toh K. PLoS genetics, 2016/05/01, Volume 12, Issue 5, p.e1006029, (2016) Read More / View Supplemental Materials
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Metabolomics in Prediabetes and Diabetes: A Systematic Review and Meta-analysis.Guasch-Ferré, M., Hruby A., Toledo E., Clish CB, Martínez-González MA, Salas-Salvadó J., and Hu FB Diabetes care, 2016/05/01, Volume 39, Issue 5, p.833-46, (2016) Read More / View Supplemental Materials
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Reduced-representation Phosphosignatures Measured by Quantitative Targeted MS Capture Cellular States and Enable Large-scale Comparison of Drug-induced Phenotypes.Abelin, JG, Patel J., Lu X., Feeney CM, Fagbami L., Creech AL, Hu R., Lam D., Davison D., Pino L., Qiao JW, Kuhn E., Officer A., Li J., Abbatiello S., Subramanian A., Sidman R., Snyder E., Carr SA, and Jaffe JD Molecular & cellular proteomics : MCP, 2016/05/01, Volume 15, Issue 5, p.1622-41, (2016) Read More / View Supplemental Materials
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Silencing FOXP2 in breast cancer cells promotes cancer stem cell traits and metastasis.Cuiffo, BG, and Karnoub AE Molecular & cellular oncology, 2016/05/01, Volume 3, Issue 3, p.e1019022, (2016) Read More / View Supplemental Materials
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Utilizing the Dog Genome in the Search for Novel Candidate Genes Involved in Glioma Development-Genome Wide Association Mapping followed by Targeted Massive Parallel Sequencing Identifies a Strongly Associated Locus.Truvé, K., Dickinson P., Xiong A., York D., Jayashankar K., Pielberg G., Koltookian M., Murén E., Fuxelius HH, Weishaupt H., Swartling FJ, Andersson G., Hedhammar Å., Bongcam-Rudloff E., Forsberg-Nilsson K., Bannasch D., and Lindblad-Toh K. PLoS genetics, 2016/05/01, Volume 12, Issue 5, p.e1006000, (2016) Read More / View Supplemental Materials
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Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity.Zhernakova, A., Kurilshikov A., Bonder MJ, Tigchelaar EF, Schirmer M., Vatanen T., Mujagic Z., Vila AV, Falony G., Vieira-Silva S., Wang J., Imhann F., Brandsma E., Jankipersadsing SA, Joossens M., Cenit MC, Deelen P., Swertz MA, study LifeLines Cohort, Weersma RK, et al. Science (New York, N.Y.), 2016/04/29, Volume 352, Issue 6285, p.565-9, (2016) Read More / View Supplemental Materials
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Subacute decline in serum lipids precedes the occurrence of primary intracerebral hemorrhage.Phuah, CL, Raffeld MR, Ayres AM, Viswanathan A., Greenberg SM, Biffi A., Rosand J., and Anderson CD Neurology, 2016/04/29, (2016) Read More / View Supplemental Materials
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Abundant PD-L1 expression in Epstein-Barr Virus-infected gastric cancers.Derks, S., Liao X., Chiaravalli AM, Xu X., Camargo MC, Solcia E., Sessa F., Fleitas T., Freeman GJ, Rodig SJ, Rabkin CS, and Bass AJ Oncotarget, 2016/04/28, (2016) Read More / View Supplemental Materials
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CEL-Seq2: sensitive highly-multiplexed single-cell RNA-Seq.Hashimshony, T., Senderovich N., Avital G., Klochendler A., de Leeuw Y., Anavy L., Gennert D., Li S., Livak KJ, Rozenblatt-Rosen O., Dor Y., Regev A., and Yanai I. Genome biology, 2016/04/28, Volume 17, Issue 1, p.77, (2016) Read More / View Supplemental Materials
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Clinical, Molecular, and Immune Analysis of Dabrafenib-Trametinib Combination Treatment for BRAF Inhibitor-Refractory Metastatic Melanoma: A Phase 2 Clinical Trial.Chen, G., McQuade JL, Panka DJ, Hudgens CW, Amin-Mansour A., Mu XJ, Bahl S., Jané-Valbuena J., Wani KM, Reuben A., Creasy CA, Jiang H., Cooper ZA, Roszik J., Bassett RL Jr, Joon AY, Simpson LM, Mouton RD, Glitza IC, Patel SP, et al. JAMA oncology, 2016/04/28, (2016) Read More / View Supplemental Materials
