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2015
Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility.Wessel, J., Chu AY, Willems SM, Wang S., Yaghootkar H., Brody JA, Dauriz M., Hivert MF, Raghavan S., Lipovich L., Hidalgo B., Fox K., Huffman JE, An P., Lu Y., Rasmussen-Torvik LJ, Grarup N., Ehm MG, Li L., Baldridge AS, et al. Nature communications, 2015/01/29, Volume 6, p.5897, (2015) Read More / View Supplemental Materials
Abstract
Dysregulation of miR-34a links neuronal development to genetic risk factors for bipolar disorder.Bavamian, S., Mellios N., Lalonde J., Fass DM, Wang J., Sheridan SD, Madison JM, Zhou F., Rueckert EH, Barker D., Perlis RH, Sur M., and Haggarty SJ Molecular psychiatry, 2015/01/27, (2015) Read More / View Supplemental Materials
Abstract
Exome Sequencing in Suspected Monogenic Dyslipidemias.Stitziel, NO, Peloso GM, Abifadel M., Cefalù AB, Fouchier S., Motazacker MM, Tada H., Larach DB, Awan Z., Haller JF, Pullinger CR, Varret M., Rabès JP, Noto D., Tarugi P., Kawashiri MA, Nohara A., Yamagishi M., Risman M., Deo R., et al. Circulation. Cardiovascular genetics, 2015/01/27, (2015) Read More / View Supplemental Materials
Abstract
Convergent evolution of the genomes of marine mammals.Foote, AD, Liu Y., Thomas GW, Vinař T., Alföldi J., Deng J., Dugan S., van Elk CE, Hunter ME, Joshi V., Khan Z., Kovar C., Lee SL, Lindblad-Toh K., Mancia A., Nielsen R., Qin X., Qu J., Raney BJ, Vijay N., et al. Nature genetics, 2015/01/26, (2015) Read More / View Supplemental Materials
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Large multiallelic copy number variations in humans.Handsaker, RE, Van Doren V., Berman JR, Genovese G., Kashin S., Boettger LM, and McCarroll SA Nature genetics, 2015/01/26, (2015) Read More / View Supplemental Materials
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Next Generation Sequencing for the Diagnosis of Cardiac Arrhythmia Syndromes.Lubitz, SA, and Ellinor PT Heart rhythm : the official journal of the Heart Rhythm Society, 2015/01/24, (2015) Read More / View Supplemental Materials
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Genome-wide association study follow-up identifies cyclin A2 as a regulator of the transition through cytokinesis during terminal erythropoiesis.Ludwig, LS, Cho H., Wakabayashi A., Eng JC, Ulirsch JC, Fleming MD, Lodish HF, and Sankaran VG American journal of hematology, 2015/01/23, (2015) Read More / View Supplemental Materials
Abstract
Genetic Overlap Between Diagnostic Subtypes of Ischemic Stroke.Holliday, EG, Traylor M., Malik R., Bevan S., Falcone G., Hopewell JC, Cheng YC, Cotlarciuc I., Bis JC, Boerwinkle E., Boncoraglio GB, Clarke R., Cole JW, Fornage M., Furie KL, Ikram MA, Jannes J., Kittner SJ, Lincz LF, Maguire JM, et al. Stroke; a journal of cerebral circulation, 2015/01/22, (2015) Read More / View Supplemental Materials
Abstract
Genome-wide meta-analysis in alopecia areata resolves HLA associations and reveals two new susceptibility loci.Betz, RC, Petukhova L., Ripke S., Huang H., Menelaou A., Redler S., Becker T., Heilmann S., Yamany T., Duvic M., Hordinsky M., Norris D., Price VH, Mackay-Wiggan J., de Jong A., DeStefano GM, Moebus S., Böhm M., Blume-Peytavi U., Wolff H., et al. Nature communications, 2015/01/22, Volume 6, p.5966, (2015) Read More / View Supplemental Materials
Abstract
Quantitative visualization of alternative exon expression from RNA-seq data.Katz, Y., Wang ET, Silterra J., Schwartz S., Wong B., Thorvaldsdóttir H., Robinson JT, Mesirov J. P., Airoldi EM, and Burge CB Bioinformatics (Oxford, England), 2015/01/22, (2015) Read More / View Supplemental Materials
Abstract
Age- and Pregnancy-Associated DNA Methylation Changes in Mammary Epithelial Cells.Huh, SJ, Clement K., Jee D., Merlini A., Choudhury S., Maruyama R., Yoo R., Chytil A., Boyle P., Ran FA, Moses HL, Barcellos-Hoff MH, Jackson-Grusby L., Meissner A., and Polyak K. Stem cell reports, 2015/01/21, (2015) Read More / View Supplemental Materials
Abstract
Risk profiles for aortic dissection and ruptured or surgically treated aneurysms: a prospective cohort study.Landenhed, M., Engström G., Gottsäter A., Caulfield MP, Hedblad B., Newton-Cheh C., Melander O., and Smith JG Journal of the American Heart Association, 2015/01/21, Volume 4, Issue 1, (2015) Read More / View Supplemental Materials
Abstract
Purinosome formation as a function of the cell cycle.Chan, CY, Zhao H., Pugh RJ, Pedley AM, French J., Jones SA, Zhuang X., Jinnah H., Huang TJ, and Benkovic SJ Proceedings of the National Academy of Sciences of the United States of America, 2015/01/20, (2015) Read More / View Supplemental Materials
Abstract
