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2014
Smoking is associated with mosaic loss of chromosome Y.Dumanski, JP, Rasi C., Lönn M., Davies H., Ingelsson M., Giedraitis V., Lannfelt L., Magnusson PK, Lindgren CM, Morris AP, Cesarini D., Johannesson M., Tiensuu Janson E., Lind L., Pedersen NL, Ingelsson E., and Forsberg LA Science (New York, N.Y.), 2014/12/04, (2014) Read More / View Supplemental Materials
Abstract
Virtual karyotyping reveals greater chromosomal stability in neural cells derived by transdifferentiation than those from stem cells.Weissbein, U., Ben-David U., and Benvenisty N. Cell stem cell, 2014/12/04, Volume 15, Issue 6, p.687-91, (2014) Read More / View Supplemental Materials
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GB virus C co-infections in West African Ebola patients.Lauck, M., Bailey AL, Andersen KG, Goldberg TL, Sabeti PC, and O'Connor DH Journal of virology, 2014/12/03, (2014) Read More / View Supplemental Materials
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Novel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study.Gottlieb, DJ, Hek K., Chen TH, Watson NF, Eiriksdottir G., Byrne EM, Cornelis M., Warby SC, Bandinelli S., Cherkas L., Evans DS, Grabe HJ, Lahti J., Li M., Lehtimäki T., Lumley T., Marciante KD, Pérusse L., Psaty BM, Robbins J., et al. Molecular psychiatry, 2014/12/02, (2014) Read More / View Supplemental Materials
Abstract
Altered chromatin occupancy of master regulators underlies evolutionary divergence in the transcriptional landscape of erythroid differentiation.Ulirsch, JC, Lacy JN, An X., Mohandas N., Mikkelsen TS, and Sankaran VG PLoS genetics, 2014/12/01, Volume 10, Issue 12, p.e1004890, (2014) Read More / View Supplemental Materials
Abstract
CDK5 is a major regulator of the tumor suppressor DLC1.Tripathi, BK, Qian X., Mertins P., Wang D., Papageorge AG, Carr SA, and Lowy DR The Journal of cell biology, 2014/12/01, (2014) Read More / View Supplemental Materials
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A comparison of non-integrating reprogramming methods.Schlaeger, TM, Daheron L., Brickler TR, Entwisle S., Chan K., Cianci A., DeVine A., Ettenger A., Fitzgerald K., Godfrey M., Gupta D., McPherson J., Malwadkar P., Gupta M., Bell B., Doi A., Jung N., Li X., Lynes MS, Brookes E., et al. Nature biotechnology, 2014/12/01, (2014) Read More / View Supplemental Materials
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Genetics of immune-mediated disorders: from genome-wide association to molecular mechanism.Kumar, V., Wijmenga C., and Xavier RJ Current opinion in immunology, 2014/12/01, Volume 31C, p.51-57, (2014) Read More / View Supplemental Materials
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Genome update of the dimorphic human pathogenic fungi causing paracoccidioidomycosis.Muñoz, JF, Gallo JE, Misas E., Priest M., Imamovic A., Young S., Zeng Q., Clay OK, McEwen JG, and Cuomo CA PLoS neglected tropical diseases, 2014/12/01, Volume 8, Issue 12, p.e3348, (2014) Read More / View Supplemental Materials
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p53 prevents neurodegeneration by regulating synaptic genes.Merlo, P., Frost B., Peng S., Yang YJ, Park PJ, and Feany M. Proceedings of the National Academy of Sciences of the United States of America, 2014/12/01, (2014) Read More / View Supplemental Materials
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Probing small-molecule microarrays with tagged proteins in cell lysates.Pop, MS, Wassaf D., and Koehler AN Current protocols in chemical biology, 2014/12/01, Volume 6, Issue 4, p.209-20, (2014) Read More / View Supplemental Materials
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Stratification by Smoking Status Reveals an Association of CHRNA5-A3-B4 Genotype with Body Mass Index in Never Smokers.Taylor, AE, Morris RW, Fluharty ME, Bjorngaard JH, Asvold BO, Gabrielsen ME, Campbell A., Marioni R., Kumari M., Hällfors J., Männistö S., Marques-Vidal P., Kaakinen M., Cavadino A., Postmus I., Husemoen LL, Skaaby T., Ahluwalia TS, Treur JL, Willemsen G., et al. PLoS genetics, 2014/12/01, Volume 10, Issue 12, p.e1004799, (2014) Read More / View Supplemental Materials
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A shower of second hit events as the cause of multifocal renal cell carcinoma in Tuberous Sclerosis Complex.Tyburczy, ME, Jozwiak S., Malinowska IA, Chekaluk Y., Pugh TJ, Wu CL, Nussbaum RL, Seepo S., Dzik T., Kotulska K., and Kwiatkowski DJ Human molecular genetics, 2014/11/28, (2014) Read More / View Supplemental Materials
