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2014
Integration of Sequence Data from a Consanguineous Family with Genetic Data from an Outbred Population Identifies PLB1 as a Candidate Rheumatoid Arthritis Risk Gene.Okada, Y., Diogo D., Greenberg JD, Mouassess F., Achkar WA, Fulton RS, Denny JC, Gupta N., Mirel D., Gabriel S., Li G., Kremer JM, Pappas DA, Carroll RJ, Eyler AE, Trynka G., Stahl EA, Cui J., Saxena R., Coenen MJ, et al. PloS one, 2014/01/01, Volume 9, Issue 2, p.e87645, (2014) Read More / View Supplemental Materials
Abstract
Meta-Analysis Identifies Gene-by-Environment Interactions as Demonstrated in a Study of 4,965 Mice.Kang, EY, Han B., Furlotte N., Joo JW, Shih D., Davis RC, Lusis AJ, and Eskin E. PLoS genetics, 2014/01/01, Volume 10, Issue 1, p.e1004022, (2014) Read More / View Supplemental Materials
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MOSAIK: A Hash-Based Algorithm for Accurate Next-Generation Sequencing Short-Read Mapping.Lee, WP, Stromberg MP, Ward A., Stewart C., Garrison EP, and Marth GT PloS one, 2014/01/01, Volume 9, Issue 3, p.e90581, (2014) Read More / View Supplemental Materials
Abstract
A Pan-Cancer Analysis of Transcriptome Changes Associated with Somatic Mutations in U2AF1 Reveals Commonly Altered Splicing Events.Brooks, AN, Choi PS, de Waal L., Sharifnia T., Imielinski M., Saksena G., Pedamallu CS, Sivachenko A., Rosenberg M., Chmielecki J., Lawrence MS, Deluca DS, Getz G., and Meyerson M. PloS one, 2014/01/01, Volume 9, Issue 1, p.e87361, (2014) Read More / View Supplemental Materials
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Pathway analyses implicate glial cells in schizophrenia.Duncan, LE, Holmans PA, Lee PH, O'Dushlaine CT, Kirby AW, Smoller JW, Ongür D., and Cohen BM PloS one, 2014/01/01, Volume 9, Issue 2, p.e89441, (2014) Read More / View Supplemental Materials
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Re-sequencing Expands Our Understanding of the Phenotypic Impact of Variants at GWAS Loci.Service, SK, Teslovich TM, Fuchsberger C., Ramensky V., Yajnik P., Koboldt DC, Larson DE, Zhang Q., Lin L., Welch R., Ding L., McLellan MD, O'Laughlin M., Fronick C., Fulton LL, Magrini V., Swift A., Elliott P., Jarvelin MR, Kaakinen M., et al. PLoS genetics, 2014/01/01, Volume 10, Issue 1, p.e1004147, (2014) Read More / View Supplemental Materials
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Revitalizing psychiatric therapeutics.Hyman, SE Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2014/01/01, Volume 39, Issue 1, p.220-9, (2014) Read More / View Supplemental Materials
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RNA-Guided Genome Editing of Mammalian Cells.Pyzocha, NK, Ran FA, Hsu PD, and Zhang F. Methods in molecular biology (Clifton, N.J.), 2014/01/01, Volume 1114, p.269-77, (2014) Read More / View Supplemental Materials
Abstract
2013
S-Nitrosothiol Signaling Regulates Liver Development and Improves Outcome following Toxic Liver Injury.Cox, AG, Saunders DC, Kelsey PB Jr, Conway AA, Tesmenitsky Y., Marchini JF, Brown KK, Stamler JS, Colagiovanni DB, Rosenthal GJ, Croce KJ, North TE, and Goessling W. Cell reports, 2013/12/31, (2013) Read More / View Supplemental Materials
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Pilot investigation of isradipine in the treatment of bipolar depression motivated by genome-wide association.Ostacher, MJ, Iosifescu DV, Hay A., Blumenthal SR, Sklar P., and Perlis RH Bipolar disorders, 2013/12/27, (2013) Read More / View Supplemental Materials
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Genetics of rheumatoid arthritis contributes to biology and drug discovery.Okada, Y., Wu D., Trynka G., Raj T., Terao C., Ikari K., Kochi Y., Ohmura K., Suzuki A., Yoshida S., Graham RR, Manoharan A., Ortmann W., Bhangale T., Denny JC, Carroll RJ, Eyler AE, Greenberg JD, Kremer JM, Pappas DA, et al. Nature, 2013/12/25, (2013) Read More / View Supplemental Materials
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Landscape of genomic alterations in cervical carcinomas.Ojesina, AI, Lichtenstein L., Freeman SS, Pedamallu CS, Imaz-Rosshandler I., Pugh TJ, Cherniack AD, Ambrogio L., Cibulskis K., Bertelsen B., Romero-Cordoba S., Treviño V., Vazquez-Santillan K., Guadarrama AS, Wright AA, Rosenberg MW, Duke F., Kaplan B., Wang R., Nickerson E., et al. Nature, 2013/12/25, (2013) Read More / View Supplemental Materials
Abstract
Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico.The SIGMA Type 2 Diabetes, Consortium, team Writing, Williams AL, Jacobs SB, Moreno-Macías H., Huerta-Chagoya A., Churchhouse C., Márquez-Luna C., García-Ortíz H., José Gómez-Vázquez M., Burtt NP, Aguilar-Salinas CA, González-Villalpando C., Florez JC, Orozco L., Haiman CA, Tusié-Luna T., Altshuler D., team Analysis, Williams AL, et al. Nature, 2013/12/25, (2013) Read More / View Supplemental Materials
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Successful whole-exome sequencing from a prostate cancer bone metastasis biopsy.Van Allen, EM, Foye A., Wagle N., Kim W., Carter SL, McKenna A., Simko JP, Garraway LA, and Febbo PG Prostate cancer and prostatic diseases, 2013/12/24, (2013) Read More / View Supplemental Materials
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Bacterial toxins and small molecules elucidate endosomal trafficking.Slater, LH, Clatworthy AE, and Hung DT Trends in microbiology, 2013/12/23, (2013) Read More / View Supplemental Materials
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TRAF2 is an NF-κB-activating oncogene in epithelial cancers.Shen, RR, Zhou AY, Kim E., O'Connell JT, Hagerstrand D., Beroukhim R., and Hahn WC Oncogene, 2013/12/23, (2013) Read More / View Supplemental Materials
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Adult neural stem cells in distinct microdomains generate previously unknown interneuron types.Merkle, FT, Fuentealba LC, Sanders TA, Magno L., Kessaris N., and Alvarez-Buylla A. Nature neuroscience, 2013/12/22, (2013) Read More / View Supplemental Materials
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Genomic insights into WNT/β-catenin signaling.Rosenbluh, J., Wang X., and Hahn WC Trends in pharmacological sciences, 2013/12/20, (2013) Read More / View Supplemental Materials
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Aspirin Use, 8q24 Single Nucleotide Polymorphism rs6983267, and Colorectal Cancer According to CTNNB1 Alterations.Nan, H., Morikawa T., Suuriniemi M., Imamura Y., Werner L., Kuchiba A., Yamauchi M., Hunter DJ, Kraft P., Giovannucci EL, Fuchs CS, Ogino S., Freedman ML, and Chan AT Journal of the National Cancer Institute, 2013/12/18, Volume 105, Issue 24, p.1852-61, (2013) Read More / View Supplemental Materials
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Genome-wide probing of RNA structure reveals active unfolding of mRNA structures in vivo.Rouskin, S., Zubradt M., Washietl S., Kellis M., and Weissman JS Nature, 2013/12/15, (2013) Read More / View Supplemental Materials
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Meta-analysis of gene-level tests for rare variant association.Liu, DJ, Peloso GM, Zhan X., Holmen OL, Zawistowski M., Feng S., Nikpay M., Auer PL, Goel A., Zhang H., Peters U., Farrall M., Orho-Melander M., Kooperberg C., McPherson R., Watkins H., Willer CJ, Hveem K., Melander O., Kathiresan S., et al. Nature genetics, 2013/12/15, (2013) Read More / View Supplemental Materials
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Reduced local mutation density in regulatory DNA of cancer genomes is linked to DNA repair.Polak, P., Lawrence MS, Haugen E., Stoletzki N., Stojanov P., Thurman RE, Garraway LA, Mirkin S., Getz G., Stamatoyannopoulos JA, and Sunyaev SR Nature biotechnology, 2013/12/15, (2013) Read More / View Supplemental Materials
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Sterilization of granulomas is common in active and latent tuberculosis despite within-host variability in bacterial killing.Lin, PL, Ford CB, Coleman MT, Myers AJ, Gawande R., Ioerger T., Sacchettini J., Fortune SM, and Flynn JL Nature medicine, 2013/12/15, (2013) Read More / View Supplemental Materials
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EMRE is an essential component of the mitochondrial calcium uniporter complex.Sancak, Y., Markhard AL, Kitami T., Kovács-Bogdán E., Kamer KJ, Udeshi ND, Carr SA, Chaudhuri D., Clapham DE, Li AA, Calvo SE, Goldberger O., and Mootha VK Science (New York, N.Y.), 2013/12/13, Volume 342, Issue 6164, p.1379-82, (2013) Read More / View Supplemental Materials
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Resource competition may lead to effective treatment of antibiotic resistant infections.Gomes, AL, Galagan JE, and Segrè D. PloS one, 2013/12/13, Volume 8, Issue 12, p.e80775, (2013) Read More / View Supplemental Materials
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Systematic discovery and characterization of regulatory motifs in ENCODE TF binding experiments.Kheradpour, P., and Kellis M. Nucleic acids research, 2013/12/13, (2013) Read More / View Supplemental Materials