Biological interpretation of genome-wide association studies using predicted gene functions.Pers, TH, Karjalainen JM, Chan Y., Westra HJ, Wood AR, Yang J., Lui JC, Vedantam S., Gustafsson S., Esko T., Frayling T., Speliotes EK, Genetic Investigation of ANthropometric Traits(GIANT) Consortium, Boehnke M., Raychaudhuri S., Fehrmann RS, Hirschhorn JN, and Franke L. Nature communications, 2015/01/19, Volume 6, p.5890, (2015) Read More / View Supplemental Materials
Abstract
mTOR pathway mutations cause hemimegalencephaly and focal cortical dysplasia.D'Gama, AM, Geng Y., Couto JA, Martin B., Boyle EA, LaCoursiere CM, Hossain A., Hatem NE, Barry B., Kwiatkowski DJ, Vinters HV, Barkovich AJ, Shendure J., Mathern GW, Walsh CA, and Poduri A. Annals of neurology, 2015/01/19, (2015) Read More / View Supplemental Materials
Abstract
Partial uracil-DNA-glycosylase treatment for screening of ancient DNA.Rohland, N., Harney E., Mallick S., Nordenfelt S., and Reich D. Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2015/01/19, Volume 370, Issue 1660, (2015) Read More / View Supplemental Materials
Abstract
A kernel machine method for detecting effects of interaction between multidimensional variable sets: An imaging genetics application.Ge, T., Nichols TE, Ghosh D., Mormino EC, Smoller JW, Sabuncu MR, and for the Alzheimer's Disease Neuroimaging Initiative NeuroImage, 2015/01/16, (2015) Read More / View Supplemental Materials
Abstract
(Epi)Genomics approaches and their applications.Meissner, A. Methods (San Diego, Calif.), 2015/01/15, Volume 72, p.1-2, (2015) Read More / View Supplemental Materials
CDy6, a Photostable Probe for Long-Term Real-Time Visualization of Mitosis and Proliferating Cells.Jeong, YM, Duanting Z., Hennig H., Samanta A., Agrawalla BK, Bray MA, Carpenter AE, and Chang YT Chemistry & biology, 2015/01/15, (2015) Read More / View Supplemental Materials
Abstract
Molecular and genetic properties of tumors associated with local immune cytolytic activity.Rooney, MS, Shukla SA, Wu CJ, Getz G., and Hacohen N. Cell, 2015/01/15, Volume 160, Issue 1-2, p.48-61, (2015) Read More / View Supplemental Materials
Abstract
Nutrient-sensing mechanisms and pathways.Efeyan, A., Comb WC, and Sabatini DM Nature, 2015/01/15, Volume 517, Issue 7534, p.302-10, (2015) Read More / View Supplemental Materials
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Integrated allelic, transcriptional, and phenomic dissection of the cardiac effects of titin truncations in health and disease.Roberts, AM, Ware JS, Herman DS, Schafer S., Baksi J., Bick AG, Buchan RJ, Walsh R., John S., Wilkinson S., Mazzarotto F., Felkin LE, Gong S., L MacArthur JA, Cunningham F., Flannick J., Gabriel SB, Altshuler DM, Macdonald PS, Heinig M., et al. Science translational medicine, 2015/01/14, Volume 7, Issue 270, p.270ra6, (2015) Read More / View Supplemental Materials
Abstract
The Osteogenic Niche Promotes Early-Stage Bone Colonization of Disseminated Breast Cancer Cells.Wang, H., Yu C., Gao X., Welte T., Muscarella AM, Tian L., Zhao H., Zhao Z., Du S., Tao J., Lee B., Westbrook TF, Wong ST, Jin X., Rosen JM, Osborne CK, and Zhang XH Cancer cell, 2015/01/14, (2015) Read More / View Supplemental Materials
Abstract
The DNA-binding network of Mycobacterium tuberculosis.Minch, KJ, Rustad TR, Peterson EJ, Winkler J., Reiss DJ, Ma S., Hickey M., Brabant W., Morrison B., Turkarslan S., Mawhinney C., Galagan JE, Price ND, Baliga NS, and Sherman DR Nature communications, 2015/01/12, Volume 6, p.5829, (2015) Read More / View Supplemental Materials
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Gene expression analysis identifies global gene dosage sensitivity in cancer.Fehrmann, RS, Karjalainen JM, Krajewska M., Westra HJ, Maloney D., Simeonov A., Pers TH, Hirschhorn JN, Jansen RC, Schultes EA, van Haagen HH, de Vries EG, Te Meerman GJ, Wijmenga C., van Vugt MA, and Franke L. Nature genetics, 2015/01/12, (2015) Read More / View Supplemental Materials
Abstract
A Mechanism for Asymmetric Cell Division Resulting in Proliferative Asynchronicity.Dey-Guha, I., Alves CP, Yeh AC, Salony, Sole X., Darp R., and Ramaswamy S. Molecular cancer research : MCR, 2015/01/12, (2015) Read More / View Supplemental Materials
Abstract
No evidence that selection has been less effective at removing deleterious mutations in Europeans than in Africans.Do, R., Balick D., Li H., Adzhubei I., Sunyaev S., and Reich D. Nature genetics, 2015/01/12, (2015) Read More / View Supplemental Materials
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Pluripotency transcription factor Oct4 mediates stepwise nucleosome demethylation and depletion.Shakya, A., Callister C., Goren A., Yosef N., Garg N., Khoddami V., Nix D., Regev A., and Tantin D. Molecular and cellular biology, 2015/01/12, (2015) Read More / View Supplemental Materials
Abstract
Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1.Wang, S., Tsun ZY, Wolfson RL, Shen K., Wyant GA, Plovanich ME, Yuan ED, Jones TD, Chantranupong L., Comb W., Wang T., Bar-Peled L., Zoncu R., Straub C., Kim C., Park J., Sabatini BL, and Sabatini DM Science (New York, N.Y.), 2015/01/09, Volume 347, Issue 6218, p.188-94, (2015) Read More / View Supplemental Materials
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Htt CAG repeat expansion confers pleiotropic gains of mutant huntingtin function in chromatin regulation.Biagioli, M., Ferrari F., Mendenhall EM, Zhang Y., Erdin S., Vijayvargia R., Vallabh SM, Solomos N., Manavalan P., Ragavendran A., Ozsolak F., Lee JM, Talkowski ME, Gusella JF, Macdonald ME, Park PJ, and Seong IS Human molecular genetics, 2015/01/08, (2015) Read More / View Supplemental Materials
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Metabolite Profiling and Cardiovascular Event Risk: A Prospective Study of Three Population-Based Cohorts.Würtz, P., Havulinna AS, Soininen P., Tynkkynen T., Prieto-Merino D., Tillin T., Ghorbani A., Artati A., Wang Q., Tiainen M., Kangas AJ, Kettunen J., Kaikkonen J., Mikkilä V., Jula A., Kähönen M., Lehtimäki T., Lawlor DA, Gaunt TR, Hughes AD, et al. Circulation, 2015/01/08, (2015) Read More / View Supplemental Materials
Abstract
Synthesis of Oxazocenones via Gold(I)-Catalyzed 8-Endo-Dig Hydroalkoxylation of Alkynamides.Scully, SS, Zheng SL, Wagner BK, and Schreiber SL Organic letters, 2015/01/08, (2015) Read More / View Supplemental Materials
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Using cross-classified multilevel models to disentangle school and neighborhood effects: An example focusing on smoking behaviors among adolescents in the United States.Dunn, EC, Richmond TK, Milliren CE, and Subramanian SV Health & place, 2015/01/08, Volume 31C, p.224-232, (2015) Read More / View Supplemental Materials
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Cell lineage analysis in human brain using endogenous retroelements.Evrony, GD, Lee E., Mehta BK, Benjamini Y., Johnson RM, Cai X., Yang L., Haseley P., Lehmann HS, Park PJ, and Walsh CA Neuron, 2015/01/07, Volume 85, Issue 1, p.49-59, (2015) Read More / View Supplemental Materials
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Developmental Control of Polycomb Subunit Composition by GATA Factors Mediates a Switch to Non-Canonical Functions.Xu, J., Shao Z., Li D., Xie H., Kim W., Huang J., Taylor JE, Pinello L., Glass K., Jaffe JD, Yuan GC, and Orkin SH Molecular cell, 2015/01/07, (2015) Read More / View Supplemental Materials
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Discovery and annotation of long noncoding RNAs.Mattick, JS, and Rinn JL Nature structural & molecular biology, 2015/01/07, Volume 22, Issue 1, p.5-7, (2015) Read More / View Supplemental Materials
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Copy number variation in bipolar disorder.Green, EK, Rees E., Walters JT, Smith KG, Forty L., Grozeva D., Moran JL, Sklar P., Ripke S., Chambert KD, Genovese G., McCarroll SA, Jones I., Jones L., Owen MJ, O'Donovan MC, Craddock N., and Kirov G. Molecular psychiatry, 2015/01/06, (2015) Read More / View Supplemental Materials
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High-throughput luminescent reporter of insulin secretion for discovering regulators of pancreatic Beta-cell function.Burns, SM, Vetere A., Walpita D., Dančík V., Khodier C., Perez J., Clemons PA, Wagner BK, and Altshuler D. Cell metabolism, 2015/01/06, Volume 21, Issue 1, p.126-37, (2015) Read More / View Supplemental Materials
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An in-tumor genetic screen reveals that the BET bromodomain protein, BRD4, is a potential therapeutic target in ovarian carcinoma.Baratta, MG, Schinzel AC, Zwang Y., Bandopadhayay P., Bowman-Colin C., Kutt J., Curtis J., Piao H., Wong LC, Kung AL, Beroukhim R., Bradner JE, Drapkin R., Hahn WC, Liu JF, and Livingston DM Proceedings of the National Academy of Sciences of the United States of America, 2015/01/06, Volume 112, Issue 1, p.232-7, (2015) Read More / View Supplemental Materials
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Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages.Palsson-McDermott, EM, Curtis AM, Goel G., Lauterbach MA, Sheedy FJ, Gleeson LE, van den Bosch MW, Quinn SR, Domingo-Fernandez R., Johnson DG, Jiang JK, Israelsen WJ, Keane J., Thomas C., Clish C., Vanden Heiden M., Xavier RJ, and O'Neill LA Cell metabolism, 2015/01/06, Volume 21, Issue 1, p.65-80, (2015) Read More / View Supplemental Materials
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Synthetic lethal screening in the mammalian central nervous system identifies Gpx6 as a modulator of Huntington's disease.Shema, R., Kulicke R., Cowley GS, Stein R., Root DE, and Heiman M. Proceedings of the National Academy of Sciences of the United States of America, 2015/01/06, Volume 112, Issue 1, p.268-72, (2015) Read More / View Supplemental Materials