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Extensive introgression in a malaria vector species complex revealed by phylogenomics.Fontaine, MC, Pease JB, Steele A., Waterhouse RM, Neafsey DE, Sharakhov IV, Jiang X., Hall AB, Catteruccia F., Kakani E., Mitchell SN, Wu YC, Smith HA, Love RR, Lawniczak MK, Slotman MA, Emrich SJ, Hahn MW, and Besansky NJ Science (New York, N.Y.), 2014/11/27, (2014) Read More / View Supplemental Materials
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Regulation of Drosophila intestinal stem cell maintenance and differentiation by the transcription factor Escargot.Loza-Coll, MA, Southall TD, Sandall SL, Brand AH, and Jones DL The EMBO journal, 2014/11/27, (2014) Read More / View Supplemental Materials
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Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes.Jaiswal, S., Fontanillas P., Flannick J., Manning A., Grauman PV, Mar BG, Lindsley RC, Mermel CH, Burtt N., Chavez A., Higgins JM, Moltchanov V., Kuo FC, Kluk MJ, Henderson B., Kinnunen L., Koistinen HA, Ladenvall C., Getz G., Correa A., et al. The New England journal of medicine, 2014/11/26, (2014) Read More / View Supplemental Materials
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Association of Sickle Cell Trait With Chronic Kidney Disease and Albuminuria in African Americans.Naik, RP, Derebail VK, Grams ME, Franceschini N., Auer PL, Peloso GM, Young BA, Lettre G., Peralta CA, Katz R., Hyacinth HI, Quarells RC, Grove ML, Bick AG, Fontanillas P., Rich SS, Smith JD, Boerwinkle E., Rosamond WD, Ito K., et al. JAMA, 2014/11/26, Volume 312, Issue 20, p.2115-2125, (2014) Read More / View Supplemental Materials
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BreaKmer: detection of structural variation in targeted massively parallel sequencing data using kmers.Abo, RP, Ducar M., Garcia EP, Thorner AR, Rojas-Rudilla V., Lin L., Sholl LM, Hahn WC, Meyerson M., Lindeman NI, Van Hummelen P., and Macconaill LE Nucleic acids research, 2014/11/26, (2014) Read More / View Supplemental Materials
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Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence.Genovese, G., Kähler AK, Handsaker RE, Lindberg J., Rose SA, Bakhoum SF, Chambert K., Mick E., Neale BM, Fromer M., Purcell SM, Svantesson O., Landén M., Höglund M., Lehmann S., Gabriel SB, Moran JL, Lander E. S., Sullivan PF, Sklar P., et al. The New England journal of medicine, 2014/11/26, (2014) Read More / View Supplemental Materials
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DNA methylation signatures link prenatal famine exposure to growth and metabolism.Tobi, EW, Goeman JJ, Monajemi R., Gu H., Putter H., Zhang Y., Slieker RC, Stok AP, Thijssen PE, Müller F., van Zwet EW, Bock C., Meissner A., Lumey LH, Eline Slagboom P., and Heijmans BT Nature communications, 2014/11/26, Volume 5, p.5592, (2014) Read More / View Supplemental Materials
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Global Proteome Turnover Analyses of the Yeasts S. cerevisiae and S. pombe.Christiano, R., Nagaraj N., Fröhlich F., and Walther TC Cell reports, 2014/11/26, (2014) Read More / View Supplemental Materials
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Targeted and genome-wide sequencing reveal single nucleotide variations impacting specificity of Cas9 in human stem cells.Yang, L., Grishin D., Wang G., Aach J., Zhang CZ, Chari R., Homsy J., Cai X., Zhao Y., Fan JB, Seidman C., Seidman J., Pu W., and Church G. Nature communications, 2014/11/26, Volume 5, p.5507, (2014) Read More / View Supplemental Materials
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Functional optimization of gene clusters by combinatorial design and assembly.Smanski, MJ, Bhatia S., Zhao D., Park Y., B A Woodruff L., Giannoukos G., Ciulla D., Busby M., Calderon J., Nicol R., Gordon DB, Densmore D., and Voigt CA Nature biotechnology, 2014/11/24, (2014) Read More / View Supplemental Materials
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Measuring missing heritability: Inferring the contribution of common variants.Golan, D., Lander E. S., and Rosset S. Proceedings of the National Academy of Sciences of the United States of America, 2014/11/24, (2014) Read More / View Supplemental Materials
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Modeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts.Wainger, BJ, Buttermore ED, Oliveira JT, Mellin C., Lee S., Saber WA, Wang AJ, Ichida JK, Chiu IM, Barrett L., Huebner EA, Bilgin C., Tsujimoto N., Brenneis C., Kapur K., Rubin LL, Eggan K., and Woolf CJ Nature neuroscience, 2014/11/24, (2014) Read More / View Supplemental Materials
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A Predictive Model of Bifunctional Transcription Factor Signaling during Embryonic Tissue Patterning.Junker, JP, Peterson KA, Nishi Y., Mao J., McMahon AP, and van Oudenaarden A. Developmental cell, 2014/11/24, Volume 31, Issue 4, p.448-60, (2014) Read More / View Supplemental Materials
