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2016
Common and rare forms of diabetes mellitus: towards a continuum of diabetes subtypes.Flannick, J., Johansson S., and Njølstad PR Nature reviews. Endocrinology, 2016/04/15, (2016) Read More / View Supplemental Materials
Abstract
Genomic Correlates of Immune-Cell Infiltrates in Colorectal Carcinoma.Giannakis, M., Mu XJ, Shukla SA, Qian ZR, Cohen O., Nishihara R., Bahl S., Cao Y., Amin-Mansour A., Yamauchi M., Sukawa Y., Stewart C., Rosenberg M., Mima K., Inamura K., Nosho K., Nowak JA, Lawrence MS, Giovannucci EL, Chan AT, et al. Cell reports, 2016/04/14, (2016) Read More / View Supplemental Materials
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A distant trophoblast-specific enhancer controls HLA-G expression at the maternal-fetal interface.Ferreira, LM, Meissner TB, Mikkelsen TS, Mallard W., O'Donnell CW, Tilburgs T., Gomes HA, Camahort R., Sherwood RI, Gifford DK, Rinn JL, Cowan CA, and Strominger JL Proceedings of the National Academy of Sciences of the United States of America, 2016/04/13, (2016) Read More / View Supplemental Materials
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The Human Vaccines Project: A roadmap for cancer vaccine development.Romero, P., Banchereau J., Bhardwaj N., Cockett M., Disis ML, Dranoff G., Gilboa E., Hammond SA, Hershberg R., Korman AJ, Kvistborg P., Melief C., Mellman I., Palucka AK, Redchenko I., Robins H., Sallusto F., Schenkelberg T., Schoenberger S., Sosman J., et al. Science translational medicine, 2016/04/13, Volume 8, Issue 334, p.334ps9, (2016) Read More / View Supplemental Materials
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A Method to Exploit the Structure of Genetic Ancestry Space to Enhance Case-Control Studies.Bodea, CA, Neale BM, Ripke S., International IBD Genetics Consortium, Daly M. J., Devlin B., and Roeder K. American journal of human genetics, 2016/04/13, (2016) Read More / View Supplemental Materials
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Polq-Mediated End Joining Is Essential for Surviving DNA Double-Strand Breaks during Early Zebrafish Development.Thyme, SB, and Schier AF Cell reports, 2016/04/13, (2016) Read More / View Supplemental Materials
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Vinca alkaloid drugs promote stress-induced translational repression and stress granule formation.Szaflarski, W., Fay MM, Kedersha N., Zabel M., Anderson P., and Ivanov P. Oncotarget, 2016/04/13, (2016) Read More / View Supplemental Materials
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Wisteria Floribunda Agglutinin-Labeled Perineuronal Nets in the Mouse Inferior Colliculus, Thalamic Reticular Nucleus and Auditory Cortex.Fader, SM, Imaizumi K., Yanagawa Y., and Lee CC Brain sciences, 2016/04/13, Volume 6, Issue 2, (2016) Read More / View Supplemental Materials
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Genome-wide analysis of over 106 000 individuals identifies 9 neuroticism-associated loci.Smith, DJ, Escott-Price V., Davies G., Bailey ME, Colodro-Conde L., Ward J., Vedernikov A., Marioni R., Cullen B., Lyall D., Hagenaars SP, Liewald DC, Luciano M., Gale CR, Ritchie SJ, Hayward C., Nicholl B., Bulik-Sullivan B., Adams M., Couvy-Duchesne B., et al. Molecular psychiatry, 2016/04/12, (2016) Read More / View Supplemental Materials
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The statistical properties of gene-set analysis.de Leeuw, CA, Neale BM, Heskes T., and Posthuma D. Nature reviews. Genetics, 2016/04/12, (2016) Read More / View Supplemental Materials
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Crowdsourced estimation of cognitive decline and resilience in Alzheimer's disease.Allen, GI, Amoroso N., Anghel C., Balagurusamy V., Bare CJ, Beaton D., Bellotti R., Bennett DA, Boehme K., Boutros PC, Caberlotto L., Caloian C., Campbell F., Neto EC, Chang YC, Chen B., Chen CY, Chien TY, Clark T., Das S., et al. Alzheimer's & dementia : the journal of the Alzheimer's Association, 2016/04/11, (2016) Read More / View Supplemental Materials
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Genomic and functional analyses of Mycobacterium tuberculosis strains implicate ald in D-cycloserine resistance.Desjardins, CA, Cohen KA, Munsamy V., Abeel T., Maharaj K., Walker BJ, Shea TP, Almeida DV, Manson AL, Salazar A., Padayatchi N., O'Donnell MR, Mlisana KP, Wortman J., Birren BW, Grosset J., Earl AM, and Pym AS Nature genetics, 2016/04/11, (2016) Read More / View Supplemental Materials
