Publications

Regulated Phosphosignaling Associated with Breast Cancer Subtypes and Druggability.

Huang K-lin, Wu Y, Primeau T, et al. Regulated Phosphosignaling Associated with Breast Cancer Subtypes and Druggability. Mol Cell Proteomics. 2019. doi:10.1074/mcp.RA118.001243.

RNA sequence analysis reveals macroscopic somatic clonal expansion across normal tissues.

Yizhak K, Aguet F, Kim J, et al. RNA sequence analysis reveals macroscopic somatic clonal expansion across normal tissues. Science. 2019;364(6444). doi:10.1126/science.aaw0726.

Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma.

Bandopadhayay P, Piccioni F, O'Rourke R, et al. Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma. Nat Commun. 2019;10(1):2400. doi:10.1038/s41467-019-10307-9.

Growth dynamics in naturally progressing chronic lymphocytic leukaemia.

Gruber M, Bozic I, Leshchiner I, et al. Growth dynamics in naturally progressing chronic lymphocytic leukaemia. Nature. 2019;570(7762):474-479. doi:10.1038/s41586-019-1252-x.

Selenium Deficiency Is Associated with Pro-longevity Mechanisms.

Yim SHee, Clish CB, Gladyshev VN. Selenium Deficiency Is Associated with Pro-longevity Mechanisms. Cell Rep. 2019;27(9):2785-2797.e3. doi:10.1016/j.celrep.2019.05.001.

Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls.

Flannick J, Mercader JM, Fuchsberger C, et al. Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls. Nature. 2019. doi:10.1038/s41586-019-1231-2.

The lncRNA SLNCR Recruits the Androgen Receptor to EGR1-Bound Genes in Melanoma and Inhibits Expression of Tumor Suppressor p21.

Schmidt K, Carroll JS, Yee E, et al. The lncRNA SLNCR Recruits the Androgen Receptor to EGR1-Bound Genes in Melanoma and Inhibits Expression of Tumor Suppressor p21. Cell Rep. 2019;27(8):2493-2507.e4. doi:10.1016/j.celrep.2019.04.101.

Chemical disarming of isoniazid resistance in .

Flentie K, Harrison GA, Tükenmez H, et al. Chemical disarming of isoniazid resistance in . Proc Natl Acad Sci U S A. 2019;116(21):10510-10517. doi:10.1073/pnas.1818009116.

Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors.

Huang TP, Zhao KT, Miller SM, et al. Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors. Nat Biotechnol. 2019. doi:10.1038/s41587-019-0134-y.

Molecular recording of mammalian embryogenesis.

Chan MM, Smith ZD, Grosswendt S, et al. Molecular recording of mammalian embryogenesis. Nature. 2019. doi:10.1038/s41586-019-1184-5.