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A Clinician's perspective on clinical exome sequencing.O'Donnell-Luria, AH, and Miller DT Human genetics, 2016/04/28, (2016) Read More / View Supplemental Materials
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Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma.Dayton, TL, Gocheva V., Miller KM, Israelsen WJ, Bhutkar A., Clish CB, Davidson SM, Luengo A., Bronson RT, Jacks T., and Vander Heiden MG Genes & development, 2016/04/28, (2016) Read More / View Supplemental Materials
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The healthy human microbiome.Lloyd-Price, J., Abu-Ali G., and Huttenhower C. Genome medicine, 2016/04/27, Volume 8, Issue 1, p.51, (2016) Read More / View Supplemental Materials
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IRF7 inhibition prevents destructive innate immunity-A target for nonantibiotic therapy of bacterial infections.Puthia, M., Ambite I., Cafaro C., Butler D., Huang Y., Lutay N., Rydström G., Gullstrand B., Swaminathan B., Nadeem A., Nilsson B., and Svanborg C. Science translational medicine, 2016/04/27, Volume 8, Issue 336, p.336ra59, (2016) Read More / View Supplemental Materials
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Neurobiology of social behavior abnormalities in autism and Williams syndrome.Barak, B., and Feng G. Nature neuroscience, 2016/04/26, Volume 19, Issue 6, p.647-55, (2016) Read More / View Supplemental Materials
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A Spectrum of CodY Activities Drives Metabolic Reorganization and Virulence Gene Expression in Staphylococcus aureus.Waters, NR, Samuels DJ, Behera RK, Livny J., Rhee KY, Sadykov MR, and Brinsmade SR Molecular microbiology, 2016/04/26, (2016) Read More / View Supplemental Materials
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A genetic basis for the variation in the vulnerability of cancer to DNA damage.Yard, BD, Adams DJ, Chie EK, Tamayo P., Battaglia JS, Gopal P., Rogacki K., Pearson BE, Phillips J., Raymond DP, Pennell NA, Almeida F., Cheah JH, Clemons PA, Shamji A., Peacock CD, Schreiber SL, Hammerman PS, and Abazeed ME Nature communications, 2016/04/25, Volume 7, p.11428, (2016) Read More / View Supplemental Materials
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A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.Pacold, ME, Brimacombe KR, Chan SH, Rohde JM, Lewis CA, Swier LJ, Possemato R., Chen WW, Sullivan LB, Fiske BP, Cho S., Freinkman E., Birsoy K., Abu-Remaileh M., Shaul YD, Liu CM, Zhou M., Koh MJ, Chung H., Davidson SM, et al. Nature chemical biology, 2016/04/25, (2016) Read More / View Supplemental Materials
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Punctuated bursts in human male demography inferred from 1,244 worldwide Y-chromosome sequences.Poznik, GD, Xue Y., Mendez FL, Willems TF, Massaia A., Wilson Sayres MA, Ayub Q., McCarthy SA, Narechania A., Kashin S., Chen Y., Banerjee R., Rodriguez-Flores JL, Cerezo M., Shao H., Gymrek M., Malhotra A., Louzada S., Desalle R., Ritchie GR, et al. Nature genetics, 2016/04/25, (2016) Read More / View Supplemental Materials
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Somatic ERCC2 mutations are associated with a distinct genomic signature in urothelial tumors.Kim, J., Mouw KW, Polak P., Braunstein LZ, Kamburov A., Tiao G., Kwiatkowski DJ, Rosenberg JE, Van Allen EM, D'Andrea AD, and Getz G. Nature genetics, 2016/04/25, (2016) Read More / View Supplemental Materials
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Targeted erythropoietin selectively stimulates red blood cell expansion in vivo.Burrill, DR, Vernet A., Collins JJ, Silver PA, and Way JC Proceedings of the National Academy of Sciences of the United States of America, 2016/04/25, (2016) Read More / View Supplemental Materials