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The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice.Townsend, EC, Murakami MA, Christodoulou A., Christie AL, Köster J., DeSouza TA, Morgan EA, Kallgren SP, Liu H., Wu SC, Plana O., Montero J., Stevenson KE, Rao P., Vadhi R., Andreeff M., Armand P., Ballen KK, Barzaghi-Rinaudo P., Cahill S., et al. Cancer cell, 2016/04/11, Volume 29, Issue 4, p.574-86, (2016) Read More / View Supplemental Materials
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Superheroes of disease resistance.Macarthur, D. Nature biotechnology, 2016/04/11, (2016) Read More / View Supplemental Materials
The Chthonomonas calidirosea genome is highly conserved across geography and distinct chemical and microbial environments in the Taupō Volcanic Zone, New Zealand.Lee, KC, Stott MB, Dunfield PF, Huttenhower C., McDonald IR, and Morgan XC Applied and environmental microbiology, 2016/04/08, (2016) Read More / View Supplemental Materials
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Complementation of mitochondrial electron transport chain by manipulation of the NAD+/NADH ratio.Titov, DV, Cracan V., Goodman RP, Peng J., Grabarek Z., and Mootha VK Science (New York, N.Y.), 2016/04/08, Volume 352, Issue 6282, p.231-5, (2016) Read More / View Supplemental Materials
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Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq.Tirosh, I., Izar B., Prakadan SM, Wadsworth MH 2nd, Treacy D., Trombetta JJ, Rotem A., Rodman C., Lian C., Murphy G., Fallahi-Sichani M., Dutton-Regester K., Lin JR, Cohen O., Shah P., Lu D., Genshaft AS, Hughes TK, Ziegler CG, Kazer SW, et al. Science (New York, N.Y.), 2016/04/08, Volume 352, Issue 6282, p.189-96, (2016) Read More / View Supplemental Materials
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Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation.Gusev, A., Shi H., Kichaev G., Pomerantz M., Li F., Long HW, Ingles SA, Kittles RA, Strom SS, Rybicki BA, Nemesure B., Isaacs WB, Zheng W., Pettaway CA, Yeboah ED, Tettey Y., Biritwum RB, Adjei AA, Tay E., Truelove A., et al. Nature communications, 2016/04/07, Volume 7, p.10979, (2016) Read More / View Supplemental Materials
Abstract
Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML.Puram, RV, Kowalczyk MS, de Boer CG, Schneider RK, Miller PG, McConkey M., Tothova Z., Tejero H., Heckl D., Järås M., Chen MC, Li H., Tamayo A., Cowley GS, Rozenblatt-Rosen O., Al-Shahrour F., Regev A., and Ebert BL Cell, 2016/04/07, Volume 165, Issue 2, p.303-16, (2016) Read More / View Supplemental Materials
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Polymorphic tandem repeats within gene promoters act as modifiers of gene expression and DNA methylation in humans.Quilez, J., Guilmatre A., Garg P., Highnam G., Gymrek M., Erlich Y., Joshi RS, Mittelman D., and Sharp AJ Nucleic acids research, 2016/04/07, (2016) Read More / View Supplemental Materials
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Whole exome sequencing of urachal adenocarcinoma reveals recurrent NF1 mutations.Singh, H., Liu Y., Xiao X., Lin L., Kim J., Van Hummelen P., Wu CL, Bass AJ, and Saylor PJ Oncotarget, 2016/04/07, (2016) Read More / View Supplemental Materials
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Metabolomic Biomarkers of Prostate Cancer: Prediction, Diagnosis, Progression, Prognosis, and Recurrence.Kelly, RS, Vander Heiden MG, Giovannucci E., and Mucci LA Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2016/04/06, (2016) Read More / View Supplemental Materials
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Enhanced CLIP Uncovers IMP Protein-RNA Targets in Human Pluripotent Stem Cells Important for Cell Adhesion and Survival.Conway, AE, Van Nostrand EL, Pratt GA, Aigner S., Wilbert ML, Sundararaman B., Freese P., Lambert NJ, Sathe S., Liang TY, Essex A., Landais S., Burge CB, Jones DL, and Yeo GW Cell reports, 2016/04/05, (2016) Read More / View Supplemental Materials
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Novel diversity-oriented synthesis-derived respiratory syncytial virus inhibitors identified via a high throughput replicon-based screen.Duvall, JR, VerPlank L., Ludeke B., McLeod SM, Lee MD 4th, Vishwanathan K., Mulrooney CA, le Quement S., Yu Q., Palmer MA, Fleming P., Fearns R., Foley MA, and Scherer CA Antiviral research, 2016/04/05, (2016) Read More / View Supplemental Materials
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Insight into GATA1 transcriptional activity through interrogation of cis elements disrupted in human erythroid disorders.Wakabayashi, A., Ulirsch JC, Ludwig LS, Fiorini C., Yasuda M., Choudhuri A., McDonel P., Zon LI, and Sankaran VG Proceedings of the National Academy of Sciences of the United States of America, 2016/04/04, (2016) Read More / View Supplemental Materials
