Publications

Growth dynamics in naturally progressing chronic lymphocytic leukaemia.

Gruber M, Bozic I, Leshchiner I, et al. Growth dynamics in naturally progressing chronic lymphocytic leukaemia. Nature. 2019. doi:10.1038/s41586-019-1252-x.

Selenium Deficiency Is Associated with Pro-longevity Mechanisms.

Yim SHee, Clish CB, Gladyshev VN. Selenium Deficiency Is Associated with Pro-longevity Mechanisms. Cell Rep. 2019;27(9):2785-2797.e3. doi:10.1016/j.celrep.2019.05.001.

Mitochondrial metabolism promotes adaptation to proteotoxic stress.

Tsvetkov P, Detappe A, Cai K, et al. Mitochondrial metabolism promotes adaptation to proteotoxic stress. Nat Chem Biol. 2019. doi:10.1038/s41589-019-0291-9.

Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls.

Flannick J, Mercader JM, Fuchsberger C, et al. Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls. Nature. 2019. doi:10.1038/s41586-019-1231-2.

The lncRNA SLNCR Recruits the Androgen Receptor to EGR1-Bound Genes in Melanoma and Inhibits Expression of Tumor Suppressor p21.

Schmidt K, Carroll JS, Yee E, et al. The lncRNA SLNCR Recruits the Androgen Receptor to EGR1-Bound Genes in Melanoma and Inhibits Expression of Tumor Suppressor p21. Cell Rep. 2019;27(8):2493-2507.e4. doi:10.1016/j.celrep.2019.04.101.

Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors.

Huang TP, Zhao KT, Miller SM, et al. Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors. Nat Biotechnol. 2019. doi:10.1038/s41587-019-0134-y.

Molecular recording of mammalian embryogenesis.

Chan MM, Smith ZD, Grosswendt S, et al. Molecular recording of mammalian embryogenesis. Nature. 2019. doi:10.1038/s41586-019-1184-5.

Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme.

Maianti JPablo, Tan GA, Vetere A, et al. Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme. Nat Chem Biol. 2019. doi:10.1038/s41589-019-0271-0.

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Ghandi M, Huang FW, Jané-Valbuena J, et al. Next-generation characterization of the Cancer Cell Line Encyclopedia. Nature. 2019. doi:10.1038/s41586-019-1186-3.

Bacteroides-Derived Sphingolipids Are Critical for Maintaining Intestinal Homeostasis and Symbiosis.

Brown EM, Ke X, Hitchcock D, et al. Bacteroides-Derived Sphingolipids Are Critical for Maintaining Intestinal Homeostasis and Symbiosis. Cell Host Microbe. 2019;25(5):668-680.e7. doi:10.1016/j.chom.2019.04.002.