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Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B.Karlsson, EK, Sigurdsson S., Ivansson E., Thomas R., Elvers I., Wright J., Howald C., Tonomura N., Perloski M., Swofford R., Biagi T., Fryc S., Anderson N., Courtay-Cahen C., Youell L., Ricketts SL, Mandlebaum S., Rivera P., von Euler H., Kisseberth WC, et al. Genome biology, 2013/12/12, Volume 14, Issue 12, p.R132, (2013) Read More / View Supplemental Materials
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High-throughput genetic screen for synaptogenic factors: identification of LRP6 as critical for excitatory synapse development.Sharma, K., Choi SY, Zhang Y., Nieland TJ, Long S., Li M., and Huganir RL Cell reports, 2013/12/12, Volume 5, Issue 5, p.1330-41, (2013) Read More / View Supplemental Materials
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Discovery and characterization of super-enhancer-associated dependencies in diffuse large B cell lymphoma.Chapuy, B., McKeown MR, Lin CY, Monti S., Roemer MG, Qi J., Rahl PB, Sun HH, Yeda KT, Doench JG, Reichert E., Kung AL, Rodig SJ, Young RA, Shipp M. A., and Bradner JE Cancer cell, 2013/12/09, Volume 24, Issue 6, p.777-90, (2013) Read More / View Supplemental Materials
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Integrative and Comparative Genomic Analysis of Lung Squamous Cell Carcinomas in East Asian Patients.Kim, Y., Hammerman PS, Kim J., Yoon JA, Lee Y., Sun JM, Wilkerson MD, Pedamallu CS, Cibulskis K., Yoo YK, Lawrence MS, Stojanov P., Carter SL, McKenna A., Stewart C., Sivachenko AY, Oh IJ, Kim HK, Choi YS, Kim K., et al. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2013/12/09, (2013) Read More / View Supplemental Materials
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SQSTM1 Is a Pathogenic Target of 5q Copy Number Gains in Kidney Cancer.Li, L., Shen C., Nakamura E., Ando K., Signoretti S., Beroukhim R., Cowley GS, Lizotte P., Liberzon E., Bair S., Root DE, Tamayo P., Tsherniak A., Cheng SC, Tabak B., Jacobsen A., Hakimi AA, Schultz N., Ciriello G., Sander C., et al. Cancer cell, 2013/12/09, Volume 24, Issue 6, p.738-50, (2013) Read More / View Supplemental Materials
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Statistical design for biospecimen cohort size in proteomics-based biomarker discovery and verification studies.Skates, SJ, Gillette MA, LaBaer J., Carr SA, Anderson L., Liebler DC, Ransohoff D., Rifai N., Kondratovich M., Težak Ž., Mansfield E., Oberg AL, Wright I., Barnes G., Gail M., Mesri M., Kinsinger CR, Rodriguez H., and Boja ES Journal of proteome research, 2013/12/06, Volume 12, Issue 12, p.5383-94, (2013) Read More / View Supplemental Materials
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Health disparities in kidney disease--emerging data from the human genome.Williams, WW, and Pollak MR The New England journal of medicine, 2013/12/05, Volume 369, Issue 23, p.2260-1, (2013) Read More / View Supplemental Materials
High-resolution mapping reveals a conserved, widespread, dynamic mRNA methylation program in yeast meiosis.Schwartz, S., Agarwala SD, Mumbach MR, Jovanovic M., Mertins P., Shishkin A., Tabach Y., Mikkelsen TS, Satija R., Ruvkun G., Carr SA, Lander E. S., Fink GR, and Regev A. Cell, 2013/12/05, Volume 155, Issue 6, p.1409-21, (2013) Read More / View Supplemental Materials
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Multiplex cytological profiling assay to measure diverse cellular States.Gustafsdottir, SM, Ljosa V., Sokolnicki KL, Anthony Wilson J., Walpita D., Kemp MM, Petri Seiler K., Carrel HA, Golub T. R., Schreiber SL, Clemons PA, Carpenter AE, and Shamji AF PloS one, 2013/12/02, Volume 8, Issue 12, p.e80999, (2013) Read More / View Supplemental Materials
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Transcriptome complexity in germ cells .Soumillon, M. Medecine sciences : M/S, 2013/12/01, Volume 29, Issue 12, p.1077-9, (2013) Read More / View Supplemental Materials
Chromothripsis and beyond: rapid genome evolution from complex chromosomal rearrangements.Zhang, CZ, Leibowitz ML, and Pellman D. Genes & development, 2013/12/01, Volume 27, Issue 23, p.2513-30, (2013) Read More / View Supplemental Materials
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Comparison of methods for image-based profiling of cellular morphological responses to small-molecule treatment.Ljosa, V., Caie PD, Ter Horst R., Sokolnicki KL, Jenkins EL, Daya S., Roberts ME, Jones TR, Singh S., Genovesio A., Clemons PA, Carragher NO, and Carpenter AE Journal of biomolecular screening, 2013/12/01, Volume 18, Issue 10, p.1321-9, (2013) Read More / View Supplemental Materials