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In vitro alterations do not reflect a requirement for host cell cycle progression during Plasmodium liver stage infection.Hanson, KK, March S., Ng S., Bhatia S., and Mota MM Eukaryotic cell, 2014/11/21, (2014) Read More / View Supplemental Materials
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A comparative encyclopedia of DNA elements in the mouse genome.Yue, F., Cheng Y., Breschi A., Vierstra J., Wu W., Ryba T., Sandstrom R., Ma Z., Davis C., Pope BD, Shen Y., Pervouchine DD, Djebali S., Thurman RE, Kaul R., Rynes E., Kirilusha A., Marinov GK, Williams BA, Trout D., et al. Nature, 2014/11/20, Volume 515, Issue 7527, p.355-64, (2014) Read More / View Supplemental Materials
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Genetic variation in human DNA replication timing.Koren, A., Handsaker RE, Kamitaki N., Karli R., Ghosh S., Polak P., Eggan K., and McCarroll SA Cell, 2014/11/20, Volume 159, Issue 5, p.1015-26, (2014) Read More / View Supplemental Materials
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iPSC-derived dopamine neurons reveal differences between monozygotic twins discordant for Parkinson's disease.Woodard, CM, Campos BA, Kuo SH, Nirenberg MJ, Nestor MW, Zimmer M., Mosharov EV, Sulzer D., Zhou H., Paull D., Clark L., Schadt EE, Sardi SP, Rubin L., Eggan K., Brock M., Lipnick S., Rao M., Chang S., Li A., et al. Cell reports, 2014/11/20, Volume 9, Issue 4, p.1173-82, (2014) Read More / View Supplemental Materials
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A Negative Feedback Loop of Transcription Factors Specifies Alternative Dendritic Cell Chromatin States.Bornstein, C., Winter D., Barnett-Itzhaki Z., David E., Kadri S., Garber M., and Amit I. Molecular cell, 2014/11/20, (2014) Read More / View Supplemental Materials
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A role for noncoding variation in schizophrenia.Roussos, P., Mitchell AC, Voloudakis G., Fullard JF, Pothula VM, Tsang J., Stahl EA, Georgakopoulos A., Ruderfer DM, Charney A., Okada Y., Siminovitch KA, Worthington J., Padyukov L., Klareskog L., Gregersen PK, Plenge RM, Raychaudhuri S., Fromer M., Purcell SM, et al. Cell reports, 2014/11/20, Volume 9, Issue 4, p.1417-29, (2014) Read More / View Supplemental Materials
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SGK3 Mediates INPP4B-Dependent PI3K Signaling in Breast Cancer.Gasser, JA, Inuzuka H., Lau AW, Wei W., Beroukhim R., and Toker A. Molecular cell, 2014/11/20, Volume 56, Issue 4, p.595-607, (2014) Read More / View Supplemental Materials
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Novel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study.Gottlieb, DJ, Hek K., Chen TH, Watson NF, Eiriksdottir G., Byrne EM, Cornelis M., Warby SC, Bandinelli S., Cherkas L., Evans DS, Grabe HJ, Lahti J., Li M., Lehtimäki T., Lumley T., Marciante KD, Pérusse L., Psaty BM, Robbins J., et al. Molecular psychiatry, 2014/11/18, (2014) Read More / View Supplemental Materials
The draft genome sequence of the ferret (Mustela putorius furo) facilitates study of human respiratory disease.Peng, X., Alföldi J., Gori K., Eisfeld AJ, Tyler SR, Tisoncik-Go J., Brawand D., Law GL, Skunca N., Hatta M., Gasper DJ, Kelly SM, Chang J., Thomas MJ, Johnson J., Berlin AM, Lara M., Russell P., Swofford R., Turner-Maier J., et al. Nature biotechnology, 2014/11/17, (2014) Read More / View Supplemental Materials
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Long-term persistence and development of induced pancreatic beta cells generated by lineage conversion of acinar cells.Li, W., Cavelti-Weder C., Zhang Y., Clement K., Donovan S., Gonzalez G., Zhu J., Stemann M., Xu K., Hashimoto T., Yamada T., Nakanishi M., Zhang Y., Zeng S., Gifford D., Meissner A., Weir G., and Zhou Q. Nature biotechnology, 2014/11/17, (2014) Read More / View Supplemental Materials
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Rapid neurogenesis through transcriptional activation in human stem cells.Busskamp, V., Lewis NE, Guye P., Ng AH, Shipman SL, Byrne SM, Sanjana NE, Murn J., Li Y., Li S., Stadler M., Weiss R., and Church GM Molecular systems biology, 2014/11/17, Volume 10, Issue 11, p.760, (2014) Read More / View Supplemental Materials
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A recurrent de novo mutation in KCNC1 causes progressive myoclonus epilepsy.Muona, M., Berkovic SF, Dibbens LM, Oliver KL, Maljevic S., Bayly MA, Joensuu T., Canafoglia L., Franceschetti S., Michelucci R., Markkinen S., Heron SE, Hildebrand MS, Andermann E., Andermann F., Gambardella A., Tinuper P., Licchetta L., Scheffer IE, Criscuolo C., et al. Nature genetics, 2014/11/17, (2014) Read More / View Supplemental Materials