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Comparative proteomic analysis reveals activation of mucosal innate immune signaling pathways during cholera.Ellis, CN, LaRocque RC, Uddin T., Krastins B., Mayo-Smith L., Sarracino D., Karlsson E., Rahman A., Shirin T., Bhuiyan TR, Chowdhury F., Kahn AI, Ryan ET, Calderwood SB, Qadri F., and Harris JB Infection and immunity, 2015/01/05, (2015) Read More / View Supplemental Materials
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Extracardiac control of embryonic cardiomyocyte proliferation and ventricular wall expansion.Shen, H., Cavallero S., Estrada KD, Sandovici I., Kumar SR, Makita T., Lien CL, Constancia M., and Sucov HM Cardiovascular research, 2015/01/05, (2015) Read More / View Supplemental Materials
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High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis.Goyette, P., Boucher G., Mallon D., Ellinghaus E., Jostins L., Huang H., Ripke S., Gusareva ES, Annese V., Hauser SL, Oksenberg JR, Thomsen I., Leslie S., International Inflammatory Bowel Disease Genetics Consortium, Australia and New Zealand IBDGC, Belgium IBD Genetics Consortium, Italian Group for IBD Genetic Consortium, NIDDK Inflammatory Bowel Disease Genetics Consortium, United Kingdom IBDGC, Wellcome Trust Case Control Consortium, et al. Nature genetics, 2015/01/05, (2015) Read More / View Supplemental Materials
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Using CellProfiler for Automatic Identification and Measurement of Biological Objects in Images.Bray, MA, Vokes MS, and Carpenter AE Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.], 2015/01/05, Volume 109, p.14.17.1-14.17.13, (2015) Read More / View Supplemental Materials
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Mosquito genomics. Highly evolvable malaria vectors: the genomes of 16 Anopheles mosquitoes.Neafsey, DE, Waterhouse RM, Abai MR, Aganezov SS, Alekseyev MA, Allen JE, Amon J., Arcà B., Arensburger P., Artemov G., Assour LA, Basseri H., Berlin A., Birren BW, Blandin SA, Brockman AI, Burkot TR, Burt A., Chan CS, Chauve C., et al. Science (New York, N.Y.), 2015/01/02, Volume 347, Issue 6217, p.1258522, (2015) Read More / View Supplemental Materials
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Analysis of Gene-Gene Interactions among Common Variants in Candidate Cardiovascular Genes in Coronary Artery Disease.Musameh, MD, Wang WY, Nelson CP, Lluís-Ganella C., Debiec R., Subirana I., Elosua R., Balmforth AJ, Ball SG, Hall AS, Kathiresan S., Thompson JR, Lucas G., Samani NJ, and Tomaszewski M. PloS one, 2015/01/01, Volume 10, Issue 2, p.e0117684, (2015) Read More / View Supplemental Materials
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CCAAT/Enhancer Binding Protein β Is Dispensable for Development of Lung Adenocarcinoma.Cai, Y., Hirata A., Nakayama S., VanderLaan PA, Levantini E., Yamamoto M., Hirai H., Wong KK, Costa DB, Watanabe H., and Kobayashi SS PloS one, 2015/01/01, Volume 10, Issue 3, p.e0120647, (2015) Read More / View Supplemental Materials
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Effects of sodium benzoate, a widely used food preservative, on glucose homeostasis and metabolic profiles in humans.Lennerz, BS, Vafai SB, Delaney NF, Clish CB, Deik AA, Pierce KA, Ludwig DS, and Mootha VK Molecular genetics and metabolism, 2015/01/01, Volume 114, Issue 1, p.73-9, (2015) Read More / View Supplemental Materials
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Efficient Differentiation of Steroidogenic and Germ-Like Cells from Epigenetically-Related iPSCs Derived from Ovarian Granulosa Cells.Anchan, R., Gerami-Naini B., Lindsey JS, Ho JW, Kiezun A., Lipskind S., Ng N., LiCausi JA, Kim CS, Brezina P., Tuschl T., Maas R., Kearns WG, and Williams Z. PloS one, 2015/01/01, Volume 10, Issue 3, p.e0119275, (2015) Read More / View Supplemental Materials
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Fructose ingestion acutely stimulates circulating FGF21 levels in humans.Dushay, JR, Toschi E., Mitten EK, Fisher FM, Herman MA, and Maratos-Flier E. Molecular metabolism, 2015/01/01, Volume 4, Issue 1, p.51-7, (2015) Read More / View Supplemental Materials
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Genome Engineering Using CRISPR-Cas9 System.Cong, L., and Zhang F. Methods in molecular biology (Clifton, N.J.), 2015/01/01, Volume 1239, p.197-217, (2015) Read More / View Supplemental Materials
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A Genome-Wide siRNA Screen in Mammalian Cells for Regulators of S6 Phosphorylation.Papageorgiou, A., Rapley J., Mesirov J. P., Tamayo P., and Avruch J. PloS one, 2015/01/01, Volume 10, Issue 3, p.e0116096, (2015) Read More / View Supplemental Materials
