Publications

Disease stages and therapeutic hypotheses in two decades of neurodegenerative disease clinical trials.

Mortberg MA, Vallabh SM, Minikel EVallabh. Disease stages and therapeutic hypotheses in two decades of neurodegenerative disease clinical trials. Sci Rep. 2022;12(1):17708. doi:10.1038/s41598-022-21820-1.

Transcriptional and functional consequences of alterations to MEF2C and its topological organization in neuronal models.

Mohajeri K, Yadav R, D'haene E, et al. Transcriptional and functional consequences of alterations to MEF2C and its topological organization in neuronal models. Am J Hum Genet. 2022. doi:10.1016/j.ajhg.2022.09.015.

Structure of the OMEGA nickase IsrB in complex with ωRNA and target DNA.

Hirano S, Kappel K, Altae-Tran H, et al. Structure of the OMEGA nickase IsrB in complex with ωRNA and target DNA. Nature. 2022. doi:10.1038/s41586-022-05324-6.

A saturated map of common genetic variants associated with human height.

Yengo L, Vedantam S, Marouli E, et al. A saturated map of common genetic variants associated with human height. Nature. 2022. doi:10.1038/s41586-022-05275-y.

Spatial maps of T cell receptors and transcriptomes reveal distinct immune niches and interactions in the adaptive immune response.

Liu S, J Iorgulescu B, Li S, et al. Spatial maps of T cell receptors and transcriptomes reveal distinct immune niches and interactions in the adaptive immune response. Immunity. 2022;55(10):1940-1952.e5. doi:10.1016/j.immuni.2022.09.002.

The diverse genetic origins of a Classical period Greek army.

Reitsema LJ, Mittnik A, Kyle B, et al. The diverse genetic origins of a Classical period Greek army. Proc Natl Acad Sci U S A. 2022;119(41):e2205272119. doi:10.1073/pnas.2205272119.

Single-cell dissection of the obesity-exercise axis in adipose-muscle tissues implies a critical role for mesenchymal stem cells.

Yang J, Vamvini M, Nigro P, et al. Single-cell dissection of the obesity-exercise axis in adipose-muscle tissues implies a critical role for mesenchymal stem cells. Cell Metab. 2022;34(10):1578-1593.e6. doi:10.1016/j.cmet.2022.09.004.

Multiscale profiling of protease activity in cancer.

Amini AP, Kirkpatrick JD, Wang CS, et al. Multiscale profiling of protease activity in cancer. Nat Commun. 2022;13(1):5745. doi:10.1038/s41467-022-32988-5.

In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer.

Dubrot J, Du PP, Lane-Reticker SKate, et al. In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer. Nat Immunol. 2022;23(10):1495-1506. doi:10.1038/s41590-022-01315-x.

Long-range phasing of dynamic, tissue-specific and allele-specific regulatory elements.

Battaglia S, Dong K, Wu J, et al. Long-range phasing of dynamic, tissue-specific and allele-specific regulatory elements. Nat Genet. 2022;54(10):1504-1513. doi:10.1038/s41588-022-01188-8.