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15 years of zebrafish chemical screening.Rennekamp, AJ, and Peterson RT Current opinion in chemical biology, 2014/11/15, Volume 24C, p.58-70, (2014) Read More / View Supplemental Materials
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Mental health: depression needs large human-genetics studies.Hyman, S. Nature, 2014/11/13, Volume 515, Issue 7526, p.189-91, (2014) Read More / View Supplemental Materials
Subclonal mutations in SETBP1 confer a poor prognosis in juvenile myelomonocytic leukemia.Stieglitz, E., Troup CB, Gelston LC, Haliburton J., Chow ED, Yu KB, Akutagawa J., Taylor-Weiner AN, Liu YL, Wang YD, Beckman K., Emanuel PD, Braun BS, Abate A., Gerbing RB, Alonzo TA, and Loh M. L. Blood, 2014/11/13, (2014) Read More / View Supplemental Materials
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Synaptic, transcriptional and chromatin genes disrupted in autism.De Rubeis, S., He X., Goldberg AP, Poultney CS, Samocha K., Ercument Cicek A., Kou Y., Liu L., Fromer M., Walker S., Singh T., Klei L., Kosmicki J., Fu SC, Aleksic B., Biscaldi M., Bolton PF, Brownfeld JM, Cai J., Campbell NG, et al. Nature, 2014/11/13, Volume 515, Issue 7526, p.209-15, (2014) Read More / View Supplemental Materials
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Unencapsulated Streptococcus pneumoniae from conjunctivitis encode variant traits and belong to a distinct phylogenetic cluster.Valentino, MD, McGuire AM, Rosch JW, Bispo PJ, Burnham C., Sanfilippo CM, Carter RA, Zegans ME, Beall B., Earl AM, Tuomanen EI, Morris TW, Haas W., and Gilmore MS Nature communications, 2014/11/12, Volume 5, p.5411, (2014) Read More / View Supplemental Materials
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FASTKD2 is associated with memory and hippocampal structure in older adults.Ramanan, VK, Nho K., Shen L., Risacher SL, Kim S., McDonald BC, Farlow MR, Foroud TM, Gao S., Soininen H., Kłoszewska I., Mecocci P., Tsolaki M., Vellas B., Lovestone S., Aisen PS, Petersen RC, Jack CR Jr, Shaw LM, Trojanowski JQ, et al. Molecular psychiatry, 2014/11/11, (2014) Read More / View Supplemental Materials
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EWS-FLI1 Utilizes Divergent Chromatin Remodeling Mechanisms to Directly Activate or Repress Enhancer Elements in Ewing Sarcoma.Riggi, N., Knoechel B., Gillespie SM, Rheinbay E., Boulay G., Suvà ML, Rossetti NE, Boonseng WE, Oksuz O., Cook EB, Formey A., Patel A., Gymrek M., Thapar V., Deshpande V., Ting DT, Hornicek FJ, Nielsen GP, Stamenkovic I., Aryee MJ, et al. Cancer cell, 2014/11/10, Volume 26, Issue 5, p.668-81, (2014) Read More / View Supplemental Materials
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Leveraging population admixture to characterize the heritability of complex traits.Zaitlen, N., Pasaniuc B., Sankararaman S., Bhatia G., Zhang J., Gusev A., Young T., Tandon A., Pollack S., Vilhjálmsson BJ, Assimes TL, Berndt SI, Blot WJ, Chanock S., Franceschini N., Goodman PG, He J., Hennis AJ, Hsing A., Ingles SA, et al. Nature genetics, 2014/11/10, (2014) Read More / View Supplemental Materials
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Variation at HLA-DRB1 is associated with resistance to enteric fever.Dunstan, SJ, Hue NT, Han B., Li Z., Tram TT, Sim KS, Parry CM, Chinh NT, Vinh H., Lan NP, Thieu NT, Vinh PV, Koirala S., Dongol S., Arjyal A., Karkey A., Shilpakar O., Dolecek C., Foo JN, Phuong LT, et al. Nature genetics, 2014/11/10, (2014) Read More / View Supplemental Materials
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Genome-Level Determination of Plasmodium falciparum Blood Stage Targets of Malarial Clinical Immunity in the Peruvian Amazon.Torres, KJ, Castrillon CE, Moss EL, Saito M., Tenorio R., Molina DM, Davies H., Neafsey DE, Felgner P., Vinetz JM, and Gamboa D. The Journal of infectious diseases, 2014/11/07, (2014) Read More / View Supplemental Materials
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Magnetic resonance detection of individual proton spins using quantum reporters.Sushkov, AO, Lovchinsky I., Chisholm N., Walsworth RL, Park H., and Lukin MD Physical review letters, 2014/11/07, Volume 113, Issue 19, p.197601, (2014) Read More / View Supplemental Materials
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5-hydroxymethylcytosine is not present in appreciable quantities in Arabidopsis DNA.Erdmann, RM, Souza AL, Clish CB, and Gehring M. G3 (Bethesda, Md.), 2014/11/06, Volume 5, Issue 1, p.1-8, (2014) Read More / View Supplemental Materials