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High-resolution microbial community reconstruction by integrating short reads from multiple 16S rRNA regions.Amir, A., Zeisel A., Zuk O., Elgart M., Stern S., Shamir O., Turnbaugh PJ, Soen Y., and Shental N. Nucleic acids research, 2013/12/01, Volume 41, Issue 22, p.e205, (2013) Read More / View Supplemental Materials
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Inferring developmental stage composition from gene expression in human malaria.Joice, R., Narasimhan V., Montgomery J., Sidhu AB, Oh K., Meyer E., Pierre-Louis W., Seydel K., Milner D., Williamson K., Wiegand R., Ndiaye D., Daily J., Wirth D., Taylor T., Huttenhower C., and Marti M. PLoS computational biology, 2013/12/01, Volume 9, Issue 12, p.e1003392, (2013) Read More / View Supplemental Materials
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Niche-based screening identifies small-molecule inhibitors of leukemia stem cells.Hartwell, KA, Miller PG, Mukherjee S., Kahn AR, Stewart AL, Logan DJ, Negri JM, Duvet M., Järås M., Puram R., Dancik V., Al-Shahrour F., Kindler T., Tothova Z., Chattopadhyay S., Hasaka T., Narayan R., Dai M., Huang C., Shterental S., et al. Nature chemical biology, 2013/12/01, Volume 9, Issue 12, p.840-8, (2013) Read More / View Supplemental Materials
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Poly-combing the genome for RNA.Goff, LA, and Rinn JL Nature structural & molecular biology, 2013/12/01, Volume 20, Issue 12, p.1344-6, (2013) Read More / View Supplemental Materials
Quantifying Missing Heritability at Known GWAS Loci.Gusev, A., Bhatia G., Zaitlen N., Vilhjalmsson BJ, Diogo D., Stahl EA, Gregersen PK, Worthington J., Klareskog L., Raychaudhuri S., Plenge RM, Pasaniuc B., and Price AL PLoS genetics, 2013/12/01, Volume 9, Issue 12, p.e1003993, (2013) Read More / View Supplemental Materials
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Somatic mutation of CDKN1B in small intestine neuroendocrine tumors.Francis, JM, Kiezun A., Ramos AH, Serra S., Pedamallu CS, Qian ZR, Banck MS, Kanwar R., Kulkarni AA, Karpathakis A., Manzo V., Contractor T., Philips J., Nickerson E., Pho N., Hooshmand SM, Brais LK, Lawrence MS, Pugh T., McKenna A., et al. Nature genetics, 2013/12/01, Volume 45, Issue 12, p.1483-6, (2013) Read More / View Supplemental Materials
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The spirit of competition: to win or not to win.Szczepinska, T., Iwasaki W., and Abeel T. PLoS computational biology, 2013/12/01, Volume 9, Issue 12, p.e1003413, (2013) Read More / View Supplemental Materials
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Using chromatin marks to interpret and localize genetic associations to complex human traits and diseases.Trynka, G., and Raychaudhuri S. Current opinion in genetics & development, 2013/12/01, Volume 23, Issue 6, p.635-41, (2013) Read More / View Supplemental Materials
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Picking the lock on pluripotency.Eggan, K. The New England journal of medicine, 2013/11/28, Volume 369, Issue 22, p.2150-1, (2013) Read More / View Supplemental Materials
Clinical relevance and functional consequences of the TNFRSF1A multiple sclerosis locus.Ottoboni, L., Frohlich IY, Lee M., Healy BC, Keenan BT, Xia Z., Chitnis T., Guttmann CR, Khoury SJ, Weiner HL, Hafler DA, and De Jager PL Neurology, 2013/11/26, Volume 81, Issue 22, p.1891-9, (2013) Read More / View Supplemental Materials
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Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia.Ruderfer, DM, Fanous AH, Ripke S., McQuillin A., Amdur RL, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Cross-Disorder Working Group of the Psychiatric Genomics Consortium, Gejman PV, O'Donovan MC, Andreassen OA, Djurovic S., Hultman CM, Kelsoe JR, Jamain S., Landén M., Leboyer M., Nimgaonkar V., Nurnberger J., Smoller JW, et al. Molecular psychiatry, 2013/11/26, (2013) Read More / View Supplemental Materials
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A Small-Molecule Inducer of PDX1 Expression Identified by High-Throughput Screening.Yuan, Y., Hartland K., Boskovic Z., Wang Y., Walpita D., Lysy PA, Zhong C., Young DW, Kim YK, Tolliday NJ, Sokal EM, Schreiber SL, and Wagner BK Chemistry & biology, 2013/11/23, (2013) Read More / View Supplemental Materials
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Shared Genetic Susceptibility to Ischemic Stroke and Coronary Artery Disease: A Genome-Wide Analysis of Common Variants.Dichgans, M., Malik R., König IR, Rosand J., Clarke R., Gretarsdottir S., Thorleifsson G., Mitchell BD, Assimes TL, Levi C., Odonnell CJ, Fornage M., Thorsteinsdottir U., Psaty BM, Hengstenberg C., Seshadri S., Erdmann J., Bis JC, Peters A., Boncoraglio GB, et al. Stroke; a journal of cerebral circulation, 2013/11/21, (2013) Read More / View Supplemental Materials
