Publications

High-Throughput Neutralization and Serology Assays Reveal Correlated but Highly Variable Humoral Immune Responses in a Large Population of Individuals Infected with SARS-CoV-2 in the US between March and August 2020.

Zhang S, Ma P, Orzechowski M, et al. High-Throughput Neutralization and Serology Assays Reveal Correlated but Highly Variable Humoral Immune Responses in a Large Population of Individuals Infected with SARS-CoV-2 in the US between March and August 2020. mBio. 2023:e0352322. doi:10.1128/mbio.03523-22.DOI Google Scholar PubMed

Discovery and characterization of orally bioavailable 4-chloro-6-fluoroisophthalamides as covalent PPARG inverse-agonists.

Orsi D, Ferrara S, Siegel S, et al. Discovery and characterization of orally bioavailable 4-chloro-6-fluoroisophthalamides as covalent PPARG inverse-agonists. Bioorganic & medicinal chemistry. 2023;78:117130. doi:10.1016/j.bmc.2022.117130.DOI Google Scholar PubMed

Delineation of functionally essential protein regions for 242 neurodevelopmental genes.

Iqbal S, Brünger T, Pérez-Palma E, et al. Delineation of functionally essential protein regions for 242 neurodevelopmental genes. Brain : a journal of neurology. 2023;146(2):519-533. doi:10.1093/brain/awac381.DOI Google Scholar PubMed

BMI-adjusted adipose tissue volumes exhibit depot-specific and divergent associations with cardiometabolic diseases.

Agrawal S, Klarqvist M, Diamant N, et al. BMI-adjusted adipose tissue volumes exhibit depot-specific and divergent associations with cardiometabolic diseases. Nature communications. 2023;14(1):266. doi:10.1038/s41467-022-35704-5.DOI Google Scholar PubMed

The ETS transcription factor ETV6 constrains the transcriptional activity of EWS-FLI to promote Ewing sarcoma.

Lu D, Ellegast J, Ross K, et al. The ETS transcription factor ETV6 constrains the transcriptional activity of EWS-FLI to promote Ewing sarcoma. Nature cell biology. 2023. doi:10.1038/s41556-022-01059-8.DOI Google Scholar PubMed

Astrocytic cell adhesion genes linked to schizophrenia correlate with synaptic programs in neurons.

Pietiläinen O, Trehan A, Meyer D, et al. Astrocytic cell adhesion genes linked to schizophrenia correlate with synaptic programs in neurons. Cell reports. 2023;42(1):111988. doi:10.1016/j.celrep.2022.111988.DOI Google Scholar PubMed

Combined PD-1, BRAF and MEK inhibition in BRAF colorectal cancer: a phase 2 trial.

Tian J. Combined PD-1, BRAF and MEK inhibition in BRAF colorectal cancer: a phase 2 trial. Nature medicine. 2023. doi:10.1038/s41591-022-02181-8.DOI Google Scholar PubMed

Integrative in situ mapping of single-cell transcriptional states and tissue histopathology in a mouse model of Alzheimer's disease.

Zeng H, Huang J, Zhou H, et al. Integrative in situ mapping of single-cell transcriptional states and tissue histopathology in a mouse model of Alzheimer's disease. Nature neuroscience. 2023. doi:10.1038/s41593-022-01251-x.DOI Google Scholar PubMed

The landscape of immune dysregulation in Crohn's disease revealed through single-cell transcriptomic profiling in the ileum and colon.

Kong L, Pokatayev V, Lefkovith A, et al. The landscape of immune dysregulation in Crohn's disease revealed through single-cell transcriptomic profiling in the ileum and colon. Immunity. 2023. doi:10.1016/j.immuni.2023.01.002.DOI Google Scholar PubMed

Targeting TBK1 to overcome resistance to cancer immunotherapy.

Sun Y, Revach O-Y, Anderson S, et al. Targeting TBK1 to overcome resistance to cancer immunotherapy. Nature. 2023. doi:10.1038/s41586-023-05704-6.DOI Google Scholar PubMed