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Building the Connectivity Map of epigenetics: Chromatin profiling by quantitative targeted mass spectrometry.Creech, AL, Taylor JE, Maier VK, Wu X., Feeney CM, Udeshi ND, Peach SE, Boehm JS, Lee JT, Carr SA, and Jaffe JD Methods (San Diego, Calif.), 2014/11/06, (2014) Read More / View Supplemental Materials
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Changes in Nucleosome Occupancy Associated with Metabolic Alterations in Aged Mammalian Liver.Bochkis, IM, Przybylski D., Chen J., and Regev A. Cell reports, 2014/11/06, Volume 9, Issue 3, p.996-1006, (2014) Read More / View Supplemental Materials
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Controlling the survival of human pluripotent stem cells by small molecule-based targeting of topoisomerase II alpha.Ben-David, U., Cowell IG, Austin CA, and Benvenisty N. Stem cells (Dayton, Ohio), 2014/11/06, (2014) Read More / View Supplemental Materials
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Efficient Ablation of Genes in Human Hematopoietic Stem and Effector Cells using CRISPR/Cas9.Mandal, PK, Ferreira LM, Collins R., Meissner TB, Boutwell CL, Friesen M., Vrbanac V., Garrison BS, Stortchevoi A., Bryder D., Musunuru K., Brand H., Tager AM, Allen TM, Talkowski ME, Rossi DJ, and Cowan CA Cell stem cell, 2014/11/06, Volume 15, Issue 5, p.643-52, (2014) Read More / View Supplemental Materials
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A Novel Test for Recessive Contributions to Complex Diseases Implicates Bardet-Biedl Syndrome Gene BBS10 in Idiopathic Type 2 Diabetes and Obesity.Lim, ET, Liu YP, Chan Y., Tiinamaija T., Käräjämäki A., Madsen E., Go-T2D Consortium, Altshuler DM, Raychaudhuri S., Groop L., Flannick J., Hirschhorn JN, Katsanis N., and Daly M. J. American journal of human genetics, 2014/11/06, Volume 95, Issue 5, p.509-20, (2014) Read More / View Supplemental Materials
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Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases.Gusev, A., Lee SH, Trynka G., Finucane H., Vilhjálmsson BJ, Xu H., Zang C., Ripke S., Bulik-Sullivan B., Stahl E., Schizophrenia Working Group of the Psychiatric Genomics Consortium, SWE-SCZ Consortium, Kähler AK, Hultman CM, Purcell SM, McCarroll SA, Daly M., Pasaniuc B., Sullivan PF, Neale BM, et al. American journal of human genetics, 2014/11/06, Volume 95, Issue 5, p.535-52, (2014) Read More / View Supplemental Materials
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Association of Low-Density Lipoprotein Cholesterol-Related Genetic Variants With Aortic Valve Calcium and Incident Aortic Stenosis.Smith, JG, Luk K., Schulz CA, Engert JC, Do R., Hindy G., Rukh G., Dufresne L., Almgren P., Owens DS, Harris TB, Peloso GM, Kerr KF, Wong Q., Smith AV, Budoff MJ, Rotter JI, Cupples LA, Rich S., Kathiresan S., et al. JAMA, 2014/11/05, Volume 312, Issue 17, p.1764-1771, (2014) Read More / View Supplemental Materials
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Improving and accelerating drug development for nervous system disorders.Pankevich, DE, Altevogt BM, Dunlop J., Gage FH, and Hyman SE Neuron, 2014/11/05, Volume 84, Issue 3, p.546-53, (2014) Read More / View Supplemental Materials
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Medicines for the Mind: Policy-Based "Pull" Incentives for Creating Breakthrough CNS Drugs.Choi, DW, Armitage R., Brady LS, Coetzee T., Fisher W., Hyman S., Pande A., Paul S., Potter W., Roin B., and Sherer T. Neuron, 2014/11/05, Volume 84, Issue 3, p.554-563, (2014) Read More / View Supplemental Materials
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No evidence for rare recessive and compound heterozygous disruptive variants in schizophrenia.Ruderfer, DM, Lim ET, Genovese G., Moran JL, Hultman CM, Sullivan PF, McCarroll SA, Holmans P., Sklar P., and Purcell SM European journal of human genetics : EJHG, 2014/11/05, (2014) Read More / View Supplemental Materials
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Optimization of transcription factor binding map accuracy utilizing knockout-mouse models.Krebs, W., Schmidt SV, Goren A., De Nardo D., Labzin L., Bovier A., Ulas T., Theis H., Kraut M., Latz E., Beyer M., and Schultze JL Nucleic acids research, 2014/11/05, (2014) Read More / View Supplemental Materials
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Determining Microbial Products and Identifying Molecular Targets in the Human Microbiome.Joice, R., Yasuda K., Shafquat A., Morgan XC, and Huttenhower C. Cell metabolism, 2014/11/04, Volume 20, Issue 5, p.731-741, (2014) Read More / View Supplemental Materials