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An open-source computational tool to automatically quantify immunolabeled retinal ganglion cells.Dordea, AC, Bray MA, Allen K., Logan D., Fei F., Malhotra R., Gregory M., Carpenter AE, and Buys ES Experimental eye research, 2016/04/24, (2016) Read More / View Supplemental Materials
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Targeted exonic sequencing of GWAS loci in the high extremes of the plasma lipids distribution.Patel, AP, Peloso GM, Pirruccello JP, Johansen CT, Dubé JB, Larach DB, Ban MR, Dallinge-Thie GM, Gupta N., Boehnke M., Abecasis GR, Kastelein JJ, Hovingh GK, Hegele RA, Rader DJ, and Kathiresan S. Atherosclerosis, 2016/04/23, Volume 250, p.63-68, (2016) Read More / View Supplemental Materials
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Trained immunity: A program of innate immune memory in health and disease.Netea, MG, Joosten LA, Latz E., Mills KH, Natoli G., Stunnenberg HG, O'Neill LA, and Xavier RJ Science (New York, N.Y.), 2016/04/22, Volume 352, Issue 6284, p.aaf1098, (2016) Read More / View Supplemental Materials
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Crystal Structure of Cpf1 in Complex with Guide RNA and Target DNA.Yamano, T., Nishimasu H., Zetsche B., Hirano H., Slaymaker IM, Li Y., Fedorova I., Nakane T., Makarova KS, Koonin EV, Ishitani R., Zhang F., and Nureki O. Cell, 2016/04/21, (2016) Read More / View Supplemental Materials
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Engineering Models to Scale.Dy, AJ, and Collins JJ Cell, 2016/04/21, Volume 165, Issue 3, p.516-7, (2016) Read More / View Supplemental Materials
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The influence of a short-term gluten-free diet on the human gut microbiome.Bonder, MJ, Tigchelaar EF, Cai X., Trynka G., Cenit MC, Hrdlickova B., Zhong H., Vatanen T., Gevers D., Wijmenga C., Wang Y., and Zhernakova A. Genome medicine, 2016/04/21, Volume 8, Issue 1, p.45, (2016) Read More / View Supplemental Materials
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PD-1 marks dysfunctional regulatory T cells in malignant gliomas.Lowther, DE, Goods BA, Lucca LE, Lerner BA, Raddassi K., van Dijk D., Hernandez AL, Duan X., Gunel M., Coric V., Krishnaswamy S., Love JC, and Hafler DA JCI insight, 2016/04/21, Volume 1, Issue 5, (2016) Read More / View Supplemental Materials
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High fat diet and stem cells: Linking diet to intestinal tumor formation.Cangelosi, AL, and Yilmaz Ö. H. Cell cycle (Georgetown, Tex.), 2016/04/20, (2016) Read More / View Supplemental Materials
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Plasma acylcarnitines and risk of cardiovascular disease: effect of Mediterranean diet interventions.Guasch-Ferré, M., Zheng Y., Ruiz-Canela M., Hruby A., Martínez-González MA, Clish CB, Corella D., Estruch R., Ros E., Fitó M., Dennis C., Morales-Gil IM, Arós F., Fiol M., Lapetra J., Serra-Majem L., Hu FB, and Salas-Salvadó J. The American journal of clinical nutrition, 2016/04/20, (2016) Read More / View Supplemental Materials
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gkmSVM: an R package for gapped-kmer SVM.Ghandi, M., Mohammad-Noori M., Ghareghani N., Lee D., Garraway L., and Beer MA Bioinformatics (Oxford, England), 2016/04/19, (2016) Read More / View Supplemental Materials
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Characterizing genomic alterations in cancer by complementary functional associations.Kim, JW, Botvinnik OB, Abudayyeh O., Birger C., Rosenbluh J., Shrestha Y., Abazeed ME, Hammerman PS, Dicara D., Konieczkowski DJ, Johannessen CM, Liberzon A., Alizad-Rahvar AR, Alexe G., Aguirre A., Ghandi M., Greulich H., Vazquez F., Weir BA, Van Allen EM, et al. Nature biotechnology, 2016/04/18, (2016) Read More / View Supplemental Materials
