Publications

Elucidating the path to Plasmodium prolyl-tRNA synthetase inhibitors that overcome halofuginone resistance.

Tye MA, N Payne C, Johansson C, et al. Elucidating the path to Plasmodium prolyl-tRNA synthetase inhibitors that overcome halofuginone resistance. Nat Commun. 2022;13(1):4976. doi:10.1038/s41467-022-32630-4.

Rare coding variation provides insight into the genetic architecture and phenotypic context of autism.

Fu JM, F Satterstrom K, Peng M, et al. Rare coding variation provides insight into the genetic architecture and phenotypic context of autism. Nat Genet. 2022. doi:10.1038/s41588-022-01104-0.

Chromatin-bound RB targets promoters, enhancers, and CTCF-bound loci and is redistributed by cell-cycle progression.

Sanidas I, Lee H, Rumde PH, et al. Chromatin-bound RB targets promoters, enhancers, and CTCF-bound loci and is redistributed by cell-cycle progression. Mol Cell. 2022. doi:10.1016/j.molcel.2022.07.014.

Pyramidal neuron subtype diversity governs microglia states in the neocortex.

Stogsdill JA, Kim K, Binan L, Farhi SL, Levin JZ, Arlotta P. Pyramidal neuron subtype diversity governs microglia states in the neocortex. Nature. 2022. doi:10.1038/s41586-022-05056-7.

Reactive metabolic byproducts contribute to antibiotic lethality under anaerobic conditions.

Wong F, Stokes JM, Bening SC, Vidoudez C, Trauger SA, Collins JJ. Reactive metabolic byproducts contribute to antibiotic lethality under anaerobic conditions. Mol Cell. 2022. doi:10.1016/j.molcel.2022.07.009.

Pan-cancer integrative histology-genomic analysis via multimodal deep learning.

Chen RJ, Lu MY, Williamson DFK, et al. Pan-cancer integrative histology-genomic analysis via multimodal deep learning. Cancer Cell. 2022;40(8):865-878.e6. doi:10.1016/j.ccell.2022.07.004.

A lab-on-a-chip for the concurrent electrochemical detection of SARS-CoV-2 RNA and anti-SARS-CoV-2 antibodies in saliva and plasma.

Najjar D, Rainbow J, Timilsina SSharma, et al. A lab-on-a-chip for the concurrent electrochemical detection of SARS-CoV-2 RNA and anti-SARS-CoV-2 antibodies in saliva and plasma. Nat Biomed Eng. 2022. doi:10.1038/s41551-022-00919-w.

Molecular map of chronic lymphocytic leukemia and its impact on outcome.

Knisbacher BA, Lin Z, Hahn CK, et al. Molecular map of chronic lymphocytic leukemia and its impact on outcome. Nat Genet. 2022. doi:10.1038/s41588-022-01140-w.

A cross-disorder dosage sensitivity map of the human genome.

Collins RL, Glessner JT, Porcu E, et al. A cross-disorder dosage sensitivity map of the human genome. Cell. 2022;185(16):3041-3055.e25. doi:10.1016/j.cell.2022.06.036.

Nanozyme-catalysed CRISPR assay for preamplification-free detection of non-coding RNAs.

Broto M, Kaminski MM, Adrianus C, et al. Nanozyme-catalysed CRISPR assay for preamplification-free detection of non-coding RNAs. Nat Nanotechnol. 2022. doi:10.1038/s41565-022-01179-0.