Publications

A combination CDK4/6 and IGF1R inhibitor strategy for Ewing sarcoma.

Guenther LM, Dharia NV, Ross L, et al. A combination CDK4/6 and IGF1R inhibitor strategy for Ewing sarcoma. Clin Cancer Res. 2018. doi:10.1158/1078-0432.CCR-18-0372.

Tumor fraction in cell-free DNA as a biomarker in prostate cancer.

Choudhury AD, Werner L, Francini E, et al. Tumor fraction in cell-free DNA as a biomarker in prostate cancer. JCI Insight. 2018;3(21). doi:10.1172/jci.insight.122109.

Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN.

Sievers QL, Petzold G, Bunker RD, et al. Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN. Science. 2018;362(6414). doi:10.1126/science.aat0572.

Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration.

McFarland JM, Ho ZV, Kugener G, et al. Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration. Nat Commun. 2018;9(1):4610. doi:10.1038/s41467-018-06916-5.

Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma.

Sade-Feldman M, Yizhak K, Bjorgaard SL, et al. Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma. Cell. 2018;175(4):998-1013.e20. doi:10.1016/j.cell.2018.10.038.

A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade.

Jerby-Arnon L, Shah P, Cuoco MS, et al. A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade. Cell. 2018;175(4):984-997.e24. doi:10.1016/j.cell.2018.09.006.

Species-level functional profiling of metagenomes and metatranscriptomes.

Franzosa EA, McIver LJ, Rahnavard G, et al. Species-level functional profiling of metagenomes and metatranscriptomes. Nat Methods. 2018;15(11):962-968. doi:10.1038/s41592-018-0176-y.

SynerClust: a highly scalable, synteny-aware orthologue clustering tool.

Georgescu CH, Manson AL, Griggs AD, et al. SynerClust: a highly scalable, synteny-aware orthologue clustering tool. Microb Genom. 2018;4(11). doi:10.1099/mgen.0.000231.

National-scale precision medicine for psychiatric disorders in Sweden.

Bergen SE, Sullivan PF. National-scale precision medicine for psychiatric disorders in Sweden. Am J Med Genet B Neuropsychiatr Genet. 2018;177(7):630-634. doi:10.1002/ajmg.b.32562.

The use of electronic health records for psychiatric phenotyping and genomics.

Smoller JW. The use of electronic health records for psychiatric phenotyping and genomics. Am J Med Genet B Neuropsychiatr Genet. 2018;177(7):601-612. doi:10.1002/ajmg.b.32548.