Publications

Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection.

Li B, Clohisey SM, Chia BShao, et al. Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection. Nat Commun. 2020;11(1):164. doi:10.1038/s41467-019-13965-x.

Defining the landscape of ATP-competitive inhibitor resistance residues in protein kinases.

Persky NS, Hernandez D, M Carmo D, et al. Defining the landscape of ATP-competitive inhibitor resistance residues in protein kinases. Nat Struct Mol Biol. 2020;27(1):92-104. doi:10.1038/s41594-019-0358-z.

A brief history of human disease genetics.

Claussnitzer M, Cho JH, Collins R, et al. A brief history of human disease genetics. Nature. 2020;577(7789):179-189. doi:10.1038/s41586-019-1879-7.

Human Primordial Germ Cells Are Specified from Lineage-Primed Progenitors.

Chen D, Sun N, Hou L, et al. Human Primordial Germ Cells Are Specified from Lineage-Primed Progenitors. Cell Rep. 2019;29(13):4568-4582.e5. doi:10.1016/j.celrep.2019.11.083.

A large peptidome dataset improves HLA class I epitope prediction across most of the human population.

Sarkizova S, Klaeger S, Le PM, et al. A large peptidome dataset improves HLA class I epitope prediction across most of the human population. Nat Biotechnol. 2019. doi:10.1038/s41587-019-0322-9.

TCR sequencing paired with massively parallel 3' RNA-seq reveals clonotypic T cell signatures.

Tu AA, Gierahn TM, Monian B, et al. TCR sequencing paired with massively parallel 3' RNA-seq reveals clonotypic T cell signatures. Nat Immunol. 2019;20(12):1692-1699. doi:10.1038/s41590-019-0544-5.

Fibroblastic reticular cells enhance T cell metabolism and survival via epigenetic remodeling.

Brown FD, Sen DR, LaFleur MW, et al. Fibroblastic reticular cells enhance T cell metabolism and survival via epigenetic remodeling. Nat Immunol. 2019;20(12):1668-1680. doi:10.1038/s41590-019-0515-x.

Integrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanoma.

Liu D, Schilling B, Liu D, et al. Integrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanoma. Nat Med. 2019;25(12):1916-1927. doi:10.1038/s41591-019-0654-5.

The History of Farm Foxes Undermines the Animal Domestication Syndrome.

Lord KA, Larson G, Coppinger RP, Karlsson EK. The History of Farm Foxes Undermines the Animal Domestication Syndrome. Trends Ecol Evol. 2019. doi:10.1016/j.tree.2019.10.011.

Recurrent SMARCB1 Mutations Reveal a Nucleosome Acidic Patch Interaction Site That Potentiates mSWI/SNF Complex Chromatin Remodeling.

Valencia AM, Collings CK, Dao HT, et al. Recurrent SMARCB1 Mutations Reveal a Nucleosome Acidic Patch Interaction Site That Potentiates mSWI/SNF Complex Chromatin Remodeling. Cell. 2019;179(6):1342-1356.e23. doi:10.1016/j.cell.2019.10.044.