Publications

STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformation of human cells.

Kim JWook, Berrios C, Kim M, et al. STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformation of human cells. Elife. 2020;9. doi:10.7554/eLife.53003.

Defining the landscape of ATP-competitive inhibitor resistance residues in protein kinases.

Persky NS, Hernandez D, M Carmo D, et al. Defining the landscape of ATP-competitive inhibitor resistance residues in protein kinases. Nat Struct Mol Biol. 2020;27(1):92-104. doi:10.1038/s41594-019-0358-z.

A brief history of human disease genetics.

Claussnitzer M, Cho JH, Collins R, et al. A brief history of human disease genetics. Nature. 2020;577(7789):179-189. doi:10.1038/s41586-019-1879-7.

Ancient West African foragers in the context of African population history.

Lipson M, Ribot I, Mallick S, et al. Ancient West African foragers in the context of African population history. Nature. 2020;577(7792):665-670. doi:10.1038/s41586-020-1929-1.

Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells.

Zhang B, Ma S, Rachmin I, et al. Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells. Nature. 2020;577(7792):676-681. doi:10.1038/s41586-020-1935-3.

Genomic analyses of PMBL reveal new drivers and mechanisms of sensitivity to PD-1 blockade.

Chapuy B, Stewart C, Dunford AJ, et al. Genomic analyses of PMBL reveal new drivers and mechanisms of sensitivity to PD-1 blockade. Blood. 2019;134(26):2369-2382. doi:10.1182/blood.2019002067.

Human Primordial Germ Cells Are Specified from Lineage-Primed Progenitors.

Chen D, Sun N, Hou L, et al. Human Primordial Germ Cells Are Specified from Lineage-Primed Progenitors. Cell Rep. 2019;29(13):4568-4582.e5. doi:10.1016/j.celrep.2019.11.083.

Agreement between two large pan-cancer CRISPR-Cas9 gene dependency data sets.

Dempster JM, Pacini C, Pantel S, et al. Agreement between two large pan-cancer CRISPR-Cas9 gene dependency data sets. Nat Commun. 2019;10(1):5817. doi:10.1038/s41467-019-13805-y.

A large peptidome dataset improves HLA class I epitope prediction across most of the human population.

Sarkizova S, Klaeger S, Le PM, et al. A large peptidome dataset improves HLA class I epitope prediction across most of the human population. Nat Biotechnol. 2019. doi:10.1038/s41587-019-0322-9.

Fibroblastic reticular cells enhance T cell metabolism and survival via epigenetic remodeling.

Brown FD, Sen DR, LaFleur MW, et al. Fibroblastic reticular cells enhance T cell metabolism and survival via epigenetic remodeling. Nat Immunol. 2019;20(12):1668-1680. doi:10.1038/s41590-019-0515-x.