Publications

Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition.

Wong GS, Zhou J, Bin Liu J, et al. Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition. Nat Med. 2018. doi:10.1038/s41591-018-0022-x.

Interrogation of Mammalian Protein Complex Structure, Function, and Membership Using Genome-Scale Fitness Screens.

Pan J, Meyers RM, Michel BC, et al. Interrogation of Mammalian Protein Complex Structure, Function, and Membership Using Genome-Scale Fitness Screens. Cell Syst. 2018;6(5):555-568.e7. doi:10.1016/j.cels.2018.04.011.

Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models.

Ng SY, Yoshida N, Christie AL, et al. Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models. Nat Commun. 2018;9(1):2024. doi:10.1038/s41467-018-04356-9.

Anti-apoptotic Protein BIRC5 Maintains Survival of HIV-1-Infected CD4 T Cells.

Kuo H-H, Ahmad R, Lee GQ, et al. Anti-apoptotic Protein BIRC5 Maintains Survival of HIV-1-Infected CD4 T Cells. Immunity. 2018. doi:10.1016/j.immuni.2018.04.004.

A Convergence-Based Framework for Cancer Drug Resistance.

Konieczkowski DJ, Johannessen CM, Garraway LA. A Convergence-Based Framework for Cancer Drug Resistance. Cancer Cell. 2018;33(5):801-815. doi:10.1016/j.ccell.2018.03.025.

Discovery of proteins associated with a predefined genomic locus via dCas9-APEX-mediated proximity labeling.

Myers SA, Wright J, Peckner R, Kalish BT, Zhang F, Carr SA. Discovery of proteins associated with a predefined genomic locus via dCas9-APEX-mediated proximity labeling. Nat Methods. 2018. doi:10.1038/s41592-018-0007-1.

Specter: linear deconvolution for targeted analysis of data-independent acquisition mass spectrometry proteomics.

Peckner R, Myers SA, Jacome ASebastian, et al. Specter: linear deconvolution for targeted analysis of data-independent acquisition mass spectrometry proteomics. Nat Methods. 2018;15(5):371-378. doi:10.1038/nmeth.4643.

Distinct mutational signatures characterize concurrent loss of polymerase proofreading and mismatch repair.

Haradhvala NJ, Kim J, Maruvka YE, et al. Distinct mutational signatures characterize concurrent loss of polymerase proofreading and mismatch repair. Nat Commun. 2018;9(1):1746. doi:10.1038/s41467-018-04002-4.

Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes.

Chapuy B, Stewart C, Dunford AJ, et al. Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes. Nat Med. 2018;24(5):679-690. doi:10.1038/s41591-018-0016-8.

Distinguishing postpartum and antepartum depressive trajectories in a large population-based cohort: the impact of exposure to adversity and offspring gender.

Denckla CA, Mancini AD, Consedine NS, et al. Distinguishing postpartum and antepartum depressive trajectories in a large population-based cohort: the impact of exposure to adversity and offspring gender. Psychol Med. 2018;48(7):1139-1147. doi:10.1017/S0033291717002549.