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DNA Sequencing of Cancer: What Have We Learned?Chmielecki, J., and Meyerson M. Annual review of medicine, 2013/11/20, (2013) Read More / View Supplemental Materials
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A Novel Deletion of IGF1 in a Patient With Idiopathic Short Stature Provides Insight Into IGF1 Haploinsufficiency.Batey, L., Moon JE, Yu Y., Wu B., Hirschhorn JN, Shen Y., and Dauber A. The Journal of clinical endocrinology and metabolism, 2013/11/15, (2013) Read More / View Supplemental Materials
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The plasticity of human Treg and Th17 cells and its role in autoimmunity.Kleinewietfeld, M., and Hafler DA Seminars in immunology, 2013/11/15, Volume 25, Issue 4, p.305-12, (2013) Read More / View Supplemental Materials
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Synthesis and structure-activity relationships of phenyl-substituted coumarins with anti-tubercular activity that target FadD32.Kawate, T., Iwase N., Shimizu M., Stanley SA, Wellington S., Kazyanskaya E., and Hung DT Bioorganic & medicinal chemistry letters, 2013/11/15, Volume 23, Issue 22, p.6052-9, (2013) Read More / View Supplemental Materials
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Modeling disease severity in multiple sclerosis using electronic health records.Xia, Z., Secor E., Chibnik LB, Bove RM, Cheng S., Chitnis T., Cagan A., Gainer VS, Chen PJ, Liao KP, Shaw SY, Ananthakrishnan AN, Szolovits P., Weiner HL, Karlson EW, Murphy SN, Savova GK, Cai T., Churchill SE, Plenge RM, et al. PloS one, 2013/11/11, Volume 8, Issue 11, p.e78927, (2013) Read More / View Supplemental Materials
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SCRIB and PUF60 Are Primary Drivers of the Multisystemic Phenotypes of the 8q24.3 Copy-Number Variant.Dauber, A., Golzio C., Guenot C., Jodelka FM, Kibaek M., Kjaergaard S., Leheup B., Martinet D., Nowaczyk MJ, Rosenfeld JA, Zeesman S., Zunich J., Beckmann JS, Hirschhorn JN, Hastings ML, Jacquemont S., and Katsanis N. American journal of human genetics, 2013/11/07, Volume 93, Issue 5, p.798-811, (2013) Read More / View Supplemental Materials
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MetaRef: a pan-genomic database for comparative and community microbial genomics.Huang, K., Brady A., Mahurkar A., White O., Gevers D., Huttenhower C., and Segata N. Nucleic acids research, 2013/11/06, (2013) Read More / View Supplemental Materials
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A phase II study of the EGFR inhibitor gefitinib in patients with acute myeloid leukemia.DeAngelo, DJ, Neuberg D., Amrein PC, Berchuck J., Wadleigh M., Sirulnik LA, Galinsky I., Golub T., Stegmaier K., and Stone RM Leukemia research, 2013/11/05, (2013) Read More / View Supplemental Materials
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The Aspergillus genome database: multispecies curation and incorporation of RNA-Seq data to improve structural gene annotations.Cerqueira, GC, Arnaud MB, Inglis DO, Skrzypek MS, Binkley G., Simison M., Miyasato SR, Binkley J., Orvis J., Shah P., Wymore F., Sherlock G., and Wortman JR Nucleic acids research, 2013/11/04, (2013) Read More / View Supplemental Materials
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A melanocyte lineage program confers resistance to MAP kinase pathway inhibition.Johannessen, CM, Johnson LA, Piccioni F., Townes A., Frederick DT, Donahue MK, Narayan R., Flaherty KT, Wargo JA, Root DE, and Garraway LA Nature, 2013/11/03, (2013) Read More / View Supplemental Materials
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Apolipoprotein e, statins, and risk of intracerebral hemorrhage.Woo, D., Deka R., Falcone GJ, Flaherty ML, Haverbusch M., Martini SR, Greenberg SM, Ayres AM, Sauerbeck L., Kissela BM, Kleindorfer DO, Moomaw CJ, Anderson CD, Broderick JP, Rosand J., Langefeld CD, and Woo JG Stroke; a journal of cerebral circulation, 2013/11/01, Volume 44, Issue 11, p.3013-7, (2013) Read More / View Supplemental Materials
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Assessing the phenotypic effects in the general population of rare variants in genes for a dominant Mendelian form of diabetes.Flannick, J., Beer NL, Bick AG, Agarwala V., Molnes J., Gupta N., Burtt NP, Florez JC, Meigs JB, Taylor H., Lyssenko V., Irgens H., Fox E., Burslem F., Johansson S., Brosnan MJ, Trimmer JK, Newton-Cheh C., Tuomi T., Molven A., et al. Nature genetics, 2013/11/01, Volume 45, Issue 11, p.1380-5, (2013) Read More / View Supplemental Materials