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Circadian gene variants influence sleep and the sleep electroencephalogram in humans.Chang, AM, Bjonnes AC, Aeschbach D., Buxton OM, Gooley JJ, Anderson C., Reen EV, Cain SW, Czeisler CA, Duffy JF, Lockley SW, Shea SA, Scheer FA, and Saxena R. Chronobiology international, 2016/04/18, p.1-13, (2016) Read More / View Supplemental Materials
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Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.Okbay, A., Baselmans BM, De Neve JE, Turley P., Nivard MG, Fontana MA, Meddens SF, Linnér RK, Rietveld CA, Derringer J., Gratten J., Lee JJ, Liu JZ, de Vlaming R., Ahluwalia TS, Buchwald J., Cavadino A., Frazier-Wood AC, Furlotte NA, Garfield V., et al. Nature genetics, 2016/04/18, (2016) Read More / View Supplemental Materials
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Physical and neurobehavioral determinants of reproductive onset and success.Day, FR, Helgason H., Chasman DI, Rose LM, Loh PR, Scott RA, Helgason A., Kong A., Masson G., Magnusson OT, Gudbjartsson D., Thorsteinsdottir U., Buring JE, Ridker PM, Sulem P., Stefansson K., Ong KK, and Perry JR Nature genetics, 2016/04/18, (2016) Read More / View Supplemental Materials
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Recurrent Clostridium difficile infection associates with distinct bile acid and microbiome profiles.Allegretti, JR, Kearney S., Li N., Bogart E., Bullock K., Gerber GK, Bry L., Clish CB, Alm E., and Korzenik JR Alimentary pharmacology & therapeutics, 2016/04/18, (2016) Read More / View Supplemental Materials
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The reproductive tracts of two malaria vectors are populated by a core microbiome and by gender- and swarm-enriched microbial biomarkers.Segata, N., Baldini F., Pompon J., Garrett WS, Truong DT, Dabiré RK, Diabaté A., Levashina EA, and Catteruccia F. Scientific reports, 2016/04/18, Volume 6, p.24207, (2016) Read More / View Supplemental Materials
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Sequential Infection with Common Pathogens Promotes Human-like Immune Gene Expression and Altered Vaccine Response.Reese, TA, Bi K., Kambal A., Filali-Mouhim A., Beura LK, Bürger MC, Pulendran B., Sekaly RP, Jameson SC, Masopust D., Haining WN, and Virgin HW Cell host & microbe, 2016/04/18, (2016) Read More / View Supplemental Materials
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Synthetic biology platform technologies for antimicrobial applications.Braff, D., Shis D., and Collins JJ Advanced drug delivery reviews, 2016/04/18, (2016) Read More / View Supplemental Materials
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Applications in image-based profiling of perturbations.Caicedo, JC, Singh S., and Carpenter AE Current opinion in biotechnology, 2016/04/15, Volume 39, p.134-142, (2016) Read More / View Supplemental Materials
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Common and rare forms of diabetes mellitus: towards a continuum of diabetes subtypes.Flannick, J., Johansson S., and Njølstad PR Nature reviews. Endocrinology, 2016/04/15, (2016) Read More / View Supplemental Materials
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Genomic Correlates of Immune-Cell Infiltrates in Colorectal Carcinoma.Giannakis, M., Mu XJ, Shukla SA, Qian ZR, Cohen O., Nishihara R., Bahl S., Cao Y., Amin-Mansour A., Yamauchi M., Sukawa Y., Stewart C., Rosenberg M., Mima K., Inamura K., Nosho K., Nowak JA, Lawrence MS, Giovannucci EL, Chan AT, et al. Cell reports, 2016/04/14, (2016) Read More / View Supplemental Materials