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Ancient mitochondrial DNA provides high-resolution time scale of the peopling of the Americas.Llamas, B., Fehren-Schmitz L., Valverde G., Soubrier J., Mallick S., Rohland N., Nordenfelt S., Valdiosera C., Richards SM, Rohrlach A., Romero MI, Espinoza IF, Cagigao ET, Jiménez LW, Makowski K., Reyna IS, Lory JM, Torrez JA, Rivera MA, Burger RL, et al. Science advances, 2016/04/01, Volume 2, Issue 4, p.e1501385, (2016) Read More / View Supplemental Materials
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Comparison of Heritability Estimation and Linkage Analysis for Multiple Traits Using Principal Component Analyses.Liang, J., Cade BE, Wang H., Chen H., Gleason KJ, Larkin EK, Saxena R., Lin X., Redline S., and Zhu X. Genetic epidemiology, 2016/04/01, Volume 40, Issue 3, p.222-32, (2016) Read More / View Supplemental Materials
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Computational Reconstruction of NFκB Pathway Interaction Mechanisms during Prostate Cancer.Börnigen, D., Tyekucheva S., Wang X., Rider JR, Lee GS, Mucci LA, Sweeney C., and Huttenhower C. PLoS computational biology, 2016/04/01, Volume 12, Issue 4, p.e1004820, (2016) Read More / View Supplemental Materials
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GENOME-WIDE ASSOCIATION STUDY (GWAS) AND GENOME-WIDE BY ENVIRONMENT INTERACTION STUDY (GWEIS) OF DEPRESSIVE SYMPTOMS IN AFRICAN AMERICAN AND HISPANIC/LATINA WOMEN.Dunn, EC, Wiste A., Radmanesh F., Almli LM, Gogarten SM, Sofer T., Faul JD, Kardia SL, Smith JA, Weir DR, Zhao W., Soare TW, Mirza SS, Hek K., Tiemeier H., Goveas JS, Sarto GE, Snively BM, Cornelis M., Koenen KC, et al. Depression and anxiety, 2016/04/01, Volume 33, Issue 4, p.265-80, (2016) Read More / View Supplemental Materials
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Homozygous deletion in MICU1 presenting with fatigue and lethargy in childhood.Lewis-Smith, D., Kamer KJ, Griffin H., Childs AM, Pysden K., Titov D., Duff J., Pyle A., Taylor RW, Yu-Wai-Man P., Ramesh V., Horvath R., Mootha VK, and Chinnery PF Neurology. Genetics, 2016/04/01, Volume 2, Issue 2, p.e59, (2016) Read More / View Supplemental Materials
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Lifting Up the HAT: Synthetic Lethal Screening Reveals a Novel Vulnerability at the CBP-p300 Axis.Kadoch, C. Cancer discovery, 2016/04/01, Volume 6, Issue 4, p.350-2, (2016) Read More / View Supplemental Materials
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Polygenic overlap between schizophrenia risk and antipsychotic response: a genomic medicine approach.Ruderfer, DM, Charney AW, Readhead B., Kidd BA, Kähler AK, Kenny PJ, Keiser MJ, Moran JL, Hultman CM, Scott SA, Sullivan PF, Purcell SM, Dudley JT, and Sklar P. The lancet. Psychiatry, 2016/04/01, Volume 3, Issue 4, p.350-7, (2016) Read More / View Supplemental Materials
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Rare loss-of-function variants in SETD1A are associated with schizophrenia and developmental disorders.Singh, T., Kurki MI, Curtis D., Purcell SM, Crooks L., McRae J., Suvisaari J., Chheda H., Blackwood D., Breen G., Pietiläinen O., Gerety SS, Ayub M., Blyth M., Cole T., Collier D., Coomber EL, Craddock N., Daly M. J., Danesh J., et al. Nature neuroscience, 2016/04/01, Volume 19, Issue 4, p.571-7, (2016) Read More / View Supplemental Materials
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Complement and microglia mediate early synapse loss in Alzheimer mouse models.Hong, S., Beja-Glasser VF, Nfonoyim BM, Frouin A., Li S., Ramakrishnan S., Merry KM, Shi Q., Rosenthal A., Barres BA, Lemere CA, Selkoe DJ, and Stevens B. Science (New York, N.Y.), 2016/03/31, (2016) Read More / View Supplemental Materials
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Variants near CHRNA3/5 and APOE have age- and sex-related effects on human lifespan.Joshi, PK, Fischer K., Schraut KE, Campbell H., Esko T., and Wilson JF Nature communications, 2016/03/31, Volume 7, p.11174, (2016) Read More / View Supplemental Materials
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Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1.Chouchani, ET, Kazak L., Jedrychowski MP, Lu GZ, Erickson BK, Szpyt J., Pierce KA, Laznik-Bogoslavski D., Vetrivelan R., Clish CB, Robinson AJ, Gygi SP, and Spiegelman BM Nature, 2016/03/30, (2016) Read More / View Supplemental Materials