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Common variants associated with plasma triglycerides and risk for coronary artery disease.Do, R., Willer CJ, Schmidt EM, Sengupta S., Gao C., Peloso GM, Gustafsson S., Kanoni S., Ganna A., Chen J., Buchkovich ML, Mora S., Beckmann JS, Bragg-Gresham JL, Chang HY, Demirkan A., Den Hertog HM, Donnelly LA, Ehret GB, Esko T., et al. Nature genetics, 2013/11/01, Volume 45, Issue 11, p.1345-52, (2013) Read More / View Supplemental Materials
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DSM-5 and RDoC: progress in psychiatry research?Casey, BJ, Craddock N., Cuthbert BN, Hyman SE, Lee FS, and Ressler KJ Nature reviews. Neuroscience, 2013/11/01, Volume 14, Issue 11, p.810-4, (2013) Read More / View Supplemental Materials
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Fine-Mapping the Genetic Association of the Major Histocompatibility Complex in Multiple Sclerosis: HLA and Non-HLA Effects.Patsopoulos, NA, Barcellos LF, Hintzen RQ, Schaefer C., van Duijn CM, Noble JA, Raj T., IMSGC, ANZgene, Gourraud PA, Stranger BE, Oksenberg J., Olsson T., Taylor BV, Sawcer S., Hafler DA, Carrington M., De Jager PL, and de Bakker PI PLoS genetics, 2013/11/01, Volume 9, Issue 11, p.e1003926, (2013) Read More / View Supplemental Materials
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Genome engineering using the CRISPR-Cas9 system.Ran, FA, Hsu PD, Wright J., Agarwala V., Scott DA, and Zhang F. Nature protocols, 2013/11/01, Volume 8, Issue 11, p.2281-308, (2013) Read More / View Supplemental Materials
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Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia.Jaffe, JD, Wang Y., Chan HM, Zhang J., Huether R., Kryukov GV, Bhang HE, Taylor JE, Hu M., Englund NP, Yan F., Wang Z., Robert McDonald E 3rd, Wei L., Ma J., Easton J., Yu Z., Debeaumount R., Gibaja V., Venkatesan K., et al. Nature genetics, 2013/11/01, Volume 45, Issue 11, p.1386-91, (2013) Read More / View Supplemental Materials
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Oncogenic mutations in cervical cancer: Genomic differences between adenocarcinomas and squamous cell carcinomas of the cervix.Wright, AA, Howitt BE, Myers AP, Dahlberg SE, Palescandolo E., Van Hummelen P., Macconaill LE, Shoni M., Wagle N., Jones RT, Quick CM, Laury A., Katz IT, Hahn WC, Matulonis UA, and Hirsch MS Cancer, 2013/11/01, Volume 119, Issue 21, p.3776-83, (2013) Read More / View Supplemental Materials
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Progress in the genetics of polygenic brain disorders: significant new challenges for neurobiology.McCarroll, SA, and Hyman SE Neuron, 2013/10/30, Volume 80, Issue 3, p.578-87, (2013) Read More / View Supplemental Materials
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The use of small molecules in somatic-cell reprogramming.Federation, AJ, Bradner JE, and Meissner A. Trends in cell biology, 2013/10/30, (2013) Read More / View Supplemental Materials
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Oncogenic and drug-sensitive NTRK1 rearrangements in lung cancer.Vaishnavi, A., Capelletti M., Le AT, Kako S., Butaney M., Ercan D., Mahale S., Davies KD, Aisner DL, Pilling AB, Berge EM, Kim J., Sasaki H., Park SI, Kryukov G., Garraway LA, Hammerman PS, Haas J., Andrews SW, Lipson D., et al. Nature medicine, 2013/10/27, (2013) Read More / View Supplemental Materials
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Semiconductor-based DNA sequencing of histone modification states.Cheng, CS, Rai K., Garber M., Hollinger A., Robbins D., Anderson S., Macbeth A., Tzou A., Carneiro MO, Raychowdhury R., Russ C., Hacohen N., Gershenwald JE, Lennon N., Nusbaum C., Chin L., Regev A., and Amit I. Nature communications, 2013/10/25, Volume 4, p.2672, (2013) Read More / View Supplemental Materials
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Fast Pairwise IBD Association Testing in Genome-wide Association Studies.Han, B., Kang EY, Raychaudhuri S., de Bakker PI, and Eskin E. Bioinformatics (Oxford, England), 2013/10/24, (2013) Read More / View Supplemental Materials
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Response to 'Predicting the diagnosis of autism spectrum disorder using gene pathway analysis'Robinson, EB, Howrigan D., Yang J., Ripke S., Anttila V., Duncan LE, Jostins L., Barrett JC, Medland SE, Macarthur DG, Breen G., O'Donovan MC, Wray NR, Devlin B., Daly M. J., Visscher PM, Sullivan PF, and Neale BM Molecular psychiatry, 2013/10/22, (2013) Read More / View Supplemental Materials