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Identification and Functional Characterization of G6PC2 Coding Variants Influencing Glycemic Traits Define an Effector Transcript at the G6PC2-ABCB11 Locus.Mahajan, A., Sim X., Ng HJ, Manning A., Rivas MA, Highland HM, Locke AE, Grarup N., Im HK, Cingolani P., Flannick J., Fontanillas P., Fuchsberger C., Gaulton KJ, Teslovich TM, Rayner NW, Robertson NR, Beer NL, Rundle JK, Bork-Jensen J., et al. PLoS genetics, 2015/01/01, Volume 11, Issue 1, p.e1004876, (2015) Read More / View Supplemental Materials
Abstract
ISCB Ebola Award for Important Future Research on the Computational Biology of Ebola Virus.Karp, PD, Berger B., Kovats D., Lengauer T., Linial M., Sabeti P., Hide W., and Rost B. PLoS computational biology, 2015/01/01, Volume 11, Issue 1, p.e1004087, (2015) Read More / View Supplemental Materials
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Kinetically Selective Inhibitors of Histone Deacetylase 2 (HDAC2) as Cognition Enhancers.Wagner, FF, Zhang YL, Fass DM, Joseph N., Gale JP, Weïwer M., McCarren P., Fisher SL, Kaya T., Zhao WN, Reis SA, Hennig KM, Thomas M., Lemercier BC, Lewis MC, Guan JS, Moyer MP, Scolnick E., Haggarty SJ, Tsai LH, et al. Chemical science (Royal Society of Chemistry : 2010), 2015/01/01, Volume 6, Issue 1, p.804-815, (2015) Read More / View Supplemental Materials
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Modulation of Genetic Associations with Serum Urate Levels by Body-Mass-Index in Humans.Huffman, JE, Albrecht E., Teumer A., Mangino M., Kapur K., Johnson T., Kutalik Z., Pirastu N., Pistis G., Lopez LM, Haller T., Salo P., Goel A., Li M., Tanaka T., Dehghan A., Ruggiero D., Malerba G., Smith AV, Nolte IM, et al. PloS one, 2015/01/01, Volume 10, Issue 3, p.e0119752, (2015) Read More / View Supplemental Materials
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Modulators of Hepatic Lipoprotein Metabolism Identified in a Search for Small-Molecule Inducers of Tribbles Pseudokinase 1 Expression.Nagiec, MM, Skepner AP, Negri J., Eichhorn M., Kuperwasser N., Comer E., Muncipinto G., Subramanian A., Clish C., Musunuru K., Duvall JR, Foley M., Perez JR, and Palmer MA PloS one, 2015/01/01, Volume 10, Issue 3, p.e0120295, (2015) Read More / View Supplemental Materials
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No Evidence for Association of Autism with Rare Heterozygous Point Mutations in Contactin-Associated Protein-Like 2 (CNTNAP2), or in Other Contactin-Associated Proteins or Contactins.Murdoch, JD, Gupta AR, Sanders SJ, Walker MF, Keaney J., Fernandez TV, Murtha MT, Anyanwu S., Ober GT, Raubeson MJ, DiLullo NM, Villa N., Waqar Z., Sullivan C., Gonzalez L., Willsey AJ, Choe SY, Neale BM, Daly M. J., and State MW PLoS genetics, 2015/01/01, Volume 11, Issue 1, p.e1004852, (2015) Read More / View Supplemental Materials
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RNA Antisense Purification (RAP) for Mapping RNA Interactions with Chromatin.Engreitz, J., Lander E. S., and Guttman M. Methods in molecular biology (Clifton, N.J.), 2015/01/01, Volume 1262, p.183-97, (2015) Read More / View Supplemental Materials
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Second-generation PLINK: rising to the challenge of larger and richer datasets.Chang, CC, Chow CC, Tellier LC, Vattikuti S., Purcell SM, and Lee JJ GigaScience, 2015/01/01, Volume 4, p.7, (2015) Read More / View Supplemental Materials
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The Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans (SUGAR-MGH): Design of a pharmacogenetic Resource for Type 2 Diabetes.Walford, GA, Colomo N., Todd JN, Billings LK, Fernandez M., Chamarthi B., Warner AS, Davis J., Littleton KR, Hernandez AM, Fanelli RR, Lanier A., Barbato C., Ackerman RJ, Khan SQ, Bui R., Garber L., Stolerman ES, Moore AF, Huang C., et al. PloS one, 2015/01/01, Volume 10, Issue 3, p.e0121553, (2015) Read More / View Supplemental Materials
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Transcriptional profiling defines dynamics of parasite tissue sequestration during malaria infection.Pelle, KG, Oh K., Buchholz K., Narasimhan V., Joice R., Milner DA, Brancucci NM, Ma S., Voss TS, Ketman K., Seydel KB, Taylor TE, Barteneva NS, Huttenhower C., and Marti M. Genome medicine, 2015/01/01, Volume 7, Issue 1, p.19, (2015) Read More / View Supplemental Materials
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Using modelling to disentangle the relative contributions of zoonotic and anthroponotic transmission: the case of lassa Fever.Lo Iacono, G., Cunningham AA, Fichet-Calvet E., Garry RF, Grant DS, Khan SH, Leach M., Moses LM, Schieffelin JS, Shaffer JG, Webb CT, and Wood JL PLoS neglected tropical diseases, 2015/01/01, Volume 9, Issue 1, p.e3398, (2015) Read More / View Supplemental Materials
