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Rare coding variants in ten genes confer substantial risk for schizophrenia.
Singh T, Poterba T, Curtis D, et al. Rare coding variants in ten genes confer substantial risk for schizophrenia. Nature. 2022;604(7906):509-516. doi:10.1038/s41586-022-04556-w.
TAILS Identifies Candidate Substrates and Biomarkers of ADAMTS7, a Therapeutic Protease Target in Coronary Artery Disease.
MacDonald BT, Keshishian H, Mundorff CC, et al. TAILS Identifies Candidate Substrates and Biomarkers of ADAMTS7, a Therapeutic Protease Target in Coronary Artery Disease. Mol Cell Proteomics. 2022;21(4):100223. doi:10.1016/j.mcpro.2022.100223.
CRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicity.
Joung J, Kirchgatterer PC, Singh A, et al. CRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicity. Nat Commun. 2022;13(1):1606. doi:10.1038/s41467-022-29205-8.
Prevalence of monoclonal gammopathies and clinical outcomes in a high-risk US population screened by mass spectrometry: a multicentre cohort study.
El-Khoury H, Lee DJ, Alberge J-B, et al. Prevalence of monoclonal gammopathies and clinical outcomes in a high-risk US population screened by mass spectrometry: a multicentre cohort study. Lancet Haematol. 2022. doi:10.1016/S2352-3026(22)00069-2.
HLA autoimmune risk alleles restrict the hypervariable region of T cell receptors.
Ishigaki K, Lagattuta KA, Luo Y, James EA, Buckner JH, Raychaudhuri S. HLA autoimmune risk alleles restrict the hypervariable region of T cell receptors. Nat Genet. 2022. doi:10.1038/s41588-022-01032-z.
Systematic identification of biomarker-driven drug combinations to overcome resistance.
Rees MG, Brenan L, Carmo Mdo, et al. Systematic identification of biomarker-driven drug combinations to overcome resistance. Nat Chem Biol. 2022. doi:10.1038/s41589-022-00996-7.
Hepatic IRF3 fuels dysglycemia in obesity through direct regulation of Ppp2r1b.
Patel SJ, Liu N, Piaker S, et al. Hepatic IRF3 fuels dysglycemia in obesity through direct regulation of Ppp2r1b. Sci Transl Med. 2022;14(637):eabh3831. doi:10.1126/scitranslmed.abh3831.
Multiplexed action-outcome representation by striatal striosome-matrix compartments detected with a mouse cost-benefit foraging task.
Bloem B, Huda R, Amemori K-I, et al. Multiplexed action-outcome representation by striatal striosome-matrix compartments detected with a mouse cost-benefit foraging task. Nat Commun. 2022;13(1):1541. doi:10.1038/s41467-022-28983-5.
Screening for modulators of the cellular composition of gut epithelia via organoid models of intestinal stem cell differentiation.
Mead BE, Hattori K, Levy L, et al. Screening for modulators of the cellular composition of gut epithelia via organoid models of intestinal stem cell differentiation. Nat Biomed Eng. 2022. doi:10.1038/s41551-022-00863-9.
A non-dividing cell population with high pyruvate dehydrogenase kinase activity regulates metabolic heterogeneity and tumorigenesis in the intestine.
Sebastián C, Ferrer C, Serra M, et al. A non-dividing cell population with high pyruvate dehydrogenase kinase activity regulates metabolic heterogeneity and tumorigenesis in the intestine. Nat Commun. 2022;13(1):1503. doi:10.1038/s41467-022-29085-y.