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Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium.Stringer, S., Minică CC, Verweij KJ, Mbarek H., Bernard M., Derringer J., van Eijk KR, Isen JD, Loukola A., Maciejewski DF, Mihailov E., van der Most PJ, Sánchez-Mora C., Roos L., Sherva R., Walters R., Ware JJ, Abdellaoui A., Bigdeli TB, Branje SJ, et al. Translational psychiatry, 2016/03/29, Volume 6, p.e769, (2016) Read More / View Supplemental Materials
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Genome-wide interaction study of brain beta-amyloid burden and cognitive impairment in Alzheimer's disease.Roostaei, T., Nazeri A., Felsky D., De Jager PL, Schneider JA, Pollock BG, Bennett DA, Voineskos AN, and Alzheimer’s Disease Neuroimaging Initiative(ADNI) Molecular psychiatry, 2016/03/29, (2016) Read More / View Supplemental Materials
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Leveraging signaling research to understand and treat disease.Yaffe, MB, and Gough NR Science signaling, 2016/03/29, Volume 9, Issue 421, p.eg4, (2016) Read More / View Supplemental Materials
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18F CFA as a clinically translatable probe for PET imaging of deoxycytidine kinase activity.Kim, W., Le TM, Wei L., Poddar S., Bazzy J., Wang X., Uong NT, Abt ER, Capri JR, Austin WR, Van Valkenburgh JS, Steele D., Gipson RM, Slavik R., Cabebe AE, Taechariyakul T., Yaghoubi SS, Lee JT, Sadeghi S., Lavie A., et al. Proceedings of the National Academy of Sciences of the United States of America, 2016/03/28, (2016) Read More / View Supplemental Materials
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Diagnostic Yield of Sequencing Familial Hypercholesterolemia Genes in Patients with Severe Hypercholesterolemia.Khera, AV, Won HH, Peloso GM, Lawson KS, Bartz TM, Deng X., van Leeuwen EM, Natarajan P., Emdin CA, Bick AG, Morrison AC, Brody JA, Gupta N., Nomura A., Kessler T., Duga S., Bis JC, van Duijn CM, Cupples LA, Psaty B., et al. Journal of the American College of Cardiology, 2016/03/28, (2016) Read More / View Supplemental Materials
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G3BP-Caprin1-USP10 complexes mediate stress granule condensation and associate with 40S subunits.Kedersha, N., Panas MD, Achorn CA, Lyons S., Tisdale S., Hickman T., Thomas M., Lieberman J., McInerney GM, Ivanov P., and Anderson P. The Journal of cell biology, 2016/03/28, Volume 212, Issue 7, p.845-60, (2016) Read More / View Supplemental Materials
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The Combined Landscape of Denisovan and Neanderthal Ancestry in Present-Day Humans.Sankararaman, S., Mallick S., Patterson N., and Reich D. Current biology : CB, 2016/03/26, (2016) Read More / View Supplemental Materials
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CANCER. The oncogene makes its escape.Wala, J., and Beroukhim R. Science (New York, N.Y.), 2016/03/25, Volume 351, Issue 6280, p.1398-9, (2016) Read More / View Supplemental Materials
Personal Genome Sequencing in Ostensibly Healthy Individuals and the PeopleSeq Consortium.Linderman, MD, Nielsen DE, and Green RC Journal of personalized medicine, 2016/03/25, Volume 6, Issue 2, (2016) Read More / View Supplemental Materials
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Survey of variation in human transcription factors reveals prevalent DNA binding changes.Barrera, LA, Vedenko A., Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J., Mariani L., Kock KH, Inukai S., Siggers T., Shokri L., Gordân R., Sahni N., Cotsapas C., Hao T., Yi S., Kellis M., Daly M. J., Vidal M., et al. Science (New York, N.Y.), 2016/03/25, Volume 351, Issue 6280, p.1450-4, (2016) Read More / View Supplemental Materials
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Common and Rare Genetic Variation in CCR2, CCR5, or CX3CR1 and Risk of Atherosclerotic Coronary Heart Disease and Glucometabolic Traits.Golbus, JR, Stitziel NO, Zhao W., Xue C., Farrall M., McPherson R., Erdmann J., Deloukas P., Watkins H., Schunkert H., Samani NJ, Saleheen D., Kathiresan S., and Reilly MP Circulation. Cardiovascular genetics, 2016/03/24, (2016) Read More / View Supplemental Materials
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Differential dopaminergic regulation of inwardly rectifying potassium channel mediated subthreshold dynamics in striatal medium spiny neurons.Zhao, B., Zhu J., Dai D., Xing J., He J., Fu Z., Zhang L., Li Z., and Wang W. Neuropharmacology, 2016/03/24, Volume 107, p.396-410, (2016) Read More / View Supplemental Materials
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Function and evolution of local repeats in the Firre locus.Hacisuleyman, E., Shukla CJ, Weiner CL, and Rinn JL Nature communications, 2016/03/24, Volume 7, p.11021, (2016) Read More / View Supplemental Materials