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Evolution of invasion in a diverse set of fusobacterium species.Manson McGuire, A., Cochrane K., Griggs AD, Haas BJ, Abeel T., Zeng Q., Nice JB, MacDonald H., Birren BW, Berger BW, Allen-Vercoe E., and Earl AM mBio, 2014/11/04, Volume 5, Issue 6, (2014) Read More / View Supplemental Materials
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Molecular profiling of endometrial carcinoma precursor, primary and metastatic lesions suggests different targets for treatment in obese compared to non-obese patients.Berg, A., Hoivik EA, Mjøs S., Holst F., Werner HM, Tangen IL, Taylor-Weiner A., Gibson WJ, Kusonmano K., Wik E., Trovik J., Halle MK, Oyan AM, Kalland KH, Cherniack AD, Beroukhim R., Stefansson I., Mills GB, Krakstad C., and Salvesen HB Oncotarget, 2014/11/04, (2014) Read More / View Supplemental Materials
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Association of Brain DNA Methylation in SORL1, ABCA7, HLA-DRB5, SLC24A4, and BIN1 With Pathological Diagnosis of Alzheimer Disease.Yu, L., Chibnik LB, Srivastava GP, Pochet N., Yang J., Xu J., Kozubek J., Obholzer N., Leurgans SE, Schneider JA, Meissner A., De Jager PL, and Bennett DA JAMA neurology, 2014/11/03, (2014) Read More / View Supplemental Materials
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Immune characterization of P. falciparum parasites with a shared genetic signature in a region of decreasing transmission.Bei, AK, Diouf A., Miura K., Larremore DB, Ribacke U., Tullo G., Moss EL, Neafsey DE, Daniels RF, Zeituni AE, Nosamiefan I., Volkman SK, Ahouidi AD, Ndiaye D., Dieye T., Mboup S., Buckee CO, Long CA, and Wirth DF Infection and immunity, 2014/11/03, (2014) Read More / View Supplemental Materials
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Pathways targeted by anti-diabetes drugs are enriched for multiple genes associated with type 2 diabetes risk.Segrè, AV, Wei N., DIAGRAM Consortium, investigators MAGIC, Altshuler D., and Florez JC Diabetes, 2014/11/03, (2014) Read More / View Supplemental Materials
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Coverage recommendations for methylation analysis by whole-genome bisulfite sequencing.Ziller, MJ, Hansen KD, Meissner A., and Aryee MJ Nature methods, 2014/11/02, (2014) Read More / View Supplemental Materials
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24-hour rhythms of DNA methylation and their relation with rhythms of RNA expression in the human dorsolateral prefrontal cortex.Lim, AS, Srivastava GP, Yu L., Chibnik LB, Xu J., Buchman AS, Schneider JA, Myers AJ, Bennett DA, and De Jager PL PLoS genetics, 2014/11/01, Volume 10, Issue 11, p.e1004792, (2014) Read More / View Supplemental Materials
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Gray matter myelination of 1555 human brains using partial volume corrected MRI images.Shafee, R., Buckner RL, and Fischl B. NeuroImage, 2014/11/01, (2014) Read More / View Supplemental Materials
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Utilizing diversity-oriented synthesis in antimicrobial drug discovery.Comer, E., Duvall JR, and duPont Lee M 4th Future medicinal chemistry, 2014/11/01, Volume 6, Issue 17, p.1927-42, (2014) Read More / View Supplemental Materials
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Cell type-specific plasticity of striatal projection neurons in parkinsonism and L-DOPA-induced dyskinesia.Fieblinger, T., Graves SM, Sebel LE, Alcacer C., Plotkin JL, Gertler TS, Chan CS, Heiman M., Greengard P., Cenci MA, and Surmeier DJ Nature communications, 2014/10/31, Volume 5, p.5316, (2014) Read More / View Supplemental Materials
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Wildlife disease. Recent introduction of a chytrid fungus endangers Western Palearctic salamanders.Martel, A., Blooi M., Adriaensen C., Van Rooij P., Beukema W., Fisher MC, Farrer RA, Schmidt BR, Tobler U., Goka K., Lips KR, Muletz C., Zamudio KR, Bosch J., Lötters S., Wombwell E., Garner TW, Cunningham AA, Spitzen-van der Sluijs A., Salvidio S., et al. Science (New York, N.Y.), 2014/10/31, Volume 346, Issue 6209, p.630-1, (2014) Read More / View Supplemental Materials
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Genetic and epigenetic fine mapping of causal autoimmune disease variants.Farh, KK, Marson A., Zhu J., Kleinewietfeld M., Housley WJ, Beik S., Shoresh N., Whitton H., Ryan RJ, Shishkin AA, Hatan M., Carrasco-Alfonso MJ, Mayer D., Luckey CJ, Patsopoulos NA, De Jager PL, Kuchroo VK, Epstein CB, Daly M. J., Hafler DA, et al. Nature, 2014/10/29, (2014) Read More / View Supplemental Materials
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Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis.Benyamin, B., Esko T., Ried JS, Radhakrishnan A., Vermeulen SH, Traglia M., Gögele M., Anderson D., Broer L., Podmore C., Luan J., Kutalik Z., Sanna S., van der Meer P., Tanaka T., Wang F., Westra HJ, Franke L., Mihailov E., Milani L., et al. Nature communications, 2014/10/29, Volume 5, p.4926, (2014) Read More / View Supplemental Materials