Evaluating empirical bounds on complex disease genetic architecture.Agarwala, V., Flannick J., Sunyaev S., GoT2D Consortium, and Altshuler D. Nature genetics, 2013/10/20, (2013) Read More / View Supplemental Materials
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Criteria for the use of omics-based predictors in clinical trials.McShane, LM, Cavenagh MM, Lively TG, Eberhard DA, Bigbee WL, Williams PM, Mesirov J. P., Polley MY, Kim KY, Tricoli JV, Taylor JM, Shuman DJ, Simon RM, Doroshow JH, and Conley BA Nature, 2013/10/17, Volume 502, Issue 7471, p.317-20, (2013) Read More / View Supplemental Materials
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Gene signatures related to B-cell proliferation predict influenza vaccine-induced antibody response.Tan, Y., Tamayo P., Nakaya H., Pulendran B., Mesirov J. P., and Haining WN European journal of immunology, 2013/10/17, (2013) Read More / View Supplemental Materials
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Development of transgenic animals for optogenetic manipulation of mammalian nervous system function: progress and prospects for behavioral neuroscience.Ting, JT, and Feng G. Behavioural brain research, 2013/10/15, Volume 255, p.3-18, (2013) Read More / View Supplemental Materials
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Integrative radiogenomic profiling of squamous cell lung cancer.Abazeed, ME, Adams DJ, Hurov KE, Tamayo P., Creighton CJ, Sonkin D., Giacomelli AO, Du C., Fries DF, Wong KK, Mesirov J. P., Loeffler JS, Schreiber SL, Hammerman PS, and Meyerson M. Cancer research, 2013/10/15, Volume 73, Issue 20, p.6289-98, (2013) Read More / View Supplemental Materials
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The somatic genomic landscape of glioblastoma.Brennan, CW, Verhaak RG, McKenna A., Campos B., Noushmehr H., Salama SR, Zheng S., Chakravarty D., Sanborn JZ, Berman SH, Beroukhim R., Bernard B., Wu CJ, Genovese G., Shmulevich I., Barnholtz-Sloan J., Zou L., Vegesna R., Shukla SA, Ciriello G., et al. Cell, 2013/10/10, Volume 155, Issue 2, p.462-77, (2013) Read More / View Supplemental Materials
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Comprehensive identification of mutational cancer driver genes across 12 tumor types.Tamborero, D., Gonzalez-Perez A., Perez-Llamas C., Deu-Pons J., Kandoth C., Reimand J., Lawrence MS, Getz G., Bader GD, Ding L., and Lopez-Bigas N. Scientific reports, 2013/10/02, Volume 3, p.2650, (2013) Read More / View Supplemental Materials
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Advances in inflammatory bowel disease pathogenesis: linking host genetics and the microbiome.Knights, D., Lassen KG, and Xavier RJ Gut, 2013/10/01, Volume 62, Issue 10, p.1505-10, (2013) Read More / View Supplemental Materials
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Calculating statistical power in Mendelian randomization studies.Brion, MJ, Shakhbazov K., and Visscher PM International journal of epidemiology, 2013/10/01, Volume 42, Issue 5, p.1497-501, (2013) Read More / View Supplemental Materials
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A Central Role for mTOR in Lipid Homeostasis.Lamming, DW, and Sabatini DM Cell metabolism, 2013/10/01, Volume 18, Issue 4, p.465-469, (2013) Read More / View Supplemental Materials
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Connecting Genomic Alterations to Cancer Biology with Proteomics: The NCI Clinical Proteomic Tumor Analysis Consortium.Ellis, MJ, Gillette M., Carr SA, Paulovich AG, Smith RD, Rodland KK, Townsend RR, Kinsinger C., Mesri M., Rodriguez H., Liebler DC, and Clinical Proteomic Tumor Analysis Consortium(CPTAC) Cancer discovery, 2013/10/01, Volume 3, Issue 10, p.1108-12, (2013) Read More / View Supplemental Materials
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Genome-wide association analysis identifies 13 new risk loci for schizophrenia.Ripke, S., O'Dushlaine C., Chambert K., Moran JL, Kähler AK, Akterin S., Bergen SE, Collins AL, Crowley JJ, Fromer M., Kim Y., Lee SH, Magnusson PK, Sanchez N., Stahl EA, Williams S., Wray NR, Xia K., Bettella F., Borglum AD, et al. Nature genetics, 2013/10/01, Volume 45, Issue 10, p.1150-9, (2013) Read More / View Supplemental Materials
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Large-scale identification of ubiquitination sites by mass spectrometry.Udeshi, ND, Mertins P., Svinkina T., and Carr SA Nature protocols, 2013/10/01, Volume 8, Issue 10, p.1950-60, (2013) Read More / View Supplemental Materials
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Small molecule inhibitors of zinc-dependent histone deacetylases.Wagner, FF, Weїwer M., Lewis MC, and Holson EB Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2013/10/01, Volume 10, Issue 4, p.589-604, (2013) Read More / View Supplemental Materials
