Publications

Programmable mA modification of cellular RNAs with a Cas13-directed methyltransferase.

Wilson C, Chen PJ, Miao Z, Liu DR. Programmable mA modification of cellular RNAs with a Cas13-directed methyltransferase. Nat Biotechnol. 2020. doi:10.1038/s41587-020-0572-6.

Monogenic and polygenic inheritance become instruments for clonal selection.

Loh P-R, Genovese G, McCarroll SA. Monogenic and polygenic inheritance become instruments for clonal selection. Nature. 2020. doi:10.1038/s41586-020-2430-6.

Cholesterol Metabolism by Uncultured Human Gut Bacteria Influences Host Cholesterol Level.

Kenny DJ, Plichta DR, Shungin D, et al. Cholesterol Metabolism by Uncultured Human Gut Bacteria Influences Host Cholesterol Level. Cell Host Microbe. 2020. doi:10.1016/j.chom.2020.05.013.

Determinants of Base Editing Outcomes from Target Library Analysis and Machine Learning.

Arbab M, Shen MW, Mok B, et al. Determinants of Base Editing Outcomes from Target Library Analysis and Machine Learning. Cell. 2020. doi:10.1016/j.cell.2020.05.037.

The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K.

Słabicki M, Kozicka Z, Petzold G, et al. The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K. Nature. 2020. doi:10.1038/s41586-020-2374-x.

Insights into variation in meiosis from 31,228 human sperm genomes.

Bell ADavis, Mello CJ, Nemesh J, Brumbaugh SA, Wysoker A, McCarroll SA. Insights into variation in meiosis from 31,228 human sperm genomes. Nature. 2020. doi:10.1038/s41586-020-2347-0.

The developing toolkit of continuous directed evolution.

Morrison MS, Podracky CJ, Liu DR. The developing toolkit of continuous directed evolution. Nat Chem Biol. 2020;16(6):610-619. doi:10.1038/s41589-020-0532-y.

Distinct mitochondrial defects trigger the integrated stress response depending on the metabolic state of the cell.

Mick E, Titov DV, Skinner OS, Sharma R, Jourdain AA, Mootha VK. Distinct mitochondrial defects trigger the integrated stress response depending on the metabolic state of the cell. Elife. 2020;9. doi:10.7554/eLife.49178.

The effect of LRRK2 loss-of-function variants in humans.

Whiffin N, Armean IM, Kleinman A, et al. The effect of LRRK2 loss-of-function variants in humans. Nat Med. 2020. doi:10.1038/s41591-020-0893-5.

Hepatic NADH reductive stress underlies common variation in metabolic traits.

Goodman RP, Markhard AL, Shah H, et al. Hepatic NADH reductive stress underlies common variation in metabolic traits. Nature. 2020. doi:10.1038/s41586-020-2337-2.