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Within-trait heterogeneity in age group differences in personality domains and facets: implications for the development and coherence of personality traits.Mõttus, R., Realo A., Allik J., Esko T., Metspalu A., and Johnson W. PloS one, 2015/01/01, Volume 10, Issue 3, p.e0119667, (2015) Read More / View Supplemental Materials
Abstract
2014
Increased expression of the immune modulatory molecule PD-L1 (CD274) in anaplastic meningioma.Du, Z., Abedalthagafi M., Aizer AA, McHenry AR, Sun HH, Bray MA, Viramontes O., Machaidze R., Brastianos PK, Reardon DA, Dunn IF, Freeman GJ, Ligon KL, Carpenter AE, Alexander BM, Agar NY, Rodig SJ, Bradshaw EM, and Santagata S. Oncotarget, 2014/12/31, (2014) Read More / View Supplemental Materials
Abstract
DeCoN: Genome-wide Analysis of In Vivo Transcriptional Dynamics during Pyramidal Neuron Fate Selection in Neocortex.Molyneaux, BJ, Goff LA, Brettler AC, Chen H., Brown JR, Hrvatin S., Rinn JL, and Arlotta P. Neuron, 2014/12/30, (2014) Read More / View Supplemental Materials
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Genetic Architecture of White Matter Hyperintensities Differs in Hypertensive and Nonhypertensive Ischemic Stroke.Adib-Samii, P., Devan W., Traylor M., Lanfranconi S., Zhang CR, Cloonan L., Falcone GJ, Radmanesh F., Fitzpatrick K., Kanakis A., Rothwell PM, Sudlow C., Boncoraglio GB, Meschia JF, Levi C., Dichgans M., Bevan S., Rosand J., Rost NS, and Markus HS Stroke; a journal of cerebral circulation, 2014/12/30, (2014) Read More / View Supplemental Materials
Abstract
Target-Based Identification of Whole-Cell Active Inhibitors of Biotin Biosynthesis in Mycobacterium tuberculosis.Park, SW, Casalena DE, Wilson DJ, Dai R., Nag PP, Liu F., Boyce JP, Bittker JA, Schreiber SL, Finzel BC, Schnappinger D., and Aldrich CC Chemistry & biology, 2014/12/30, (2014) Read More / View Supplemental Materials
Abstract
Inducible RNAi in vivo reveals that the transcription factor BATF is required to initiate but not maintain CD8+ T-cell effector differentiation.Godec, J., Cowley GS, Barnitz RA, Root DE, Sharpe AH, and Haining WN Proceedings of the National Academy of Sciences of the United States of America, 2014/12/29, (2014) Read More / View Supplemental Materials
Abstract
Title (78 characters): A TREM1 variant alters the accumulation of Alzheimer-related amyloid pathology.Replogle, JM, Chan G., White CC, Raj T., Winn PA, Evans DA, Sperling RA, Chibnik LB, Bradshaw EM, Schneider JA, Bennett DA, and De Jager PL Annals of neurology, 2014/12/26, (2014) Read More / View Supplemental Materials
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Dissecting neural differentiation regulatory networks through epigenetic footprinting.Ziller, MJ, Edri R., Yaffe Y., Donaghey J., Pop R., Mallard W., Issner R., Gifford CA, Goren A., Xing J., Gu H., Cacchiarelli D., Tsankov AM, Epstein C., Rinn JL, Mikkelsen TS, Kohlbacher O., Gnirke A., Bernstein BE, Elkabetz Y., et al. Nature, 2014/12/24, (2014) Read More / View Supplemental Materials
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Genetic analysis of schizophrenia and bipolar disorder reveals polygenicity but also suggests new directions for molecular interrogation.Neale, BM, and Sklar P. Current opinion in neurobiology, 2014/12/24, Volume 30C, p.131-138, (2014) Read More / View Supplemental Materials
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The HLA-DRβ1 amino acid positions 11-13-26 explain the majority of SLE-MHC associations.Kim, K., Bang SY, Lee HS, Okada Y., Han B., Saw WY, Teo YY, and Bae SC Nature communications, 2014/12/23, Volume 5, p.5902, (2014) Read More / View Supplemental Materials
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Systematic identification of signaling pathways with potential to confer anticancer drug resistance.Martz, CA, Ottina KA, Singleton KR, Jasper JS, Wardell SE, Peraza-Penton A., Anderson GR, Winter PS, Wang T., Alley HM, Kwong LN, Cooper ZA, Tetzlaff M., Chen PL, Rathmell JC, Flaherty KT, Wargo JA, McDonnell DP, Sabatini DM, and Wood KC Science signaling, 2014/12/23, Volume 7, Issue 357, p.ra121, (2014) Read More / View Supplemental Materials
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The Genetic Ancestry of African Americans, Latinos, and European Americans across the United States.Bryc, K., Durand EY, Macpherson JM, Reich D., and Mountain JL American journal of human genetics, 2014/12/18, (2014) Read More / View Supplemental Materials
