Publications

Multiplexed single-cell transcriptional response profiling to define cancer vulnerabilities and therapeutic mechanism of action.

McFarland JM, Paolella BR, Warren A, et al. Multiplexed single-cell transcriptional response profiling to define cancer vulnerabilities and therapeutic mechanism of action. Nat Commun. 2020;11(1):4296. doi:10.1038/s41467-020-17440-w.

Polygenic background modifies penetrance of monogenic variants for tier 1 genomic conditions.

Fahed AC, Wang M, Homburger JR, et al. Polygenic background modifies penetrance of monogenic variants for tier 1 genomic conditions. Nat Commun. 2020;11(1):3635. doi:10.1038/s41467-020-17374-3.

CITED4 Protects Against Adverse Remodeling in Response to Physiological and Pathological Stress.

Lerchenmüller C, Rabolli CP, Yeri A, et al. CITED4 Protects Against Adverse Remodeling in Response to Physiological and Pathological Stress. Circ Res. 2020;127(5):631-646. doi:10.1161/CIRCRESAHA.119.315881.

Neurogranin, Encoded by the Schizophrenia Risk Gene NRGN, Bidirectionally Modulates Synaptic Plasticity via Calmodulin-Dependent Regulation of the Neuronal Phosphoproteome.

Hwang H, Szucs MJ, Ding LJ, et al. Neurogranin, Encoded by the Schizophrenia Risk Gene NRGN, Bidirectionally Modulates Synaptic Plasticity via Calmodulin-Dependent Regulation of the Neuronal Phosphoproteome. Biol Psychiatry. 2020. doi:10.1016/j.biopsych.2020.07.014.

Multimodal small-molecule screening for human prion protein binders.

Reidenbach AG, Mesleh MF, Casalena D, et al. Multimodal small-molecule screening for human prion protein binders. J Biol Chem. 2020. doi:10.1074/jbc.RA120.014905.

Rapid, deep and precise profiling of the plasma proteome with multi-nanoparticle protein corona.

Blume JE, Manning WC, Troiano G, et al. Rapid, deep and precise profiling of the plasma proteome with multi-nanoparticle protein corona. Nat Commun. 2020;11(1):3662. doi:10.1038/s41467-020-17033-7.

An essential role for cardiolipin in the stability and function of the mitochondrial calcium uniporter.

Ghosh S, Ball WBasu, Madaris TR, et al. An essential role for cardiolipin in the stability and function of the mitochondrial calcium uniporter. Proc Natl Acad Sci U S A. 2020;117(28):16383-16390. doi:10.1073/pnas.2000640117.

Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma.

Gillette MA, Satpathy S, Cao S, et al. Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma. Cell. 2020;182(1):200-225.e35. doi:10.1016/j.cell.2020.06.013.

A bacterial cytidine deaminase toxin enables CRISPR-free mitochondrial base editing.

Mok BY, de Moraes MH, Zeng J, et al. A bacterial cytidine deaminase toxin enables CRISPR-free mitochondrial base editing. Nature. 2020. doi:10.1038/s41586-020-2477-4.

Cell-free biosensors for rapid detection of water contaminants.

Jung JK, Alam KK, Verosloff MS, et al. Cell-free biosensors for rapid detection of water contaminants. Nat Biotechnol. 2020. doi:10.1038/s41587-020-0571-7.