Publications

Cohesin mutations alter DNA damage repair and chromatin structure and create therapeutic vulnerabilities in MDS/AML.

Tothova Z, Valton A-L, Gorelov R, et al. Cohesin mutations alter DNA damage repair and chromatin structure and create therapeutic vulnerabilities in MDS/AML. JCI Insight. 2020. doi:10.1172/jci.insight.142149.

The SARS-CoV-2 RNA-protein interactome in infected human cells.

Schmidt N, Lareau CA, Keshishian H, et al. The SARS-CoV-2 RNA-protein interactome in infected human cells. Nat Microbiol. 2020. doi:10.1038/s41564-020-00846-z.

Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q.

Neggers JE, Paolella BR, Asfaw A, et al. Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q. Cell Rep. 2020;33(11):108493. doi:10.1016/j.celrep.2020.108493.

Phylogenetic analysis of SARS-CoV-2 in Boston highlights the impact of superspreading events.

Lemieux JE, Siddle KJ, Shaw BM, et al. Phylogenetic analysis of SARS-CoV-2 in Boston highlights the impact of superspreading events. Science. 2020. doi:10.1126/science.abe3261.

A validated lineage-derived somatic truth data set enables benchmarking in cancer genome analysis.

Shand M, Soto J, Lichtenstein L, et al. A validated lineage-derived somatic truth data set enables benchmarking in cancer genome analysis. Commun Biol. 2020;3(1):744. doi:10.1038/s42003-020-01460-9.

BICRA, a SWI/SNF Complex Member, Is Associated with BAF-Disorder Related Phenotypes in Humans and Model Organisms.

Barish S, Barakat TStefan, Michel BC, et al. BICRA, a SWI/SNF Complex Member, Is Associated with BAF-Disorder Related Phenotypes in Humans and Model Organisms. Am J Hum Genet. 2020;107(6):1096-1112. doi:10.1016/j.ajhg.2020.11.003.

Genetic ancestry contributes to somatic mutations in lung cancers from admixed Latin American populations.

Carrot-Zhang J, Soca-Chafre G, Patterson N, et al. Genetic ancestry contributes to somatic mutations in lung cancers from admixed Latin American populations. Cancer Discov. 2020. doi:10.1158/2159-8290.CD-20-1165.

Improving the trans-ancestry portability of polygenic risk scores by prioritizing variants in predicted cell-type-specific regulatory elements.

Amariuta T, Ishigaki K, Sugishita H, et al. Improving the trans-ancestry portability of polygenic risk scores by prioritizing variants in predicted cell-type-specific regulatory elements. Nat Genet. 2020;52(12):1346-1354. doi:10.1038/s41588-020-00740-8.

Aneuploidy increases resistance to chemotherapeutics by antagonizing cell division.

Replogle JMichael, Zhou W, Amaro AE, et al. Aneuploidy increases resistance to chemotherapeutics by antagonizing cell division. Proc Natl Acad Sci U S A. 2020;117(48):30566-30576. doi:10.1073/pnas.2009506117.

Avant-garde: an automated data-driven DIA data curation tool.

Jacome ASebastian, Peckner R, Shulman N, et al. Avant-garde: an automated data-driven DIA data curation tool. Nat Methods. 2020;17(12):1237-1244. doi:10.1038/s41592-020-00986-4.