Publications

High-throughput continuous evolution of compact Cas9 variants targeting single-nucleotide-pyrimidine PAMs.

Huang TP, Heins ZJ, Miller SM, et al. High-throughput continuous evolution of compact Cas9 variants targeting single-nucleotide-pyrimidine PAMs. Nat Biotechnol. 2022. doi:10.1038/s41587-022-01410-2.

Molecular convergence between Down syndrome and fragile X syndrome identified using human pluripotent stem cell models.

Susco SG, Ghosh S, Mazzucato P, et al. Molecular convergence between Down syndrome and fragile X syndrome identified using human pluripotent stem cell models. Cell Rep. 2022;40(10):111312. doi:10.1016/j.celrep.2022.111312.

Methionine metabolism controls the B cell EBV epigenome and viral latency.

Guo R, Liang JHua, Zhang Y, et al. Methionine metabolism controls the B cell EBV epigenome and viral latency. Cell Metab. 2022;34(9):1280-1297.e9. doi:10.1016/j.cmet.2022.08.008.

High-coverage whole-genome sequencing of the expanded 1000 Genomes Project cohort including 602 trios.

Byrska-Bishop M, Evani US, Zhao X, et al. High-coverage whole-genome sequencing of the expanded 1000 Genomes Project cohort including 602 trios. Cell. 2022;185(18):3426-3440.e19. doi:10.1016/j.cell.2022.08.004.

Genetic structure correlates with ethnolinguistic diversity in eastern and southern Africa.

Atkinson EG, Dalvie S, Pichkar Y, et al. Genetic structure correlates with ethnolinguistic diversity in eastern and southern Africa. Am J Hum Genet. 2022;109(9):1667-1679. doi:10.1016/j.ajhg.2022.07.013.

Cell type-specific inference of differential expression in spatial transcriptomics.

Cable DM, Murray E, Shanmugam V, et al. Cell type-specific inference of differential expression in spatial transcriptomics. Nat Methods. 2022. doi:10.1038/s41592-022-01575-3.

Virtual screening for small-molecule pathway regulators by image-profile matching.

Rohban MH, Fuller AM, Tan C, et al. Virtual screening for small-molecule pathway regulators by image-profile matching. Cell Syst. 2022. doi:10.1016/j.cels.2022.08.003.

Single-cell profiling of environmental enteropathy reveals signatures of epithelial remodeling and immune activation.

Kummerlowe C, Mwakamui S, Hughes TK, et al. Single-cell profiling of environmental enteropathy reveals signatures of epithelial remodeling and immune activation. Sci Transl Med. 2022;14(660):eabi8633. doi:10.1126/scitranslmed.abi8633.

High-resolution profiling of lung adenocarcinoma identifies expression subtypes with specific biomarkers and clinically relevant vulnerabilities.

Roh W, Geffen Y, Cha H, et al. High-resolution profiling of lung adenocarcinoma identifies expression subtypes with specific biomarkers and clinically relevant vulnerabilities. Cancer Res. 2022. doi:10.1158/0008-5472.CAN-22-0432.

Large-scale sequencing identifies multiple genes and rare variants associated with Crohn's disease susceptibility.

Sazonovs A, Stevens CR, Venkataraman GR, et al. Large-scale sequencing identifies multiple genes and rare variants associated with Crohn's disease susceptibility. Nat Genet. 2022. doi:10.1038/s41588-022-01156-2.