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Genetic Variants Associated with Quantitative Glucose Homeostasis Traits Translate to Type 2 Diabetes in Mexican Americans: The GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium.Palmer, ND, Goodarzi MO, Langefeld CD, Wang N., Guo X., Taylor KD, Fingerlin TE, Norris JM, Buchanan TA, Xiang AH, Haritunians T., Ziegler JT, Williams AH, Stefansovski D., Cui J., Mackay AW, Henkin LF, Bergman RN, Gao X., Gauderman J., et al. Diabetes, 2014/12/18, (2014) Read More / View Supplemental Materials
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X chromosome reactivation dynamics reveal stages of reprogramming to pluripotency.Pasque, V., Tchieu J., Karnik R., Uyeda M., Sadhu Dimashkie A., Case D., Papp B., Bonora G., Patel S., Ho R., Schmidt R., McKee R., Sado T., Tada T., Meissner A., and Plath K. Cell, 2014/12/18, Volume 159, Issue 7, p.1681-97, (2014) Read More / View Supplemental Materials
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Genetic Predisposition to Dyslipidemia and Risk of Preeclampsia.Spracklen, CN, Saftlas AF, Triche EW, Bjonnes A., Keating B., Saxena R., Breheny PJ, Dewan AT, Robinson JG, Hoh J., and Ryckman KK American journal of hypertension, 2014/12/17, (2014) Read More / View Supplemental Materials
Abstract
Katanin p80 Regulates Human Cortical Development by Limiting Centriole and Cilia Number.Hu, WF, Pomp O., Ben-Omran T., Kodani A., Henke K., Mochida GH, Yu TW, Woodworth MB, Bonnard C., Raj GS, Tan TT, Hamamy H., Masri A., Shboul M., Al Saffar M., Partlow JN, Al-Dosari M., Alazami A., Alowain M., Alkuraya FS, et al. Neuron, 2014/12/17, Volume 84, Issue 6, p.1240-57, (2014) Read More / View Supplemental Materials
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The study of psychiatric disease genes and drugs in zebrafish.Haesemeyer, M., and Schier AF Current opinion in neurobiology, 2014/12/16, Volume 30C, p.122-130, (2014) Read More / View Supplemental Materials
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Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma.Perry, JA, Kiezun A., Tonzi P., Van Allen EM, Carter SL, Baca SC, Cowley GS, Bhatt AS, Rheinbay E., Pedamallu CS, Helman E., Taylor-Weiner A., McKenna A., Deluca DS, Lawrence MS, Ambrogio L., Sougnez C., Sivachenko A., Walensky LD, Wagle N., et al. Proceedings of the National Academy of Sciences of the United States of America, 2014/12/15, (2014) Read More / View Supplemental Materials
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Computational Modeling Predicts IL-10 Control of Lesion Sterilization by Balancing Early Host Immunity-Mediated Antimicrobial Responses with Caseation during Mycobacterium tuberculosis Infection.Cilfone, NA, Ford CB, Marino S., Mattila JT, Gideon HP, Flynn JL, Kirschner DE, and Linderman JJ Journal of immunology (Baltimore, Md. : 1950), 2014/12/15, (2014) Read More / View Supplemental Materials
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De novo CNVs in bipolar affective disorder and schizophrenia.Georgieva, L., Rees E., Moran JL, Chambert KD, Milanova V., Craddock N., Purcell S., Sklar P., McCarroll S., Holmans P., O'Donovan MC, Owen MJ, and Kirov G. Human molecular genetics, 2014/12/15, Volume 23, Issue 24, p.6677-83, (2014) Read More / View Supplemental Materials
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Dilazep analogues for the study of equilibrative nucleoside transporters 1 and 2 (ENT1 and ENT2).Playa, H., Lewis TA, Ting A., Suh BC, Muñoz B., Matuza R., Passer BJ, Schreiber SL, and Buolamwini JK Bioorganic & medicinal chemistry letters, 2014/12/15, Volume 24, Issue 24, p.5801-4, (2014) Read More / View Supplemental Materials
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Genetic modifiers of EGFR dependence in non-small cell lung cancer.Sharifnia, T., Rusu V., Piccioni F., Bagul M., Imielinski M., Cherniack AD, Pedamallu CS, Wong B., Wilson FH, Garraway LA, Altshuler D., Golub T. R., Root DE, Subramanian A., and Meyerson M. Proceedings of the National Academy of Sciences of the United States of America, 2014/12/15, (2014) Read More / View Supplemental Materials
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Identification of nuclear hormone receptor pathways causing insulin resistance by transcriptional and epigenomic analysis.Kang, S., Tsai LT, Zhou Y., Evertts A., Xu S., Griffin MJ, Issner R., Whitton HJ, Garcia BA, Epstein CB, Mikkelsen TS, and Rosen ED Nature cell biology, 2014/12/15, (2014) Read More / View Supplemental Materials
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Pan-cancer network analysis identifies combinations of rare somatic mutations across pathways and protein complexes.Leiserson, MD, Vandin F., Wu H., Dobson JR, Eldridge JV, Thomas JL, Papoutsaki A., Kim Y., Niu B., McLellan M., Lawrence MS, Gonzalez-Perez A., Tamborero D., Cheng Y., Ryslik GA, Lopez-Bigas N., Getz G., Ding L., and Raphael BJ Nature genetics, 2014/12/15, (2014) Read More / View Supplemental Materials