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Genetic background of extreme violent behavior.Tiihonen, J., Rautiainen MR, Ollila HM, Repo-Tiihonen E., Virkkunen M., Palotie A., Pietiläinen O., Kristiansson K., Joukamaa M., Lauerma H., Saarela J., Tyni S., Vartiainen H., Paananen J., Goldman D., and Paunio T. Molecular psychiatry, 2014/10/28, (2014) Read More / View Supplemental Materials
Abstract
Pilicide ec240 Disrupts Virulence Circuits in Uropathogenic Escherichia coli.Greene, SE, Pinkner JS, Chorell E., Dodson KW, Shaffer CL, Conover MS, Livny J., Hadjifrangiskou M., Almqvist F., and Hultgren SJ mBio, 2014/10/28, Volume 5, Issue 6, (2014) Read More / View Supplemental Materials
Abstract
Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors.Tan, L., Wang J., Tanizaki J., Huang Z., Aref AR, Rusan M., Zhu SJ, Zhang Y., Ercan D., Liao RG, Capelletti M., Zhou W., Hur W., Kim N., Sim T., Gaudet S., Barbie DA, Yeh JR, Yun CH, Hammerman PS, et al. Proceedings of the National Academy of Sciences of the United States of America, 2014/10/27, (2014) Read More / View Supplemental Materials
Abstract
RNF43 is frequently mutated in colorectal and endometrial cancers.Giannakis, M., Hodis E., Jasmine Mu X., Yamauchi M., Rosenbluh J., Cibulskis K., Saksena G., Lawrence MS, Qian ZR, Nishihara R., Allen EM, Hahn WC, Gabriel SB, Lander E. S., Getz G., Ogino S., Fuchs CS, and Garraway LA Nature genetics, 2014/10/26, (2014) Read More / View Supplemental Materials
Abstract
BCG-induced trained immunity in NK cells: Role for non-specific protection to infection.Kleinnijenhuis, J., Quintin J., Preijers F., Joosten LA, Jacobs C., Xavier RJ, van der Meer JW, van Crevel R., and Netea MG Clinical immunology (Orlando, Fla.), 2014/10/25, Volume 155, Issue 2, p.213-219, (2014) Read More / View Supplemental Materials
Abstract
Genome sequence of a 45,000-year-old modern human from western Siberia.Fu, Q., Li H., Moorjani P., Jay F., Slepchenko SM, Bondarev AA, Johnson PL, Aximu-Petri A., Prüfer K., de Filippo C., Meyer M., Zwyns N., Salazar-García DC, Kuzmin YV, Keates SG, Kosintsev PA, Razhev DI, Richards MP, Peristov NV, Lachmann M., et al. Nature, 2014/10/23, Volume 514, Issue 7523, p.445-9, (2014) Read More / View Supplemental Materials
Abstract
Hydroxamic acid-based histone deacetylase (HDAC) inhibitors can mediate neuroprotection independent of HDAC inhibition.Sleiman, SF, Olson DE, Bourassa MW, Karuppagounder SS, Zhang YL, Gale J., Wagner FF, Basso M., Coppola G., Pinto JT, Holson EB, and Ratan RR The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014/10/22, Volume 34, Issue 43, p.14328-37, (2014) Read More / View Supplemental Materials
Abstract
Autism spectrum disorder severity reflects the average contribution of de novo and familial influences.Robinson, EB, Samocha KE, Kosmicki JA, McGrath L., Neale BM, Perlis RH, and Daly M. J. Proceedings of the National Academy of Sciences of the United States of America, 2014/10/21, Volume 111, Issue 42, p.15161-5, (2014) Read More / View Supplemental Materials
Abstract
CHD8 regulates neurodevelopmental pathways associated with autism spectrum disorder in neural progenitors.Sugathan, A., Biagioli M., Golzio C., Erdin S., Blumenthal I., Manavalan P., Ragavendran A., Brand H., Lucente D., Miles J., Sheridan SD, Stortchevoi A., Kellis M., Haggarty SJ, Katsanis N., Gusella JF, and Talkowski ME Proceedings of the National Academy of Sciences of the United States of America, 2014/10/21, Volume 111, Issue 42, p.E4468-77, (2014) Read More / View Supplemental Materials
Abstract
Clonal outbreak of Plasmodium falciparum in eastern Panama.Obaldia N, 3rd, Baro NK, Calzada JE, Santamaria AM, Daniels R., Wong W., Chang HH, Hamilton EJ, Arevalo-Herrera M., Herrera S., Wirth DF, Hartl DL, Marti M., and Volkman SK The Journal of infectious diseases, 2014/10/21, (2014) Read More / View Supplemental Materials
Abstract
Diversity-Oriented Synthesis probe targets Plasmodium falciparum cytochrome b ubiquinone reduction site and synergizes with oxidation site inhibitors.Lukens, AK, Heidebrecht RW Jr, Mulrooney C., Beaudoin JA, Comer E., Duvall JR, Fitzgerald ME, Masi D., Galinsky K., Scherer CA, Palmer M., Munoz B., Foley M., Schreiber SL, Wiegand RC, and Wirth DF The Journal of infectious diseases, 2014/10/21, (2014) Read More / View Supplemental Materials
Abstract
Origin in Acinetobacter guillouiae and Dissemination of the Aminoglycoside-Modifying Enzyme Aph(3')-VI.Yoon, EJ, Goussard S., Touchon M., Krizova L., Cerqueira G., Murphy C., Lambert T., Grillot-Courvalin C., Nemec A., and Courvalin P. mBio, 2014/10/21, Volume 5, Issue 5, (2014) Read More / View Supplemental Materials