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Improved Identification and Analysis of Small Open Reading Frame Encoded Polypeptides.Ma, J., Diedrich JK, Jungreis I., Donaldson C., Vaughan J., Kellis M., Yates JR 3rd, and Saghatelian A. Analytical chemistry, 2016/03/24, (2016) Read More / View Supplemental Materials
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PGC1α drives NAD biosynthesis linking oxidative metabolism to renal protection.Tran, MT, Zsengeller ZK, Berg AH, Khankin EV, Bhasin MK, Kim W., Clish CB, Stillman IE, Karumanchi SA, Rhee EP, and Parikh SM Nature, 2016/03/24, Volume 531, Issue 7595, p.528-32, (2016) Read More / View Supplemental Materials
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Imprinted genes and imprinting control regions show predominant intermediate methylation in adult somatic tissues.Pervjakova, N., Kasela S., Morris AP, Kals M., Metspalu A., Lindgren CM, Salumets A., and Mägi R. Epigenomics, 2016/03/23, (2016) Read More / View Supplemental Materials
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Methylation profiles in peripheral blood CD4+ lymphocytes versus brain: The relation to Alzheimer's disease pathology.Yu, L., Chibnik L., Yang J., McCabe C., Xu J., Schneider JA, De Jager PL, and Bennett DA Alzheimer's & dementia : the journal of the Alzheimer's Association, 2016/03/23, (2016) Read More / View Supplemental Materials
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Thalamic reticular impairment underlies attention deficit in Ptchd1Y/- mice.Wells, MF, Wimmer RD, Schmitt LI, Feng G., and Halassa MM Nature, 2016/03/23, (2016) Read More / View Supplemental Materials
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Tractography Analysis of 5 White Matter Bundles and Their Clinical and Cognitive Correlates in Early-Course Schizophrenia.Seitz, J., Zuo JX, Lyall AE, Makris N., Kikinis Z., Bouix S., Pasternak O., Fredman E., Duskin J., Goldstein JM, Petryshen TL, Mesholam-Gately RI, Wojcik J., McCarley RW, Seidman LJ, Shenton ME, Koerte IK, and Kubicki M. Schizophrenia bulletin, 2016/03/23, (2016) Read More / View Supplemental Materials
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Fatty Acid Metabolic Defects and Right Ventricular Lipotoxicity in Human Pulmonary Arterial Hypertension.Brittain, EL, Talati M., Fessel JP, Zhu H., Penner N., Calcutt MW, West J., Funke M., Lewis GD, Gerszten RE, Hamid R., Pugh ME, Austin ED, Newman JH, and Hemnes AR Circulation, 2016/03/22, (2016) Read More / View Supplemental Materials
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Variation at 2q35 (PNKD and TMBIM1) influences colorectal cancer risk and identifies a pleiotropic effect with inflammatory bowel disease.Orlando, G., Law PJ, Palin K., Tuupanen S., Gylfe A., Hänninen U., Cajuso T., Tanskanen T., Kondelin J., Kaasinen E., Sarin AP, Kaprio J., Eriksson JG, Rissanen H., Knekt P., Pukkala E., Jousilahti P., Salomaa V., Ripatti S., Palotie A., et al. Human molecular genetics, 2016/03/22, (2016) Read More / View Supplemental Materials
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Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population.Robinson, EB, St Pourcain B., Anttila V., Kosmicki JA, Bulik-Sullivan B., Grove J., Maller J., Samocha KE, Sanders SJ, Ripke S., Martin J., Hollegaard MV, Werge T., Hougaard DM, iPSYCH-SSI-Broad Autism Group, Neale BM, Evans DM, Skuse D., Mortensen PB, Børglum AD, et al. Nature genetics, 2016/03/21, (2016) Read More / View Supplemental Materials
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A role for the bacterial GATC methylome in antibiotic stress survival.Cohen, NR, Ross CA, Jain S., Shapiro RS, Gutierrez A., Belenky P., Li H., and Collins JJ Nature genetics, 2016/03/21, (2016) Read More / View Supplemental Materials
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Stem cell models of neuropsychiatric disorders.Karmacharya, R., and Haggarty SJ Molecular and cellular neurosciences, 2016/03/21, (2016) Read More / View Supplemental Materials
3D hydrogel scaffold doped with 2D graphene materials for biosensors and bioelectronics.Song, HS, Kwon OS, Kim JH, Conde J., and Artzi N. Biosensors & bioelectronics, 2016/03/19, (2016) Read More / View Supplemental Materials
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Disseminated glioneuronal tumors occurring in childhood: treatment outcomes and BRAF alterations including V600E mutation.Dodgshun, AJ, SantaCruz N., Hwang J., Ramkissoon SH, Malkin H., Bergthold G., Manley P., Chi S., MacGregor D., Goumnerova L., Sullivan M., Ligon K., Beroukhim R., Herrington B., Kieran MW, Hansford JR, and Bandopadhayay P. Journal of neuro-oncology, 2016/03/19, (2016) Read More / View Supplemental Materials