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Core and region-enriched networks of behaviorally regulated genes and the singing genome.Whitney, O., Pfenning AR, Howard JT, Blatti CA, Liu F., Ward JM, Wang R., Audet JN, Kellis M., Mukherjee S., Sinha S., Hartemink AJ, West AE, and Jarvis ED Science (New York, N.Y.), 2014/12/12, Volume 346, Issue 6215, p.1256780, (2014) Read More / View Supplemental Materials
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Familial aggregation of arthritis-related diseases in seropositive and seronegative rheumatoid arthritis: a register-based case-control study in Sweden.Frisell, T., Hellgren K., Alfredsson L., Raychaudhuri S., Klareskog L., and Askling J. Annals of the rheumatic diseases, 2014/12/12, (2014) Read More / View Supplemental Materials
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A 3D Map of the Human Genome at Kilobase Resolution Reveals Principles of Chromatin Looping.Rao, SS, Huntley MH, Durand NC, Stamenova EK, Bochkov ID, Robinson JT, Sanborn AL, Machol I., Omer AD, Lander E. S., and Aiden EL Cell, 2014/12/11, (2014) Read More / View Supplemental Materials
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Integrating phenotypic small-molecule profiling and human genetics: the next phase in drug discovery.Johannessen, CM, Clemons PA, and Wagner BK Trends in genetics : TIG, 2014/12/11, (2014) Read More / View Supplemental Materials
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Single Diastereomer of a Macrolactam Core Binds Specifically to Myeloid Cell Leukemia 1 (MCL1).Fang, C., D'Souza B., Thompson CF, Clifton MC, Fairman JW, Fulroth B., Leed A., McCarren P., Wang L., Wang Y., Feau C., Kaushik VK, Palmer M., Wei G., Golub T. R., Hubbard BK, and Serrano-Wu MH ACS medicinal chemistry letters, 2014/12/11, Volume 5, Issue 12, p.1308-12, (2014) Read More / View Supplemental Materials
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Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex.Konermann, S., Brigham MD, Trevino AE, Joung J., Abudayyeh OO, Barcena C., Hsu PD, Habib N., Gootenberg JS, Nishimasu H., Nureki O., and Zhang F. Nature, 2014/12/10, (2014) Read More / View Supplemental Materials
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Genome-wide association study of kidney function decline in individuals of European descent.Gorski, M., Tin A., Garnaas M., McMahon GM, Chu AY, Tayo BO, Pattaro C., Teumer A., Chasman DI, Chalmers J., Hamet P., Tremblay J., Woodward M., Aspelund T., Eiriksdottir G., Gudnason V., Harris TB, Launer LJ, Smith AV, Mitchell BD, et al. Kidney international, 2014/12/10, (2014) Read More / View Supplemental Materials
Abstract
High-Resolution Sequencing and Modeling Identifies Distinct Dynamic RNA Regulatory Strategies.Rabani, M., Raychowdhury R., Jovanovic M., Rooney M., Stumpo DJ, Pauli A., Hacohen N., Schier AF, Blackshear PJ, Friedman N., Amit I., and Regev A. Cell, 2014/12/10, (2014) Read More / View Supplemental Materials
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Visnagin protects against doxorubicin-induced cardiomyopathy through modulation of mitochondrial malate dehydrogenase.Liu, Y., Asnani A., Zou L., Bentley VL, Yu M., Wang Y., Dellaire G., Sarkar KS, Dai M., Chen HH, Sosnovik DE, Shin JT, Haber DA, Berman JN, Chao W., and Peterson RT Science translational medicine, 2014/12/10, Volume 6, Issue 266, p.266ra170, (2014) Read More / View Supplemental Materials
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Recommendations From the International Stroke Genetics Consortium, Part 2: Biological Sample Collection and Storage.Battey, TW, Valant V., Kassis SB, Kourkoulis C., Lee C., Anderson CD, Falcone GJ, Jimenez-Conde J., Fernandez-Cadenas I., Pare G., Rundek T., James ML, Lemmens R., Lee TH, Tatlisumak T., Kittner SJ, Lindgren A., Mateen FJ, Berkowitz AL, Holliday EG, et al. Stroke; a journal of cerebral circulation, 2014/12/09, (2014) Read More / View Supplemental Materials
Locally disordered methylation forms the basis of intratumor methylome variation in chronic lymphocytic leukemia.Landau, DA, Clement K., Ziller MJ, Boyle P., Fan J., Gu H., Stevenson K., Sougnez C., Wang L., Li S., Kotliar D., Zhang W., Ghandi M., Garraway L., Fernandes SM, Livak KJ, Gabriel S., Gnirke A., Lander E. S., Brown JR, et al. Cancer cell, 2014/12/08, Volume 26, Issue 6, p.813-25, (2014) Read More / View Supplemental Materials
Abstract
Metabolomics of renal venous plasma from individuals with unilateral renal artery stenosis and essential hypertension.Rhee, EP, Clish CB, Pierce KA, Saad A., Lerman LO, and Textor SC Journal of hypertension, 2014/12/08, (2014) Read More / View Supplemental Materials
Abstract
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