Publications

High-dimensional gene expression and morphology profiles of cells across 28,000 genetic and chemical perturbations.

Haghighi M, Caicedo JC, Cimini BA, Carpenter AE, Singh S. High-dimensional gene expression and morphology profiles of cells across 28,000 genetic and chemical perturbations. Nat Methods. 2022. doi:10.1038/s41592-022-01667-0.

Microglia states and nomenclature: A field at its crossroads.

Paolicelli RC, Sierra A, Stevens B, et al. Microglia states and nomenclature: A field at its crossroads. Neuron. 2022;110(21):3458-3483. doi:10.1016/j.neuron.2022.10.020.

The phenotypic landscape of essential human genes.

Funk L, Su K-C, Ly J, et al. The phenotypic landscape of essential human genes. Cell. 2022. doi:10.1016/j.cell.2022.10.017.

Proteogenomic Markers of Chemotherapy Resistance and Response in Triple-Negative Breast Cancer.

Anurag M, Jaehnig EJ, Krug K, et al. Proteogenomic Markers of Chemotherapy Resistance and Response in Triple-Negative Breast Cancer. Cancer Discov. 2022;12(11):2586-2605. doi:10.1158/2159-8290.CD-22-0200.

A distinct clade of Bifidobacterium longum in the gut of Bangladeshi children thrives during weaning.

Vatanen T, Ang QYan, Siegwald L, et al. A distinct clade of Bifidobacterium longum in the gut of Bangladeshi children thrives during weaning. Cell. 2022. doi:10.1016/j.cell.2022.10.011.

Programmable eukaryotic protein synthesis with RNA sensors by harnessing ADAR.

Jiang K, Koob J, Chen XDawn, et al. Programmable eukaryotic protein synthesis with RNA sensors by harnessing ADAR. Nat Biotechnol. 2022. doi:10.1038/s41587-022-01534-5.

Influences of rare copy-number variation on human complex traits.

Hujoel MLA, Sherman MA, Barton AR, et al. Influences of rare copy-number variation on human complex traits. Cell. 2022;185(22):4233-4248.e27. doi:10.1016/j.cell.2022.09.028.

Velcrin-induced selective cleavage of tRNA(TAA) by SLFN12 causes cancer cell death.

Lee S, Hoyt S, Wu X, et al. Velcrin-induced selective cleavage of tRNA(TAA) by SLFN12 causes cancer cell death. Nat Chem Biol. 2022. doi:10.1038/s41589-022-01170-9.

Statistical and functional convergence of common and rare genetic influences on autism at chromosome 16p.

Weiner DJ, Ling E, Erdin S, et al. Statistical and functional convergence of common and rare genetic influences on autism at chromosome 16p. Nat Genet. 2022. doi:10.1038/s41588-022-01203-y.

A combined polygenic score of 21,293 rare and 22 common variants improves diabetes diagnosis based on hemoglobin A1C levels.

Dornbos P, Koesterer R, Ruttenburg A, et al. A combined polygenic score of 21,293 rare and 22 common variants improves diabetes diagnosis based on hemoglobin A1C levels. Nat Genet. 2022. doi:10.1038/s41588-022-01200-1.