Abstract
Comprehensive variation discovery in single human genomes.Weisenfeld, NI, Yin S., Sharpe T., Lau B., Hegarty R., Holmes L., Sogoloff B., Tabbaa D., Williams L., Russ C., Nusbaum C., Lander E. S., Maccallum I., and Jaffe DB Nature genetics, 2014/10/19, (2014) Read More / View Supplemental Materials
Abstract
In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9.Swiech, L., Heidenreich M., Banerjee A., Habib N., Li Y., Trombetta J., Sur M., and Zhang F. Nature biotechnology, 2014/10/19, (2014) Read More / View Supplemental Materials
Abstract
An unbiased approach to identify endogenous substrates of "histone" deacetylase 8.Olson, DE, Udeshi ND, Wolfson NA, Pitcairn CA, Sullivan ED, Jaffe JD, Svinkina T., Natoli T., Lu X., Paulk J., McCarren P., Wagner FF, Barker D., Howe E., Lazzaro F., Gale JP, Zhang YL, Subramanian A., Fierke CA, Carr SA, et al. ACS chemical biology, 2014/10/17, Volume 9, Issue 10, p.2210-6, (2014) Read More / View Supplemental Materials
Abstract
Malawi polyomavirus is a prevalent human virus that interacts with known tumor suppressors.Berrios, C., Jung J., Primi B., Wang M., Pedamallu C., Duke F., Marcelus C., Cheng J., Garcea RL, Meyerson M., DeCaprio JA, and the TEDDY Study Group Journal of virology, 2014/10/15, (2014) Read More / View Supplemental Materials
Abstract
Identification of a Multipotent Self-Renewing Stromal Progenitor Population during Mammalian Kidney Organogenesis.Kobayashi, A., Mugford JW, Krautzberger AM, Naiman N., Liao J., and McMahon AP Stem cell reports, 2014/10/14, Volume 3, Issue 4, p.650-62, (2014) Read More / View Supplemental Materials
Abstract
Characterization of HPV and host genome interactions in primary head and neck cancers.Parfenov, M., Pedamallu CS, Gehlenborg N., Freeman SS, Danilova L., Bristow CA, Lee S., Hadjipanayis AG, Ivanova EV, Wilkerson MD, Protopopov A., Yang L., Seth S., Song X., Tang J., Ren X., Zhang J., Pantazi A., Santoso N., Xu AW, et al. Proceedings of the National Academy of Sciences of the United States of America, 2014/10/13, (2014) Read More / View Supplemental Materials
Abstract
The Genomic Diversification of the Whole Acinetobacter Genus: Origins, Mechanisms, and Consequences.Touchon, M., Cury J., Yoon EJ, Krizova L., Cerqueira GC, Murphy C., Feldgarden M., Wortman J., Clermont D., Lambert T., Grillot-Courvalin C., Nemec A., Courvalin P., and Rocha EP Genome biology and evolution, 2014/10/13, (2014) Read More / View Supplemental Materials
Abstract
SNPsnap: a web-based tool for identification and annotation of matched SNPs.Pers, TH, Timshel P., and Hirschhorn JN Bioinformatics (Oxford, England), 2014/10/13, (2014) Read More / View Supplemental Materials
Abstract
Genome wide association study identifies variants in NBEA associated with migraine in bipolar disorder.Jacobsen, KK, Nievergelt CM, Zayats T., Greenwood TA, Anttila V., Akiskal HS, BiGS Consortium, IHG Consortium, include: BiGS Consortium Co-Authors, include: IHG Consortium Co-Authors, Haavik J., Bernt Fasmer O., Kelsoe JR, Johansson S., Oedegaard KJ, include BiGS Consortium Co-Authors, and include IHG Consortium Co-Authors Journal of affective disorders, 2014/10/12, Volume 172C, p.453-461, (2014) Read More / View Supplemental Materials
Abstract
Gluten sensitivity and relationship to psychiatric symptoms in people with schizophrenia.Jackson, J., Eaton W., Cascella N., Fasano A., Santora D., Sullivan K., Feldman S., Raley H., McMahon RP, Carpenter WT Jr, Demyanovich H., and Kelly DL Schizophrenia research, 2014/10/10, (2014) Read More / View Supplemental Materials
Abstract
Advancing the microbiome research community.Huttenhower, C., Knight R., Brown CT, Caporaso JG, Clemente JC, Gevers D., Franzosa EA, Kelley ST, Knights D., Ley RE, Mahurkar A., Ravel J., Scientists for Advancement of Microbiome Research, and White O. Cell, 2014/10/09, Volume 159, Issue 2, p.227-30, (2014) Read More / View Supplemental Materials
Abstract
Dnase2a Deficiency Uncovers Lysosomal Clearance of Damaged Nuclear DNA via Autophagy.Lan, YY, Londoño D., Bouley R., Rooney MS, and Hacohen N. Cell reports, 2014/10/09, Volume 9, Issue 1, p.180-92, (2014) Read More / View Supplemental Materials
Abstract
Genetic variation in the HLA region is associated with susceptibility to herpes zoster.Crosslin, DR, Carrell DS, Burt A., Kim DS, Underwood JG, Hanna DS, Comstock BA, Baldwin E., de Andrade M., Kullo IJ, Tromp G., Kuivaniemi H., Borthwick KM, McCarty CA, Peissig PL, Doheny KF, Pugh E., Kho A., Pacheco J., Hayes MG, et al. Genes and immunity, 2014/10/09, (2014) Read More / View Supplemental Materials
Abstract
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