Publications

Proteogenomic Markers of Chemotherapy Resistance and Response in Triple-Negative Breast Cancer.

Anurag M, Jaehnig EJ, Krug K, et al. Proteogenomic Markers of Chemotherapy Resistance and Response in Triple-Negative Breast Cancer. Cancer Discov. 2022;12(11):2586-2605. doi:10.1158/2159-8290.CD-22-0200.DOI Google Scholar PubMed

The phenotypic landscape of essential human genes.

Funk L, Su K-C, Ly J, et al. The phenotypic landscape of essential human genes. Cell. 2022. doi:10.1016/j.cell.2022.10.017.DOI Google Scholar PubMed

Microglia states and nomenclature: A field at its crossroads.

Paolicelli RC, Sierra A, Stevens B, et al. Microglia states and nomenclature: A field at its crossroads. Neuron. 2022;110(21):3458-3483. doi:10.1016/j.neuron.2022.10.020.DOI Google Scholar PubMed

A distinct clade of Bifidobacterium longum in the gut of Bangladeshi children thrives during weaning.

Vatanen T, Ang QY, Siegwald L, et al. A distinct clade of Bifidobacterium longum in the gut of Bangladeshi children thrives during weaning. Cell. 2022. doi:10.1016/j.cell.2022.10.011.DOI Google Scholar PubMed

Velcrin-induced selective cleavage of tRNA(TAA) by SLFN12 causes cancer cell death.

Lee S, Hoyt S, Wu X, et al. Velcrin-induced selective cleavage of tRNA(TAA) by SLFN12 causes cancer cell death. Nat Chem Biol. 2022. doi:10.1038/s41589-022-01170-9.DOI Google Scholar PubMed

Influences of rare copy-number variation on human complex traits.

Hujoel MLA, Sherman MA, Barton AR, et al. Influences of rare copy-number variation on human complex traits. Cell. 2022;185(22):4233-4248.e27. doi:10.1016/j.cell.2022.09.028.DOI Google Scholar PubMed

Programmable eukaryotic protein synthesis with RNA sensors by harnessing ADAR.

Jiang K, Koob J, Chen XD, et al. Programmable eukaryotic protein synthesis with RNA sensors by harnessing ADAR. Nat Biotechnol. 2022. doi:10.1038/s41587-022-01534-5.DOI Google Scholar PubMed

A combined polygenic score of 21,293 rare and 22 common variants improves diabetes diagnosis based on hemoglobin A1C levels.

Dornbos P, Koesterer R, Ruttenburg A, et al. A combined polygenic score of 21,293 rare and 22 common variants improves diabetes diagnosis based on hemoglobin A1C levels. Nat Genet. 2022. doi:10.1038/s41588-022-01200-1.DOI Google Scholar PubMed

Statistical and functional convergence of common and rare genetic influences on autism at chromosome 16p.

Weiner DJ, Ling E, Erdin S, et al. Statistical and functional convergence of common and rare genetic influences on autism at chromosome 16p. Nat Genet. 2022. doi:10.1038/s41588-022-01203-y.DOI Google Scholar PubMed

Disease stages and therapeutic hypotheses in two decades of neurodegenerative disease clinical trials.

Mortberg MA, Vallabh SM, Minikel EV. Disease stages and therapeutic hypotheses in two decades of neurodegenerative disease clinical trials. Sci Rep. 2022;12(1):17708. doi:10.1038/s41598-022-21820-1.DOI Google Scholar PubMed