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Minimap and miniasm: fast mapping and de novo assembly for noisy long sequences.Li, H. Bioinformatics (Oxford, England), 2016/03/19, (2016) Read More / View Supplemental Materials
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Allele-specific transcription factor binding to common and rare variants associated with disease and gene expression.Cavalli, M., Pan G., Nord H., Wallerman O., Wallén Arzt E., Berggren O., Elvers I., Eloranta ML, Rönnblom L., Lindblad Toh K., and Wadelius C. Human genetics, 2016/03/18, (2016) Read More / View Supplemental Materials
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Genetic Association of Curative and Adverse Reactions to Tyrosine Kinase Inhibitors in Chinese advanced Non-Small Cell Lung Cancer patients.Ruan, Y., Jiang J., Guo L., Li Y., Huang H., Shen L., Luan M., Li M., Du H., Ma C., He L., Zhang X., and Qin S. Scientific reports, 2016/03/18, Volume 6, p.23368, (2016) Read More / View Supplemental Materials
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Targeting Fat: Mechanisms of Protein Localization to Lipid Droplets.Kory, N., Farese RV Jr, and Walther TC Trends in cell biology, 2016/03/16, (2016) Read More / View Supplemental Materials
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Comprehensive analysis of schizophrenia-associated loci highlights ion channel pathways and biologically plausible candidate causal genes.Pers, TH, Timshel P., Ripke S., Lent S., Sullivan PF, O'Donovan MC, Franke L., Hirschhorn JN, and Schizophrenia Working Group of the Psychiatric Genomics Consortium Human molecular genetics, 2016/03/15, Volume 25, Issue 6, p.1247-54, (2016) Read More / View Supplemental Materials
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Genetic Associations with Obstructive Sleep Apnea Traits in Hispanic/Latino Americans.Cade, BE, Chen H., Stilp AM, Gleason KJ, Sofer T., Ancoli-Israel S., Arens R., Bell GI, Below JE, Bjonnes AC, Chun S., Conomos MP, Evans DS, Johnson WC, Frazier-Wood AC, Lane JM, Larkin EK, Loredo JS, Post WS, Ramos AR, et al. American journal of respiratory and critical care medicine, 2016/03/15, (2016) Read More / View Supplemental Materials
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Integrative analyses reveal a long noncoding RNA-mediated sponge regulatory network in prostate cancer.Du, Z., Sun T., Hacisuleyman E., Fei T., Wang X., Brown M., Rinn JL, Lee MG, Chen Y., Kantoff PW, and Liu XS Nature communications, 2016/03/15, Volume 7, p.10982, (2016) Read More / View Supplemental Materials
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Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.Ellinghaus, D., Jostins L., Spain SL, Cortes A., Bethune J., Han B., Park YR, Raychaudhuri S., Pouget JG, Hübenthal M., Folseraas T., Wang Y., Esko T., Metspalu A., Westra HJ, Franke L., Pers TH, Weersma RK, Collij V., D'Amato M., et al. Nature genetics, 2016/03/14, (2016) Read More / View Supplemental Materials
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Light-controlled modulation of gene expression by chemical optoepigenetic probes.Reis, SA, Ghosh B., Hendricks JA, Szantai-Kis DM, Törk L., Ross KN, Lamb J., Read-Button W., Zheng B., Wang H., Salthouse C., Haggarty SJ, and Mazitschek R. Nature chemical biology, 2016/03/14, (2016) Read More / View Supplemental Materials
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Overcoming Therapeutic Resistance in HER2-Positive Breast Cancers with CDK4/6 Inhibitors.Goel, S., Wang Q., Watt AC, Tolaney SM, Dillon DA, Li W., Ramm S., Palmer AC, Yuzugullu H., Varadan V., Tuck D., Harris LN, Wong KK, Liu XS, Sicinski P., Winer EP, Krop IE, and Zhao JJ Cancer cell, 2016/03/14, Volume 29, Issue 3, p.255-69, (2016) Read More / View Supplemental Materials
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Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1.Joyal, JS, Sun Y., Gantner ML, Shao Z., Evans LP, Saba N., Fredrick T., Burnim S., Kim JS, Patel G., Juan AM, Hurst CG, Hatton CJ, Cui Z., Pierce KA, Bherer P., Aguilar E., Powner MB, Vevis K., Boisvert M., et al. Nature medicine, 2016/03/14, (2016) Read More / View Supplemental Materials
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SLC52A3, A Brown-Vialetto-van Laere syndrome candidate gene is essential for mouse development, but dispensable for motor neuron differentiation.Intoh, A., Suzuki N., Koszka K., and Eggan K. Human molecular genetics, 2016/03/13, (2016) Read More / View Supplemental Materials
