Publications

Capturing single-cell heterogeneity via data fusion improves image-based profiling.

Rohban MH, Abbasi HS, Singh S, Carpenter AE. Capturing single-cell heterogeneity via data fusion improves image-based profiling. Nat Commun. 2019;10(1):2082. doi:10.1038/s41467-019-10154-8.

Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry.

Zhang F, Wei K, Slowikowski K, et al. Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry. Nat Immunol. 2019. doi:10.1038/s41590-019-0378-1.

A High-Throughput Platform to Identify Small-Molecule Inhibitors of CRISPR-Cas9.

Maji B, Gangopadhyay SA, Lee M, et al. A High-Throughput Platform to Identify Small-Molecule Inhibitors of CRISPR-Cas9. Cell. 2019;177(4):1067-1079.e19. doi:10.1016/j.cell.2019.04.009.

Publisher Correction: Side chain determinants of biopolymer function during selection and replication.

Lichtor PA, Chen Z, Elowe NH, Chen JC, Liu DR. Publisher Correction: Side chain determinants of biopolymer function during selection and replication. Nat Chem Biol. 2019;15(5):550. doi:10.1038/s41589-019-0254-1.

CRISPR-suppressor scanning reveals a nonenzymatic role of LSD1 in AML.

Vinyard ME, Su C, Siegenfeld AP, et al. CRISPR-suppressor scanning reveals a nonenzymatic role of LSD1 in AML. Nat Chem Biol. 2019;15(5):529-539. doi:10.1038/s41589-019-0263-0.

Neuronal deletion of Gtf2i, associated with Williams syndrome, causes behavioral and myelin alterations rescuable by a remyelinating drug.

Barak B, Zhang Z, Liu Y, et al. Neuronal deletion of Gtf2i, associated with Williams syndrome, causes behavioral and myelin alterations rescuable by a remyelinating drug. Nat Neurosci. 2019;22(5):700-708. doi:10.1038/s41593-019-0380-9.

Single-cell transcriptomic analysis of Alzheimer's disease.

Mathys H, Davila-Velderrain J, Peng Z, et al. Single-cell transcriptomic analysis of Alzheimer's disease. Nature. 2019. doi:10.1038/s41586-019-1195-2.

The landscape of cancer cell line metabolism.

Li H, Ning S, Ghandi M, et al. The landscape of cancer cell line metabolism. Nat Med. 2019;25(5):850-860. doi:10.1038/s41591-019-0404-8.

Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases.

Lloyd-Price J, Arze C, Ananthakrishnan AN, et al. Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases. Nature. 2019;569(7758):655-662. doi:10.1038/s41586-019-1237-9.

Exploring the In Vivo Role of the Mitochondrial Calcium Uniporter in Brown Fat Bioenergetics.

Flicker D, Sancak Y, Mick E, Goldberger O, Mootha VK. Exploring the In Vivo Role of the Mitochondrial Calcium Uniporter in Brown Fat Bioenergetics. Cell Rep. 2019;27(5):1364-1375.e5. doi:10.1016/j.celrep.2019.04.013.