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Stroke Genetics Network (SiGN) Study: Design and Rationale for a Genome-Wide Association Study of Ischemic Stroke Subtypes.Meschia, JF, Arnett DK, Ay H., Brown RD Jr, Benavente OR, Cole JW, de Bakker PI, Dichgans M., Doheny KF, Fornage M., Grewal RP, Gwinn K., Jern C., Conde JJ, Johnson JA, Jood K., Laurie CC, Lee JM, Lindgren A., Markus HS, et al. Stroke; a journal of cerebral circulation, 2013/10/01, Volume 44, Issue 10, p.2694-702, (2013) Read More / View Supplemental Materials
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Activation of the PD-1 pathway contributes to immune escape in EGFR-driven lung tumors.Akbay, EA, Koyama S., Carretero J., Altabef A., Tchaicha JH, Christensen CL, Mikse OR, Cherniack AD, Beauchamp EM, Pugh TJ, Wilkerson MD, Fecci PE, Butaney M., Reibel JB, Soucheray M., Cohoon TJ, Janne PA, Meyerson M., Hayes DN, Shapiro GI, et al. Cancer discovery, 2013/09/27, (2013) Read More / View Supplemental Materials
Abstract
The Cancer Genome Atlas Pan-Cancer analysis project.Cancer Genome Atlas Research, Network, Genome Characterization Center, Chang K., Creighton CJ, Davis C., Donehower L., Drummond J., Wheeler D., Ally A., Balasundaram M., Birol I., Butterfield YS, Chu A., Chuah E., Chun HJ, Dhalla N., Guin R., Hirst M., Hirst C., Holt RA, et al. Nature genetics, 2013/09/26, Volume 45, Issue 10, p.1113-20, (2013) Read More / View Supplemental Materials
Exome Sequencing and Directed Clinical Phenotyping Diagnose Cholesterol Ester Storage Disease Presenting as Autosomal Recessive Hypercholesterolemia.Stitziel, NO, Fouchier SW, Sjouke B., Peloso GM, Moscoso AM, Auer PL, Goel A., Gigante B., Barnes TA, Melander O., Orho-Melander M., Duga S., Sivapalaratnam S., Nikpay M., Martinelli N., Girelli D., Jackson RD, Kooperberg C., Lange LA, Ardissino D., et al. Arteriosclerosis, thrombosis, and vascular biology, 2013/09/26, (2013) Read More / View Supplemental Materials
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Pan-cancer patterns of somatic copy number alteration.Zack, TI, Schumacher SE, Carter SL, Cherniack AD, Saksena G., Tabak B., Lawrence MS, Zhang CZ, Wala J., Mermel CH, Sougnez C., Gabriel SB, Hernandez B., Shen H., Laird PW, Getz G., Meyerson M., and Beroukhim R. Nature genetics, 2013/09/26, Volume 45, Issue 10, p.1134-1140, (2013) Read More / View Supplemental Materials
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High reliability in respiratory rate assessment in children with respiratory symptomatology in a rural area in MozambiqueLanaspa, M., Valim C., Acacio S., Almendinger K., Ahmad R., Wiegand R., and Bassat Q. Journal of Tropical Pediatrics, 2013/09/25, (2013) Read More / View Supplemental Materials
Cetuximab response of lung cancer-derived EGF receptor mutants is associated with asymmetric dimerization.Cho, J., Chen L., Sangji N., Okabe T., Yonesaka K., Francis JM, Flavin RJ, Johnson W., Kwon J., Yu S., Greulich HE, Johnson B. E., Eck MJ, Janne PA, Wong KK, and Meyerson M. Cancer research, 2013/09/24, (2013) Read More / View Supplemental Materials
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Distinct pathways regulated by menin and by MLL1 in hematopoietic stem cells and developing B cells.Li, BE, Gan T., Meyerson M., Rabbitts TH, and Ernst P. Blood, 2013/09/19, Volume 122, Issue 12, p.2039-46, (2013) Read More / View Supplemental Materials
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Colorectal Cancers from Distinct Ancestral Populations Show Variations in BRAF Mutation Frequency.Hanna, MC, Go C., Roden C., Jones RT, Pochanard P., Javed AY, Javed A., Mondal C., Palescandolo E., Van Hummelen P., Hatton C., Bass AJ, Chun SM, Na DC, Kim TI, Jang SJ, Osarogiagbon RU, Hahn WC, Meyerson M., Garraway LA, et al. PloS one, 2013/09/16, Volume 8, Issue 9, p.e74950, (2013) Read More / View Supplemental Materials
Abstract
Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity.Ran, FA, Hsu PD, Lin CY, Gootenberg JS, Konermann S., Trevino AE, Scott DA, Inoue A., Matoba S., Zhang Y., and Zhang F. Cell, 2013/09/12, Volume 154, Issue 6, p.1380-9, (2013) Read More / View Supplemental Materials
Abstract
Protein array-based profiling of CSF identifies RBPJ as an autoantigen in multiple sclerosis.Querol, L., Clark PL, Bailey MA, Cotsapas C., Cross AH, Hafler DA, Kleinstein SH, Lee JY, Yaari G., Willis SN, and O'Connor KC Neurology, 2013/09/10, Volume 81, Issue 11, p.956-963, (2013) Read More / View Supplemental Materials
Abstract
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