Publications

Single-nucleus profiling of human dilated and hypertrophic cardiomyopathy.

Chaffin M, Papangeli I, Simonson B, et al. Single-nucleus profiling of human dilated and hypertrophic cardiomyopathy. Nature. 2022. doi:10.1038/s41586-022-04817-8.

Genome-wide mapping of somatic mutation rates uncovers drivers of cancer.

Sherman MA, Yaari AU, Priebe O, Dietlein F, Loh P-R, Berger B. Genome-wide mapping of somatic mutation rates uncovers drivers of cancer. Nat Biotechnol. 2022. doi:10.1038/s41587-022-01353-8.

Granzyme K CD8 T cells form a core population in inflamed human tissue.

A Jonsson H, Zhang F, Dunlap G, et al. Granzyme K CD8 T cells form a core population in inflamed human tissue. Sci Transl Med. 2022;14(649):eabo0686. doi:10.1126/scitranslmed.abo0686.

Genetic subtypes of smoldering multiple myeloma are associated with distinct pathogenic phenotypes and clinical outcomes.

Bustoros M, Anand S, Sklavenitis-Pistofidis R, et al. Genetic subtypes of smoldering multiple myeloma are associated with distinct pathogenic phenotypes and clinical outcomes. Nat Commun. 2022;13(1):3449. doi:10.1038/s41467-022-30694-w.

YAP1 maintains active chromatin state in head and neck squamous cell carcinomas that promotes tumorigenesis through cooperation with BRD4.

Chen N, Golczer G, Ghose S, et al. YAP1 maintains active chromatin state in head and neck squamous cell carcinomas that promotes tumorigenesis through cooperation with BRD4. Cell Rep. 2022;39(11):110970. doi:10.1016/j.celrep.2022.110970.

Genetic analysis of right heart structure and function in 40,000 people.

Pirruccello JP, Di Achille P, Nauffal V, et al. Genetic analysis of right heart structure and function in 40,000 people. Nat Genet. 2022;54(6):792-803. doi:10.1038/s41588-022-01090-3.

Allelic imbalance of chromatin accessibility in cancer identifies candidate causal risk variants and their mechanisms.

Grishin D, Gusev A. Allelic imbalance of chromatin accessibility in cancer identifies candidate causal risk variants and their mechanisms. Nat Genet. 2022;54(6):837-849. doi:10.1038/s41588-022-01075-2.

Early introduction and rise of the Omicron SARS-CoV-2 variant in highly vaccinated university populations.

Petros BA, Turcinovic J, Welch NL, et al. Early introduction and rise of the Omicron SARS-CoV-2 variant in highly vaccinated university populations. Clin Infect Dis. 2022. doi:10.1093/cid/ciac413.

Rare and Common Genetic Variation Underlying the Risk of Hypertrophic Cardiomyopathy in a National Biobank.

Biddinger KJ, Jurgens SJ, Maamari D, et al. Rare and Common Genetic Variation Underlying the Risk of Hypertrophic Cardiomyopathy in a National Biobank. JAMA Cardiol. 2022. doi:10.1001/jamacardio.2022.1061.

Non-rapid eye movement sleep and wake neurophysiology in schizophrenia.

Kozhemiako N, Wang J, Jiang C, et al. Non-rapid eye movement sleep and wake neurophysiology in schizophrenia. Elife. 2022;11. doi:10.7554/eLife.76211.