Publications

Transcriptome variation in human tissues revealed by long-read sequencing.

Glinos DA, Garborcauskas G, Hoffman P, et al. Transcriptome variation in human tissues revealed by long-read sequencing. Nature. 2022. doi:10.1038/s41586-022-05035-y.

Duration of Symptoms and Association With Positive Home Rapid Antigen Test Results After Infection With SARS-CoV-2.

Cosimi LA, Kelly C, Esposito S, et al. Duration of Symptoms and Association With Positive Home Rapid Antigen Test Results After Infection With SARS-CoV-2. JAMA Netw Open. 2022;5(8):e2225331. doi:10.1001/jamanetworkopen.2022.25331.

A first update on mapping the human genetic architecture of COVID-19.

A first update on mapping the human genetic architecture of COVID-19. Nature. 2022;608(7921):E1-E10. doi:10.1038/s41586-022-04826-7.

Huntingtin turnover: modulation of huntingtin degradation by cAMP-dependent protein kinase A (PKA) phosphorylation of C-HEAT domain Ser2550.

Lee Y, Kim H, Barker D, et al. Huntingtin turnover: modulation of huntingtin degradation by cAMP-dependent protein kinase A (PKA) phosphorylation of C-HEAT domain Ser2550. Hum Mol Genet. 2022. doi:10.1093/hmg/ddac165.

Mouse fetal growth restriction through parental and fetal immune gene variation and intercellular communications cascade.

Kaur G, Porter CBM, Ashenberg O, et al. Mouse fetal growth restriction through parental and fetal immune gene variation and intercellular communications cascade. Nat Commun. 2022;13(1):4398. doi:10.1038/s41467-022-32171-w.

Efficient in vivo base editing via single adeno-associated viruses with size-optimized genomes encoding compact adenine base editors.

Davis JR, Wang X, Witte IP, et al. Efficient in vivo base editing via single adeno-associated viruses with size-optimized genomes encoding compact adenine base editors. Nat Biomed Eng. 2022. doi:10.1038/s41551-022-00911-4.

Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment.

Hwang WL, Jagadeesh KA, Guo JA, et al. Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment. Nat Genet. 2022. doi:10.1038/s41588-022-01134-8.

Akkermansia muciniphila phospholipid induces homeostatic immune responses.

Bae M, Cassilly CD, Liu X, et al. Akkermansia muciniphila phospholipid induces homeostatic immune responses. Nature. 2022. doi:10.1038/s41586-022-04985-7.

Declines in prevalence alter the optimal level of sexual investment for the malaria parasite Plasmodium falciparum.

Early AM, Camponovo F, Pelleau S, et al. Declines in prevalence alter the optimal level of sexual investment for the malaria parasite Plasmodium falciparum. Proc Natl Acad Sci U S A. 2022;119(30):e2122165119. doi:10.1073/pnas.2122165119.

Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal HCoVs.

Rebendenne A, Roy P, Bonaventure B, et al. Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal HCoVs. Nat Genet. 2022. doi:10.1038/s41588-022-01110-2.