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From Mutational Mechanisms in Single Cells to Mutational Patterns in Cancer Genomes.Zhang, CZ, and Pellman D. Cold Spring Harbor symposia on quantitative biology, 2016/03/11, (2016) Read More / View Supplemental Materials
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Illumina error profiles: resolving fine-scale variation in metagenomic sequencing data.Schirmer, M., D'Amore R., Ijaz UZ, Hall N., and Quince C. BMC bioinformatics, 2016/03/11, Volume 17, Issue 1, p.125, (2016) Read More / View Supplemental Materials
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Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease.Zanoni, P., Khetarpal SA, Larach DB, Hancock-Cerutti WF, Millar JS, Cuchel M., DerOhannessian S., Kontush A., Surendran P., Saleheen D., Trompet S., Jukema JW, De Craen A., Deloukas P., Sattar N., Ford I., Packard C., Majumder Aa, Alam DS, Di Angelantonio E., et al. Science (New York, N.Y.), 2016/03/11, Volume 351, Issue 6278, p.1166-71, (2016) Read More / View Supplemental Materials
Abstract
Use of the MS2 aptamer and coat protein for RNA localization in yeast: A response to "MS2 coat proteins bound to yeast mRNAs block 5' to 3' degradation and trap mRNA decay products: implications for the localization of mRNAs by MS2-MCP system".Haimovich, G., Zabezhinsky D., Haas B., Slobodin B., Purushothaman P., Fan L., Levin JZ, Nusbaum C., and Gerst JE RNA (New York, N.Y.), 2016/03/11, (2016) Read More / View Supplemental Materials
Abstract
Genome-wide association analysis identifies novel loci for chronotype in 100,420 individuals from the UK Biobank.Lane, JM, Vlasac I., Anderson SG, Kyle SD, Dixon WG, Bechtold DA, Gill S., Little MA, Luik A., Loudon A., Emsley R., Scheer FA, Lawlor DA, Redline S., Ray DW, Rutter MK, and Saxena R. Nature communications, 2016/03/09, Volume 7, p.10889, (2016) Read More / View Supplemental Materials
Abstract
Protective Effects of the Mediterranean Diet on Type 2 Diabetes and Metabolic Syndrome.Salas-Salvadó, J., Guasch-Ferré M., Lee CH, Estruch R., Clish CB, and Ros E. The Journal of nutrition, 2016/03/09, (2016) Read More / View Supplemental Materials
Abstract
Regulation of the fetal hemoglobin silencing factor BCL11A.Basak, A., and Sankaran VG Annals of the New York Academy of Sciences, 2016/03/09, (2016) Read More / View Supplemental Materials
Abstract
The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway.Chantranupong, L., Scaria SM, Saxton RA, Gygi MP, Shen K., Wyant GA, Wang T., Harper JW, Gygi SP, and Sabatini DM Cell, 2016/03/08, (2016) Read More / View Supplemental Materials
Abstract
Height, body mass index, and socioeconomic status: mendelian randomisation study in UK Biobank.Tyrrell, J., Jones SE, Beaumont R., Astley CM, Lovell R., Yaghootkar H., Tuke M., Ruth KS, Freathy RM, Hirschhorn JN, Wood AR, Murray A., Weedon MN, and Frayling TM BMJ (Clinical research ed.), 2016/03/08, Volume 352, p.i582, (2016) Read More / View Supplemental Materials
Abstract
System-wide Analysis of the T Cell Response.Covacu, R., Philip H., Jaronen M., Almeida J., Kenison JE, Darko S., Chao CC, Yaari G., Louzoun Y., Carmel L., Douek DC, Efroni S., and Quintana FJ Cell reports, 2016/03/08, (2016) Read More / View Supplemental Materials
Abstract
Twenty-eight genetic loci associated with ST-T wave amplitudes of the electrocardiogram.Verweij, N., Mateo Leach I., Isaacs A., Arking DE, Bis JC, Pers TH, van den Berg ME, Lyytikäinen LP, Barnett P., Wang X., study LifeLines Cohort, Soliman EZ, van Duijn CM, Kähönen M., van Veldhuisen DJ, Kors JA, Raitakari OT, Silva CT, Lehtimäki T., Hillege HL, et al. Human molecular genetics, 2016/03/08, (2016) Read More / View Supplemental Materials
Abstract
Impaired antibacterial autophagy links granulomatous intestinal inflammation in Niemann-Pick disease type C1 and XIAP deficiency with NOD2 variants in Crohn's disease.Schwerd, T., Pandey S., Yang HT, Bagola K., Jameson E., Jung J., Lachmann RH, Shah N., Patel SY, Booth C., Runz H., Düker G., Bettels R., Rohrbach M., Kugathasan S., Chapel H., Keshav S., Elkadri A., Platt N., Muise AM, et al. Gut, 2016/03/07, (2016) Read More / View Supplemental Materials
Abstract
Inhibition of DYRK1A stimulates human beta-cell proliferation.Dirice, E., Walpita D., Vetere A., Meier BC, Kahraman S., Hu J., Dančík V., Burns SM, Gilbert TJ, Olson DE, Clemons PA, Kulkarni RN, and Wagner BK Diabetes, 2016/03/07, (2016) Read More / View Supplemental Materials
Abstract
The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons.Braasch, I., Gehrke AR, Smith JJ, Kawasaki K., Manousaki T., Pasquier J., Amores A., Desvignes T., Batzel P., Catchen J., Berlin AM, Campbell MS, Barrell D., Martin KJ, Mulley JF, Ravi V., Lee AP, Nakamura T., Chalopin D., Fan S., et al. Nature genetics, 2016/03/07, (2016) Read More / View Supplemental Materials