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A distant trophoblast-specific enhancer controls HLA-G expression at the maternal-fetal interface.Ferreira, LM, Meissner TB, Mikkelsen TS, Mallard W., O'Donnell CW, Tilburgs T., Gomes HA, Camahort R., Sherwood RI, Gifford DK, Rinn JL, Cowan CA, and Strominger JL Proceedings of the National Academy of Sciences of the United States of America, 2016/04/13, (2016) Read More / View Supplemental Materials
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The Human Vaccines Project: A roadmap for cancer vaccine development.Romero, P., Banchereau J., Bhardwaj N., Cockett M., Disis ML, Dranoff G., Gilboa E., Hammond SA, Hershberg R., Korman AJ, Kvistborg P., Melief C., Mellman I., Palucka AK, Redchenko I., Robins H., Sallusto F., Schenkelberg T., Schoenberger S., Sosman J., et al. Science translational medicine, 2016/04/13, Volume 8, Issue 334, p.334ps9, (2016) Read More / View Supplemental Materials
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A Method to Exploit the Structure of Genetic Ancestry Space to Enhance Case-Control Studies.Bodea, CA, Neale BM, Ripke S., International IBD Genetics Consortium, Daly M. J., Devlin B., and Roeder K. American journal of human genetics, 2016/04/13, (2016) Read More / View Supplemental Materials
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Polq-Mediated End Joining Is Essential for Surviving DNA Double-Strand Breaks during Early Zebrafish Development.Thyme, SB, and Schier AF Cell reports, 2016/04/13, (2016) Read More / View Supplemental Materials
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Vinca alkaloid drugs promote stress-induced translational repression and stress granule formation.Szaflarski, W., Fay MM, Kedersha N., Zabel M., Anderson P., and Ivanov P. Oncotarget, 2016/04/13, (2016) Read More / View Supplemental Materials
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Wisteria Floribunda Agglutinin-Labeled Perineuronal Nets in the Mouse Inferior Colliculus, Thalamic Reticular Nucleus and Auditory Cortex.Fader, SM, Imaizumi K., Yanagawa Y., and Lee CC Brain sciences, 2016/04/13, Volume 6, Issue 2, (2016) Read More / View Supplemental Materials
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Genome-wide analysis of over 106 000 individuals identifies 9 neuroticism-associated loci.Smith, DJ, Escott-Price V., Davies G., Bailey ME, Colodro-Conde L., Ward J., Vedernikov A., Marioni R., Cullen B., Lyall D., Hagenaars SP, Liewald DC, Luciano M., Gale CR, Ritchie SJ, Hayward C., Nicholl B., Bulik-Sullivan B., Adams M., Couvy-Duchesne B., et al. Molecular psychiatry, 2016/04/12, (2016) Read More / View Supplemental Materials
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The statistical properties of gene-set analysis.de Leeuw, CA, Neale BM, Heskes T., and Posthuma D. Nature reviews. Genetics, 2016/04/12, (2016) Read More / View Supplemental Materials
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Crowdsourced estimation of cognitive decline and resilience in Alzheimer's disease.Allen, GI, Amoroso N., Anghel C., Balagurusamy V., Bare CJ, Beaton D., Bellotti R., Bennett DA, Boehme K., Boutros PC, Caberlotto L., Caloian C., Campbell F., Neto EC, Chang YC, Chen B., Chen CY, Chien TY, Clark T., Das S., et al. Alzheimer's & dementia : the journal of the Alzheimer's Association, 2016/04/11, (2016) Read More / View Supplemental Materials
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Genomic and functional analyses of Mycobacterium tuberculosis strains implicate ald in D-cycloserine resistance.Desjardins, CA, Cohen KA, Munsamy V., Abeel T., Maharaj K., Walker BJ, Shea TP, Almeida DV, Manson AL, Salazar A., Padayatchi N., O'Donnell MR, Mlisana KP, Wortman J., Birren BW, Grosset J., Earl AM, and Pym AS Nature genetics, 2016/04/11, (2016) Read More / View Supplemental Materials
