Publications

Deep learning to design nuclear-targeting abiotic miniproteins.

Schissel CK, Mohapatra S, Wolfe JM, et al. Deep learning to design nuclear-targeting abiotic miniproteins. Nat Chem. 2021. doi:10.1038/s41557-021-00766-3.

De novo DNA methyltransferases DNMT3A and DNMT3B are essential for XIST silencing for erosion of dosage compensation in pluripotent stem cells.

Fukuda A, Hazelbaker DZ, Motosugi N, et al. De novo DNA methyltransferases DNMT3A and DNMT3B are essential for XIST silencing for erosion of dosage compensation in pluripotent stem cells. Stem Cell Reports. 2021. doi:10.1016/j.stemcr.2021.07.015.

Augmenting and directing long-range CRISPR-mediated activation in human cells.

Y Tak E, Horng JE, Perry NT, et al. Augmenting and directing long-range CRISPR-mediated activation in human cells. Nat Methods. 2021. doi:10.1038/s41592-021-01224-1.

A proteogenomic portrait of lung squamous cell carcinoma.

Satpathy S, Krug K, Beltran PMJean, et al. A proteogenomic portrait of lung squamous cell carcinoma. Cell. 2021;184(16):4348-4371.e40. doi:10.1016/j.cell.2021.07.016.

Discovery of a First-in-Class Inhibitor of the PRMT5-Substrate Adaptor Interaction.

McKinney DC, McMillan BJ, Ranaghan MJ, et al. Discovery of a First-in-Class Inhibitor of the PRMT5-Substrate Adaptor Interaction. J Med Chem. 2021. doi:10.1021/acs.jmedchem.1c00507.

Targeting serine hydroxymethyltransferases 1 and 2 for T-cell acute lymphoblastic leukemia therapy.

Pikman Y, Ocasio-Martinez N, Alexe G, et al. Targeting serine hydroxymethyltransferases 1 and 2 for T-cell acute lymphoblastic leukemia therapy. Leukemia. 2021. doi:10.1038/s41375-021-01361-8.

Phenotype, specificity and avidity of antitumour CD8 T cells in melanoma.

Oliveira G, Stromhaug K, Klaeger S, et al. Phenotype, specificity and avidity of antitumour CD8 T cells in melanoma. Nature. 2021;596(7870):119-125. doi:10.1038/s41586-021-03704-y.

Epigenetic scars of CD8 T cell exhaustion persist after cure of chronic infection in humans.

Yates KB, Tonnerre P, Martin GE, et al. Epigenetic scars of CD8 T cell exhaustion persist after cure of chronic infection in humans. Nat Immunol. 2021;22(8):1020-1029. doi:10.1038/s41590-021-00979-1.

Minimally instrumented SHERLOCK (miSHERLOCK) for CRISPR-based point-of-care diagnosis of SARS-CoV-2 and emerging variants.

de Puig H, Lee RA, Najjar D, et al. Minimally instrumented SHERLOCK (miSHERLOCK) for CRISPR-based point-of-care diagnosis of SARS-CoV-2 and emerging variants. Sci Adv. 2021;7(32). doi:10.1126/sciadv.abh2944.

Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention.

Summers RL, Pasaje CFlerida A, Pisco JP, et al. Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention. Cell Chem Biol. 2021. doi:10.1016/j.chembiol.2021.07.010.