Abstract
Tissue-specific regulatory circuits reveal variable modular perturbations across complex diseases.Marbach, D., Lamparter D., Quon G., Kellis M., Kutalik Z., and Bergmann S. Nature methods, 2016/03/07, (2016) Read More / View Supplemental Materials
Abstract
Genome sequencing of the phytoseiid predatory mite Metaseiulus occidentalis reveals completely atomised Hox genes and super-dynamic intron evolution.Hoy, MA, Waterhouse RM, Wu K., Estep AS, Ioannidis P., Palmer WJ, Pomerantz AF, Simão FA, Thomas J., Jiggins FM, Murphy TD, Pritham EJ, Robertson HM, Zdobnov EM, Gibbs RA, and Richards S. Genome biology and evolution, 2016/03/06, (2016) Read More / View Supplemental Materials
Abstract
Comparative genomics and prediction of conditionally dispensable sequences in legume-infecting Fusarium oxysporum formae speciales facilitates identification of candidate effectors.Williams, AH, Sharma M., Thatcher LF, Azam S., Hane JK, Sperschneider J., Kidd BN, Anderson JP, Ghosh R., Garg G., Lichtenzveig J., Kistler HC, Shea T., Young S., Buck SA, Kamphuis LG, Saxena R., Pande S., Ma LJ, Varshney RK, et al. BMC genomics, 2016/03/05, Volume 17, Issue 1, p.191, (2016) Read More / View Supplemental Materials
Abstract
Evaluation of DISCOVAR de novo using a mosquito sample for cost-effective short-read genome assembly.Love, RR, Weisenfeld NI, Jaffe DB, Besansky NJ, and Neafsey DE BMC genomics, 2016/03/05, Volume 17, Issue 1, p.187, (2016) Read More / View Supplemental Materials
Abstract
Reproducibility of Differential Proteomic Technologies in CPTAC Fractionated Xenografts.Tabb, DL, Wang X., Carr SA, Clauser KR, Mertins P., Chambers MC, Holman JD, Wang J., Zhang B., Zimmerman LJ, Chen X., Gunawardena HP, Davies SR, Ellis MJ, Li S., Townsend RR, Boja ES, Ketchum KA, Kinsinger CR, Mesri M., et al. Journal of proteome research, 2016/03/04, Volume 15, Issue 3, p.691-706, (2016) Read More / View Supplemental Materials
Abstract
Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade.McGranahan, N., Furness AJ, Rosenthal R., Ramskov S., Lyngaa R., Saini SK, Jamal-Hanjani M., Wilson GA, Birkbak NJ, Hiley CT, Watkins TB, Shafi S., Murugaesu N., Mitter R., Akarca AU, Linares J., Marafioti T., Henry JY, Van Allen EM, Miao D., et al. Science (New York, N.Y.), 2016/03/03, (2016) Read More / View Supplemental Materials
Abstract
CRISPR-Cas9 Targeting of PCSK9 in Human Hepatocytes In Vivo.Wang, X., Raghavan A., Chen T., Qiao L., Zhang Y., Ding Q., and Musunuru K. Arteriosclerosis, thrombosis, and vascular biology, 2016/03/03, (2016) Read More / View Supplemental Materials
Abstract
Draft Genome Sequences of Two Extensively Drug-Resistant Strains of Mycobacterium tuberculosis Belonging to the Euro-American S Lineage.Malinga, LA, Abeel T., Desjardins CA, Dlamini TC, Cassell G., Chapman SB, Birren BW, Earl AM, and van der Walt M. Genome announcements, 2016/03/03, Volume 4, Issue 2, (2016) Read More / View Supplemental Materials
Abstract
Fast Principal-Component Analysis Reveals Convergent Evolution of ADH1B in Europe and East Asia.Galinsky, KJ, Bhatia G., Loh PR, Georgiev S., Mukherjee S., Patterson NJ, and Price AL American journal of human genetics, 2016/03/03, Volume 98, Issue 3, p.456-72, (2016) Read More / View Supplemental Materials
Abstract
Health and population effects of rare gene knockouts in adult humans with related parents.Narasimhan, VM, Hunt KA, Mason D., Baker CL, Karczewski KJ, Barnes MR, Barnett AH, Bates C., Bellary S., Bockett NA, Giorda K., Griffiths CJ, Hemingway H., Jia Z., Kelly MA, Khawaja HA, Lek M., McCarthy S., McEachan R., O'Donnell-Luria A., et al. Science (New York, N.Y.), 2016/03/03, (2016) Read More / View Supplemental Materials
Abstract
High-fat diet enhances stemness and tumorigenicity of intestinal progenitors.Beyaz, S., Mana MD, Roper J., Kedrin D., Saadatpour A., Hong SJ, Bauer-Rowe KE, Xifaras ME, Akkad A., Arias E., Pinello L., Katz Y., Shinagare S., Abu-Remaileh M., Mihaylova MM, Lamming DW, Dogum R., Guo G., Bell GW, Selig M., et al. Nature, 2016/03/03, Volume 531, Issue 7592, p.53-8, (2016) Read More / View Supplemental Materials
Abstract
Steady-state and dynamic gene expression programs in Saccharomyces cerevisiae in response to variation in environmental nitrogen.Airoldi, EM, Miller D., Athanasiadou R., Brandt N., Abdul-Rhaman F., Neymotin B., Hashimoto T., Bahmani T., and Gresham D. Molecular biology of the cell, 2016/03/03, (2016) Read More / View Supplemental Materials
Abstract
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