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The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice.Townsend, EC, Murakami MA, Christodoulou A., Christie AL, Köster J., DeSouza TA, Morgan EA, Kallgren SP, Liu H., Wu SC, Plana O., Montero J., Stevenson KE, Rao P., Vadhi R., Andreeff M., Armand P., Ballen KK, Barzaghi-Rinaudo P., Cahill S., et al. Cancer cell, 2016/04/11, Volume 29, Issue 4, p.574-86, (2016) Read More / View Supplemental Materials
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Superheroes of disease resistance.Macarthur, D. Nature biotechnology, 2016/04/11, (2016) Read More / View Supplemental Materials
The Chthonomonas calidirosea genome is highly conserved across geography and distinct chemical and microbial environments in the Taupō Volcanic Zone, New Zealand.Lee, KC, Stott MB, Dunfield PF, Huttenhower C., McDonald IR, and Morgan XC Applied and environmental microbiology, 2016/04/08, (2016) Read More / View Supplemental Materials
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Complementation of mitochondrial electron transport chain by manipulation of the NAD+/NADH ratio.Titov, DV, Cracan V., Goodman RP, Peng J., Grabarek Z., and Mootha VK Science (New York, N.Y.), 2016/04/08, Volume 352, Issue 6282, p.231-5, (2016) Read More / View Supplemental Materials
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Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq.Tirosh, I., Izar B., Prakadan SM, Wadsworth MH 2nd, Treacy D., Trombetta JJ, Rotem A., Rodman C., Lian C., Murphy G., Fallahi-Sichani M., Dutton-Regester K., Lin JR, Cohen O., Shah P., Lu D., Genshaft AS, Hughes TK, Ziegler CG, Kazer SW, et al. Science (New York, N.Y.), 2016/04/08, Volume 352, Issue 6282, p.189-96, (2016) Read More / View Supplemental Materials
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High-Throughput Luciferase-Based Assay for the Discovery of Therapeutics That Prevent Malaria.Swann, J., Corey V., Scherer CA, Kato N., Comer E., Maetani M., Antonova-Koch Y., Reimer C., Gagaring K., Ibanez M., Plouffe D., Zeeman AM, Kocken CH, McNamara CW, Schreiber SL, Campo B., Winzeler EA, and Meister S. ACS infectious diseases, 2016/04/08, Volume 2, Issue 4, p.281-293, (2016) Read More / View Supplemental Materials
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Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation.Gusev, A., Shi H., Kichaev G., Pomerantz M., Li F., Long HW, Ingles SA, Kittles RA, Strom SS, Rybicki BA, Nemesure B., Isaacs WB, Zheng W., Pettaway CA, Yeboah ED, Tettey Y., Biritwum RB, Adjei AA, Tay E., Truelove A., et al. Nature communications, 2016/04/07, Volume 7, p.10979, (2016) Read More / View Supplemental Materials
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Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML.Puram, RV, Kowalczyk MS, de Boer CG, Schneider RK, Miller PG, McConkey M., Tothova Z., Tejero H., Heckl D., Järås M., Chen MC, Li H., Tamayo A., Cowley GS, Rozenblatt-Rosen O., Al-Shahrour F., Regev A., and Ebert BL Cell, 2016/04/07, Volume 165, Issue 2, p.303-16, (2016) Read More / View Supplemental Materials
Abstract
Polymorphic tandem repeats within gene promoters act as modifiers of gene expression and DNA methylation in humans.Quilez, J., Guilmatre A., Garg P., Highnam G., Gymrek M., Erlich Y., Joshi RS, Mittelman D., and Sharp AJ Nucleic acids research, 2016/04/07, (2016) Read More / View Supplemental Materials
Abstract
Whole exome sequencing of urachal adenocarcinoma reveals recurrent NF1 mutations.Singh, H., Liu Y., Xiao X., Lin L., Kim J., Van Hummelen P., Wu CL, Bass AJ, and Saylor PJ Oncotarget, 2016/04/07, (2016) Read More / View Supplemental Materials
Abstract
Metabolomic Biomarkers of Prostate Cancer: Prediction, Diagnosis, Progression, Prognosis, and Recurrence.Kelly, RS, Vander Heiden MG, Giovannucci E., and Mucci LA Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2016/04/06, (2016) Read More / View Supplemental Materials
Abstract
Enhanced CLIP Uncovers IMP Protein-RNA Targets in Human Pluripotent Stem Cells Important for Cell Adhesion and Survival.Conway, AE, Van Nostrand EL, Pratt GA, Aigner S., Wilbert ML, Sundararaman B., Freese P., Lambert NJ, Sathe S., Liang TY, Essex A., Landais S., Burge CB, Jones DL, and Yeo GW Cell reports, 2016/04/05, (2016) Read More / View Supplemental Materials
Abstract
Novel diversity-oriented synthesis-derived respiratory syncytial virus inhibitors identified via a high throughput replicon-based screen.Duvall, JR, VerPlank L., Ludeke B., McLeod SM, Lee MD 4th, Vishwanathan K., Mulrooney CA, le Quement S., Yu Q., Palmer MA, Fleming P., Fearns R., Foley MA, and Scherer CA Antiviral research, 2016/04/05, (2016) Read More / View Supplemental Materials
Abstract
Insight into GATA1 transcriptional activity through interrogation of cis elements disrupted in human erythroid disorders.Wakabayashi, A., Ulirsch JC, Ludwig LS, Fiorini C., Yasuda M., Choudhuri A., McDonel P., Zon LI, and Sankaran VG Proceedings of the National Academy of Sciences of the United States of America, 2016/04/04, (2016) Read More / View Supplemental Materials
Abstract
Ancient mitochondrial DNA provides high-resolution time scale of the peopling of the Americas.Llamas, B., Fehren-Schmitz L., Valverde G., Soubrier J., Mallick S., Rohland N., Nordenfelt S., Valdiosera C., Richards SM, Rohrlach A., Romero MI, Espinoza IF, Cagigao ET, Jiménez LW, Makowski K., Reyna IS, Lory JM, Torrez JA, Rivera MA, Burger RL, et al. Science advances, 2016/04/01, Volume 2, Issue 4, p.e1501385, (2016) Read More / View Supplemental Materials
Abstract
Comparison of Heritability Estimation and Linkage Analysis for Multiple Traits Using Principal Component Analyses.Liang, J., Cade BE, Wang H., Chen H., Gleason KJ, Larkin EK, Saxena R., Lin X., Redline S., and Zhu X. Genetic epidemiology, 2016/04/01, Volume 40, Issue 3, p.222-32, (2016) Read More / View Supplemental Materials
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Computational Reconstruction of NFκB Pathway Interaction Mechanisms during Prostate Cancer.Börnigen, D., Tyekucheva S., Wang X., Rider JR, Lee GS, Mucci LA, Sweeney C., and Huttenhower C. PLoS computational biology, 2016/04/01, Volume 12, Issue 4, p.e1004820, (2016) Read More / View Supplemental Materials
Abstract
GENOME-WIDE ASSOCIATION STUDY (GWAS) AND GENOME-WIDE BY ENVIRONMENT INTERACTION STUDY (GWEIS) OF DEPRESSIVE SYMPTOMS IN AFRICAN AMERICAN AND HISPANIC/LATINA WOMEN.Dunn, EC, Wiste A., Radmanesh F., Almli LM, Gogarten SM, Sofer T., Faul JD, Kardia SL, Smith JA, Weir DR, Zhao W., Soare TW, Mirza SS, Hek K., Tiemeier H., Goveas JS, Sarto GE, Snively BM, Cornelis M., Koenen KC, et al. Depression and anxiety, 2016/04/01, Volume 33, Issue 4, p.265-80, (2016) Read More / View Supplemental Materials
Abstract
Homozygous deletion in MICU1 presenting with fatigue and lethargy in childhood.Lewis-Smith, D., Kamer KJ, Griffin H., Childs AM, Pysden K., Titov D., Duff J., Pyle A., Taylor RW, Yu-Wai-Man P., Ramesh V., Horvath R., Mootha VK, and Chinnery PF Neurology. Genetics, 2016/04/01, Volume 2, Issue 2, p.e59, (2016) Read More / View Supplemental Materials
Abstract
Lifting Up the HAT: Synthetic Lethal Screening Reveals a Novel Vulnerability at the CBP-p300 Axis.Kadoch, C. Cancer discovery, 2016/04/01, Volume 6, Issue 4, p.350-2, (2016) Read More / View Supplemental Materials
Abstract
Parsing psychosis subtypes through investigations of rare genetic variants.Bergen, SE EBioMedicine, 2016/04/01, Volume 6, p.16-7, (2016) Read More / View Supplemental Materials
Polygenic overlap between schizophrenia risk and antipsychotic response: a genomic medicine approach.Ruderfer, DM, Charney AW, Readhead B., Kidd BA, Kähler AK, Kenny PJ, Keiser MJ, Moran JL, Hultman CM, Scott SA, Sullivan PF, Purcell SM, Dudley JT, and Sklar P. The lancet. Psychiatry, 2016/04/01, Volume 3, Issue 4, p.350-7, (2016) Read More / View Supplemental Materials
Abstract
Rare loss-of-function variants in SETD1A are associated with schizophrenia and developmental disorders.Singh, T., Kurki MI, Curtis D., Purcell SM, Crooks L., McRae J., Suvisaari J., Chheda H., Blackwood D., Breen G., Pietiläinen O., Gerety SS, Ayub M., Blyth M., Cole T., Collier D., Coomber EL, Craddock N., Daly M. J., Danesh J., et al. Nature neuroscience, 2016/04/01, Volume 19, Issue 4, p.571-7, (2016) Read More / View Supplemental Materials
Abstract
Saturation of recognition elements blocks evolution of new tRNA identities.Saint-Léger, A., Bello C., Dans PD, Torres AG, Novoa EM, Camacho N., Orozco M., Kondrashov FA, and Ribas de Pouplana L. Science advances, 2016/04/01, Volume 2, Issue 4, p.e1501860, (2016) Read More / View Supplemental Materials
Abstract
Complement and microglia mediate early synapse loss in Alzheimer mouse models.Hong, S., Beja-Glasser VF, Nfonoyim BM, Frouin A., Li S., Ramakrishnan S., Merry KM, Shi Q., Rosenthal A., Barres BA, Lemere CA, Selkoe DJ, and Stevens B. Science (New York, N.Y.), 2016/03/31, (2016) Read More / View Supplemental Materials
Abstract
Variants near CHRNA3/5 and APOE have age- and sex-related effects on human lifespan.Joshi, PK, Fischer K., Schraut KE, Campbell H., Esko T., and Wilson JF Nature communications, 2016/03/31, Volume 7, p.11174, (2016) Read More / View Supplemental Materials
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Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1.Chouchani, ET, Kazak L., Jedrychowski MP, Lu GZ, Erickson BK, Szpyt J., Pierce KA, Laznik-Bogoslavski D., Vetrivelan R., Clish CB, Robinson AJ, Gygi SP, and Spiegelman BM Nature, 2016/03/30, (2016) Read More / View Supplemental Materials
Abstract
Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium.Stringer, S., Minică CC, Verweij KJ, Mbarek H., Bernard M., Derringer J., van Eijk KR, Isen JD, Loukola A., Maciejewski DF, Mihailov E., van der Most PJ, Sánchez-Mora C., Roos L., Sherva R., Walters R., Ware JJ, Abdellaoui A., Bigdeli TB, Branje SJ, et al. Translational psychiatry, 2016/03/29, Volume 6, p.e769, (2016) Read More / View Supplemental Materials
Abstract
Genome-wide interaction study of brain beta-amyloid burden and cognitive impairment in Alzheimer's disease.Roostaei, T., Nazeri A., Felsky D., De Jager PL, Schneider JA, Pollock BG, Bennett DA, Voineskos AN, and Alzheimer’s Disease Neuroimaging Initiative(ADNI) Molecular psychiatry, 2016/03/29, (2016) Read More / View Supplemental Materials
Abstract
Leveraging signaling research to understand and treat disease.Yaffe, MB, and Gough NR Science signaling, 2016/03/29, Volume 9, Issue 421, p.eg4, (2016) Read More / View Supplemental Materials
Abstract
18F CFA as a clinically translatable probe for PET imaging of deoxycytidine kinase activity.Kim, W., Le TM, Wei L., Poddar S., Bazzy J., Wang X., Uong NT, Abt ER, Capri JR, Austin WR, Van Valkenburgh JS, Steele D., Gipson RM, Slavik R., Cabebe AE, Taechariyakul T., Yaghoubi SS, Lee JT, Sadeghi S., Lavie A., et al. Proceedings of the National Academy of Sciences of the United States of America, 2016/03/28, (2016) Read More / View Supplemental Materials
Abstract
Diagnostic Yield of Sequencing Familial Hypercholesterolemia Genes in Patients with Severe Hypercholesterolemia.Khera, AV, Won HH, Peloso GM, Lawson KS, Bartz TM, Deng X., van Leeuwen EM, Natarajan P., Emdin CA, Bick AG, Morrison AC, Brody JA, Gupta N., Nomura A., Kessler T., Duga S., Bis JC, van Duijn CM, Cupples LA, Psaty B., et al. Journal of the American College of Cardiology, 2016/03/28, (2016) Read More / View Supplemental Materials
Abstract
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